EGF receptor
Nagaraj, R., et al. (1999). Role of EGF receptor pathway in the growth and patterning of the Drosophila wing through the regulation of vestigial. Development 126: 975-985. Medline abstract: 9927598
Nagaraj, R. and Banerjee, U. (2007). Combinatorial signaling in the specification of primary pigment cells in the Drosophila eye. Development 134(5): 825-31. Medline abstract: 17251265
Nakagawa, T., et al. (2005). Characterization of a human rhomboid homolog, p100hRho/RHBDF1, which interacts with TGFalpha family ligands. Dev. Dyn. 233: 1315-1331. PubMed Citation: 15965977
Naylor, S. A. and Diantonio, A. (2011). EGFR signaling modulates synaptic connectivity via Gurken. Dev. Neurobiol. [72(9): 1229-42. PubMed Citation: 22021126
Neubueser, D. and Hipfner, D. R. (2010). Overlapping roles of Drosophila Drak and Rok kinases in epithelial tissue morphogenesis. Mol Biol Cell 21: 2869-2879. PubMed ID: 20573980
Newman, A. P. and Sternberg, P. W. (1996). Coordinated morphogenesis of epithelia during development of the Caenorhabditis elegans uterine-vulva connection. Proc. Natl. Acad. Sci. 93: 9329-33. PubMed Citation: 8790329
Neuman-Silberberg, F. S. and Schupbach, T. (1993). The Drosophila dorsoventral patterning gene gurken produces a dorsally localized RNA and encodes a TGF
alpha-like protein. Cell 75: 165-74. PubMed Citation: 7691414
Nestoras, K., Lee, H. and Mohler, J. (1997). Role of knot (kn) in wing patterning in Drosophila. Genetics 147(3): 1203-1212. PubMed Citation: 9383063
Niepielko, M. G. and Yakoby, N. (2014). Evolutionary changes in TGFalpha distribution underlie morphological diversity in eggshells from Drosophila species. Development 141: 4710-4715. PubMed ID: 25468939
Odintsova, E., Sugiura, T. and Berditchevski, F. (2000). Attenuation of EGF receptor signaling by a metastasis suppressor, the tetraspanin CD82/KAI-1. Curr. Biol. 10: 1009-1012. 10985391
Ogiso, H., et al. (2002). Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains. Cell 110: 775-787. 12297050
Oishi, K., et al. (2006). Transgenic Drosophila models of Noonan syndrome causing PTPN11 gain-of-function mutations. Hum. Mol. Genet. 15(4): 543-53. 16399795
O'Keefe, L., et al. (1997). Spitz and Wingless, emanating from distinct borders, cooperate to establish cell fate across the Engrailed domain in the Drosophila epidermis. Development 124(23): 4837-45. PubMed Citation: 9428420
Ou, C.-Y., Lin, Y.-F. Chen, Y.-J. and Chien, C.-T. (2002). Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development. Genes Dev. 16: 2403-2414. PubMed Citation: 12231629
Pai, L. M., et al. (2006). Differential effects of Cbl isoforms on Egfr signaling in Drosophila. Mech. Dev. 123(6): 450-62. 16844358
Palka, H. L., Park, M. and Tonks, N. K. (2003). Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1. J. Biol. Chem. 278: 5728-5735. PubMed Citation: 12475979
Pallavi, S. K. and Shashidhara, L. S. (2003). Egfr/Ras pathway mediates interactions between peripodial and disc proper cells in Drosophila wing discs. Development 130: 4931-4941. 12930782
Pallavi, S. K., Kannan, R. and Shashidhara, L. S. (2006). Negative regulation of Egfr/Ras pathway by Ultrabithorax during haltere development in Drosophila.
Dev. Biol. 296(2): 340-52. Medline abstract: 16815386
Palsson, A. and Gibson, G. (2004). Association between nucleotide variation
in Egfr and wing shape in Drosophila melanogaster.
Genetics 167(3): 1187-98. 15280234
Parrott, B. B., Hudson, A., Brady, R. and Schulz, C. (2012). Control of germline stem cell division frequency--a novel, developmentally regulated role for epidermal growth factor signaling. PLoS One 7(5): e36460. PubMed Citation: 22586473
Pasnuri, N., Jaiswal, M., Ray, K. and Mazumder, A. (2023). Buffered EGFR signaling regulated by spitz-to-argos expression ratio is a critical factor for patterning the Drosophila eye. PLoS Genet 19(2): e1010622. PubMed ID: 36730442
Porfiri, E. and McCormick, F. (1996). Regulation of epidermal growth factor receptor signaling by phosphorylation of the ras exchange factor hSOS1.
J. Biol. Chem. 271: 5871-5877. PubMed Citation: 8621459
Poulton, J. S. and Deng, W. M. (2006). Dystroglycan down-regulation links EGF receptor signaling and anterior-posterior polarity formation in the Drosophila oocyte. Proc. Natl. Acad. Sci. 103(34): 12775-80. Medline abstract: 16908845
Povlsen, G. K., Berezin, V. and Bock, E. (2008). Neural cell adhesion molecule-180-mediated homophilic binding induces epidermal growth factor receptor (EGFR) down-regulation and uncouples the inhibitory function of EGFR in neurite outgrowth. J. Neurochem. 104: 624-639. PubMed Citation: 17995934
Price, J. V., Clifford, R.J. and Schupbach, T. (1989). The maternal ventralizing locus torpedo is allelic to faint little ball, an embryonic lethal, and encodes the Drosophila EGF receptor homolog. Cell 56: 1085-1092. PubMed Citation: 2493993
Price, J. V., et al. (1997). Dominant enhancers of Egfr in Drosophila melanogaster: genetic
links between the Notch and Egfr signaling pathways. Genetics 147(3): 1139-1153. PubMed Citation: 9383058
Prober, D. A. and Edgar, B. A. (2002). Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing. Genes Dev. 16: 2286-2299. 12208851
Qiu, C., et al. (2008). Mechanism of activation and inhibition of the HER4/ErbB4 kinase. Structure 16: 460-467. PubMed Citation: 18334220
Queenan, A. M., Ghabrial, A. and Schupbach, T. (1997). Ectopic activation of torpedo/Egfr, a Drosophila receptor tyrosine kinase, dorsalizes both the eggshell and the embryo. Development 124(19): 3871-3880. PubMed Citation: 9367443
Radke, K., Johnson, K., Guo, R., Davidson, A. and Ambrosio, L. (2001). Drosophila-raf acts to elaborate dorsoventral pattern in the ectoderm of developing embryos.
Genetics 159(3): 1031-44. PubMed citation: 11729151
Ramanan, N., et al. (2005). SRF mediates activity-induced gene expression and synaptic plasticity but not neuronal viability. Nat. Neurosci. 8(6): 759-67. PubMed Citation: 15880109
Rambur, A., Lours-Calet, C., Beaudoin, C., Bunay, J., Vialat, M., Mirouse, V., Trousson, A., Renaud, Y., Lobaccaro, J. A., Baron, S., Morel, L. and de Joussineau, C. (2020). Sequential Ras/MAPK and PI3K/AKT/mTOR pathways recruitment drives basal extrusion in the prostate-like gland of Drosophila. Nat Commun 11(1): 2300. PubMed ID: 32385236
Rappl, A., Piontek, G. and Schlegel, J. (2008). EGFR-dependent migration of glial cells is mediated by reorganisation of N-cadherin. J. Cell Sci. 121(Pt 24): 4089-97. PubMed Citation: 19033391
Rawlins, E. L., White, N. M. and Jarman, A. P. (2003), Echinoid limits R8 photoreceptor specification by inhibiting inappropriate EGF receptor signalling within R8 equivalence groups.
Development 130: 3715-3724. 12835388
Ray, R. P. and Schüpbach, T. (1996). Intracellular signaling and the polarization of body axes during Drosophila oogenesis. Genes Dev. 10: 1711-23. PubMed Citation: 8698232
Raz, E. and Shilo, B. Z. (1993). Establishment of ventral cell fates in the Drosophila
embryonic ectoderm requires DER, the EGF receptor
homolog. Genes Dev 7: 1937-48. PubMed Citation: 8406000
Reddy, B. V., Rauskolb, C. and Irvine, K. D. (2010). Influence of fat-hippo and notch signaling on the proliferation and differentiation of Drosophila optic neuroepithelia. Development 137(14): 2397-408. PubMed Citation: 20570939
Reich, A. and Shilo, B. Z. (2002). Keren, a new ligand of the Drosophila epidermal growth factor receptor, undergoes two modes of cleavage. EMBO J. 21: 4287-4296. PubMed Citation: 12169631
Reichman-Fried, M., et al. (1994). Elucidation of the role of breathless, a Drosophila FGF
receptor homolog, in tracheal cell migration. Genes Dev. 8: 428-39. PubMed Citation: 8125257
Reneker, L. W., et al. (1995). TGF alpha can act as a chemoattractant to perioptic mesenchymal cells in developing mouse eyes. Development 121: 1669-1680. PubMed Citation: 7600984
Ribeiro, C., Ebner, A. and Affolter, M. (2002). In vivo imaging reveals different cellular functions for FGF and Dpp signaling in tracheal branching morphogenesis. Dev. Cell 2: 677-683. 12015974
Richardson, G. D., et al. (2009). KGF and EGF signalling block hair follicle induction and promote interfollicular epidermal fate in developing mouse skin
Development 136: 2153-2164. PubMed Citation: 19474150
Rimer, M., et al. (2004). Neuregulin-2 is synthesized by motor neurons and terminal Schwann cells and activates acetylcholine receptor transcription in muscle cells expressing ErbB4. Mol. Cell. Neurosci. 26(2): 271-81. 15207852
Robertson, F., Pinal, N., Fichelson, P. and Pichaud, F. (2012). Atonal and EGFR signalling orchestrate rok- and Drak-dependent adherens junction remodelling during ommatidia morphogenesis. Development 139: 3432-3441. PubMed ID: 22874916
Roch, F., et al. (1998). Genetic interactions and cell behaviour in blistered mutants during proliferation and differentiation of the Drosophila wing. Development 125(10): 1823-1832. PubMed Citation: 9550715
Roch, F., Jiménez, G. and Casanova, J. (2002). EGFR signalling inhibits Capicua-dependent repression during specification of Drosophila wing veins. Development 129: 993-1002. 11861482
Rodrigues, A. B., Werner, E. and Moses, K. (2005). Genetic and biochemical analysis of the role of Egfr in the morphogenetic furrow of the developing Drosophila eye. 132(21): 4697-707. 16207755
Rogge, R., et al. (1995). The role of yan in mediating the choice between cell division and differentiation. Development 121: 3947-3958. PubMed Citation: 8575295
Rohrbaugh, M., et al. (2002). Notch activation of yan expression is antagonized by RTK/Pointed signaling in the Drosophila eye. Curr. Biol. 12: 576-581. 11937027
Rosen, L. B. and Greenberg, M. E. (1996). Stimulation of growth factor receptor signal transduction by activation of voltage-sensitive calcium channels.
Proc. Natl. Acad. Sci. 93: 1113-1118. PubMed Citation: 8577724
Roth, S. and Schupbach, T. (1994). The relationship between ovarian and embryonic dorsoventral patterning in Drosophila. Development 120: 2245-2257. PubMed Citation: 7925025
Roth, S., et al. (1995). cornichon and the EGF receptor signaling process are necessary for both anterior-posterior and dorsal-ventral
pattern formation in Drosophila. Cell 81: 967-978. PubMed Citation: 7540118
Rozakis-Adcock, M., et al. (1993). The SH2 and SH3 domains of mammalian Grb2 couple the EGF
receptor to the Ras activator mSos1. Nature 363: 83-85. PubMed Citation: 8479540
Ruhe, J. E., Streit, S., Hart, S. and Ullrich, A. (2006). EGFR signaling leads to downregulation of PTP-LAR via TACE-mediated proteolytic processing. Cell Signal. [Epub ahead of print]. 16478662
Ruohola-Baker, H., et al. (1993). Spatially localized rhomboid is required for establishment
of the dorsal-ventral axis in Drosophila oogenesis. Cell 73: 953-65. PubMed Citation: 8500182
Sapir, A., Schweitzer, R. and Shilo, B. Z. (1998). Sequential activation of the EGF receptor pathway during Drosophila oogenesis establishes the dorsoventral axis. Development 125(2): 191-200. PubMed Citation: 9486793
Sardi, S. P., Murtie, J., Koirala, S., Patten, B. A. and Corfas, G. (2006). Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain. Cell 127: 185-197. PubMed Citation: 17018285
Sarkar, A., et al. (2007). Antagonistic roles of Rac and Rho in organizing the germ cell microenvironment. Curr. Biol. 17(14): 1253-8. PubMed citation: 17629483
Sasaoka, T., et al. (1994). The signaling pathway coupling epidermal growth factor receptors to activation of p21ras. J. Biol. Chem. 269: 32621-5. PubMed Citation: 7798267
Sato, M. and Kornberg, T. B. (2002). FGF is an essential mitogen and chemoattractant for the air sacs of the Drosophila tracheal system. Dev. Cell 3: 195-207. 12194851
Sawamoto, K., Yamada, C., Kishida, S., Hirota, Y., Taguchi, A., Kikuchi, A. and Okano, H. (1999). Ectopic expression of constitutively activated Ral GTPase inhibits cell shape changes during Drosophila eye development. Oncogene 18: 1967-1974. 10208418
Sawano, A., et al. (2002). Lateral propagation of EGF signaling after local stimulation is dependent on receptor density. Dev. Cell 3: 245-257. 12194855
Schejter, E. D., et al. (1986). Alternative 5' exons and tissue-specific expression of the
Drosophila EGF receptor homolog transcripts. Cell 46: 1091-1101. PubMed Citation: 3093080
Schmidt, M. H., Hoeller, D., Yu, J., Furnari, F. B., Cavenee, W. K., Dikic, I. and Bogler, O. (2004). Alix/AIP1 antagonizes epidermal growth factor receptor downregulation by the Cbl-SETA/CIN85 complex. Mol. Cell. Biol. 24: 8981-8993. PubMed Citation: 15456872
Schnepp, B., et al. (1996). Vein is a novel component in the Drosophila epidermal growth factor receptor pathway with similarity to the neuregulins. Genes Dev. 10: 2302-13. PubMed Citation: 8824589
Schober, M., Rebay, I. and Perrimon. N. (2005).
Function of the ETS transcription factor Yan in border cell migration.
Development 132(15): 3493-504. 16014514
Schoenherr, J. A., et al. (2012). Drosophila activated Cdc42 kinase has an anti-apoptotic function. PLoS Genet. 8(5): e1002725. PubMed ID: 22615583
Scholz, H., et al. (1997). Control of midline glia development in the embryonic Drosophila. Mech. Dev. 62: 79-91. PubMed Citation: 9106169
Schulz, C., et al. (2002). Signaling from germ cells mediated by the rhomboid homolog stet organizes encapsulation by somatic support cells. Development 129: 4523-4534. 12223409
Schweitzer, R., et al. (1995). Inhibition of Drosophila EGF receptor activation by the secreted protein Argos. Nature 376: 699-702. PubMed Citation: 7651519
Sen, A., Kuruvilla, D., Pinto, L., Sarin, A. and Rodrigues, V. (2004). Programmed cell death and context dependent activation of the EGF pathway regulate gliogenesis in the Drosophila olfactory system. Mech. Dev. 121: 65-78. 14706701
Shamloula, H. K., et al. (2002). rugose (rg), a Drosophila A kinase anchor protein, is required for retinal pattern formation and interacts genetically with multiple signaling pathways. Genetics 161(2): 693-710. 12072466
Sheikh, M. S., et al. (1997). Identification of an additional p53-responsive site in the human epidermal
growth factor receptor gene promotor. Oncogene 15(9): 1095-1101. PubMed Citation: 9285564
Shelly, M., et al. (2003). Polar expression of ErbB-2/HER2 in epithelia: bimodal regulation by Lin-7. Dev. Cell 5: 475-486. 12967566
Sibilia, M., et al. (1998). A strain-independent postnatal neurodegeneration in mice lacking
the EGF receptor. EMBO J. 17: 719-731. PubMed Citation: 9450997
Sibilia, M., et al. (2000). The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development. Cell 102: 211-220. PubMed Citation: 10943841
Sibilia, M., et al. (2003). Mice humanised for the EGF receptor display hypomorphic phenotypes in skin, bone and heart. Development 130: 4515-4525. 12925580
Sieglitz, F., Matzat, T., Yuva-Adyemir, Y., Neuert, H., Altenhein, B. and Klambt, C. (2013). Antagonistic feedback loops involving rau and sprouty in the Drosophila eye control neuronal and glial differentiation. Sci Signal 6: ra96. PubMed ID: 24194583
Sigismund, S., Woelk, T., Puri, C., Maspero, E., Tacchetti, C., Transidico, P.,
Di Fiore, P. P. and Polo, S. (2005). Clathrin-independent
endocytosis of ubiquitinated cargos. Proc. Natl. Acad. Sci. USA 102: 2760-2765.
15701692
Sigismund, S., et al. (2008). Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradation. Dev. Cell 15: 209-219. PubMed Citation: 18694561
Simoes Sde, M., Blankenship, J. T., Weitz, O., Farrell, D. L., Tamada, M., Fernandez-Gonzalez, R. and Zallen, J. A. (2010). Rho-kinase directs Bazooka/Par-3 planar polarity during Drosophila axis elongation. Dev Cell 19: 377-388. PubMed ID: 20833361
Skeath, J. B. (1998). The Drosophila EGF receptor controls the formation and
specification of neuroblasts along the dorsal-ventral axis of
the Drosophila embryo. Development 125(17): 3301-3312
Sonnenfeld, M. J., Barazesh, N., Sedaghat, Y. and Fan, C. (2004). The jing and ras1 pathways are functionally related during CNS midline and tracheal development. Mech. Dev. 121: 1531-1547. 15511644
Sorkin, A., et al. (2000). Interaction of EGF receptor and Grb2 in living cells
visualized by fluorescence resonance energy transfer (FRET) microscopy. Curr. Biol. 10: 1395-1398. 11084343
Sotillos, S. and Campuzano, S. (2000). DRacGAP, a novel Drosophila gene, inhibits Egfr/Ras signaling in the developing imaginal wing disc. Development 127: 5427-5438.
Soubeyran, P., et al. (2002). Cbl-CIN85-endophilin complex
mediates ligand-induced downregulation of EGF receptors. Nature 416: 183-187. 11894095
Spencer, S. A., et al. (1998). Regulation of EGF receptor signaling establishes pattern across the
developing Drosophila retina. Development 125: 4777-4790
Spencer, S. A. and Cagan, R. L. (2003). Echinoid is essential for regulation of Egfr signaling and R8 formation during Drosophila eye development. Development 130: 3725-3733. 12835389
Stamos, J., Sliwkowski, M. X. and Eigenbrot, C. (2002). Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor. J. Biol. Chem. 277: 46265-46272. PubMed Citation: 12196540
Stemerdink, C. and Jacobs, J. R. (1997). Argos and Spitz group genes function to regulate midline
glial cell number in Drosophila embryos. Development 124(19): 3787-3796
Stephan, R., Grevelhörster, A., Wenderdel, S., Klämbt, C. and Bogdan, S. (2008). Abi induces ectopic sensory organ formation by stimulating EGFR signaling.
Mech. Dev. 125(3-4): 183-95. PubMed Citation: 18221859
Strand, M. and Micchelli, C. A. (2013). Regional control of Drosophila gut stem cell proliferation: EGF establishes GSSC proliferative set point & controls emergence from quiescence. PLoS One 8: e80608. PubMed ID: 24236188
Sturtevant, M. A, Bier E (1995). Analysis of the genetic hierarchy guiding wing vein development in Drosophila. Development 121(3): 785-801
Sudarsan, V., et al. (2002). A genetic hierarchy establishes mitogenic signaling and mitotic competence in the renal tubules of Drosophila. Development 129: 935-944. 11861476
Sullivan, K. M. C. and Rubin, G. M. (2002). The Ca2+-calmodulin-activated protein phosphatase calcineurin negatively regulates Egf receptor signaling in Drosophila development. Genetics 161: 183-193. 12019233
Sun, Y., Goderie, S. K. and Temple, S. (2005). Asymmetric distribution of EGFR receptor during mitosis generates diverse CNS progenitor cells.
Neuron 45(6): 873-86. 15797549
Szuts, D., Freeman, M. and Bienz, M. (1997). Antagonism between EGFR and Wingless signalling in
the larval cuticle of Drosophila. Development 124(16): 3209-3219
Szuts, D., Eresh, S. and Bienz, M. (1998). Functional intertwining of Dpp and EGFR signaling during Drosophila endoderm induction. Genes Dev. 12(13): 2022-2035.
Szuts, D., and Bienz, M. (2000). An autoregulatory function of Dfos during Drosophila
endoderm induction. Mech. Dev. 98: 71-76.
Tang, J., Feng, G. S. and Li, W. (1997). Induced direct binding of the adapter protein Nck to the
GTPase-activating protein-associated protein p62 by epidermal growth factor. Oncogene 15(15): 1823-1832
Tarcic, G., Boguslavsky, S. K., Wakim, J., Kiuchi, T., Liu, A., Reinitz, F., Nathanson, D., Takahashi, T., Mischel, P. S., Ng, T. and Yarden, Y. (2009). An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis. Curr Biol 19: 1788-1798. PubMed ID: 19836242
Thiel, K. W. and Carpenter, G. (2007). Epidermal growth factor receptor juxtamembrane region regulates allosteric tyrosine kinase activation. Proc. Natl. Acad. Sci. 104: 19238-19243. PubMed Citation: 18042729
Thien, C. B. F., Walker, F. and Langdon, W. Y. (2001). RING finger mutations that abolish c-Cbl-directed polyubiquitination and downregulation of the EGF receptor are insufficient for cell transformation. Molec. Cell 7: 355-365
Tio, M., Ma, C. and Moses, K. (1994). spitz, a Drosophila homolog of transforming growth
factor-alpha, is required in the founding photoreceptor
cells of the compound eye facets. Mech Dev 48: 13-23
Tran, D. D. (2003). CAML is required for efficient EGF receptor recycling. Dev. Cell 5: 245-256. 12919676
Toyooka, S., Ouchida, M., Jitsumori, Y., Tsukuda, K., Sakai, A., Nakamura, A., Shimizu, N. and Shimizu, K. (2000). HD-PTP: A novel protein tyrosine phosphatase gene on human chromosome 3p21.3. Biochem. Biophys. Res. Commun. 278: 671-678. PubMed Citation: 11095967
Udolph G., et al. (1998). Differential effects of EGF receptor signalling on neuroblast lineages along the dorsoventral axis of the Drosophila CNS. Development 125(17): 3291-3299
Urban, S., Brown, G. and Freeman, M. (2004). EGF receptor signalling protects smooth-cuticle cells from apoptosis during Drosophila ventral epidermis development. Development 131: 1835-1845. 15084467
Van Buskirk, C. and Sternberg, P. W. (2007). Epidermal growth factor signaling induces behavioral quiescence in Caenorhabditis elegans. Nature Neurosci. 10: 1300-1307. Medline abstract: 17891142
Van Buskirk C. and Sternberg P. W. (2007). Epidermal growth factor signaling induces behavioral quiescence in Caenorhabditis elegans. Nat. Neurosci. 10: 1300-1307. PubMed Citation: 17891142
van de Poll, M. L., et al. (1997). Insertion of Argos sequences into the B-loop of epidermal growth factor results in a low-affinity ligand with strong agonistic activity. Biochemistry 36(24): 7425-7431. PubMed Citation: 9200690
van der Heyden, M. A., et al. (1997a). The actin binding domain of the epidermal growth factor receptor is required for EGF-stimulated tissue invasion. Exp. Cell Res. 234(2): 521-526. PubMed Citation: 9260923
van der Heyden, M. A., et al. (1997b). Epidermal growth factor-induced activation and translocation of c-Src to the cytoskeleton depends on the actin binding domain of the EGF-receptor. Biochim. Biophys. Acta 1359(3): 211-221. PubMed Citation: 9434127
Von Ohlen, T. and Doe, C. Q. (2000). Convergence of Dorsal, Dpp, and Egfr signaling pathways subdivides the Drosophila
neuroectoderm into three dorsal-ventral columns. Dev. Biol. 224: 362-372. PubMed Citation: 10926773
Wahlström, G., Norokorpi, H. L. and Heino, T. I. (2006). Drosophila alpha-actinin in ovarian follicle cells is regulated by EGFR and Dpp signalling and required for cytoskeletal remodelling. Mech. Dev. 123(11): 801-18. PubMed citation: 17008069
Wappner, P., Gabay, L. and Shilo, B. Z. (1997). Interactions between the EGF receptor and DPP pathways establish
distinct cell fates in the tracheal placodes. Development 124(22): 4707-4716
Walker, F., et al. (1998). Activation of the Ras/Mitogen-activated protein kinase pathway by kinase-defective Epidermal growth factor receptors results in cell survival but not proliferation. Mol. Cell. Biol. 18(12): 7192-7204
Wang, S.-H., Simcox, A. and Campbell, G. (2000). Dual role for Drosophila epidermal growth factor receptor signaling
in early wing disc development. Genes Dev. 14: 2271-2276.
Wang, X., He, L., Wu, Y. I., Hahn, K. M. and Montell, D. J. (2010). Light-mediated activation reveals a key role for Rac in collective guidance of cell movement in vivo. Nat. Cell Biol. 12: 591-597. PubMed Citation: 20473296
Ward, C. W., et al. (1996). Systematic mapping of potential binding sites for Shc and Grb2 SH2
domains on insulin receptor substrate-1 and the receptors for insulin,
epidermal growth factor, platelet-derived growth factor, and fibroblast
growth factor. J. Biol. Chem. 271(10): 5603-9
Ware, M. F., et al. (1997). Overexpression of cellular Src in fibroblasts enhances endocytic
internalization of epidermal growth factor receptor. J. Biol. Chem. 272(48): 30185-30190
Wasserman, J. D. and Freeman, M. (1998). An autoregulatory cascade of EGF receptor signaling patterns the Drosophila egg. Cell 95(3): 355-64
Waterman, H., et al. (2002). A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling
EMBO J. 21: 303-313. 11823423
Weber, U., Eroglu, C. and Mlodzik, M. (2003). Phospholipid membrane composition affects EGF Receptor and Notch signaling through effects on endocytosis during Drosophila development. Dev. Cell 5: 559-570. 14536058
Whitfield, C. W., et al. (1999). Basolateral localization of the Caenorhabditis elegans epidermal
growth factor receptor in epithelial cells by the PDZ protein LIN-10. Mol. Biol. Cell 10: 2087-2100
Wiesen, J. F., et al. (1999). Signaling through the stromal epidermal growth factor receptor is
necessary for mammary ductal development. Development 126(2): 335-344
Wilde, A., et al. (1999). EGF receptor signaling stimulates SRC kinase phosphorylation of
clathrin, influencing clathrin redistribution and EGF uptake. Cell 96(5): 677-87
Williams, E. J., et al. (1997). Selective inhibition of growth factor-stimulated mitogenesis by a
cell-permeable Grb2-binding peptide. J. Biol. Chem. 272(35): 22349-22354
Wood, E. R. et al. (2008). 6-Ethynylthieno[3,2-d]- and 6-ethynylthieno[2,3-d]pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinases. Proc. Natl. Acad. Sci. 105: 2773-2778. PubMed Citation: 18287036
Xie H., et al. (1998). EGF receptor regulation of cell motility: EGF induces disassembly of focal adhesions independently of the motility-associated PLC(gamma) signaling pathway. J. Cell Sci. 111(5): 615-624. PubMed Citation: 9454735
Xu, N., et al. (2011). EGFR, Wingless and JAK/STAT signaling cooperatively maintain Drosophila intestinal stem cells. Dev. Biol 354(1): 31-43. PubMed Citation: 21440535
Yagi, Y. and Hayashi, S. (1997). Role of the Drosophila EGF receptor in determination of the
dorsoventral domains of escargot expression during primary
neurogenesis. Genes Cells 2(1): 41-53
Yagi, Y., Suzuki, T. and Hayashi, S. (1998). Interaction between Drosophila EGF receptor and vnd
determines three dorsoventral domains of the neuroectoderm. Development 125(18): 3625-3633
Yajnik, V., et al. (1996). Identification of residues within the SHC phosphotyrosine binding/phosphotyrosine interaction domain crucial for
phosphopeptide interaction. J. Biol. Chem. 271 (4): 1813-1816
Yamaguchi, M., et al. (1995). Opposite effects of transforming growth factor alpha and epidermal
growth factor on mouse placental lactogen I secretion. Proc. Natl. Acad. Sci. 92: 2830-4
Yamauchi, T., et al. (1997). Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is
induced by growth hormone. Nature 389(6655): 91-96
Yan, Z., Zou, H., Tian, F., Grandis, J. R., Mixson, A. J., Lu, P. Y. and Li, L. Y. (2008). Human rhomboid family-1 gene silencing causes apoptosis or autophagy
to epithelial cancer cells and inhibits xenograft tumor growth. Mol. Cancer
Ther. 7: 1355-1364. PubMed Citation: 18524845
Yang, L. and Baker, N. E. (2001). Role of the EGFR/Ras/Raf pathway in specification of photoreceptor cells in the Drosophila retina. Development 128: 1183-1191. 11245584
Yang, L. and Baker, N. E. (2003). Cell cycle withdrawal, progression, and cell survival regulation by EGFR and its effectors in the differentiating Drosophila eye. Developmental Cell 4: 359-369. 12636917
Yarnitzky, T., Min, L. and Volk, T. (1997). The Drosophila neuregulin homolog vein mediates inductive interactions between myotubes and their epidermal attachment
cells. Genes Dev. 11(20):2691-2700. PubMed Citation: 9334331
Yarnitzky, T., Min, L. and Volk, T. (1998). An interplay between two EGF-receptor ligands, Vein and Spitz, is required for the formation of a subset of muscle precursors in Drosophila Mech. Dev. 79(1-2): 73-82. PubMed Citation: 10349622
Yasugi, T., Umetsu, D., Murakami, S., Sato, M. and Tabata, T. (2008). Drosophila optic lobe neuroblasts triggered by a wave of proneural gene expression that is negatively regulated by JAK/STAT. Development 135: 1471-1480. PubMed ID: 18339672
Yasugi, T., Sugie, A., Umetsu, D. and Tabata, T. (2010). Coordinated sequential action of EGFR and Notch signaling pathways regulates proneural wave progression in the Drosophila optic lobe. Development 137: 3193-3203. PubMed ID: 20724446
Yokouchi, M., et al. (1999). Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7. J. Biol. Chem. 274(44): 31707-12. PubMed Citation: 10531381
Yu, S.-Y., et al. (2002). A pathway of signals regulating effector and initiator caspases in the developing Drosophila eye. Development 129: 3269-3278. 12070100
Yu, Y., et al. (2012). Neuronal Cbl controls biosynthesis of insulin-like peptides in Drosophila melanogaster. Mol. Cell Biol. 32(18): 3610-23. PubMed Citation: 22778134
Zartman, J. J., et al. (2011). Pattern formation by a moving morphogen source.
Phys Biol. 8(4): 045003. PubMed Citation: 21750363
Zhang, Q., et al. (2006). A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor. Dev. Cell 10: 719-729. PubMed Citation: 16740475
Zecca, M. and Struhl, G. (2002a). Subdivision of the Drosophila wing imaginal disc by EGFR-mediated signaling. Development 129: 1357-1368. 11880345
Zecca, M. and Struhl, G. (2002b). Control of growth and patterning of the Drosophila wing imaginal disc by EGFR-mediated signaling. Development 129: 1369-1376. 11880346
Zenz, R., et al. (2003). c-Jun regulates eyelid closure and skin tumor development through EGFR signaling. Dev. Cell 4: 879-889. 12791272
Zettl, M., et al. (2011). Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling. Cell 145: 75-91. PubMed Citation: 21439629
Zhang, Q., Zheng, Q. and Lu, X. (1999). A genetic screen for modifiers of Drosophila Src42A identifies
mutations in Egfr, rolled and a novel signaling gene. Genetics 151: 697-711. PubMed Citation: 9927462
Zhang, X., et al. (2006). An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor. Cell 125: 1137-1149. PubMed Citation: 16777603
Zhao, D., Woolner, S. and Bownes, M. (2000). The Mirror transcription factor links signalling pathways in Drosophila oogenesis. Dev. Genes Evol. 210: 449-457. PubMed Citation: 11180850
Zhao, G. and Skeath, J. B. (2002). The Sox-domain containing gene Dichaete/fish-hook acts in concert with vnd and ind to regulate cell fate in the Drosophila neuroectoderm. Development 129: 1165-1174. 11874912
Zhao, G., Wheeler, S. R. and Skeath, J. B. (2007).
Genetic control of dorsoventral patterning and neuroblast specification in the Drosophila central nervous system. Int. J. Dev. Biol. 51(2): 107-15. Medline abstract: 17294361
Zou, H., et al. (2009). Human rhomboid family-1 gene RHBDF1 participates in GPCR-mediated transactivation of EGFR growth signals in head and neck squamous cancer
cells. FASEB J. 23: 425-432. PubMed Citation: 18832597
Zschatzsch, M., Oliva, C., Langen, M., De Geest, N., Ozel, M. N., Williamson, W. R., Lemon, W. C., Soldano, A., Munck, S., Hiesinger, P. R., Sanchez-Soriano, N. and Hassan, B. A. (2014). Regulation of branching dynamics by axon-intrinsic asymmetries in tyrosine kinase receptor signaling. Elife 3: e01699. PubMed ID: 24755286
zur Lage, P., Jan, Y. N. and Jarman, A. P. (1997). Requirement for EGF
receptor signalling in neural recruitment during formation of Drosophila
chordotonal sense organ clusters. Curr. Biol. 7: 166-175. PubMed Citation: 9395407
zur Lage, P. and Jarman, A. P. (1999). Antagonism of EGFR and Notch signalling in the reiterative recruitment of
Drosophila adult chordotonal sense organ precursors. Development 126: 3149-3157. PubMed Citation: 10375505
Zwick, E., et al. (1997). Critical role of calcium- dependent epidermal growth factor
receptor transactivation in PC12 cell membrane depolarization and
bradykinin signaling. J. Biol. Chem. 272(40): 24767-24770. PubMed Citation: 9312072
Return: References part 1/2
EGF receptor
:
Biological Overview
| Evolutionary Homologs
| Regulation
| Protein Interactions
| Developmental Biology
| Effects of Mutation
date revised: 20 December 2020Home page: The Interactive Fly © 1995, 1996 Thomas B. Brody, Ph.D.
The Interactive Fly resides on the
Society for Developmental Biology's Web server.