dror

DEVELOPMENTAL BIOLOGY

Embryonic

dror transcripts are found in the extended germ band [Image] stage (stage 11). Many, if not all, neurons in the brain and central nervous system express dror. Transcripts are also found in sense organs of the peripheral nervous system (Wilson, 1993).

Afzal, A. R., et al. (2000). Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of ROR2. Nat. Genet. 25(4): 419-22. 10932186

Al-Shawi, R., et al. (2001). Expression of the Ror1 and Ror2 receptor tyrosine kinase genes during mouse development. Dev. Genes Evol. 211: 161-171. 11455430

Atwall, J. K., et al. (2000). The TrkB-Shc site signals neuronal survival and local axon growth via MEK and PI3-kinase. Neuron 27: 265-277. 10985347

Billiard, J., Way, D. S., Seestaller-Wehr, L. M., Moran, R. A., Mangine, A. and Bodine, P. V. (2005). The orphan receptor tyrosine kinase Ror2 modulates canonical Wnt signaling in osteoblastic cells. Mol. Endocrinol. 19: 90-101. PubMed citation: 18215320

Canossa, M., Rovelli, G. and Shooter, E. M. (1996). Transphosphorylation of the neurotrophin Trk receptors. J. Biol. Chem. 271: 5812-5818. 8621450

Carter, D. B., et al. (1996). Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75. Science 272: 542-545. PubMed Citation: 8614802

Coudreuse, D. Y., Roel, G., Betist, M. C., Destree, O. and Korswagen, H. C. (2006). Wnt gradient formation requires retromer function in Wnt-producing cells. Science 312: 921-924. PubMed citation: 16645052

DeChiara, T. M., et al. (2000). Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development. Nat. Genet. 24(3): 271-4. 10700181

Dobrowsky, R. T., Jenkins, G. M. and Hannun, Y. A. (1995). Neurotrophins induce sphingomyelin hydrolysis. Modulation by co-expression of p75NTR with Trk receptors. J. Biol. Chem. 270: 22135-22142. PubMed Citation: 7673191

Forrester, W. C., et al. (1999). A C. elegans Ror receptor tyrosine kinase regulates cell motility and asymmetric cell division. Nature 400(6747): 881-5. PubMed Citation: 10476968

Forrester, W. C., Kim, C. and Garriga, G. (2004). The Caenorhabditis elegans Ror RTK CAM-1 inhibits EGL-20/Wnt signaling in cell migration. Genetics 168(4): 1951-62. 15371357

Francis, M. M., et al. (2005). The Ror receptor tyrosine kinase CAM-1 is required for ACR-16-mediated synaptic transmission at the C. elegans neuromuscular junction. Neuron 46(4): 581-94. 15944127

Gaiddon, C., Loeffler, J. P., and Larmet, Y. (1996). Brain-derived neurotrophic factor stimulates AP-1 and cyclic AMP-responsive element dependent transcriptional activity in central nervous system neurons. J. Neurochem. 66: 2279-2286. PubMed Citation: 8632149

Green, J. L., Inoue, T. and Sternberg, P. W. (2007). The C. elegans ROR receptor tyrosine kinase, CAM-1, non-autonomously inhibits the Wnt pathway. Development 134(22): 4053-62. PubMed citation: 17942487

Green, J. L., Inoue, T. and Sternberg, P. W. (2008). Opposing Wnt pathways orient cell polarity during organogenesis. Cell 134(4): 646-56. PubMed Citation: 18724937

Grumolato, L., et al. (2010). Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors. Genes Dev. 24(22): 2517-30. PubMed Citation: 21078818

Hallberg, B., et al. (1998). Nerve growth factor induced stimulation of Ras requires Trk interaction with Shc but does not involve phosphoinositide 3-OH kinase. Oncogene 17(6): 691-7. PubMed Citation: 9715270

Hikasa, H., et al. (2005). The Xenopus receptor tyrosine kinase Xror2 modulates morphogenetic movements of the axial mesoderm and neuroectoderm via Wnt signaling. Development 129(22): 5227-39. 12399314

Kani, S., Oishi, I., Yamamoto, H., Yoda, A., Suzuki, H., Nomachi, A., Iozumi, K., Nishita, M., Kikuchi, A., Takumi, T. et al. (2004). The receptor tyrosine kinase Ror2 associates with and is activated by casein kinase Iepsilon. J. Biol. Chem. 279: 50102-50109. PubMed citation: 15375164

Kim, C., and Forrester, W. C. (2003). Functional analysis of the domains of the C. elegans Ror receptor tyrosine kinase CAM-1. Dev. Biol. 264: 376-390. PubMed citation: 14651925

Kennerdell, J. R., Fetter, R. D. and Bargmann, C. I. (2009). Wnt-Ror signaling to SIA and SIB neurons directs anterior axon guidance and nerve ring placement in C. elegans. Development 136(22): 3801-10. PubMed Citation: 19855022

Koga, M., et al. (1999). Control of DAF-7 TGF-beta expression and neuronal process development by a receptor tyrosine kinase KIN-8 in Caenorhabditis elegans. Development 126: 5387-5398. 10556063

Mikels, A. J. and Nusse, R. (2006a). Purified Wnt5a protein activates or inhibits beta-Catenin-TCF signaling depending on receptor context. PLoS Biol. 4: e115. PubMed citation: 16602827

Mikels, A. J. and Nusse, R. (2006b). Wnts as ligands: processing, secretion and reception. Oncogene 25: 7461-7468. PubMed citation: 17143290

Kuruvilla, R., Ye, H. and Ginty, D. D. (2000). Spatially and functionally distinct roles of the PI3-K effector pathway during NGF signaling in sympathetic neurons. Neuron 27: 499-512. PubMed Citation: 11055433

Lefcort, F., et al. (1996). Inhibition of the NT-3 receptor TrkC, early in chick embryogenesis, results in severe reductions in multiple neuronal subpopulations in the dorsal root ganglia. J. Neurosci. 16: 3704-3713. PubMed Citation: 8642413

Li, C., et al. (2008). Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2. BMC Mol. Biol. 9: 11. PubMed citation: 18215320

Kennerdell, J. R., Fetter, R. D. and Bargmann, C. I. (2009). Wnt-Ror signaling to SIA and SIB neurons directs anterior axon guidance and nerve ring placement in C. elegans. Development 136(22): 3801-10. PubMed Citation: 19855022

Masiakowski, P. and Carroll, R. D. (1992). A novel family of cell surface receptors with tyrosine kinase-like domain. J. Biol. Chem. 267: 26181-90. PubMed Citation: 1334494

Matsuda, T., et al. (2001). Expression of the receptor tyrosine kinase genes, Ror1 and Ror2, during mouse development. Mech. Dev. 105: 153-156. 11429290

McCarty, J. H. and Feinstein, S. C. (1999). The TrkB receptor tyrosine kinase regulates cellular proliferation via signal transduction pathways involving SHC, PLCgamma, and CBL. J. Recept. Signal Transduct. Res. 19: 953-74. PubMed Citation: 10533983

Meakin, S. O., et al. (1999). The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation. J. Biol. Chem. 274(14): 9861-70. PubMed Citation: 10092678

Minichiello, L., et al. (1995). Differential effects of combined trk receptor mutations on dorsal root ganglion and inner ear sensory neurons. Development 121: 4067-4075. PubMed Citation: 8575307

Minichiello, L., et al. (1998). Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses. Neuron 21(2): 335-45. PubMed Citation: 9728915

Moffat, L. L., Robinson, R. E., Bakoulis, A. and Clark, S. G. (2014). The conserved transmembrane RING finger protein PLR-1 downregulates Wnt signaling by reducing Frizzled, Ror and Ryk cell-surface levels in C. elegans. Development 141: 617-628 PubMed ID: 24401370

Nomi, M., et al. (2001). Loss of mRor1 enhances the heart and skeletal abnormalities in mRor2-deficient mice: redundant and pleiotropic functions of mRor1 and mRor2 receptor tyrosine kinases. Mol. Cell. Biol. 21(24): 8329-35. 11713269

Nye, D. M. R., Albertson, R. M., Weiner, A. T., Hertzler, J. I., Shorey, M., Goberdhan, D. C. I., Wilson, C., Janes, K. A. and Rolls, M. M. (2020). The receptor tyrosine kinase Ror is required for dendrite regeneration in Drosophila neurons. PLoS Biol 18(3): e3000657. PubMed ID: 32163406

Oishi, I., et al. (1997). A novel Drosophila receptor tyrosine kinase expressed specifically in the nervous system. J. Biol. Chem. 272: 11916-25. PubMed Citation: 9115253

Oishi, I., et al. (1999). Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system. Genes Cells 4(1): 41-56. PubMed Citation: 10231392

Oishi, I., et al. (2001). Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system. Genes to Cells 4: 41-56. 10231392

Oishi, I., et al. (2003). The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway. Genes Cells 8: 645-654. PubMed citation: 12839624

Oldridge, M., et al. (2000). Dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B. Nat. Genet. 24(3): 275-8. 10700182

Ossipova, O. and Sokol, S. Y. (2011). Neural crest specification by noncanonical Wnt signaling and PAR-1. Development 138(24): 5441-50. PubMed Citation: 22110058

Paganoni, S. and Ferreira, A. (2005). Neurite extension in central neurons: a novel role for the receptor tyrosine kinases Ror1 and Ror2. J. Cell Sci. 118: 433-46. 15654020

Patel, T. D., et al. (2000). Development of sensory neurons in the absence of NGF/TrkA signaling in vivo. Neuron 25(2): 345-57. PubMed Citation: 10719890

Perez, P., et al. (1995). NGF binding to the trk tyrosine kinase receptor requires the extracellular immunoglobulin-like domains. Mol Cell Neurosci 6: 97-105. PubMed Citation: 7551570

Pulido, D., Campuzano, S., Koda, T., Modolell, J. and Barbacid, M. (1992). Dtrk, a Drosophila gene related to the trk family of neurotrophin receptors, encodes a novel class of neural cell adhesion molecule. EMBO J. 11: 391-404. PubMed Citation: 1371458

Qian, X., et al. (1998). Identification and characterization of novel substrates of Trk receptors in developing neurons. Neuron 21(5): 1017-29. PubMed Citation: 9856458

Riccio, A., et al. (1997). An NGF-TrkA-mediated retrograde signal to transcription factor CREB in sympathetic neurons. Science 277(5329): 1097-1100. PubMed Citation: 9262478

Riccio, A., et al. (1999). Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons. Science 286: 2358-2361. PubMed Citation: 10600750

Roszmusz, E., et al. (2001). Localization of disulfide bonds in the frizzled module of Ror1 receptor tyrosine kinase. J. Biol. Chem. 276(21): 18485-90. 11279007

Schwabe, G. C., et al. (2004). Ror2 knockout mouse as a model for the developmental pathology of autosomal recessive Robinow syndrome. Dev. Dyn. 229(2): 400-10. 14745966

Takeuchi, S., et al. (2000). Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation. Genes Cells 5(1): 71-8. PubMed Citation: 10651906

van Bokhoven, H., et al. (2000). Mutation of the gene encoding the ROR2 tyrosine kinase causes autosomal recessive Robinow syndrome. Nat. Genet. 25(4): 423-6. 10932187

van Kesteren, R. E., et al. (1998). Early evolutionary origin of the neurotrophin receptor family. Embo J. 17(9): 2534-2542. 9564036

von Bartheld, C. S., et al. (1996). Retrograde transport of neurotrophins from the eye to the brain in chick embryos: roles of the p75NTR and trkB receptors. J. Neurosci. 16: 2995-3008. PubMed Citation: 8622129

Wang, J. and Ding, M. (2018). Robo and Ror function in a common receptor complex to regulate Wnt-mediated neurite outgrowth in Caenorhabditis elegans. Proc Natl Acad Sci U S A 115(10): E2254-E2263. PubMed ID: 29463707

Wang, T., Xie, K. and Lu, B. (1995). Neurotrophins promote maturation of developing neuromuscular synapses. J Neurosci 15: 4796-4805. PubMed Citation: 7623111

Wang, T., Martin, S., Nguyen, T. H., Harper, C. B., Gormal, R. S., Martinez-Marmol, R., Karunanithi, S., Coulson, E. J., Glass, N. R., Cooper-White, J. J., van Swinderen, B. and Meunier, F. A. (2016). Flux of signalling endosomes undergoing axonal retrograde transport is encoded by presynaptic activity and TrkB. Nat Commun 7: 12976. PubMed ID: 27687129

Wilson, C., Goberdhan, D. C. I., and Steller, H. (1993). Dror, a potential neurotrophic receptor gene, encodes a Drosophila homolog of the vertebrate Ror family of Trk-related receptor tyrosine kinases. Proc. Natl. Acad. Sci. 90: 7109-7113. PubMed Citation: 8394009

Zirrgiebel, U., et al. (1995). Characterization of TrkB receptor-mediated signaling pathways in rat cerebellar granule neurons: involvement of protein kinase C in neuronal survival. J Neurochem 65: 2241-2250. PubMed Citation: 7595513

date revised: 5 November 2020
 

Home page: The Interactive Fly © 1997 Thomas B. Brody, Ph.D.

The Interactive Fly resides on the
Society for Developmental Biology's Web server.