- RECEPTOR TYROSINE KINASES AND PHOSPHATASES AND SERINE/THREONINE KINASES
- Anaplastic lymphoma kinase
- transmembrane protein - receptor tyrosine kinase - the ligand Jelly belly activates Alk
- to specify a select group of visceral muscle precursors as muscle-patterning pioneers
- baboon
- transmembrane protein - Type 1 activin-A-receptor - receptor serine/threonine kinase
- breathless
- transmembrane FGF receptor
- DER (preferred name: EGF-R, common alternative name: Torpedo)
- receptor- tk - EGF-R homology
- derailed
- receptor TK
- Dlar
- receptor tyrosine phosphatase - axon guidance
- Dror
- receptor tyrosine kinase - trk homolog
- Eph receptor tyrosine kinase
- receptor tyrosine kinase
- Epidermal growth factor receptor (common alternative name: Torpedo)
- receptor tyrosine kinase
- fgf-receptor homolog 1 (common alternative name: heartless or DFR1)
- transmembrane - receptor - Ig superfamily
- heartless (commonly known as Fibroblast growth factor receptor 1 or DFR-1)
- receptor tyrosine kinase - involved in the development of
mesodermal and neuronal cells - supports Drosophila fertility by
- regulating development of ovarian muscle tissues - Pebble is required for cell shape changes during cell migration triggered by Heartless
- Insulin-like receptor
-
receptor tyrosine kinase - a key component of an evolutionarily conserved signaling pathway that plays an essential role in controlling body, organ, and cell size
- off-track
- CCK-4 family of 'dead' receptor tyrosine kinases, Ig-domains - required for lamina-specific targeting of R1-R6 axons -
- associates with Plexin, the receptor for Semaphorin ligand
- PDGF- and VEGF-receptor related
-
Ig C-2 type domain receptor tyrosine kinase - required for border cell migration
- Protein tyrosine phosphatase 4E
- broadly expressed type III receptor tyrosine phosphatase closely related to Ptp10D - shows synthetic phenotypes with other Pdps
- Protein tyrosine phosphatase 10D
- receptor tyrosine phosphatase - required for embryonic and larval axon guidance - along with Ptp69D regulates segregation
- of the young axons into a single core bundle in the larval mushroom body - mutants are defective in long-term memory formation
- Protein tyrosine phosphatase 69D
- receptor tyrosine phosphatase
- punt
- receptor for DPP - type II receptor serine/threonine kinase
- Ret oncogene
- regulates dendrite patterning, adhesion and stability - rescues mitochondrial morphology and muscle degeneration of Pink1 mutants
- saxophone
- receptor serine/threonine kinase - a DPP receptor
- sevenless
- receptor tyrosine kinase - Boss receptor
- thickveins
- receptor serine/threonine kinase for DPP
- torpedo (preferred name: Epidermal growth factor receptor, common alternative name: ellipse)
- receptor-tk egf-r homology
- torso
- receptorTK
- wishful thinking
- type II TGFß receptor - functions presynaptically to regulate synaptic size at the neuromuscular junction - receptor serine/threonine kinase
- TRANSMEMBRANE ADHESION PROTEINS
- anakonda
-
transmembrane receptor protein - interacts extracellularly to mediate assembly of tricellular junctions - septate junctions - ectodermal and endodermal epithelia
- Basigin
-
conserved IgCAM required pre- and post-synaptically at neuromuscular junctions to restrict synaptic bouton size,
- controls distribution of synaptic vesicles and organization of the presynaptic cortical actin cytoskeleton
- borderless
-
Ig superfamily transmembrane protein that coordinates neurite-neurite interactions in the developing optic lobe
- Cadherin-E (preferred name: shotgun)
- cadherin - cell aggregation
- Cadherin-N
- transmembrane receptor, cadherin homolog
- Cad99C
- receptor - cadherin superfamily - expressed in follicle cells - regulator of microvillus length
- commissureless
- novel transmembrane protein
- capricious
- leucine-rich repeat transmembrane protein involved in selective synapse formation;
- contributes to formation of the affinity boundary between dorsal and ventral compartments of the wing
- Contactin
-
required for organization of septate junctions and for function of the paracellular barrier -
- Forms a tripartite complex with Neuroglian and Neurexin
- crumbs
- egf repeats - laminin A homolog
- dachsous
- cadherin superfamily
- DE-cadherin (preferred name: shotgun)
- E-cadherin homolog
- Delta
- EGF family - Notch ligand
- dumbfounded (preferred name: kin of irre)
- IG superfamily - required for myoblast aggregation and fusion
-
Dystroglycan
-
transmembrane receptor for extracellular matrix molecules - required for cellular polarity in epithelial cells and the oocyte
- Dscam
- multiple Ig domain protein
- E-cadherin (preferred name: shotgun)
- tm - E-cadherin homolog
- echinoid & friend of echinoid
-
cell-adhesion molecules (CAMs) - Ig and fibronectin domains proteins - The genes are adjacent to one another and co-ordinately regulated -
- Echinoid acts to antagonize Egf receptor signaling - Friend of echinoid exhibits interaction with the Notch pathway
- 18 wheeler
- transmembrane protein with with leucine-rich motif (LRR)
- Fasciclin I
- cam - lipid linked to membrane - novel
- Fasciclin II
- NCAM homolog - Ig superfamily
- Fasciclin III
- cam - novel
- fat
- cadherin domain transmembrane receptor that negatively controls cell proliferation - also functions in planar polarity
- furrowed
- selectin (carbohydrate binding protein)
- Gliolectin
- lectin (carbohydrate binding protein)
- Gliotactin
- novel serine esterase homolog
- hibris
- Ig repeat transmembrane protein with fibronectin type III domain - a receptor involved in muscle cell fusion
- integrin - beta PS (preferred name: myospheroid)
- integrin - beta subunit
- kekkon-1
-
Ig domain protein, Leucine-rich repeat protein
- kuzbanian
-
disintegrin and metalloprotease motifs - neurogenic
- Lachesin
-
GPI-anchored surface immunoglobulin domain cell adhesion molecule required for the proper morphogenesis of the tracheal system
- leak (common alternative name: robo2)
- transmembrane receptor that regulates axon guidance and heart cell and tracheal branch migration
- multiple edematous wings *
- alpha PS1 integrin - see myospheroid
- myospheroid
- integrin-beta subunit of PS1 & PS2
- Neuroglian
- IG superfamily - NgCAM related
- neuroligin-1 and neuroligin-2
-
Postsynaptic receptor that interacts with presynaptic Neurexins - recruits scaffolding proteins for organization of postsynaptic neurotransmitter receptors -
- mediates the precise apposition of presynaptic and postsynaptic membranes
- Neuroligin 4
-
neural cell adhesion molecule - neuromuscular junction BMP signaling pathway - sleep social behavior, interacts physically interact with Thickveins
- Neurotactin
- serine esterase homolog
- Notch
- receptor - neurogenic
- pollux
- novel cell surface receptor, leucine zipper protein
- roughest
- Ig-C2-type-domain protein - transmembrane
- roundabout
- immunoglobulin and fibronectin repeats transmembrane receptor that regulates axon guidance
- robo2 (preferred name: leak)
- transmembrane receptor that regulates axon guidance and heart cell and tracheal branch migration
- semaphorin-1a
- axon guidance transmembrane protein
- Serrate
- transmembrane - EGF homolog - ligand for Notch - involved in the induction, through Notch, of the wing margin at the dorsal-ventral interface of the wing
- imaginal disc - a Serrate-Notch-Canoe complex mediates essential interactions between glia and neuroepithelial cells during Drosophila optic lobe development
- scab
- α-PS3 integrin - involved in dorsal closure, tracheal and salivary gland development and in the localization of pericardial cells - thought to dimerize
- with Myospheroid and possibly Integrin betanu subunit - Scb regulates adhesion, signalling, polarity and cell migration - genetic interaction
- with Laminin genes implicates them as extracellular matrix ligands
- shotgun
- cadherin - regulates cell aggregation preventing mixing of cells at tissue boundaries - Neuroblast niche position is controlled by PI3-kinase
- dependent DE-Cadherin adhesion - required for the maintenance of ring canals anchoring to mechanically withstand tissue growth during oogenesis
- sidekick
-
Ig domain receptor - accumulates in specific synaptic layers of the developing motion detection circuit - necessary for
- normal optomotor behavior - adherens junctions - tricellular junction protein - regulates vertex
- dynamics to promote bicellular junction extension - necessary to maintain normal levels of cell bond tension
- starry night
- Cadherin-related 7TM protein
- sticks and stones
- transmembrane protein expressed on the surface of fusion competent myoblasts - essential for fusion of embryonic myoblasts
- strabismus (preferred name: Van Gogh)
- novel protein
- tartan
- Leucine-rich repeat transmembrane protein - along with Capricious, contributes to the adhesive properties of the cells
- in the morphogenetic furrow, thus regulating control of spacing ommatidial clusters - regulates boundary formation in the leg and wing -
- regulates tracheal branching
- teiresias
-
Ig superfamily transmembrane protein - sex determination - feminizing function, interacts with other Ig superfamily transmembrane proteins, including
- Robo1, to feminize the neurite patterns in females - FruBM represses tei transcription in males - axon guidance, brain and ventral cord
- Tenascin accessory
-
transmembrane partner of Tenascin major acting in synapse assembly at the neuromuscular junction - synaptic partner matching in olfactory system -
- regulates fusion of central complex primordia and eye patterning
- Tenascin major
- transmembrane protein that acts together with the Filamin Cheerio to influence growth cone progression
- Van Gogh (common alternative name: strabismus)
- novel, potentially transmembrane protein
- Miscellaneous Transmembrane Proteins
- beta amyloid protein precursor-like
- beta amyloid homolog
- Anktm1
(common alternative name: dTrpA1)
- heat-activated TRP family ion channel that is essential for thermotaxis
- arrow
- LDL-receptor-related protein (LRP) family - Wingless pathway
- atlastin
- dynamin-family transmembrane GTPase that drives endoplasmic reticulum membrane fusion in a GTP-dependent fashion - self-associating protein
- that is able to form trans-oligomeric complexes - required for normal growth of muscles and synapses at the neuromuscular junction
- Autophagy-specific gene 9
-
a vesicular transmembrane protein that is a constituent of autophagic vesicles and is required for oxidative stress-induced JNK activation
- Bride of sevenless (Boss)
- ligand of Sevenless - 7 transmembrane segments
- brivido-1
-
cation channel that mediates the mechanotransduction of class III dendritic arborization neurons of the PNS
- cacophony
- voltage sensitive calcium channel that stimulates neurotransmetter release at the presynaptic terminus at the neuromuscular junction
- Ca2+-channel protein α1 subunit D
- α subunit of an L-type voltage-gated Ca[2+] channel - there is a strict functional separation of AP-triggered neurotransmitter release
- by Cav2 (Cacophony) and activity-dependent modulation of SV recycling and short-term plasticity by Cav1 -
- Cav1
channels within the periphery of AZs are a distinct entry route for Ca2+-dependent augmentation of SV endocytosis - Ca-α1D is a
- downstream target of a tyramine (honoka) receptor activation - Ca-alpha1D is the primary functioning Ca(2+) channel in Drosophila hearts - synaptic
-
Dmca1D channels increase burst duration and maximum intraburst firing frequencies during crawling-like motor patterns - stac and Dmca1D are
- required for excitation-contraction coupling - Dstac appears to be required for normal expression levels of Dmca1D in body-wall muscles
- Ca2+-channel protein α1 subunit T
- voltage-gated calcium channel underlying the amiloride-sensitive transient current, projection neurons located in the antennal lobe,
- negative modulation of sleep, voltage-activated calcium currents in Drosophila motoneurons
- cornichon
- cargo receptor required for transport of the TGFalpha growth factor Gurken to the oocyte surface
- croquemort
- a member of the CD36 family of scavenger receptors - required for microbial phagocytosis and efficient
- bacterial clearance - booster for croquemort interacts with the zinc finger domain of the GATA transcription
- factor Serpent (Srp), to enhance its direct binding to the crq promoter; thus, Crq and Srp function
- together in regulating crq expression and efferocytosis, the action of removing apoptotic particles
- death executioner Bcl-2 homologue
- Bcl-2/CED-9 family protein involved in regulating apoptosis
- dispatched
-
patched family protein regulating Hedgehog release
- domeless
-
a divergent member of the cytokine class I receptor family - required for segmentation and functions in trachea specification
- Dopamine transporter
- mediates uptake of dopamine in dopamine positive neurons - functions in regulating sleep and arousal
- draper
-
encoding an EGF-repeat single-pass transmembrane domain receptor - required during metamorphosis for recognition and engulfment of degenerating axon branches by glia
- Dscam2
- immunoglobulin superfamily - Dscam2 homophilic interactions mediate repulsion between neurites of L1 laminar cells in neighbouring columns of the optic lobe
- eater
- EGF-like repeat transmembrane protein located on phagocytic cells - mediates resistence to bacteria
- ether a go-go
- a voltage-gated delayed rectifier K+ channel subunit - responsible for repolarization phase that returns synaptic membrane potential back to the resting membrane
- potential - inhibited by high Ca(2+) concentrations that are only present at plasma membrane Ca(2+) channel microdomains - regulated by Calmodulin binding - neuromuscular junction - Multiple
- K+ channel α-subunits coassemble with Hyperkinetic, including Shaker, Ether-a-go-go, and Ether-a-go-go-related gene are ion conducting channels for Cry/Hk-coupled light response
- Excitatory amino acid transporter 1
- tranmembrane excitatory amino acid transporter expressed in glial cells - tightly regulates
- extracellular glutamate levels to control neurotransmission functions in locomotor behavior
- fear of intimacy
-
transmembrane domain protein - FICL family - zinc transporter - required in the mesoderm for gonad morphogenesis - required for tracheal branch fusion
- flower
- transmembrane protein - expressed in 'loser' cells to mediate win/lose decisions in cell competition by means of differentially expressed isoforms
- four-jointed
-
type 2 transmembrane kinase - regulates tissue polarity - phosphorylates of the atypical cadherins Fat and Dachsous - regulates growth via the Hippo/Warts pathway
- frazzled
- Ig superfamily - Netrin receptor
- genderblind
- glutamate permease - regulates ambient extracellular glutamate to suppress glutamatergic synapse strength - controls mate choice
- Glial cell line-derived neurotrophic family receptor-like
- a GPI-anchored membrane protein with four GDNF family receptor-like domains - regulates oogenesis and male fertility -
- expressed in the central and peripheral nervous systems
- GluClα
- glutamate-gated chloride channel, component of the ON and OFF pathway in the optic lobe - together with Rdl serves
- as a co-receptor for the insecticides nodulisporic acid and ivermectin - open-channel conformation
- causes a continuous inflow of chloride ions and sustained membrane hyperpolarization - antenna lobe
- Glutamate receptor IIA and Glutamate receptor IIB
- transmembrane Ca2+ channel protein
- Golden goal
-
transmembrane receptor that is dynamically expressed in all photoreceptor neurons and localizes predominantly to growth cones - regulates axon-axon
- and axon-target interactions in R8 photoreceptor axon - acts as a functional partner of Flamingo for R8 photoreceptor axon targeting in the medulla
- grindelwald
- tumour necrosis factor receptor - JNK signalling - integrates apoptotic functions from Eiger
- with signaling from apical polarity determinants to induce JNK-dependent cell death or tumour growth
- Histamine-gated chloride channel subunit 1
- an ion transmembrane transport complex subunit that contributes to thermotaxis and chloride transport - color-opponent processing
- of UVshort/blue and UVlong/green is implemented in R7/R8 inner photoreceptor terminals of "pale" and "yellow" ommatidia, respectively
- . R7 and R8 photoreceptors of the each ommatidium mutually inhibit each other directly via HisCl1 and receive additional feedback inhibition that requires
- the second histamine receptor Ort - color-opponent processing at the first visual synapse represents an unexpected commonality between Drosophila and vertebrates
- hoka
-
smooth septate junction component - transmembrane protein forms a complex with Ssk, Mesh, and Tsp2A and is required for the correct
- localization of these proteins to septate junctions - knockdown in the adult midgut leads to intestinal barrier dysfunction and stem cell
- overproliferation - required for maintaining intestinal stem cell homeostasis through the regulation of aPKC and Yki activities
- I'm not dead yet
- plasma membrane transporter of Krebs cycle intermediates - midgut - regulation of lifespan - regulation of mitochondrial function
- inactive
- transient receptor potential vanilloid channel - expressed in chordotonal neurons where it is involved in temperature preference -
- expressed in antenna were it is involved in hearing
- inebriated
-
neurotransmitter:sodium symporter - mutations appear to cause increased excitability of the motor neuron by causing defective reuptake of a substrate neurotransmitter
- Inositol 1,4,5,-tris-phosphate receptor
- calcium channel
- Innexin 2
- gap junction protein; blood-brain barrier glia - mediates the influence of metabolic changes on stem cell behavior;
- response of glia nutritional signals - functions in oogenesis, visual transmission in lamina glia,
- and proventriculus development; crucial for epithelial organization and polarity of the embryonic epidermis
- interference Hedgehog
- IGcam membrane protein - binds Hedgehog and mediates Hedgehog response
- Inwardly rectifying potassium channel 1, 2, and 3
-
potassium inward rectifier (Kir) superfamily of channels - inward rectifiers allow a much greater K(+) influx than efflux -
- osmoregulation - hind gut - Malpighian tubules - regulation of spike discharge frequency and amplitude of the evoked EPSPa at the
- neuromuscular junction - a principal potassium conductance pathway in the salivary gland that is required for sucrose feeding
- KaiR1D (CG3822)
- glutamate channel - kainate family protein - localized to presynaptic terminals of the neuromuscular junction - eya - homeostatic potentiation of synaptic strength
-
kon-tiki
- conserved multi-domain transmembrane receptor required cell autonomously for myotubes to recognize their tendon cell targets -
- signals through the intracellular adaptor Grip in a conserved molecular pathway
- kugelei (common alternative names: fat-like, fat2)
- a cadherin related to Fat - required for the planar polarity of actin filament orientation
- at the basal side of ovarian follicle cells - acts non-autonomously in follicle cells in the transmission of polarity information
- required for morphogenesis and maintenance of tubular structures of ectodermal origin
-
Leucine-rich repeat-containing G protein-coupled receptor 3
-
receptor for Insulin-like peptide 8 - regulation of growth - attenuation growth and maturation - neurosecretory cell-rich pars intercerebralis
-
LDL receptor related protein 4
-
low-density lipoprotein receptor-related protein in the same family as Arrow, a Wingless co-receptor - coordinates synapse number and function
- in the brain - functions via the conserved kinase SRPK79D to ensure normal synapse number and behavior, occurs preferentially in excitatory neurons
- megatrachea (accepted Flybase name: pickel)
- claudin required for septate junction formation and barrier function - control of secretion processes specific
- to septate junction and dependent on Sec61p may involve Megatrachea interaction with Sec61 subunits, trachea
-
mesh
-
transmembrane protein - component of smooth septate junctions, functions cooperates with Tetraspanin 2A and Snakeskin to organize
- septate junctions - midgut - Malpighian tubules
- Mitoguardin
-
a mitochondrial outer-membrane protein that regulates endoplasmic reticulum-mitochondrial contact sites (ERMCSs) - required for autophagy
- Na/Ca-exchange protein
-
involved in phototransduction and response to endoplasmic reticulum stress
- nanchung
-
calcium channel, TRP family - partners with the channel Inactive in hearing transduction - in labellar mechanosensory neurons involved in
- preference for soft food - Nan-expressing neurons under recurved bristles along the wing margin are essential sensory components for defensive
- behavior - insecticides serve as specific agonists of Nan-Iav complexes that, by promoting cellular calcium influx, silence the stretch receptor cells
- Na pump α subunit
- ion pump responsible for the cellular balance of sodium and potassium ions - regulation of neuronal excitability and auditory mechanosensation -
- epithelial junction function - tracheal tube-size control - septate junction function - neurodegeneration - muscles - malpighian tubules
- Neither inactivation nor afterpotential E (common alternative name: Rh1)
- rhodopsin expressed in photoreceptors R1-R6, response to light intensity, phototransduction, thermotaxis
- Neuropilin and tolloid-like (common alternative name: Neto)
- transmembrane protein - auxiliary subunit of ionic Glutamate receptor required for clustering of ionotropic glutamate receptors
- at the neuromuscular junction, for organization of postsynaptic densities and for synapse functionality
- nervana 1 and nervana 2
- β subunit of Na,K-ATPase, plays an ion-pump-independent role in junction formation and tracheal morphogenesis
- Neurexin
- multifunctional protein located at septate junctions
- nicotinic Acetylcholine Receptor α5, nicotinic Acetylcholine Receptor α6 & nicotinic Acetylcholine Receptor α7
- neurotransmitter-gated ion-channels - cholinergic synapse formation and dendritic refinement - site of action of insecticides
- nicotinic Acetylcholine Receptor α1
- forms pentameric receptors involved in fast excitatory synaptic neurotransmission - associated with changes in courtship, sleep longevity and insecticide resistance
- Niemann-Pick Type C-1
- a transmembrane protein related to the Hedgehog receptor Patched - mutants have a shortage of sterol, and, as a consequence, inadequate ecdysone synthesis
- Nimrod C1
- EGF-like repeat transmembrane protein located on phagocytic cells - mediates resistence to bacteria
- NMDA receptor 1 and NMDA receptor 2
- voltage/Mg2+-dependent Ca2+ channels activated by glutamate - required for olfactory learning
- no mechanoreceptor potential C
- a mechanosensitive Ca2+ TRP family channel, mediates locomotion related proprioception (touch sensation)
- in PNS localized neurons - mediates sound detection in Johnston's organ
- olf186-F (common alternative name: Orai)
- store-operated Ca2+ channel involved in rhythmic firing of the flight motoneurons - physically interacts with
- the Ca2+ store sensor Stim (Stromal interaction molecule) to form the Ca2+ release-activated Ca2+ (CRAC) channel
- optic ganglion reduced (common alternative names: Ogre and Inx-1)
- gap junction protein functioning in blood-brain barrier glia - mediate the influence
- of metabolic changes on stem cell behavior; response of glia to nutritional signals
- otopterin-like a
- mediates acid taste - functions in distinct subsets of gustatory receptor
- neurons for repulsion and attraction to high and low levels of protons, respectively
- Ora transientless
- histamine-gated chloride channel required for synaptic transmission at the photoreceptor-large monopolar cells synapse and
- for orientation and motion vision - responsible for synaptic transients in electroretinograms -
- modulates temperature preference and controls tolerance of low and high temperature
- painless
- calcium channel - nociceptor - mutant is pain response defective
- paralytic
-
α-subunit of voltage-gated sodium channel - neuromuscular junction - required for locomotor activity - generates sodium-dependent
- action potentials - regulated by RNA alternative splicing and translational repression
-
Pasiflora1 and Pasiflora2
- tetraspan proteins - core components of septate junctions - blood-brain and tracheal barriers
- patched
- segment polarity gene
- pathetic
-
expressed in both neuroblasts and glia - In NBs, path is directly targeted by Notch signalling via Su(H) binding - Loss of path in
- larval brain neural stem cells delays proliferation - important in glial cells to help protect brain growth under conditions of nutrient
- restriction - a candidate gene in the nutritional circuit between systemic muscle wasting and tumour growth in proline vulnerable
- cancers - mutation of path impinges on nutrient responses and protein homeostasis specifically in neurons with large dendrite arbors but not in other cells
-
perdido (common alternative name: Kon-tiki)
-
conserved multi-domain transmembrane receptor required cell autonomously for myotubes to recognize their tendon cell targets -
- signals through the intracellular adaptor Grip in a conserved molecular pathway
- pickel (common alternative name: Megatrachea)
- claudin required for septate junction formation and barrier function - control of secretion processes specific
- to septate junction and dependent on Sec61p may involve Megatrachea interaction with Sec61 subunits, trachea
-
pickpocket
-
subunit of the epithelial sodium channel (ENaC) family - plays an essential role in controlling rhythmic locomotion
- by providing mechanosensory signal transduction of proprioceptive sensory information
- pickpocket 11 & pickpocket 16
- DEG/ENaC sodium channel subunits - homeostatic modulation of presynaptic neurotransmitter release
- pickpocket 23, pickpocket 25 and pickpocket 28
- DEG/ENaC sodium channel subunits - required for activation of courtship behavior by chemosensory perception of female pheromones
- pickpocket 28
- amiloride-sensitive Na+ channel - osmosensitive ion channel that mediates response to water -
- expressed in labellar gustatory chemosensory bristles
-
Piezo
- mechanically activated cation channel - stretch-activated mechanotransduction - mechanical nociceptor
- plexin A
- semaphorin domain protein, semaphorin receptor
- plexin B
- semaphorin domain protein, receptor for the secreted semaphorin Sema-2a -
- regulates axon extension from the sensory neuron cell body in regions of direct contact with oenocytes
- Peptidoglycan recognition protein LC
- transmembrane receptor involved in antimicrobial response, recognizes bacterial toxins, expressed in fat body and midgut
- porin
- main pore-forming protein of the outer mitochondrial membrane - multi-functional channel protein that shuttles
- metabolites between the mitochondria and the cytosol and implicated in cellular life and death decisions
- Presenilin
-
transmembrane protein involved in proteolysis of Notch
- pretaporter
- transmembrane protein - a ligand for the engulfment receptor Draper. It resides in the endoplasmic reticulum. During apoptosis it is
- exposed at the cell surface where it binds the product of Drpr to induce phagocytosis - RNA-binding protein FMRP binds pretaporter (Prtp)
- and amyloid precursor protein-like (APPL) signals directing this glial clearance - transmembrane protein trafficked from the
- endoplasmic reticulum (ER) to the cell surface of a neuron thus marked for removal, where it binds the Drpr engulfment receptor on glia
- rickets
-
timing of metamorphosis - activation of - stereotyped behavioral program - migration of the border cells
- Resistant to dieldrin
-
GABA-A receptor that negatively modulates olfactory associative learning, possibly by gating the input of olfactory information
- into the mushroom bodies - regulates the length of time required to fall asleep
- Reticulon-like1
- a reticulon family member, with intramembrane hairpin domains that insert into the cytosolic face of the endoplasmic reticulum (ER)
- thereby curving it and promoting ER tubule formation - enriched on tubular ER, including axons and egg chamber fusomes - high level
- leads to ER fragmentation - microtubule cytoskeleton is involved in Rtnl1 localization to spindles during mitosis
- rhomboid (preferred name: veinlet)
- serine protease - transmembrane protein involved with Epidermal growth factor receptor signaling - required for the production or processing of Spitz, the Egfr ligand
- rhomboid-7
- transmembrane mitochondrial protease required for spermatogenesis and muscle maturation
- roughoid
- EGF pathway
- Ryanodine receptor 44F
- Ca2+-induced Ca2+ release channel located in presynaptic endoplasmic reticulum membranes -
- sustains vesicular mobilization thus enhancing release of transmitters and neuropeptides
- sanpodo
-
encodes a four-pass transmembrane protein that localizes to the cell membrane - specifies Notch-dependent fate - Notch and Numb physically associate with Sanpodo
- Sarco/endoplasmic reticulum Ca(2+)-ATPase (common althernative name: SERCA)
- endoplasmic reticulum calcium pump - mutants disrupt Wingless signaling by sequestering Armadillo/beta-catenin
- away from the signaling pool - Seipin interacts with SERCA, whose activity is reduced in Seipin mutants, leading
- to reduced ER calcium levels - THADA binds SERCA and acts on it as an uncoupler - tracheal budding
- semaphorin-1a
- Axon guidance transmembrane protein
- Sensory neuron membrane protein
- CD36-related transmembrane protein - essential for the response of olfactory sensory neurons to cis-vaccenyl acetate,
- a male-specific fatty-acid-derived pheromone that regulates sexual and social aggregation behaviours
- Seipin
- Transmembrane lipid-binding protein - promotes adipose tissue lipid storage via calcium-dependent mitochondrial metabolism
- seizure
-
voltage-gated potassium channel - essential for protecting flies from acute heat-induced seizures -acts in excitatory neurons -
- the octopaminergic system and neuropile ensheathing and perineurial glia - mutations in sei cause extensive
- structural remodeling of the myofibrillar organization - expressed widely in the CNS - neuromuscular junction - heart
- Serotonin transporter
- regulates serotonergic neurotransmission by retrieving released serotonin and replenishing vesicular stores - expressed in brain and CNS
- Shaker
- Integral membrane voltage-gated potassium ion channel - carries type-A potassium current responsible for the repolarization
- of the cell - regulates neurotransmitter release at the synapse - regulates sleep - neuromuscular junction
- shaking b
- gap junction protein - innexin - motor neuron pattern regulation - giant fiber system -Johnston's organ neurons - optic lobe
- Shaker cognate l
- voltage-gated potassium channel - neuromuscular junction - regulation of action potential waveform, back-propagation and firing
- frequency - eliminating Shal invokes Kruppel-dependent homeostatic rebalancing of ion channel gene expression including enhanced
- slo, Shab, and Shaker - photoperiod, contributes to currents in the motoneurons - locomotion, SIDL regulates LL-motif-dependent
- targeting of K(+) channels, shal and shaker, are reciprocally, transcriptionally coupled to maintain A-type channel expression
- sinuous
- claudin - localizes to septate junctions and is required for junction organization and paracellular barrier function -
- required fo maintenance of cardiac integrity
- SLC22A family member
-
a plasma membrane transporter - localizes in the dendrites of mushroom body neurons - terminates synaptic
- transmission from cholinergic projection neurons through uptake of the released neurotransmitter acetylcholine - enhances
- olfactory memory by allowing the neurotransmitter signal from projection neurons to be more persistent
- slimfast
- Amino acid transporter - downregulation within the fat body causes a global growth defect involving TSC/TOR signaling
- in the fat body and a remote inhibition of organismal growth
- slowpoke
- Ca-activated, voltage-activated potassium channel
- small conductance calcium-activated potassium channel
- potassium channel - negatively regulates nociception - interacts with calmodulin, which acts as a Ca2+ sensor - regulates synaptic excitation in the visual network -
- postsynapse of the NMJ - contributes to photoreceptor performance by mediating sensitivity control at the first negatively regulates the acquisition of short-term memory
- smoothened
- seven-pass transmembrane protein - putative hedgehog receptor
- Snakeskin
- Four transmembrane protein required for assembly of smooth septate junctions (sSJs) together with mesh and Tsp2A - required
- for maintaining intestinal stem cell homeostasis through the regulation of aPKC and Yki activities in the Drosophila
- midgut - expressed in Malpighian tubule, embryonic/larval visceral muscle, gut section and primordial germ cells
