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Drosophila genes listed by biochemical function |
Zinc finger transcription factors A - L || M - Z
abrupt zinc finger - BTD domain
apterous LIM zinc finger domain and homeodomain
Arrowhead LIM domains and LIM homeodomain
Beadex (common alternative name: Lim-only (LMO) LIM-only protein
Blimp-1
zinc finger transcriptional repressor - developmental timing - pupation - chitin deposition - tracheal
maturation - fat body - regulated by the ubiquitin proteasome system - photoreceptors
Boundary element-associated factor of 32kD (common alternative name: BEAF)chromatin protein required for insulator function, and chromatin structure and dynamics - required for oogenesis and zygotic development
brother of odd with entrails limited (common alternative name: bowel)zinc finger transcription factor - required for the elaboration of pattern in the tarsus - promotes morphological changes associated with joint formation during leg development
broad (common alternative name: Broad Complex) zinc finger - BTD domain
buttonhead zinc finger
cabut zinc finger transcription factor, dorsal closure, wing disc, regulator of growth, transcriptional partner of Yorkie, promotes cell cycling, essential for dietary sugar tolerance, modulates Dpp signalling and the JAK/STAT pathway
castor zinc finger transcription factor that serves as a temporal lineage determinant during embryonic neurogenesis
CTCF
CCCTC-binding factor is a zinc finger transcription factor that confers enhancer blocking in all known chromatin insulators
charlatan
facilitates accumulation of proneural proteins Achaete and Scute by forming a transcriptional stimulatory loop
Chorion factor 2
zinc finger transcription factor - along with Mef2, Cf2 functions as critical regulator of the myogenic program - a mediator of EGF-R-activated dorsoventral patterning in oogenesis
Chromatin-linked adaptor for MSL proteins (common alternative name: Clamp)
zinc finger transcription factor - dosage compensation - essential in both males and females - also functions outside of the dosage compensation pathway
combgap zinc finger transcription factor
crooked legsmultiple zinc finger transcription factor
cubitus interruptus zinc finger
dendritic arbor reduction 1
zinc finger transcription factor that promotes dendrite growth in part by suppressing the expression of the microtubule-severing protein Spastin
DHR3 (preferred name: Hormone receptor-like/Hr46) nuclear receptor superfamily
disconnected and disco-related zinc finger transcription factors - required for head segment identitity during Drosophila embryogenesis - required for optic lobe development and ventral appendage development
dissatisfaction nuclear receptor superfamily
doublesex novel zinc finger
drumstick zinc finger transcription factor - regulates epidermal cell differentiation and patterning in the epithelia of the foregut, hindgut, and imaginal discs
eaglenuclear receptor - zinc finger
earmuff zinc finger transcription factor - functions cell-autonomously to maintain the restricted developmental potential of the intermediate neural progenitors generated by type II neuroblasts in Drosophila larval brains
Ecdysone-induced protein 75B
nuclear receptor - ensures proper temporal progression of larval development
Ecdysone receptornuclear receptor - zinc finger
elbow B
Sp1-type zinc finger - specifies distinct tracheal cell fates
escargot zinc finger
fruitless zinc finger - sex determination
estrogen-related receptor
nuclear receptor - regulates a coordinate switch in gene expression that drives a metabolic program normally associated with proliferating cells - supports growth during larval development
ftz transcription factor 1 nuclear receptor - zinc finger
FTZ-F2 (preferred name: tramtrack) zinc finger
GAGA (preferred name: Trithorax like) zinc finger - BTD domain
gata-2 (preferred name: pannier) zinc finger - GATA family
GATAe GATA family zinc finger transcription factor - required downstream of serpent for the expression of specific genes in the differentiated midgut
glass zinc finger
grain (common alternative name: dGATAc) zinc finger - GATA family
hamlet zinc finger - regulates cell identity in the peripheral nervous system - a binary genetic switch that acts to repress a multiple dendritic arbor and promote single-dendrite morphology
Hepatocyte nuclear factor 4 zinc finger
hermaphrodite(C2 H2) zinc finger protein
hindsight (preferred name: pebbled) multiple zinc finger transcription factor
Hnf-4 (preferred name: Hepatocyte nuclear factor 4)nuclear receptor - zinc finger - activated by fatty acids released from triglycerides, inducing enzymes that drive fatty acid oxidation for energy production
Hormone receptor-like in 38 nuclear receptor superfamily - participates in a second ecdysteroid signaling pathway that responds to a distinct class of ecdysteroids in a manner that is independent of EcR
Hormone receptor-like in 46 nuclear receptor superfamily - a mediator of ecdysone signaling - coordinates metamorphosis by acting together with the dS6K pathway, which controls nutrient-dependent growth
Hormone receptor 51 (common alternative name: Unfulfilled)
nuclear receptor superfamily - a thiolate heme-binding protein - necessary for mushroom body axon extension and branching mutants modulate wing expansion and fertility through underlying neurological defects
Hormone receptor-like in 39 nuclear receptor superfamily - master regulator of a program for the production of female reproductive glands and other secretory tissues
Hormone-receptor-like in 78 nuclear receptor superfamily
Hormone receptor-like in 96 nuclear receptor superfamily - regulation of cholesterol and triacylglycerol homeostasis, genetic control of xenobiotic stress responses
Hr4
steroid hormone receptor - coordinates growth and maturation in Drosophila by mediating endocrine responses to the attainment of critical weight during larval development
huckebein zinc finger - terminal gap gene
hunchback zinc finger
islet LIM zinc finger domain and homeodomain
jim lovell
BTB/POZ zinc finger transcription factor - required for endopolyploid growth in larval trachea - functions in the late specification of several classes of sensory neurons - mutant larvae show feeding and locomotor defects
jing zinc finger transcription factor - a downstream target of slbo required for border cell migration - also plays an essential role in controlling CNS midline and tracheal cell differentiation
ken and barbie BTB-POZ domain transcription factor with C-terminal zinc finger - recruits NURF by physical interaction to engender transcriptional repression - involved in genital disc development
klumpfuss transcription factor - zinc finger - egr family
knirps steroid receptor - zinc finger
Krüppel zinc finger, gap gene, segmentation
Kruppel homolog 1 zinc finger transcription factor - mediates some of the juvenile hormone signaling in the adult abdominal epidermis and is upstream of broad in this pathway
lame duck
zinc finger transcription factor - has an essential regulatory role in the specification and function of fusion-competent myoblasts
Lobe
zinc finger transcription factor required for eye cell survival - regulates eye development through the TOR pathway
longitudinals lacking zinc finger - BTD domain
luna zinc finger transcription factor - maternally supplied - required during the syncytial stages for coupling of rapid mitotic cycles and centrosome cycles
Lyra zinc finger - target of proneural genes
Metal response element-binding Transcription Factor-1 zinc finger transcription factor known familiarly as metal transcription factor - controls heavy metal detoxification
ming (preferred name: castor) zinc finger transcription factor that serves as a temporal lineage determinant during embryonic neurogenesis
Muscle LIM protein at 60A LIM zinc finger domains - LIM-only protein
nervous fingers 1 (nerfin-1) zinc finger transcription factor required for the proper development of CNS commissural and connective axon fascicles
odd skipped zinc finger - pair rule gene
odd-paired zinc finger - pair rule gene
ovo zinc finger - ovarian maturation, sex determination, segment polarity
pannier (common alternative name: dGATAa) zinc finger - GATA family
pebbled multiple zinc finger transcription factor
pita (alternative name: spotted dick) zinc finger transcription factor that serves as an activator of expression of a set of genes required for initiation of DNA replication
pleiohomeotic zinc finger - Polycomb group
poils au dos zinc finger transcription factor - repressor of achaete and scute during bristle development
polyhomeotic proximal & distal zinc finger - Polycomb group
Posterior sexcombs zinc finger - ring motif - Polycomb group
putzig zinc finger transcription factor that acts as key regulator of cell proliferation and as a positive of Notch target genes
rotund
transcription factor - zinc finger - required for proper imaginal disc development
schnurri zinc finger - target of DPP
scratch transcription factor - zinc finger - panneural repressor
scribbler novel protein with a single zinc finger
senseless (preferred name: Lyra) zinc finger - target of proneural genes
sequoia zinc finger - required for specification of a subset of neurons - functions in regulating dendrite and axon development
serpent (common alternative name: dGATAb) zinc finger - GATA family
seven up transcription factor - orphan nuclear receptor - zinc finger
Sex combs on midleg
Polycomb group - C2C2 type zinc finger
shuttle craft zinc finger, C4HC3 type (PHD finger), and RD-domain protein
snail zinc finger - DV polarity
Sp1
master regulator of both wing and leg development
spalt zinc finger - PRDII-BF1 homolog
squeeze zinc finger transcription factor - regulates neuropeptidergic cellular identity and FMRFamide expression
stripe zinc finger - muscle development
sunspot zinc finger transcription factor that interacts with Armadillo - acts downstream of wingless to positively regulate the proliferation of imaginal disc cells and the endoreplication of salivary gland cells - activates E2F-1 and PCNA expression
suppressor of Hairy wing zinc fingers and leucine zipper - binds gypsy insulator element
Suppressor of variegation 3-7
chromatin constituent - zinc finger protein - required for X-restricted dosage compensation complex targeting
tailless nuclear receptor - zinc finger
teashirt zinc finger
teflon
zinc finger transcription factor - required in males for the maintenance of pairing between homologs at meiosis - required for the localization of the product of mod(mdg4) to paired autosomal bivalents - promotes alternative homolog conjunction during male meiosis without being part of the final physical linkage between chromosomes
tramtrack (common alternative name: FTZ-F2) zinc finger - BTD domain
trithorax histone methyltransferase activity (H3-K4 specific), zinc finger - trithorax group
Trithorax-like (common alternative name: GAGA) GAGA - Zinc finger, BTD domain
u-shaped multiple zinc finger protein
ultraspiracle RXR homolog - nuclear receptor
vielfaltig (common alternative name: zelda) zinc finger transcription factor - functions in the cellular blastoderm to activate many genes essential for cellularization, sex determination and pattern formation
worniu
zinc finger transcriptional repressor - required in neuroblasts to maintain self-renewal by promoting cell-cycle progression and inhibiting premature differentiation - expressed in the neuroblasts of brain hemispheres and the ventral ganglion - promotes ommatidial death during eye development and subsequent photoreceptor formation - controls both
asymmetry and cell division of neuroblasts
Zinc-finger protein
zinc finger transcription factor required for the expression and asymmetric localization of aPKC, thus establishing cell polarity and controlling neuroblast self-renewal
Zinc finger protein RP-8
control of heterochromatin silencing - interacts with the piRNA pathway that is essential for the maintenance of germline stem cells, a component of the small ribosomal subunit (40S), controls RNA processing, regulates cell proliferation
Zn finger homeodomain 1 zinc finger domain and homeodomain protein - mutation results in various degrees of local errors in mesodermal cell fate or positioning
Zn finger homeodomain 2
transcription factor - zinc finger domain and homeodomain - required for correct proximal wing development
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Drosophila genes listed by biochemical function
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