Sex lethal
Abaza, I., Coll, O., Patalano, S. and Gebauer, F. (2006). Drosophila UNR is required for translational repression of male-specific-lethal 2 mRNA during regulation of X-chromosome dosage compensation. Genes Dev. 20: 380-389. PubMed ID: 16452509
An, W. and Wensink, P.D. (1995). Integrating sex- and tissue-specific regulation within a single Drosophila enhancer. Genes Dev 9: 256-266. PubMed ID: 7851798
Avila, F. W. and Erickson, J. W. (2007). Drosophila JAK/STAT pathway reveals distinct initiation and reinforcement steps in early transcription of Sxl. Curr. Biol. 17: 643-648. PubMed ID: 17363251
Barbash, D. A. and Cline, T. W. (1995). Genetic and molecular analysis of the autosomal component of the primary sex determination signal of Drosophila melanogaster. Genetics 141(4): 1451-71. PubMed ID: 8601486
Bashaw, G. J. and Baker, B. S., (1995). The msl-2 dosage compensation gene of Drosophila encodes a putative DNA-binding protein whose expression is sex specifically regulated by Sex-lethal. Development 121: 3245-3258. PubMed ID: 7588059
Bashaw, G. J. and Baker, B. S. (1997). The regulation of Drosophila msl-2 gene reveals a function for Sex-lethal in translational control. Cell 89: 789-798. PubMed ID: 9182767
Beckmann, K., et al. (2005). A dual inhibitory mechanism restricts msl-2 mRNA translation for dosage compensation in Drosophila. Cell 122: 529-540. PubMed ID: 16122421
Bell, L. R., et al. (1988). Sex-lethal, a Drosophila sex determination switch gene, exhibits sex-specific RNA splicing and sequence similarity to RNA binding proteins. Cell 55: 1037-1046. PubMed ID: 3144435
Bernstein, M. and Cline, T. W. (1994). Differential effects of Sex-lethal mutations on dosage compensation early in Drosophila development. Genetics 136: 1051-61. PubMed ID: 8005414
Bhadra, U., Pal-Bhadra, M. and Birchler, J. A. (2000). Histone acetylation and gene expression analysis of Sex lethal mutants in Drosophila. Genetics 155: 753-763. PubMed ID: 10835396
Bhaskar, P. K., Southard, S., Baxter, K. and Van Doren, M. (2022). Germline sex determination regulates sex-specific signaling between germline stem cells and their niche. Cell Rep 39(1): 110620. PubMed ID: 35385723
Bhattacharya, A., et al. (1999). flex, an X-linked female-lethal mutation in Drosophila melanogaster controls the expression of Sex-lethal. Development 126: 5485-5493. PubMed ID: 10556072
Bopp, D., et al. (1993). Expression of the Sex-lethal gene is controlled at multiple levels during Drosophila oogenesis. Development 118: 797-812. PubMed ID: 8076518
Bopp, D., et al. (1996). Sex-specific control of Sex-lethal is a conserved mechanism for sex determination in the genus Drosophila. Development 122: 971-982. PubMed ID: 8631274
Bopp, D., et al. (1999). Recombination and disjunction in female germ cells of Drosophila depend on the germline activity of the gene Sex-lethal. Development 126: 5785-5794. PubMed ID: 10572053
Chaouki, A. S. and Salz, H. K. (2006). Drosophila SPF45: A bifunctional protein with roles in both splicing and DNA repair. PLoS Genet. 2(12): e178. PubMed ID: 17154718
Chau, J., Kulnane, L. S. and Salz, H. K. (2009). Sex-lethal facilitates the transition from germline stem cell to committed daughter cell in the Drosophila ovary. Genetics 182(1): 121-32. PubMed ID: 19237687
Chau, J., Kulnane, L. S. and Salz, H. K. (2012). Sex-lethal enables germline stem cell differentiation by down-regulating Nanos protein levels during Drosophila oogenesis. Proc Natl Acad Sci U S A 109: 9465-9470. PubMed ID: 22645327
Cline, T. W., et al. (1999). Functioning of the Drosophila integral U1/U2 protein Snf independent of U1 and U2 small nuclear ribonucleoprotein particles is revealed by snf+ gene dose effects. Proc. Natl. Acad. Sci. 96(25): 14451-8. PubMed ID: 10588726
Colonnetta, M. M., Lym, L. R., Wilkins, L., Kappes, G., Castro, E. A., Ryder, P. V., Schedl, P., Lerit, D. A. and Deshpande, G. (2021). Antagonism between germ cell-less and Torso receptor regulates transcriptional quiescence underlying germline/soma distinction. Elife 10. PubMed ID: 33459591
Deckert, J., et al. (2006). Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions. Mol. Cell. Biol. 26: 5528-5543. PubMed ID: 16809785
Deshpande, G., Samuels, M. E. and Schedl, P. D. (1996). Sex-lethal interacts with splicing factors in vitro and in vivo. Mol. Cell. Biol. 16: 5036-5047. PubMed ID: 8756662
Deshpande, G., Calhoun, G. and Schedl, P. D. (1999). The N-terminal domain of Sxl protein disrupts Sxl autoregulation in females and promotes female-specific splicing of tra in males. Development 126: 2841-2853. PubMed ID: 10357929
Deshpande, G., et al. (2005). Nanos downregulates transcription and modulates CTD phosphorylation in the soma of early Drosophila embryos. Mech. Dev. 122(5): 645-57. PubMed ID: 15817222
Duncan, K., et al. (2006). Sex-lethal imparts a sex-specific function to UNR by recruiting it to the msl-2 mRNA 3' UTR: translational repression for dosage compensation. Genes Dev. 20: 368-379. PubMed ID: 16452508
Erickson, J. W. and Cline, T. W. (1993). A bZIP protein, sisterless-a, collaborates with bHLH transcription factors early in Drosophila development to determine sex. Genes Dev 7: 1688-702. PubMed ID: 8370520
Erickson, J. W., Cline, T. W. (1998). Key aspects of the primary sex determination mechanism are conserved across the genus Drosophila. Development 125(16): 3259-3268. PubMed ID: 9671597
Estes, P. A., Keyes, L. N. and Schedl, P. (1995). Multiple response elements in the Sex-lethal early promoter ensure its female-specific expression pattern. Mol Cell Biol 15: 904-917. PubMed ID: 7823955
Evans, D. S. and Cline, T. W. (2007). Drosophila melanogaster male somatic cells feminized solely by TraF can collaborate with female germ cells to make functional eggs. Genetics 175: 631-642. PubMed ID: 17110478
Evans, D. S. and Cline, T. W. (2013). Drosophila switch gene Sex-lethal can bypass its switch-gene target transformer to regulate aspects of female behavior. Proc Natl Acad Sci U S A. PubMed ID: 24191002
Flickinger, T. W. and Salz, H. K. (1994). The Drosophila sex determination gene snf encodes a nuclear protein with sequence and functional similarity to the mammalian U1A snRNP protein. Genes Dev. 8: 914-925. PubMed ID: 7926776
Gawande, B., Robida, M. D., Rahn, A. and Singh, R. (2006) Drosophila Sex-lethal protein mediates polyadenylation switching in the female germline. EMBO J. 25(6): 1263-72. PubMed ID: 16511567
Gebauer, F., et al. (1998). The Drosophila splicing regulator Sex-lethal directly inhibits translation of Male-specific-lethal 2 mRNA. RNA 4(2): 142-50. PubMed ID: 9570314
Gebauer, F., et al. (1999). Translational control of dosage compensation in Drosophila by Sex-lethal: cooperative silencing via the 5' and 3' UTRs of msl-2 mRNA is independent of the poly(A) tail. EMBO J. 18: 6146-6154. PubMed ID: 10545124
Gebauer, F., Grskovic, M. and Hentze, M. W. (2003). Drosophila Sex-lethal inhibits the stable association of the 40S ribosomal subunit with msl-2 mRNA. Molec. Cell 11: 1397-1404. PubMed ID: 12769862
González, A. N., Lu, H., Erickson, J. W. (2008). A shared enhancer controls a temporal switch between promoters during Drosophila primary sex determination. Proc. Natl. Acad. Sci. 105(47): 18436-41. PubMed ID: 19011108
Gorman, M. Kuroda, M. I. and Baker, B. S. (1993). Regulation of the sex-specific binding of the maleless dosage compensation protein to the male X chromosome in Drosophila. Cell 72: 39-49. PubMed ID: 8422681
Graham, P. L., Yanowitz, J. L., Penn, J. K., Deshpande, G. and Schedl, P. (2011). The translation initiation factor eIF4E regulates the sex-specific expression of the master switch gene Sxl in Drosophila melanogaster. PLoS Genet. 7(7): e1002185. PubMed ID: 21829374
Granadino, B., Santamaria, P. and Sanchez, L. (1993). Sex determination in the germ line of Drosophila melanogaster: activation of the gene Sex-lethal. Development 118: 813-816. PubMed ID: 8076519
Granadino, B., et al. (1997). Distinct mechanisms of splicing regulation in vivo by the Drosophila protein sex-lethal. Proc. Natl. Acad. Sci. 94(14): 7343-7348. PubMed ID: 9207093
Grskovic, M., Hentze, M. W. and Gebauer, F. (2003). A co-repressor assembly nucleated by Sex-lethal in the 3'UTR mediates translational control of Drosophila msl-2 mRNA. EMBO J. 22: 5571-5581. PubMed ID: 14532129
Haag, E. S. and Doty, A. V. (2005). Sex determination across evolution: connecting the dots. PLoS Biol. 3(1): e21. PubMed ID: 15660158
Hager, J. H. and Cline, T. W. (1997). Induction of female Sex-lethal RNA splicing in male germ cells: implications for Drosophila germline sex determination. Development 124(24): 5033-5048
Handa, N., et al. (1999). Structural basis for recognition of the tra mRNA precursor by the Sex-lethal protein. Nature 398(6728): 579-85. PubMed ID: 10217141
Hashiyama, K., Hayashi, Y. and Kobayashi, S. (2011). Drosophila Sex lethal gene initiates female development in germline progenitors. Science 333(6044): 885-8. PubMed ID: 21737698
Haussmann, I. U., Bodi, Z., Sanchez-Moran, E., Mongan, N. P., Archer, N., Fray, R. G. and Soller, M. (2016). m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination. Nature 540(7632): 301-304. PubMed ID: 27919081
Haussmann, I. U., Bodi, Z., Sanchez-Moran, E., Mongan, N. P., Archer, N., Fray, R. G. and Soller, M. (2016). m(6)A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination. Nature 540(7632): 301-304. PubMed ID: 27919081
Hennig, J., Militti, C., Popowicz, G. M., Wang, I., Sonntag, M., Geerlof, A., Gabel, F., Gebauer, F., Sattler, M. (2014) Structural basis for the assembly of the Sxl-Unr translation regulatory complex. Nature. PubMed ID: 25209665
Hilfiker, A., et al. (1995). The gene virilizer is required for female-specific splicing controlled by Sxl, the master gene for sexual development in Drosophila. Development 121: 4017-4026. PubMed ID: 8575302
Hillman, M. A. and Gecz, J. (2001). Fragile XE-associated familial mental retardation protein 2 (FMR2) acts as a potent transcription activator. J. Hum. Genet. 46: 251-259. PubMed ID: 11355014
Horabin, J. I. and Schedl, P. (1993a). Regulated splicing of the Drosophila sex-lethal male exon involves a blockage mechanism. Mol. Cell. Biol. 13: 1408-14. PubMed ID: 8441386
Horabin, J. I. and Schedl, P. (1993b). Sex-lethal autoregulation requires multiple cis-acting elements upstream and downstream of the male exon and appears to depend largely on controlling the use of the male exon 5' splice site. Mol Cell Biol 13: 7734-46. PubMed ID: 8246990
Horabin, J. I., Walthall, S., Vied, C. and Moses, M. (2003). A positive role for Patched in Hedgehog signaling revealed by the intracellular trafficking of Sex-lethal, the Drosophila sex determination master switch. Development 130: 6101-6109. PubMed ID: 14597576
Horabin, J. I. (2005). Splitting the Hedgehog signal: sex and patterning in Drosophila. Development 132(21): 4801-10. PubMed ID: 16207758
Hoshijima, K., et al. (1995). Transcriptional regulation of the Sex-lethal gene by helix-loop-helix proteins. Nucleic Acids Res 23: 3441-3448. PubMed ID: 7567454
Inoue, K., Hoshijima, K., Sakamoto, H. and Shimura, Y. (1990). Binding of the Drosophila Sex-lethal gene product to the alternative splice site of transformer primary transcript. Nature 344: 461-463. PubMed ID: 1690860
Janzer, B. and Steinmann-Zwicky, M. (2001). Cell-autonomous and somatic signals control sex-specific gene expression in XY germ cells of Drosophila. Mech. Dev. 100: 3-13. PubMed ID: 11118879
Jiménez, G., Pinchin, S. M. and Ish-Horowicz, D. (1996). In vivo interactions of the Drosophila Hairy and Runt transcriptional repressors with target promoters. EMBO J. 15: 7088-7098. PubMed ID: 9003784
Jinks, T. M., et al. (2000). The JAK/STAT signaling pathway is required for the initial choice of sexual identity in Drosophila melanogaster. Mol. Cell 5: 581-587. PubMed ID: 10882142
Jurica, M. S. and Moore, M. J. (2003). Pre-mRNA splicing: awash in a sea of proteins. Mol. Cell 12: 5-14. PubMed ID: 12887888
Jursnich, V. A. and Burtis, K. C. (1993). A positive role in differentiation for the male doublesex protein of Drosophila. Dev Biol 155: 235-49. PubMed ID: 8416836
Kanaar, R., et al. (1995). Interaction of the sex-lethal RNA binding domains with RNA. EMBO J. 14: 4530-4539. PubMed ID: 7556096
Kelley, R. L., et al. (1997). Sex lethal controls dosage compensation in Drosophila by a non-splicing mechanism. Nature 387 (6629): 195-199. PubMed ID: 9144292
Keyes, L. N., Cline, T. W. and Schedl, P. (1992). The primary sex determination signal of Drosophila acts at the level of transcription. Cell 68: 933-943. PubMed ID: 1547493
Kolander, K. D., Holtz, M. L., Cossette, S. M., Duncan, S. A. and Misra, R. P. (2014). Epicardial GATA factors regulate early coronary vascular plexus formation. Dev Biol 386: 204-215. PubMed ID: 24380800
Kramer, S. G., et al. (1999). Direct activation of Sex-lethal transcription by the Drosophila Runt protein. Development 126: 191-200. PubMed ID: 9834198
Lallena, M. J., et al. (2002). Splicing regulation at the second catalytic step by Sex-lethal involves 3' splice site recognition by SPF45. Cell 109(3): 285-96. PubMed ID: 12015979
Leatherman, J. L., Levin, L., Boero, J. and Jongens, T. A. (2002). germ cell-less acts to repress transcription during the establishment of the Drosophila germ cell lineage. Curr Biol 12(19): 1681-1685. PubMed ID: 12361572
Lee, A. L., et al. (1997). Chemical shift mapping of the RNA-binding interface of the multiple-RBD protein Sex-lethal. Biochemistry 36(47): 14306-17. PubMed ID: 9398148
Li, L.-H. and Gergen, J. P. (1999). Differential interactions between Brother proteins and Runt domain proteins in the Drosophila embryo and eye. Development 126: 3313-3322. PubMed ID: 10393111
Li, H., et al. (2011). Cooperative and antagonistic contributions of two heterochromatin proteins to transcriptional regulation of the Drosophila sex determination decision. PLoS Genet. 7(6): e1002122. PubMed ID: 21695246
Li, Y., Zhang, Q., Carreira-Rosario, A., Maines, J. Z., McKearin, D. M. and Buszczak, M. (2013). Mei-p26 cooperates with Bam, Bgcn and Sxl to promote early germline development in the Drosophila ovary. PLoS One 8: e58301. PubMed ID: 23526974
Liu, N., Han, H. and Lasko, P. (2009). Vasa promotes Drosophila germline stem cell differentiation by activating mei-P26 translation by directly interacting with a (U)-rich motif in its 3' UTR. Genes Dev 23: 2742-2752. PubMed ID: 19952109
Liu, W. J., Reece-Hoyes, J. S., Walhout, A. J. and Eisenmann, D. M. (2014). Multiple transcription factors directly regulate Hox gene lin-39 expression in ventral hypodermal cells of the C. elegans embryo and larva, including the hypodermal fate regulators LIN-26 and ELT-6. BMC Dev Biol 14: 17. PubMed ID: 24885717
McDowell, K. A., Hilfiker, A. and Lucchesi, J. C. (1996). Dosage compensation in Drosophila: the X chromosome binding of MSL-1 and MSL-2 in female embryos is prevented by the early expression of the Sxl gene. Mech. Dev. 57 113-119. PubMed ID: 8817458
Mével-Nino, M., et al. (1996). The three dominant female-sterile mutations of the Drosophila ovo gene are point mutations that create new translation-initiator AUG codons. Dev. Biol 122: 4131-38. PubMed ID: 9012532
Meise, M., et al. (1998). Sex-lethal, the master sex-determining gene in Drosophila, is not sex-specifically regulated in Musca domestica. Development 125(8): 1487-1494. PubMed ID: 9502729
Meller, V. H., et al. (1997). roX1 RNA paints the X chromosome of male Drosophila and is regulated by the dosage compensation system. Cell 88: 445-457. PubMed ID: 9038336
Nagengast, A. A., et al. (2003). Sex-lethal splicing autoregulation in vivo: interactions between SEX-LETHAL, the U1 snRNP and U2AF underlie male exon skipping. Development 130: 463-471. PubMed ID: 12490553
Oliver, B., Kim, Y. J. and Baker, B. S. (1993). Sex-lethal, master and slave: a hierarchy of germ-line sex determination in Drosophila. Development 119: 897-908. PubMed ID: 8187645
Oliver, B., et al. (1994). Function of Drosophila ovo+ in germ-line sex determination depends on X-chromosome number. Development 120: 3185-3195. PubMed ID: 7720561
Pae, J., Cinalli, R. M., Marzio, A., Pagano, M. and Lehmann, R. (2017). GCL and CUL3 control the switch between cell lineages by mediating localized degradation of an RTK. Dev Cell 42(2): 130-142 e137. PubMed ID: 28743001
Palmer, M. J., et al. (1994). Sex-specific regulation of the male-specific lethal-1 dosage compensation gene in Drosophila. Genes Dev 8: 698-706. PubMed ID: 7926760
Pauli, D., Oliver, B. and Mahowald, P. A. (1993). The role of the ovarian tumor locus in Drosophila melanogaster germ line sex determination. Development 119: 123-34. PubMed ID: 8275850
Penalva, L. O. F., et al. (2000). The Drosophila fl(2)d gene, required for female-specific splicing of Sxl and tra pre-mRNAs, encodes a novel nuclear protein with a HQ-rich romain. Genetics 155: 129-139. PubMed ID: 10790389
Penn, J. K. M. and Schedl, P. (2007). The master switch gene Sex-lethal promotes female development by negatively regulating the N-signaling pathway. Dev. Cell 12: 275-286. PubMed ID: 17276344
Penn, J. K., et al. (2008). Functioning of the Drosophila Wilms'-tumor-1-associated protein homolog, Fl(2)d, in Sex-lethal-dependent alternative splicing. Genetics 178(2): 737-48. PubMed ID: 18245840
Primus, S., Pozmanter, C., Baxter, K. and Van Doren, M. (2019). Tudor-domain containing protein 5-like promotes male sexual identity in the Drosophila germline and is repressed in females by Sex lethal. PLoS Genet 15(7): e1007617. PubMed ID: 31329582
Pultz, M.A. and Baker, B.S. (1995). The dual role of hermaphrodite in the Drosophila sex determination regulatory hierarchy. Development 121: 99-111. PubMed ID: 7867511
Rideout, E. J., Narsaiya, M. S. and Grewal, S. S. (2015). The sex determination gene transformer regulates male-female differences in Drosophila body size. PLoS Genet 11(12): e1005683. PubMed ID: 26710087
Saccone, G., et al. (1998). The Ceratitis capitata homologue of the Drosophila sex-determining gene Sex-lethal is structurally conserved, but not sex-specifically regulated. Development 125(8): 1495-1500. PubMed ID: 9502730
Sakashita, E. and Sakamoto, H. (1994). Characterization of RNA binding specificity of the Drosophila sex-lethal protein by in vitro ligand selection. Nucleic Acids Res 22: 4082-4086 . PubMed ID: 7524034
Salz, H. K. and Flickinger, T. W. (1996). Both loss-of-function and gain-of-function mutations in snf define a role for snRNP proteins in regulating Sex-lethal pre-mRNA splicing in Drosophila development. Genetics 144: 95-108. PubMed ID: 8878676
Samuels, M. E., Schedl, P. and Cline, T. W. (1991). The complex set of late transcripts from the Drosophila sex determination gene sex-lethal encodes multiple related polypeptides. Mol Cell Biol 11: 3584-602. PubMed ID: 1710769
Samuels, M., Deshpande, G. and Schedl, P. (1998). Activities of the Sex-lethal protein in RNA binding and protein:protein interactions. Nucleic Acids Res. 26(11): 2625-37. PubMed ID: 9592147
Sawala, A. and Gould, A. P. (2017). The sex of specific neurons controls female body growth in Drosophila. PLoS Biol 15(10): e2002252. PubMed ID: 28976974
Schutt, C., Hilfiker, A. and Nothiger, R. (1998). virilizer regulates Sex-lethal in the germline of Drosophila melanogaster. Development 125(8): 1501-1507. PubMed ID: 9502731
Sefton, L., et al. (2000). An extracellular activator of the Drosophila JAK/STAT pathway is a sex-determination signal element. Nature 405: 970-973. PubMed ID: 10879541
Serna, E., Gorab, E., Ruiz, M. F,, Goday, C., Eirin-Lopez, J. M. and Sanchez, L. (2004). The gene Sex-lethal of the Sciaridae family (order Diptera, suborder Nematocera) and its phylogeny in dipteran insects. Genetics 168(2): 907-21. 15514063
Smolko, A. E., Shapiro-Kulnane, L. and Salz, H. K. (2018). The H3K9 methyltransferase SETDB1 maintains female identity in Drosophila germ cells. Nat Commun 9(1): 4155. PubMed ID: 30297796
Sosnowski, B. A., Belote, J. M. and McKeown, M. (1989). Sex-specific alternative splicing of RNA from the transformer gene results from sequence-dependent splice site blockage. Cell 58: 449-459. PubMed ID: 2503251
Sosnowski, B. A., et al. (1994). Multiple portions of a small region of the Drosophila transformer gene are required for efficient in vivo sex-specific regulated RNA splicing and in vitro sex-lethal binding. Dev Biol 161: 302-12. PubMed ID: 8293881
Starr, D. and Cline, T. W. (2002). A hostparasite interaction rescues Drosophila oogenesis defects. Nature 418: 76-79. PubMed ID: 12097909
Sun, S. and Cline, T. W. (2009). Effects of Wolbachia infection and ovarian tumor mutations on Sex-lethal germline functioning in Drosophila. Genetics 181: 1291-1301. PubMed ID: 19171941
Sun, X., Yang, H., Sturgill, D., Oliver, B., Rabinow, L. and Samson, M. L. (2015). Sxl-dependent, tra/tra2-independent alternative splicing of the Drosophila melanogaster X-Linked gene found in neurons. G3 (Bethesda) 5(12):2865-74. PubMed ID: 26511498
Tang, A. H., et al. (2001). Transcriptional regulation of cytoskeletal functions and segmentation by a novel maternal pair-rule gene, lilliputian. Development 128(5): 801-813. PubMed ID: 11171404
Taylor, B. J., (1992). Differentiation of a male-specific muscle in Drosophila melanogaster does not require the sex-determining genes doublesex or intersex. Genetics 132: 179-91. PubMed ID: 1398052
Testa, N. D., Ghosh, S. M. and Shingleton, A. W. (2013). Sex-specific weight loss mediates sexual size dimorphism in Drosophila melanogaster. PLoS One 8(3): e58936. PubMed ID: 23555608
Tompkins, L. and McRobert, S. P. (1995). Behavioral and pheromonal phenotypes associated with expression of loss-of-function mutations in the sex-lethal gene of Drosophila melanogaster. J. Neurogenet. 9: 219-226. PubMed ID: 7760212
Torres, M and Sanchez, L. (1992). The segmentation gene runt is needed to activate Sex-lethal, a gene that controls sex determination and dosage compensation in Drosophila. Genet Res 59: 189-98. PubMed ID: 1511868
Vander Zwan, C. J., et al. (2003). A DNA-binding-independent pathway of repression by the Drosophila Runt protein. Blood Cells Mol. Dis. 30: 207-222. PubMed ID: 12732185
Vanderzwan-Butler, C. J., Prazak, L. M. and Gergen, J. P. (2006). The HMG-box protein Lilliputian is required for Runt-dependent activation of the pair-rule gene fushi-tarazu. Dev. Biol. 301(2): 350-60. PubMed ID: 17137570
Vied, C. and Horabin, J. I. (2001). The sex determination master switch, Sex-lethal, responds to Hedgehog signaling in the Drosophila germline. Development 128: 2649-2660. PubMed ID: 11526072
Vied, C., Halachmi, N., Salzberg, A. and Horabin, J. I. (2003). Antizyme is a target of Sex-lethal in the Drosophila germline and appears to act downstream of Hedgehog to regulate Sex-lethal and Cyclin B. Dev. Bio. 253: 214-229. PubMed ID: 12645926
Wang, J, and Bell, R. L. (1994). The Sex-lethal amino terminus mediates cooperative interactions in RNA binding and is essential for splicing regulation. Genes Dev. 8: 2072-85. PubMed ID: 7958879
Wang, J., Dong, Z. and Bell, L. R. (1997). Sex-lethal interactions with protein and RNA. Roles Of glycine-rich and RNA binding domains. J. Biol. Chem. 272(35): 22227-22235. PubMed ID: 9268369
Wang, Y., Zhang, L., Ren, H., Ma, L., Guo, J., Mao, D., Lu, Z., Lu, L. and Yan, D. (2021). Role of Hakai in m6A modification pathway in Drosophila. Nat Commun 12(1): 2159. PubMed ID: 33846330
Waterbury, J. A., Horabin, J. I., Bopp, D. and Schedl, (2000). Sex determination in the Drosophila germline is dictated by the sexual identity of the surrounding soma. Genetics 155: 1741-1756. PubMed ID: 10924471
Wehr Mathews, K., Cavegn, M. and Zwicky, M. (2017). Sexual dimorphism of body size is controlled by dosage of the X-chromosomal gene Myc and by the sex-determining gene tra in Drosophila. Genetics 205(3):1215-1228. PubMed ID: 28064166
Yang, D., et al. (2001). Interpretation of X chromosome dose at Sex-lethal requires non-E-Box sites for the basic helix-loop-helix proteins SISB and Daughterless. Mol. Cell. Bio. 21: 1581-1592. PubMed ID: 11238895
Yang, S. Y., Baxter, E. M. and Van Doren, M. (2012). Phf7 controls male sex determination in the Drosophila germline. Dev Cell 22(5): 1041-1051. PubMed ID: 22595675
Yanowitz, J. L., et al. (1999). An N-terminal truncation uncouples the sex-transforming and dosage compensation functions of Sex-lethal. Mol. Cell. Biol. 19: 3018-3028. PubMed ID: 10082569
Zhou, S., et al. (1995). Male-specific lethal 2, a dosage compensation gene of Drosophila, undergoes sex-specific regulation and encodes a protein with a RING finger and a metallothionein-like cysteine cluster. EMBO J. 14: 2884-2895. PubMed ID: 7796814
Zhu, C., Urano, J. and Bell. L. R. (1997). The Sex-lethal early splicing pattern uses a default mechanism dependent on the alternative 5' Splice Sites. Mol. Cell. Biol. 17: 1674-81. PubMed ID: 9032294
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