Division of Molecular and Cellular Biology (DMCB) is seeking a highly motivated postdoctoral fellow to study the genetics of tissue aging.
Tissue homeostasis requires a precise balance between the production of new cells and the elimination of old or damaged cells. The midgut of the fly Drosophila melanogaster is an important and well-studied model system for understanding tissue homeostasis during aging, and it shows many similarities to the human intestine. The project will incorporate a range of experimental cell biological, bioinformatics, genetics and biochemical approaches to advance our understanding how organism’s genetic information contributes to its aging. We aim to unravel the underlying linkages between age-related changes in gene expression within the intestine and physiological decline of this organ. The long-term goal of these studies is to identify genomic elements whose controlled modulations would allow maintenance of healthy and functional intestine throughout fly’s life, allowing application of this knowledge toward analysis of mammalian intestinal tissue homeostasis and its disruption during disease.
The DMCB is a vibrant, multi-disciplinary community of biologists studying many aspects of molecular, cellular and developmental biology. The NICHD Intramural Program offers a wide variety of training opportunities, excellent core support and access to the diverse array of biomedical studies within the NIH Bethesda campus.
Skills and Qualification:
To apply, please email CV, summary of research interests and three letters of reference to Alexei Arnaoutov (firstname.lastname@example.org) or Mary Dasso (email@example.com).
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