The Özbudak Lab is looking for a postdoctoral fellow interested in combining interdisciplinary approaches to discover systems-level mechanisms governing spatiotemporal pattern formation during embryonic development.
Despite unavoidable heterogeneity in gene expression, embryonic development is robust and reproducible, which necessitates several mechanisms buffering stochastic gene expression. A striking example of robust spatiotemporal patterning is the rhythmic segmentation of somites, which are precursors of the vertebral column. Segmentation of somites is controlled by: 1) oscillatory expression of Hes/Her gene family, known as the vertebrate segmentation clock, 2) short-distance Notch signaling, and 3) long-distance Fgf and Wnt signaling gradients. Errors in this regulatory cascade result in various birth defects.
We combine single-cell microscopy measurements, time-resolved perturbation experiments, biophysical modeling and computational simulations to decipher the mechanism underlying robust spatiotemporal pattern formation and cell fate determination.
Relevant publications: Nature 2021 589:431-436; Cell Reports 2018 24:66-78; Cell Reports 2018 23:2175-2185.
Interested candidate must have a PhD and have a strong record of accomplishments and experience in:
1- Genetics, developmental biology, microscopy, and image analysis; OR
2- Mathematical and computational modeling, or theoretical physics
Please send a cover letter detailing your research accomplishments and future research goals, and your CV by email to: Ertugrul.Ozbudak@cchmc.org