Ras oncogene at 85D


REFERENCES (part 2/3)

Laberge, G., Douziech, M. and Therrien, M. (2005). Src42 binding activity regulates Drosophila RAF by a novel CNK-dependent derepression mechanism. EMBO J. 24(3): 487-98. 15660123

Lamming, D. W., Ye, L., Sabatini, D. M. and Baur, J. A. (2013). Rapalogs and mTOR inhibitors as anti-aging therapeutics. J Clin Invest 123: 980-989. PubMed ID: 23454761

Lavery, W., et al. (2007). Phosphatidylinositol 3-kinase and Akt nonautonomously promote perineurial glial growth in Drosophila peripheral nerves. J. Neurosci. 27(2): 279-88. PubMed Citation: 17215387

Lavoie, J. N., et al. (1996). Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway. J. Biol. Chem. 271(34): 20608-16. PubMed Citation: 8702807

Lazarovici, P., et al. (1997). Down-regulation of Epidermal Growth Factor Receptors by Nerve Growth Factor in PC12 Cells Is p140(trk)-, Ras-, and Src-dependent. J. Biol. Chem. 272 (17): 11026-11034. PubMed Citation: 9110995

Le, N. and Simon, M. A. (1998). Disabled is a putative adaptor protein that functions during signaling by the sevenless receptor tyrosine kinase. Mol. Cell. Biol. 18(8): 4844-4854. PubMed Citation: 9671493

Leblanc, V., Tocque, B. and Delumeau, I. (1998). Ras-GAP controls Rho-mediated cytoskeletal reorganization through its SH3 domain. Mol. Cell. Biol. 18(9): 5567-78. PubMed Citation: 9710640

Lee, S., Escalante, R. and Firtel, R. A. (1997). A Ras GAP is essential for cytokinesis and spatial patterning in Dictyostelium. Development 124: 983-996. PubMed Citation: 9056774

Lee, T., Feig, L. and Montell, D. J. (1996). Two distinct roles for Ras in a developmentally regulated cell migration. Development 122: 409-418. PubMed Citation: 8625792

Lee, T., and Montell, D. J. (1997). Multiple Ras signals pattern the Drosophila ovarian follicle cells. Dev. Biol. 185: 25-33. PubMed Citation: 9169047

Leone, G., et al. (1997). Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F. Nature 387 (6631): 422-426. PubMed Citation: 9163430

Li, G., et al. (1997). Uncoupling of Membrane Ruffling and Pinocytosis during Ras Signal Transduction. J. Biol Chem 272 (16): 10337-10340. PubMed Citation: 9099668

Li, J., Xia, F. and Li, W. X. (2003). Coactivation of STAT and Ras is required for germ cell proliferation and invasive migration in Drosophila. Dev. Cell 5: 787-798. 14602078

Li, N., et al. (1993). Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling. Nature 363: 85-88. PubMed Citation: 8479541

Li, Q., Hariharan, I. K., Chen, F., Huang, Y., and Fischer, J. A. (1997). Genetic interactions with rap1 and ras1 reveal a second function for the Fat facets deubiquitinating enzyme in Drosophila eye development. Proc. Natl. Acad. Sci. 94(23): 12515-12520. PubMed Citation: 9356481

Li, W., et al. (1997). The Drosophila 14-3-3 protein Leonardo enhances Torso signaling through D-Raf in a Ras 1-dependent manner. Development 124(20): 4163-4171. PubMed Citation: 9374412

Li, W., Melnick, M. and Perrimon, N. (1998). Dual function of Ras in Raf activation. Development 125: 4999-5008. PubMed citation; Online text

Li, W., Noll, E. and Perrimon. N. (2000). Identification of autosomal regions involved in Drosophila Raf function. Genetics 156: 763-774. PubMed citation; Online text

Li, Y., Li, S., Jin, P., Chen, L. and Ma, F. (2016). miR-11 regulates pupal size of Drosophila melanogaster via directly targeting Ras85D. Am J Physiol Cell Physiol: ajpcell 00190 02016. PubMed ID: 27733364

Lightfoot, K., et al. (1994). Conserved cis-elements bind a protein complex that regulates Drosophila ras2/rop bidirectional expression. Br. J. Cancer 69 (2): 264-273. PubMed Citation: 8297724

Lim, K. H., et al. (2006). Divergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells. Curr. Biol. 16(24): 2385-94. Medline abstract: 17174914

Lim, Y. M., et al. (1997). Dominant mutations of Drosophila MAP kinase kinase and their activities in Drosophila and yeast MAP kinase cascades. Genetics 146 (1): 263-273. PubMed Citation: 9136016

Lin, A. W., et al. (1998). Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev. 12(19): 3008-19. PubMed Citation: 9765203

Liu, J. J., et al. (1995). Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH 3T3 cells. Mol. Cell. Biol. 15: 3654-3663

Lo, R. S., Wotton, D. and Massague, J. (2001). Epidermal growth factor signaling via Ras controls the Smad transcriptional co-repressor TGIF. EMBO J. 20: 128-136

Lockyer, P. J., et al. (1999). Identification of the ras GTPase-activating protein GAP1(m) as a phosphatidylinositol-3,4,5-trisphosphate-binding protein in vivo. Curr. Biol. 9(5): 265-8

Lu, X., et al. (1993). Control of cell fate determination by p21ras/Ras1, an essential component of torso signaling in Drosophila. Genes Dev. 7 (4): 621-632

Lu, X. and Horvitz, R. (1998). lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48. Cell 95: 981-991

Lu, X. and Li, Y. (1999). Drosophila Src42A is a negative regulator of RTK signaling. Dev. Biol. 208(1): 233-43. PubMed ID: 10075855

Ma, J. and Karplus, M. (1997). Molecular switch in signal transduction: reaction paths of the conformational changes in ras p21. Proc. Natl. Acad. Sci. 94(22): 11905-11910

Ma, X., Shao, Y., Zheng, H., Li, M., Li, W. and Xue, L. (2013). Src42A modulates tumor invasion and cell death via Ben/dUev1a-mediated JNK activation in Drosophila. Cell Death Dis 4: e864. PubMed ID: 24136228

Ma, X., Lu, J. Y., Dong, Y., Li, D., Malagon, J. N. and Xu, T. (2017). PP6 disruption synergizes with oncogenic Ras to promote JNK-dependent tumor growth and invasion. Cell Rep 19(13): 2657-2664. PubMed ID: 28658615

Maegley, K. A., Admiraal, S. J. and Herschlag, D. (1996). Ras-catalyzed hydrolysis of GTP: a new perspective from model studies. Proc. Natl. Acad. Sci. 93: 8160-8166

Mainiero, F., et al. (1995). Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes. EMBO J. 14 (18): 4470-4481

Mainiero, F., et al. (1997). The coupling of alpha6beta4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation. EMBO J. 16 (9): 2365-2375

Maloof, J. N. and Kenyon, C. (1998). The Hox gene lin-39 is required during C. elegans vulval induction to select the outcome of Ras signaling. Development 125(2): 181-190

Mao, J.-H., et al. (2004). Mutually exclusive mutations of the Pten and ras pathways in skin tumor progression. Genes Dev. 18: 1800-1805. 15289454

Margarit, S. M., et al. (2003). Structural evidence for feedback activation by Ras-GTP of the Ras-specific nucleotide exchange factor SOS. Cell 112: 685-695. 12628188

Markus, A., et al. (1997). NGF-mediated survival depends on p21ras in chick sympathetic neurons from the superior cervical but not from lumbosacral ganglia. Dev. Biol. 191(2): 306-310

Markus, A., Zhong, J. and Snider, W. D. (2002). Raf and Akt mediate distinct aspects of sensory axon growth. Neuron 35: 65-76. 12123609

Marshall, M. (1995a). Interactions between Ras and Raf: key regulatory proteins in cellular transformation. Mol. Reprod. Dev. 42: 493-499

Martorell, O., Merlos-Suarez, A., Campbell, K., Barriga, F. M., Christov, C. P., Miguel-Aliaga, I., Batlle, E., Casanova, J. and Casali, A. (2014). Conserved mechanisms of tumorigenesis in the Drosophila adult midgut. PLoS One 9: e88413. PubMed ID: 24516653

Mason, C. S., et al. (1999). Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation. EMBO J. 18(8): 2137-2148

Matsubara, K., et al. (1999). Plasma membrane recruitment of RalGDS is critical for Ras-dependent Ral activation. Oncogene 18(6): 1303-12. 10022812

Matsui, T., et al. (2002). K-Ras mediates cytokine-induced formation of E-cadherin-based adherens junctions during liver development. EMBO J. 21: 1021-1030. 11867530

Matsuo, T., et al. (1997). Regulation of cone cell formation by Canoe and Ras in the developing Drosophila eye. Development 124(14): 2671-2680

Matsuno, K., et al. (1998). Human deltex is a conserved regulator of Notch signalling. Nat. Genet. 19(1): 74-78

Matuoka, K., et al. (1993). Ash/Grb-2, a SH2/SH3-containing protein, couples to signaling for mitogenesis and cytoskeletal reorganization by EGF and PDGF. EMBO J. 12: 3467-73

McCollam, L., et al. (1995). Functional roles for the pleckstrin and Dbl homology regions in the Ras exchange factor Son-of-sevenless. J. Biol. Chem. 270 (27): 15954-15957

Meijne, A. M., et al. (1997). v-src-induced cell shape changes in rat fibroblasts require new gene transcription and precede loss of focal adhesions. Exp. Cell Res. 234(2): 477-485.

Melnick, M. B., et al. (1993). Developmental and molecular characterization of mutations in the Drosophila-raf serine/threonine protein kinase. Development 118(1): 127-38. 8375330

Michelson, A. M., et al. (1998a). Dual functions of the heartless fibroblast growth factor receptor in development of the Drosophila embryonic mesoderm. Dev. Genet. 22(3): 212-229

Michelson, A. M., et al. (1998b). Heartbroken is a specific downstream mediator of FGF receptor signalling in Drosophila. Development 125(22): 4379-4389

Miller, D. T. and Cagan, R. L. (1998). Local induction of patterning and programmed cell death in the developing Drosophila retina. Development 125: 2327-2335

Miller, M. J., et al. (1998). Differential effects of protein kinase A on Ras effector pathways. Mol. Cell. Biol. 18(7): 3718-3726

Mineo, C., Anderson, R. G. W. and White, M. A. (1997). Physical Association with Ras Enhances Activation of Membrane-bound Raf (RafCAAX). J. Biol. Chem. 272 (16): 10345-10348

Michaud, N. R., et al. (1997). KSR stimulates Raf-1 activity in a kinase-independent manner. Proc. Natl. Acad. Sci. 94(24): 12792-12796

Mirey, G., et al. (2003). A Ral guanine exchange factor-Ral pathway is conserved in Drosophila melanogaster and sheds new light on the connectivity of the Ral, Ras, and Rap pathways. Mol. Cell Biol. 23(3): 1112-24. PubMed citation: 12529414

Mochizuki, N., Yamashita, S., Kurokawa, K., Ohba, Y., Nagai, T., Miyawaki, A. and Matsuda, M. (2001). Spatio-temporal images of growth-factor-induced activation of Ras and Rap1. Nature 411: 1065-1068. 11429608

Mohammadi, M., et al. (1996). Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction. Mol. Cell. Biol. 16: 977-989

Montagner, A., et al. (2005). A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation. J. Biol. Chem. 280(7): 5350-60. 15574420

Mora, N., Almudi, I., Alsina, B., Corominas, M. and Serras, F. (2013). beta amyloid protein precursor-like (Appl) is a Ras1/MAPK-regulated gene required for axonal targeting in Drosophila photoreceptor neurons. J Cell Sci 126: 53-59. PubMed ID: 23178937

Morcos, P., et al. (1996). Identification of neurofibromin mutants that exhibit allele specificity or increased Ras affinity resulting in suppression of activated ras alleles. Mol. Cell. Biol. 16: 2496-2503

Moressis, A. et al. (2009). A dual role for the adaptor protein DRK in Drosophila olfactory learning and memory. J. Neurosci. 29: 2611-2625. PubMed Citation: 19244537

Morrison, D. K. (1995b). Mechanisms regulating Raf-1 activity in signal transduction pathways. Mol. Reprod. Dev. 42: 507-514

Muchardt, C., et al. (1998). ras transformation is associated with decreased expression of the brm/SNF2alpha ATPase from the mammalian SWI-SNF complex. EMBO J. 17: 223-231

Müller, G., et al. (1998). Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signalling. EMBO J. 17: 732-742

Muller, J., et al. (2000). Identification of B-KSR1, a novel brain-specific isoform of KSR1 that functions in neuronal signaling. Mol. Cell. Biol. 20(15): 5529-39. 10891492

Muller, J., et al. (2001). C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1. Molec. Cell 8: 983-993. 11741534

Murcia, L., Clemente-Ruiz, M., Pierre-Elies, P., Royou, A. and Milan, M. (2019). Selective killing of RAS-malignant tissues by exploiting oncogene-induced DNA damage. Cell Rep 28(1): 119-131. PubMed ID: 31269434

Nakajima, T., et al. (1996). The signal-dependent coactivator CBP is a nuclear target for pp90RSK. Cell 86(3): 465-474

Nakatani, Y. and Nishida, H. (1997). Ras is an essential component for notochord formation during ascidian embryogenesis. Mech. Dev. 68(1-2): 81-89

Neuman-Silberberg, F. S., et al. (1984). The Drosophila ras oncogenes: structure and nucleotide sequence. Cell 37 (3): 1027-1033

Ng, N. F. and Shooter, E. F. (1993). Activation of p21ras by nerve growth factor in embryonic sensory neurons and PC12 cells. J. Biol. Chem. 268: 25329-33

Noguchi, T., et al. (1999). Tyrosine phosphorylation of p62(Dok) induced by cell adhesion and insulin: possible role in cell migration. EMBO J. 18(7): 1748-1760

Noyes, N. C., Walkinshaw, E. and Davis, R. L. (2020). Ras acts as a molecular switch between two forms of consolidated memory in Drosophila. Proc Natl Acad Sci U S A 117(4): 2133-2139. PubMed ID: 31932418

O'Bryan, J. P., Mohney, R. P. and Oldham, C. E. (2001). Mitogenesis and endocytosis: What's at the INTERSECTIoN? Oncogene 20(44): 6300-8. 11607832

Oh-hora, M., Johmura, S., Hashimoto, A., Hikida, M. and Kurosaki, T. (2003). Requirement for Ras guanine nucleotide releasing protein 3 in coupling phospholipase C-gamma2 to Ras in B cell receptor signaling. J. Exp. Med. 198(12): 1841-51. 14676298

Oinuma, I., Ito, Y., Katoh, H. and Negishi, M. (2010). Semaphorin 4D/Plexin-B1 stimulates PTEN activity through R-Ras GTPase-activating protein activity, inducing growth cone collapse in hippocampal neurons. J. Biol. Chem. 285(36): 28200-9. PubMed Citation: 20610402

Okada, S., et al. (1998). Insulin regulates the dynamic balance between Ras and Rap1 signaling by coordinating the assembly states of the Grb2-SOS and CrkII-C3G complexes. Embo J. 17(9): 2554-2565

Olivier, J. P., et al. (1993). A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos. Cell 73: 179-191

Olson, M. F., Paterson, H. F. and Marshall, C. J. (1998). Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1. Nature 394: 295-299

Oinuma, I., Katoh, H. and Negishi, M. (2004). Molecular dissection of the semaphorin 4D receptor plexin-B1-stimulated R-Ras GTPase-activating protein activity and neurite remodeling in hippocampal neurons. J. Neurosci. 24(50): 11473-80. PubMed Citation: 15601954

Ordentlich, P., et al. (1998). Notch inhibition of E47 supports the existence of a novel signaling pathway. Mol. Cell. Biol. 18(4): 2230-2239

Orme, M. H. et al. (2006). Input from Ras is required for maximal PI(3)K signalling in Drosophila. Nat. Cell Biol. 8: 1298-1302. PubMed citation: 17041587

Ory, S., et al. (2003). Protein phosphatase 2A positively regulates ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites. Curr. Biol. 13: 1356-1364. 12932319

Pacold, M. E., et al. (2000). Crystal structure and runctional analysis of Ras binding to its effector Phosphoinositide 3-kinase. Cell 103: 931-943

Pagliarini, R. A. and Xu. T. (2003), A genetic screen in Drosophila for metastatic behavior. Science 302: 1227-1231. 14551319

Pan, Y., Carbe, C., Powers, A., Feng, G. S. and Zhang, X. (2010). Sprouty2-modulated Kras signaling rescues Shp2 deficiency during lens and lacrimal gland development. Development 137(7): 1085-93. PubMed Citation: 20215346

Pasca di Magliano, M., et al. (2007). Hedgehog/Ras interactions regulate early stages of pancreatic cancer. Genes Dev. 20: 3161-3173. Medline abstract: 17114586

Peeper, D. S., et al. (1997). Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein. Nature 386: 177-181

Peli, J., et al. (1999). Oncogenic Ras inhibits Fas ligand-mediated apoptosis by downregulating the expression of Fas. EMBO J. 18(7): 1824-1831

Peineau, S., et al. (2007). LTP inhibits LTD in the hippocampus via regulation of GSK3beta. Neuron 53: 703-717. PubMed Citation: 17329210

Pells, S., et al. (1997). Developmentally-regulated expression of murine K-ras isoforms. Oncogene 15(15): 1781-1786

Perez, E., Das, G., Bergmann, A. and Baehrecke, E. H. (2014). Autophagy regulates tissue overgrowth in a context-dependent manner. Oncogene [Epub ahead of print]. PubMed ID: 25174403

Petit, V., Nussbaumer, U., Dossenbach, C. and Affolter, M. (2004). Downstream-of-FGFR is a fibroblast growth factor-specific scaffolding protein and recruits Corkscrew upon receptor activation. Mol. Cell. Biol. 24(9): 3769-81. 15082772

Phelps, R. A., et al. (2009). A two-step model for colon adenoma initiation and progression caused by APC loss. Cell 137(4): 623-34. PubMed Citation: 19450512

Pomerance, M., et al. (1996). The Ras-GTPase-activating protein SH3 domain is required for Cdc2 activation and mos induction by oncogenic Ras in Xenopus oocytes independently of mitogen-activated protein kinase activation. Mol. Cell. Biol. 16: 3179-3186

Porfiri, E. and McCormick, F. (1996). Regulation of epidermal growth factor receptor signaling by phosphorylation of the ras exchange factor hSOS1. J. Biol. Chem. 271: 5871-5877

Potempa, S. and Ridley, A. J. (1998). Activation of both MAP kinase and Phosphatidylinositide 3-kinase by Ras Is required for Hepatocyte growth factor/Scatter factor-induced adherens junction disassembly. Mol. Biol. Cell 9(8): 2185-2200

Prober, D. A. and Edgar, B. A. (2000). Ras1 promotes cellular growth in the Drosophila wing. Cell 100: 435-446

Prober, D. A. and Edgar, B. A. (2002). Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing. Genes Dev. 16: 2286-2299. 12208851

Qin, Y., et al. (2005). State-dependent Ras signaling and AMPA receptor trafficking. Genes Dev. 19: 2000-2015. 16107614

Quilliam, L. A., et al. (1995). Biological and structural characterization of a Ras transforming mutation at the phenylalanine-156 residue, which is conserved in all members of the Ras superfamily. Proc. Natl. Acad. Sci. 92 (5): 1272-1276

Raabe, T., et al. (1995). Biochemical and genetic analysis of the Drk SH2/SH3 adaptor protein of Drosophila. EMBO J. 14: 2509-2518

Raabe, T., et al. (1996). DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila. Cell 85: 911-920

Rabizadeh, S., et al. (2004). The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death. J. Biol. Chem. 279: 29247-29254. 15075335

Radke, K., Johnson, K., Guo, R., Davidson, A. and Ambrosio, L. (2001). Drosophila-raf acts to elaborate dorsoventral pattern in the ectoderm of developing embryos. Genetics 159(3): 1031-44. PubMed citation: 11729151

Raffel, G. D., Parmar, K, and Rosenberg, N. (1996). In vivo association of v-Abl with Shc mediated by a non-phosphotyrosine-dependent SH2 interaction. J. Biol. Chem. 271: 4640-4645

Ramana, C. V., et al. (2000). Regulation of c-myc expression by IFN- through Stat1-dependent and -independent pathways. EMBO J. 19: 263-272

Rambur, A., Lours-Calet, C., Beaudoin, C., Bunay, J., Vialat, M., Mirouse, V., Trousson, A., Renaud, Y., Lobaccaro, J. A., Baron, S., Morel, L. and de Joussineau, C. (2020). Sequential Ras/MAPK and PI3K/AKT/mTOR pathways recruitment drives basal extrusion in the prostate-like gland of Drosophila. Nat Commun 11(1): 2300. PubMed ID: 32385236

Ramocki, M. B., et al. (1997). Signaling through mitogen-activated protein kinase and Rac/Rho does not duplicate the effects of activated Ras on skeletal myogenesis. Mol. Cell. Biol. (7): 3547-3555

Ramocki, M. B., et al. (1998). A role for RalGDS and a novel Ras effector in the Ras-mediated inhibition of skeletal myogenesis. J. Biol. Chem. 273(28): 17696-701

Raptis, L., et al. (1997). v-Ras and v-Raf block differentiation of transformable C3H10T1/2-derived preadipocytes at lower levels than required for neoplastic transformation. Exp. Cell Res. 235(1): 188-197

Reddy, B. V., Rauskolb, C. and Irvine, K. D. (2010). Influence of fat-hippo and notch signaling on the proliferation and differentiation of Drosophila optic neuroepithelia. Development 137(14): 2397-408. PubMed Citation: 20570939

Reichman-Fried, M., et al. (1994). Elucidation of the role of breathless, a Drosophila FGF receptor homolog, in tracheal cell migration. Genes Dev. 8: 428-39

Rhee, D. Y., Cho, D. Y., Zhai, B., Slattery, M., Ma, L., Mintseris, J., Wong, C. Y., White, K. P., Celniker, S. E., Przytycka, T. M., Gygi, S. P., Obar, R. A. and Artavanis-Tsakonas, S. (2014). Transcription factor networks in Drosophila melanogaster. Cell Rep 8: 2031-2043. PubMed ID: 25242320

Ribeiro, C., Ebner, A. and Affolter, M. (2002). In vivo imaging reveals different cellular functions for FGF and Dpp signaling in tracheal branching morphogenesis. Dev. Cell 2: 677-683. 12015974

Ribisi, S., et al. (2000). Ras-mediated FGF signaling is required for the formation of posterior but not anterior neural tissue in Xenopus laevis. Dev. Bio. 227: 183-196.

Ries, S., et al. (2000). Opposing effects of ras on p53: transcriptional activation of mdm2 and induction of p19ARF. Cell 103: 321-330.

Rime, H., et al. (1998). Inhibition of small G proteins by clostridium sordellii lethal toxin activates cdc2 and MAP kinase in Xenopus oocytes. Dev. Biol. 204(2): 592-602

Roberts, R. L., Mosch, H. U. and Fink, G. R. (1997). 14-3-3 proteins are essential for RAS/MAPK cascade signaling during pseudohyphal development in S. cerevisiae. Cell 89(7): 1055-1065

Robinson, L. J., et al. (1994). Evidence that p21ras mediates the neurotrophic effects of insulin and insulin-like growth factor I in chick forebrain neurons. Endocrinology 135: 2568-73

Rocheleau, C. E., et al. (2002). A lin-45 raf enhancer screen identifies eor-1, eor-2 and unusual alleles of ras pathway genes in Caenorhabditis elegans. Genetics 161: 121-131. 12019228

Rodriguez-Viciana P., et al. (1997). Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell 89 (3): 457-467

Rohrbaugh, M., et al. (2002). Notch activation of yan expression is antagonized by RTK/Pointed signaling in the Drosophila eye. Curr. Biol. 12: 576-581. 11937027

Rong, R., Ahn, J. Y., Chen, P., Suh, P. G. and Ye, K. (2004) Phospholipase activity of phospholipase C-gamma1 is required for nerve growth factor-regulated MAP kinase signaling cascade in PC12 cells. J. Biol. Chem. 278(52): 52497-503. 14570902

Roux, P., et al. (1997). The small GTPases Cdc42Hs, rac1 and RhoG delineate raf-independent pathways that cooperate to transform NIH3T3 cells. Curr. Biol. 7(9): 629-637

Roy, S., et al. (1998). 14-3-3 facilitates Ras-dependent Raf-1 activation in vitro and in vivo. Mol. Cell. Biol. 18(7): 3947-3955

Roy, F., Laberge, G., Douziech, M., Ferland-McCollough, D. and Therrien, M. (2002). KSR is a scaffold required for activation of the ERK/MAPK module. Genes Dev. 16(4): 427-438. 11850406

Rozakis-Adcock, M., et al. (1993). The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1. Nature 363 (6424): 83-85

Roy, S., et al. (1997). Activity of plasma membrane-recruited Raf-1 is regulated by Ras via the Raf zinc finger. J. Biol. Chem. 272(32): 20139-20145

Rusanescu, G., et al. (2001). Regulation of ras signaling specificity by Protein kinase C. Mol. Cell. Bio. 21: 2650-2658. 11283245

Ryu, J. R., et al. (1997). Transcriptional regulation of the Drosophila-raf proto-oncogene by the DNA replication-related element (DRE)/DRE-binding factor (DREF) system. Nucleic Acids Res. 25(4): 794-799

Continued Ras85 References: part 3/3 | Return: part 1/3


Ras85D: Biological Overview | Evolutionary Homologs | Regulation | Protein Interactions | Effects of Mutation | Ras as Oncogene

Home page: The Interactive Fly © 1997 Thomas B. Brody, Ph.D.

The Interactive Fly resides on the
Society for Developmental Biology's Web server.