Sex lethal
Promoter Structure
Transcriptional Regulation
Regulation of splicing by SXL: 1. General considerations
Determination of male somatic sex and function of Sxl in XY germ cells
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Sxl is part of the Hedgehog signaling complex
Sex-lethal protein mediates polyadenylation switching in the female germline
Splicing mechanism of SXL: 2. Sxl's role in Transformer pre-mRNA splicing
Sex-lethal can bypass its switch-gene target transformer to regulate aspects of female behavior
Sex-lethal enables germline stem cell differentiation by down-regulating Nanos protein levels during Drosophila oogenesis
Splicing mechanism of SXL: 3. Proteins involved in splicing of SXL mRNA
Splicing mechanism of SXL: 4. Sxl autoregulation
Sex-lethal promotes female development by negatively regulating the N-signaling pathway
Female fate maintenance in Drosophila germ cells: The H3K9 methyltransferase SETDB1 maintains female identity in Drosophila germ cells
Structural basis for the assembly of the Sxl-Unr translation regulatory complex
Germ line regulation of Sxl
m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination
Factors influencing somatic sex characteristics
Post-splicing regulation of Sxl
Sxl and msl2 splicing
Sxl is in a complex that contains all of the known Hh cytoplasmic components:
Hh promotes the entry of Sxl into the nucleus in the wing disc
Splicing regulation at the second catalytic step by Sex-lethal involves
3' splice site recognition by SPF45
Sex lethal and U2 small nuclear ribonucleoprotein auxiliary factor (U2AF65)
recognize polypyrimidine tracts using multiple modes of binding
Sex-lethal imparts a sex-specific function to UNR by recruiting it to the
msl-2 mRNA 3' UTR: translational repression for dosage compensation
Mei-p26 cooperates with Bam, Bgcn and Sxl to promote early germline development in the Drosophila ovary
Sex lethal:
Biological Overview
| Evolutionary Homologs
| Developmental Biology
| Effects of Mutation
| References
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