The Chuong lab seeks a highly motivated Research Associate to study the epigenetic basis of tissue patterns.
Our postdoc will study the epigenetic basis of skin regional specificity, using the feather model which shows distinct regional phenotypes. Both epidermal stem cells and dermal papilla are studied.
Areas of interest:
1) How region-specific feather morphologies are made (Chang et al. The Making of a Flight Feather Cell 179: 1409, 2019). Various feather types derived from epidermal stem cells provide a great opportunity to study the molecular control of functional forms.
2) Region-specific regulation of keratin gene cluster in keratinocytes (Liang et al. Folding Keratin Gene Clusters during Skin Regional Specification Dev. Cell 561, 2020). Explore how high order chromatin configurations can regulate the beta-keratin gene cluster (members of epidermal differentiation complex) to generate complexity.
3) Dermal control. Body wide dermal codes are mapped with RNA-seq, ATAC-seq, scRNA seq, and methylome analyses. Candidate molecule roles are mapped and functionally tested by lentivirus-mediated gene mis-expression, promoter-reporter, high order chromatin technology, etc.
Contact information: Please send a curriculum vitae, personal statement on research and 3 references to Dr. Chuong (firstname.lastname@example.org).