Postdoctoral Position in Programmed DNA Elimination, University of Colorado School of Medicine

Posted 7/26/2017

A postdoctoral position is available to study PROGRAMMED DNA ELIMINATION in the Davis Lab at the University of Colorado School of Medicine in Denver, CO. Programmed DNA elimination is a developmental process in which portions of the genome are reproducibly eliminated. This process occurs in diverse eukaryotes ranging from single-celled ciliates, nematodes, and crustaceans to birds and jawless fish (lampreys). In some nematodes, ~15-90% of the genome is eliminated in the somatic lineages during the 3rd through 5th cleavage (4 to 16 cell stage), while the germline genome remains intact. ~1000-2000 germline and early development expressed genes are eliminated.  Chromosomes break, regions are lost, and new and increased numbers of chromosomes are formed. Areas under investigation include analysis in nematodes of

  1. How genome regions are marked for retention or elimination
  2. How break regions are identified and the mechanism of chromosome breaks
  3. How eliminated chromosome regions are selectively lost from holocentric chromosomes
  4. The contributions of epigenetic factors including histone modifications and non-coding RNAs to DNA elimination.

For information on how to apply for the postdoctoral position, see

For additional information on the laboratory's research and recent publications, see

Last Updated 07/26/2017