rhomboid
Adrain, C., Strisovsky, K., Zettl, M., Hu, L., Lemberg, M. K. and Freeman, M. (2011). Mammalian EGF receptor activation by the rhomboid protease RHBDL2. EMBO Rep 12: 421-427. PubMed ID: 21494248
Alexandre, C., Lecourtois, M. and Vincent, J.-P. (1999). Wingless and Hedgehog pattern Drosophila denticle belts by regulating the production of short-range signals. Development 126: 5689-5698. PubMed Citation: 10572045
Adrain, C., Strisovsky, K., Zettl, M., Hu, L., Lemberg, M.K., and Freeman, M. (2011). Mammalian EGF receptor activation by the rhomboid protease RHBDL2. EMBO Rep. 12(5): 421-7. PubMed Citation: 21494248
Angulo, M., Corominas, M. and Serras, F. (2004). Activation and repression activities of ash2 in Drosophila wing imaginal discs. Development 131(20): 4943-53. 15371308
Bang, A. G. and Kintner, C. (2000). Rhomboid and Star facilitate presentation and processing of the Drosophila TGF-alpha homolog Spitz. Genes Dev. 14: 177-186. PubMed Citation: 10652272
Baonza, A. and Garcia-Bellido, A. (1999). Dual role of extramacrochaetae in cell proliferation and cell differentiation during wing morphogenesis in Drosophila. Mech. Dev. 80(2): 133-46. PubMed Citation: 10072780
Bidet, Y., et al. (2003). Modifiers of muscle and heart cell fate specification identified by gain-of-function screen in Drosophila. Mech. Dev. 120: 991-1007. 14550529
Biehs, B., François, V. and Bier, E. (1996). The Drosophila short gastrulation gene prevents Dpp from autoactivating a suppressing neurogenesis in the neuroectoderm. Genes Dev. 10: 2922-34. PubMed Citation: 8918893
Biehs, B., Sturtevant, M. A. and Bier, E. (1998). Boundaries in the Drosophila wing imaginal disc organize vein-specific genetic programs. Development 125: 4245-4257. PubMed Citation: 9753679
Bier, E., Yan, L.Y. and Yan, Y.N. (1990). rhomboid, a gene required for dorsoventral axis establishment and peripheral neuron system development in Drosophila melanogaster. Genes Dev 4: 190-203. PubMed Citation: 2110920
Boube, M., Llimargas, M. and Casanova, J. (2000). Cross-regulatory interactions among tracheal genes support a co-operative model for the induction of tracheal fates in the Drosophila embryo. Mech. Dev. 91: 271-278. PubMed Citation: 10704851
Brentrup, D., Lerch, H.-P., Jackle, H. and Noll, M. (2000). Regulation of Drosophila wing vein patterning: net encodes a bHLH protein repressing rhomboid and is repressed by rhomboid-dependent Egfr signaling. Development 127: 4729-4741. PubMed Citation: 11023875
Brodu, V., Elstob, P. R. and Gould, A. P. (2002). abdominal A specifies one cell type in Drosophila by regulating one principal target gene. Development 129: 2957-2963. 12050142
Buff, E., et al. (1998). Signalling by the Drosophila epidermal growth factor receptor is required for the specification and diversification of embryonic muscle progenitors. Development 125: 2075-2086. PubMed Citation: 9570772
Campbell, G. (2002). Distalization of the Drosophila leg by graded EGF-receptor activity. Nature 418: 781-785. 12181568
Carmena, A., et al. (2002). Reciprocal regulatory interactions between the Notch and Ras signaling pathways in the Drosophila embryonic mesoderm. Dev. Biol. 244: 226-242. 11944933
Chang, J., et al. (2001). The CNS midline cells control the spitz class and Egfr signaling genes to establish the proper cell fate of the Drosophila ventral neuroectoderm. Int. J. Dev. Biol. 45(5-6): 715-24. 11669373
Cheung, L. S., Simakov, D. S., Fuchs, A., Pyrowolakis, G. and Shvartsman, S. Y. (2013). Dynamic model for the coordination of two enhancers of broad by EGFR signaling. Proc Natl Acad Sci U S A. PubMed ID: 24127599
Chiba, A., et al. (1993). Growth cone choices of Drosophila motoneurons in response to muscle fiber mismatch. J Neurosci 13: 714-32. PubMed Citation: 8426233
Cook, O., Biehs, B. and Bier, E. (2004). brinker and optomotor-blind act coordinately to initiate development of the L5 wing vein primordium in Drosophila. Development 131: 2113-2124. 15073155
Cortesio, C. L., Lewellyn, E. B. and Drubin, D. G. (2015). Control of lipid organization and actin assembly during clathrin-mediated endocytosis by the cytoplasmic tail of the rhomboid protein Rbd2. Mol Biol Cell 26(8): 1509-1522. PubMed ID: 25694450
Crozatier, M., Glise, B., Khemici, V. and Vincent, A. (2003). Vein-positioning in the Drosophila wing in response to Hh; new roles of Notch signaling. Mech. Dev. 120: 529-535. 12782270
Culí, J., Martín-Blanco, E. and Modolell, J. (2001). The EGF receptor and N signalling pathways act antagonistically in Drosophila mesothorax bristle patterning. Development 128: 299-308. PubMed Citation: 11124124
Curtis, B. J., Zraly, C. B. and Dingwall, A. K. (2013). Drosophila LSD1-CoREST demethylase complex regulates DPP/TGFbeta signaling during wing development. Genesis 51: 16-31. Pubmed: 22965777
Daniel, A., Dumstrei, K., Lengyel, J. A. and Hartenstein, V. (1999). The control of cell fate in the embryonic visual system by atonal, tailless and EGFR signaling. Development 126: 2945-2954. PubMed Citation: 10357938
del Álamo, A., Terriente, J. and Díaz-Benjumea, F. J. (2002). Spitz/EGFr signalling via the Ras/MAPK pathway mediates the induction of bract cells in Drosophila legs. Development 129: 1975-1982. 11934863
de Celis, J. F., Bray, S. and Garcia-Bellido, A. (1997). Notch signalling regulates veinlet expression and establishes boundaries between veins and interveins in the Drosophila wing. Development 124: 1919-1928. PubMed Citation: 9169839
Dubois, L., et al. (2001). Regulated endocytic routing modulates Wingless signaling in Drosophila embryos. Cell 105: 613-624. 11389831
Dumstrei, K., et al. (1998). EGFR signaling is required for the differentiation and maintenance of neural progenitors along the dorsal midline of the Drosophila embryonic head. Development 125(17): 3417-3426. PubMed Citation: 9693145
Dumstrei, K., et al. (2002). Interaction between EGFR signaling and DE-cadherin during nervous system morphogenesis. Development 129: 3983-3994. 12163402
Fakhouri, W. D., Ay, A., Sayal, R., Dresch, J., Dayringer, E. and Arnosti, D. N. (2010). Deciphering a transcriptional regulatory code: modeling short-range repression in the Drosophila embryo. Mol. Syst. Biol. 6: 341. PubMed Citation: 20087339
Figeac, N., Jagla, T., Aradhya, R., Da Ponte, J. P. and Jagla, K. (2010). Drosophila adult muscle precursors form a network of interconnected cells and are specified by the rhomboid-triggered EGF pathway. Development 137(12): 1965-73. PubMed Citation: 20463031
Foltenyi, K., Greenspan, R. J. and Newport, J. W. (2007). Activation of EGFR and ERK by rhomboid signaling regulates the consolidation and maintenance of sleep in Drosophila. Nature Neurosci. 10: 1160-1167. Medline abstract: 17694052
Frankfort, B. J. and Mardon, G. (2004). Senseless represses nuclear transduction of Egfr pathway activation. Development 131: 563-570. 14711872
Fristrom, D., et al. (1994). Blistered: a gene required for vein/intervein formation in wings of Drosophila. Development 120: 2661-71. PubMed Citation: 7956840
Fusse, B. and Hoch, M. (2002). Notch signaling controls cell fate specification along the dorsoventral axis of the Drosophila gut. Curr. Biol. 12: 171-179. 11839268
Gallet, A., et al. (2000). Cubitus interruptus-independent transduction of the Hedgehog signal in Drosophila. Development 127: 5509-5522. PubMed Citation: 11076770
Gallet, A., Rodriguez, R., Ruel, L. and Therond, P. P. (2003). Cholesterol modification of Hedgehog is required for trafficking and movement, revealing an asymmetric cellular response to Hedgehog. Dev. Cell 4: 191-204. 12586063
Gallio, M. and Kylsten, P. (2000). Providencia may help find a function for a novel, widespread protein family. Curr. Biol. 10: R693-R694. 11050401
Gebelein, B., McKay, D. J. and Mann, R. S. (2004). Direct integration of Hox and segmentation gene inputs during Drosophila development. Nature 431: 653-659. PubMed Citation: 15470419
Gerber, M., Eissenberg, J. C., Kong, S., Tenney, K., Conaway, J. W., Conaway, R. C. and Shilatifard, A. (2004). In vivo requirement of the RNA polymerase II elongation factor elongin A for proper gene expression and development. Mol Cell Biol 24: 9911-9919. PubMed ID: 15509793
Ghiglione, C., et al. (2002). Mechanism of activation of the Drosophila EGF Receptor by the TGFalpha ligand Gurken during oogenesis. Development 129: 175-186. 11782411
Golembo, M., Raz, E. and Shilo, B.-Z. (1996). The Drosophila embryonic midline is the site of Spitz processing, and induces activation of the EGF receptor in the ventral ectoderm. Development 122, 3363-3370
Gomez-Skarmeta, J.-L., et al. (1996). araucan and caupolican, two members of the novel iroquois complex, encode homeoproteins that control proneural and vein-forming genes. Cell 85: 95-105
Gonzalez-Crespo, S. and Levine, M. (1994). Related target enhancers for dorsal and NF-kappa B signaling pathways. Science 264: 255-8
Goto, S., Taniguchi, M., Muraoka, M., Toyoda, H., Sado, Y., Kawakita, M. and Hayashi, S. (2001). UDP-sugar transporter implicated in glycosylation and processing of Notch. Nat. Cell Biol. 3: 816-822. 11533661
Gray, S. and Levine, M. (1996). Short-range transcriptional repressors mediate both quenching and direct repression within complex loci in Drosophila. Genes and Dev: 10: 700-710
Greaves, S., et al. (1999). A screen for identifying genes interacting with Armadillo, the Drosophila homolog of ß-catenin. Genetics 153: 1753-1766.
Guichard, A., et al. (1999). rhomboid and Star interact synergistically to promote Egfr/MAPK signaling during Drosophila wing vein development. Development 126(12): 2663-2676
Gutzwiller, L. M., et al. (2010). Proneural and abdominal Hox inputs synergize to promote sensory organ formation in the Drosophila abdomen. Dev. Biol. 348(2): 231-43. PubMed Citation: 20875816
Hammerle, B. and Tejedor, F. J. (2007). A novel function of DELTA-NOTCH signalling mediates the transition from proliferation to neurogenesis in neural progenitor cells. PLoS One 2: e1169. PubMed ID: 18000541
Hatini, V., Bokor, P., Goto-Mandeville, R. and DiNardo, S. (2000). Tissue- and stage-specific modulation of Wingless signaling by the segment polarity gene lines. Genes Dev. 11: 1364-1376.
Hemavathy, K., Meng, X. and Ip, Y. T. (1997). Differential regulation of gastrulation and neuroectodermal gene expression by Snail in the Drosophila embryo. Development 124: 3683-3691
Herlan, M., et al. (2004). Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA. J. Biol. Chem. 278(30): 27781-8. 12707284
Hsu, T., Bagni, C., Sutherland, J. D. and Kafatos, F. C. (1996). The transcriptional factor CF2 is a mediator of EGF-R-activated dorsoventral patterning in Drosophila oogenesis. Genes Dev. 10(11): 1411-21. PubMed Citation: 8647437
Hsu, T., McRackan, D., Vincent, T. S. and de Couet, H. G. (2001). Drosophila Pin1 prolyl isomerase Dodo is a MAP kinase signal responder during oogenesis. Nature Cell Biol. 3: 538-543. 11389437
Ip, Y. T., et al. (1992). The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryo. Genes Dev 6: 1728-39
Jaszai, J. and Brand, M. (2002). Cloning and expression of Ventrhoid, a novel vertebrate homologue of the Drosophila EGF pathway gene rhomboid. Mech. Dev. 113(1): 73-7. 11900977
Johannes, B. and Preiss, A. (2002). Wing vein formation in Drosophila melanogaster: Hairless is involved in the cross-talk between Notch and EGF signaling pathways. Mech. Dev. 115: 3-14. 12183378
Kawamori, H., Tai, M., Sato, M., Yasugi, T. and Tabata, T. (2011). Fat/Hippo pathway regulates the progress of neural differentiation signaling in the Drosophila optic lobe. Dev. Growth Differ. 53(5): 653-67. PubMed Citation: 21671914
Kerber, B., Fellert, S. and Hoch, M., (1998). Seven-up, the Drosophila homolog of the COUP-TF orphan receptors, controls cell proliferation in the insect kidney. Genes Dev. 12(12): 1781-1786
Kondo, T. and Hayashi, S. (2013). Mitotic cell rounding accelerates epithelial invagination. Nature 494: 125-129. PubMed ID: 23334416
Krejci, A., et al. (2009). Direct response to Notch activation: signaling crosstalk and incoherent logic. Sci. Signal. 2: ra1. PubMed Citation: 19176515
Kubota, K., et al. (2000). EGF receptor attenuates Dpp signaling and helps to distinguish the wing and leg cell fates in Drosophila. Development 127: 3769-3776.
LaRonde-LeBlanc, N. A. and Wolberger, C. (2003). Structure of HoxA9 and Pbx1 bound to DNA: Hox hexapeptide and DNA recognition anterior to posterior. Genes Dev. 17: 2060-2072. PubMed Citation: 12923056
Lee, J. R., Urban, S. Garvey, C. F. and Freeman, M. (2001). Regulated intracellular ligand transport and proteolysis control EGF signal activation in Drosophila. Cell 107: 161-171. 11672524
Lemberg, M. K., et al. (2005). Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases. EMBO J. 24: 464-472. 15616571
Lemberg, M. K. and Freeman, M. (2007). Functional and evolutionary implications of enhanced genomic analysis of rhomboid intramembrane proteases. Genome Res. 17: 1634-1646. PubMed Citation: 17938163
Li-Kroeger, D., Witt, L. M., Grimes, H. L., Cook, T. A. and Gebelein, B. (2008). Hox and senseless antagonism functions as a molecular switch to regulate EGF secretion in the Drosophila PNS. Dev. Cell 15(2): 298-308. PubMed Citation: 18694568
Llimargas, M. and Casanova, J. (1997). ventral veinless, a POU domain transcription factor, regulates different transduction pathways required for tracheal branching in Drosophila. Development 124(17): 3273-3281
Llimargas, M. and Casanova, J. (1999). EGF signalling regulates cell invagination as well as cell migration during formation of tracheal system in Drosophila. Dev. Genes Evol. 209: 174-179
Lohi, O., Urban, S. and Freeman, M. (2004). Diverse substrate recognition mechanisms for rhomboids: Thrombomodulin is cleaved by mammalian rhomboids. Curr. Biol. 14: 236-241. 14761657
Lunde, K., Biehs, B., Nauber, U. and Bier, E. (1998). The knirps and knirps-related genes organize development of the second wing vein in Drosophila. Development 125(21): 4145-4154
Lunde, K., et al. (2003). Activation of the knirps locus links patterning to morphogenesis of the second wing vein in Drosophila. Development 130: 235-248. 12466192
Major, R. J. and Irvine, K. D. (2005). Influence of Notch on dorsoventral compartmentalization and actin organization in the Drosophila wing. Development 132(17): 3823-33. 16049109
Mantrova, E. Y. and Hsu, T. (1998). Down-regulation of transcription factor CF2 by Drosophila Ras/MAP kinase signaling in oogenesis: cytoplasmic retention and degradation. Genes Dev. 12(8): 1166-1175
Markstein, M., et al. (2004). A regulatory code for neurogenic gene expression in the Drosophila embryo. Development 131: 2387-2394. 15128669
Mayer, U. and Nusslein-Volhard, C. (1988). A group of genes required for pattern formation in the ventral ectoderm of the Drosophila embryo. Genes Dev. 2: 1496-1511. 3209069
Merabet, S., Hombria, J. C., Hu, N., Pradel, J. and Graba, Y. (2005). Hox-controlled reorganisation of intrasegmental patterning cues underlies Drosophila posterior spiracle organogenesis. Development 132(13): 3093-3102. 15930099
Milan, M., Baonza, A. and Garcia-Bellido, A. (1997). Wing surface interactions in venation patterning in Drosophila. Mech. Dev. 67(2): 203-213
Mouchel-Vielh, E., Rougeot, J., Decoville, M. and Peronnet, F. (2011). The MAP kinase ERK and its scaffold protein MP1 interact with the chromatin regulator Corto during Drosophila wing tissue development. BMC Dev Biol 11: 17. PubMed ID: 21401930
Nakagawa, T., et al. (2005). Characterization of a human rhomboid homolog, p100hRho/RHBDF1, which interacts with TGFalpha family ligands. Dev. Dyn. 233: 1315-1331. PubMed Citation: 15965977
Nakamura, Y. and Matsuno, K. (2003). Species-specific activation of EGF receptor signaling underlies evolutionary diversity in the dorsal appendage number of the genus Drosophila eggshells. Mech. Dev. 120: 897-907. 12963110
Nakamura, Y., et al. (2007). Soma-dependent modulations contribute to divergence of rhomboid expression during evolution of Drosophila eggshell morphology. Development 134: 1529-1537. Medline abstract: 17360774
Nambu, J. R., et al. (1990). The single-minded gene of Drosophila is required for the expression of genes important for the development of CNS midline cells. Cell 63: 63-75
Newcomb, S., Voutev, R., Jory, A., Delker, R. K., Slattery, M. and Mann, R. S. (2018). cis-regulatory architecture of a short-range EGFR organizing center in the Drosophila melanogaster leg. PLoS Genet 14(8): e1007568. PubMed ID: 30142157
Noll, R., et al. (1994). New functions of the Drosophila rhomboid gene during embryonic and adult development are revealed by a novel genetic method, enhancer piracy. Development 120: 2329-2338
Ohtsuki, S., Levine, M. and Cai, H. N. (1998). Different core promoters possess distinct regulatory activities in the Drosophila embryo. Genes Dev. 12: 547-556.
Okabe, M., Sawamoto, K. and Okano, H. (1996). The function of the Drosophila argos gene product in the development of embryonic chordotonal organs. Dev. Biol. 175: 37-49
Okabe, M. and Okano, H. (1997). Two-step induction of chordotonal organ precursors in Drosophila embryogenesis. Development 124: 1045-1053
Pascall, J. C. and Brown, K. D. (1998). Characterization of a mammalian cDNA encoding a protein with high sequence similarity to the Drosophila regulatory protein Rhomboid. FEBS Lett. 429(3): 337-40. 9662444
Pascall, J. C. and Brown, K. D. (2004). Intramembrane cleavage of ephrinB3 by the human rhomboid family protease, RHBDL2. Biochem. Biophys. Res. Commun. 317(1): 244-52. 15047175
Peri, F., Bokel, C. and Roth, S. (1999). Local gurken signaling and dynamic MAPK activation during Drosophila oogenesis. Mech. Dev. 81(1-2): 75-88. PubMed Citation: 10330486
Peri, F. and Roth, S. (2000). Combined activities of Gurken and Decapentaplegic specify dorsal chorion structures of the Drosophila egg. Development 127: 841-850. PubMed Citation: 10648242
Protzer, C. E., Wech, I. and Nagel, A. C. (2008). Hairless induces cell death by downregulation of EGFR signalling activity. J. Cell Sci. 121(Pt 19): 3167-76. PubMed Citation: 18765565
Queenan, A. M., Ghabrial, A. and Schupbach, T. (1997). Ectopic activation of torpedo/Egfr, a Drosophila receptor tyrosine kinase, dorsalizes both the eggshell and the embryo. Development 124(19): 3871-3880. PubMed Citation: 9367443
Rather, P. N., et al. (1999). Providencia stuartii genes activated by cell-to-cell signaling and identification of a gene required for production or activity of an extracellular factor. J. Bacteriol. 181: 7185-7191. 10572119
Reddy, B. V., Rauskolb, C. and Irvine, K. D. (2010). Influence of fat-hippo and notch signaling on the proliferation and differentiation of Drosophila optic neuroepithelia. Development 137(14): 2397-408. PubMed Citation: 20570939
Reeves, N. and Posakony, J. W. (2005). Genetic programs activated by proneural proteins in the developing Drosophila PNS. Dev. Cell 8(3): 413-25. 15737936
Reich, A. and Shilo, B.-Z. (2002). Keren, a new ligand of the Drosophila epidermal growth factor receptor, undergoes two modes of cleavage. EMBO J. 21: 4287-4296. 12169631
Roch, F., et al. (1998). Genetic interactions and cell behaviour in blistered mutants during proliferation and differentiation of the Drosophila wing. Development 125(10): 1823-1832
Rougeot, J., Renard, M., Randsholt, N. B., Peronnet, F. and Mouchel-Vielh, E. (2013). The Elongin complex antagonizes the chromatin factor Corto for Vein versus intervein cell identity in Drosophila wings. PLoS One 8: e77592. PubMed ID: 24204884
Ruohola-Baker, H., et al. (1993). Spatially localized rhomboid is required for establishment of the dorsal-ventral axis in Drosophila oogenesis. Cell 73: 953-65
Sanson, B., et al. (1999). Engrailed and Hedgehog make the range of Wingless asymmetric in Drosophila embryos. Cell 98: 207-216
Sapir, A., Schweitzer, R. and Shilo, B. Z. (1998). Sequential activation of the EGF receptor pathway during Drosophila oogenesis establishes the dorsoventral axis. Development 125(2): 191-200
Scholz, H., et al. (1997). Control of midline glia development in the embryonic Drosophila. Mech. Dev. 62: 79-91
Schnepp, B., et al. (1996). Vein is a novel component in the Drosophila epidermal growth factor receptor pathway with similarity to the neuregulins. Genes Dev. 10: 2302-13
Schweitzer, R., et al. (1995). Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination. Genes Dev 9: 1518-1529
Selva, E. M., Hong, K., Baeg, G. H., Beverley, S. M., Turco, S. J., Perrimon, N. and Hacker, U. (2001). Dual role of the fringe connection gene in both heparan sulphate and fringe-dependent signalling events. Nat. Cell Biol. 3: 809-815. 11533660
Shamloula, H. K., et al. (2002). rugose (rg), a Drosophila A kinase anchor protein, is required for retinal pattern formation and interacts genetically with multiple signaling pathways. Genetics 161(2): 693-710. 12072466
Shimamura, M., Kyotani, A., Azuma, Y., Yoshida, H., Binh Nguyen, T., Mizuta, I., Yoshida, T., Mizuno, T., Nakagawa, M., Tokuda, T. and Yamaguchi, M. (2014). Genetic link between Cabeza, a Drosophila homologue of fused in sarcoma (FUS), and the EGFR signaling pathway. Exp Cell Res. PubMed ID: 24928275
Shvartsman, S. Y., Muratov, C. B. and Lauffenburger, D. A. (2002). Modeling and computational analysis of EGF receptor-mediated cell communication in Drosophila oogenesis. Development 129: 2577-2589. 12015287
Skeath, J. B. (1998). The Drosophila EGF receptor controls the formation and specification of neuroblasts along the dorsal-ventral axis of the Drosophila embryo. Development 125(17): 3301-331. PubMed ID: 9693134
Sonnenfeld, M. J. and Jacobs, J. R. (1994). Mesectodermal cell fate analysis in Drosophila midline mutants. Mech Dev 46: 3-13. PubMed ID: 8068547
Sonnenfeld, M. J. and Jacobs, J. R. (1995).Apoptosis of the midline glia during Drosophila embryogenesis: a correlation with axon contact. Development 121: 569-578. PubMed ID: 7768193
Spencer, S. A., et al. (1998). Regulation of EGF receptor signaling establishes pattern across the developing Drosophila retina. Development 125: 4777-4790. PubMed ID: 9806926
Sturtevant, M. A., Roark, M. and Bier, E. (1993). The Drosophila rhomboid gene mediates the localized formation of wing veins and interacts genetically with components of the EGF-R signaling pathway. Genes Dev 7: 961-73. PubMed ID: 8504935
Sturtevant, M. A., O'Neill, J. W. and Bier, E. (1994). Down-regulation of Drosophila Egf-r mRNA levels following hyperactivated receptor signaling. Development 120: 2593-600. PubMed ID: 7956834
Sturtevant, M. A. and Bier, E. (1995). Analysis of the genetic hierarchy guiding wing vein development in Drosophila. Development 121: 785-801. PubMed ID: 7720583
Sturtevant, M. A., et al. (1997). The spalt gene links the A/P compartment boundary to a linear adult structure in the Drosophila wing. Development 124: 21-32. PubMed ID: 9006064
Szuts, D., Freeman, M. and Bienz, M. (1997). Antagonism between EGFR and Wingless signalling in the larval cuticle of Drosophila. Development 124(16): 3209-3219. PubMed ID: 9272961
Terriente-Félix, A. and de Celis. J. F. (2009). Osa, a subunit of the BAP chromatin-remodelling complex, participates in the regulation of gene expression in response to EGFR signalling in the Drosophila wing. Dev. Biol. 329(2): 350-61. PubMed Citation: 19306864
Tsruya, R., et al. (2002). Intracellular trafficking by Star regulates cleavage of the Drosophila EGF receptor ligand Spitz. Genes Dev. 16: 222-234. 11799065
Turing, A. M. (1952). The chemical basis of morphogenesis. Philos. Trans. R. Soc. London B237: 37-72
Urban, S., Lee, J. R. and Freeman, M. (2001). Drosophila Rhomboid-1 defines a family of putative intramembrane serine proteases. Cell 107: 173-182. 11672525
Urban, S., Lee, J. R. and Freeman, M. (2002). A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands. EMBO J. 21: 4277-4286. 12169630
Urban, S., Brown, G. and Freeman, M. (2004). EGF receptor signalling protects smooth-cuticle cells from apoptosis during Drosophila ventral epidermis development. Development 131: 1835-1845. 15084467
Urban, S. and Moin, S. M. (2014). A subset of membrane-altering agents and gamma-secretase modulators provoke nonsubstrate cleavage by rhomboid proteases. Cell Rep 8: 1241-1247. PubMed ID: 25159145
Verheyen, E. M., et al. (2001). The tissue polarity gene nemo carries out multiple roles in patterning during Drosophila development. Mech Dev. 101: 119-32. 11231065
Walsh, C. M. and Carroll, S. B. (2007). Collaboration between Smads and a Hox protein in target gene repression. Development 134: 3585-3592. PubMed Citation: 17855427
Wappner, P., Gabay, L. and Shilo, B. Z. (1997). Interactions between the EGF receptor and DPP pathways establish distinct cell fates in the tracheal placodes. Development 124(22): 4707-4716
Ward, E. J. and Berg, C. A. (2005). Juxtaposition between two cell types is necessary for dorsal appendage tube formation. Mech. Dev. 122: 241-255. 15652711
Ward, E. J., Zhou, X., Riddiford, L. M., Berg, C. A. and Ruohola-Baker, H. (2006). Border of Notch activity establishes a boundary between the two dorsal appendage tube cell types. Dev. Biol. 297: 461-470. Medline abstract: 16828735
Wasserman, J. D. and Freeman, M. (1998). An autoregulatory cascade of EGF receptor signaling patterns the Drosophila egg. Cell 95(3): 355-64
Wasserman, J. D., et al. (2000). A family of rhomboid-like genes: Drosophila rhomboid-1 and roughoid/rhomboid-3 cooperate to activate EGF receptor signaling. Genes Dev. 14: 1651-1663.
Wiellette, E. L. and McGinnis, W. (1999). Hox genes differentially regulate Serrate to generate segment-specific structures. Development 126(9): 1985-1995
Witt, L. M. et al. (2010). Atonal, senseless, and abdominal-A regulate rhomboid enhancer activity in abdominal sensory organ precursors. Dev. Biol. 344: 1060-1070. PubMed Citation: 20478292
Xiao, H., Hrdlicka, L. A. and Nambu, J. R. (1996). Alternate functions of single-minded and rhomboid genes in development of the Drosophila ventral neuroectoderm. Mech. Dev. 58: 65-74
Yagi, Y., Suzuki, T. and Hayashi, S. (1998). Interaction between Drosophila EGF receptor and vnd determines three dorsoventral domains of the neuroectoderm. Development 125(18): 3625-3633
Yakoby, N., Lembong, J., Schupbach, T. and Shvartsman, S. Y. (2008a). Drosophila eggshell is patterned by sequential action of feedforward and feedback loops. Development 135: 343-351. PubMed Citation: 18077592
Yakoby, N., et al. (2008b). A combinatorial code for pattern formation in Drosophila oogenesis. Dev. Cell 15(5): 725-37. PubMed Citation: 19000837
Yamada, T., Okabe, M. and Hiromi, Y. EDL/MAE regulates EGF-mediated induction by antagonizing Ets transcription factor Pointed. Development 130: 4085-4096. 12874129
Yan, S.-J., et al. (2004). Multiple signaling pathways and a selector protein sequentially regulate Drosophila wing development. Development 131: 285-298. 14701680
Yan, Z., Zou, H., Tian, F., Grandis, J. R., Mixson, A. J., Lu, P. Y. and Li, L. Y. (2008). Human rhomboid family-1 gene silencing causes apoptosis or autophagy to epithelial cancer cells and inhibits xenograft tumor growth. Mol. Cancer Ther. 7: 1355-1364. PubMed Citation: 18524845
Yano, H., et al. (2005). Distinct functional units of the Golgi complex in Drosophila cells. Proc. Natl. Acad. Sci 102: 13467-13472. 16174741
Yasugi, T., Umetsu, D., Murakami, S., Sato, M. and Tabata, T. (2008). Drosophila optic lobe neuroblasts triggered by a wave of proneural gene expression that is negatively regulated by JAK/STAT. Development 135: 1471-1480. PubMed ID: 18339672
Yasugi, T., Sugie, A., Umetsu, D. and Tabata, T. (2010). Coordinated sequential action of EGFR and Notch signaling pathways regulates proneural wave progression in the Drosophila optic lobe. Development 137: 3193-3203. PubMed ID: 20724446
Zelzer, E. and Shilo, B.-Z. (2000). Interaction between the bHLH-PAS protein Trachealess and the POU-domain protein Drifter, specifies tracheal cell fates. Mech. Dev. 91: 163-173.
Zettl, M., et al. (2011). Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling. Cell 145: 75-91. PubMed Citation: 21439629
Zhou, L., Xiao, H. and Nambu, J. R. (1997). CNS midline to mesoderm signaling in Drosophila. Mech. Dev. 67(1): 59-68
Zou, H., et al. (2009). Human rhomboid family-1 gene RHBDF1 participates in GPCR-mediated transactivation of EGFR growth signals in head and neck squamous cancer cells. FASEB J. 23: 425-432. PubMed Citation: 18832597
zur Lage, P., Jan, Y. N. and Jarman, A. P. (1997). Requirement for EGF receptor signalling in neural recruitment during formation of Drosophila chordotonal sense organ clusters. Curr. Biol. 7: 166-175. PubMed Citation: 9395407
zur Lage, P. and Jarman, A. P. (1999). Antagonism of EGFR and Notch signalling in the reiterative recruitment of Drosophila adult chordotonal sense organ precursors. Development 126: 3149-3157. PubMed Citation: 10375505
date revised: 24 December 2018
Home page: The Interactive Fly © 1997 Thomas B. Brody, Ph.D.
The Interactive Fly resides on the
Society for Developmental Biology's Web server.