Medea

Abdollah, S., et al. (1997). TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling. J. Biol. Chem. 272: 27678-27685. PubMed Citation: 9346908

Abe, T., et al. (2005). Notch signaling modulates the nuclear localization of carboxy-terminal-phosphorylated smad2 and controls the competence of ectodermal cells for activin A. Mech. Dev. 122: 671-680. 15817224

Adorno, M., et al. (2009). A mutant-p53/Smad complex opposes p63 to empower TGFβ-induced metastasis. Cell 137: 87-98. PubMed Citation: 19345189

Atfi, A., et al. (1997). Induction of apoptosis by DPC4, a transcriptional factor regulated by transforming growth factor-beta through stress-activated protein Kinase/c-Jun N-terminal kinase (SAPK/JNK) signaling pathway. J. Biol. Chem. 272(40): 24731-24734. PubMed Citation: 9312063

Baird, S. E. and Ellazar, S. A. (1999). TGFbeta-like signaling and spicule development in Caenorhabditis elegans. Dev. Biol. 212(1): 93-100. PubMed Citation: 10419688

Brummel, T., et al. (1999). The Drosophila activin receptor baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development. Genes Dev. 13(1): 98-111. PubMed Citation: 9887103

Candia, A. F., et al. (1997). Cellular interpretation of multiple TGF-beta signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads. Development 124(22): 4467-4480. PubMed Citation: 9409665

Chen, D. and McKearin, D. (2003). Dpp signaling silences bam transcription directly to establish asymmetric divisions of germline stem cells. Curr. Biol. 13: 1786-1791. 14561403

Chen, W., et al. (2007). Competition between Ski and CBP for binding to Smads in TGF-β signaling. J. Biol. Chem. 282(15): 11365-76. Medline abstract: 17283070

Chen, X., Rubock, M. J. and Whitman, M. (1996). A transcriptional partner for MAD proteins in TGF-ß signalling. Nature 383: 691-696. PubMed Citation: 8878477

Chen, X., et al. (1997). Smad4 and FAST-1 in the assembly of activin-responsive factor. Nature 389: 85-89. PubMed Citation: 9288972

Chen, Y. G., et al. (1998). Determinants of specificity in TGF-beta signal transduction. Genes Dev. 12(14): 2144-2152. PubMed Citation: 9679059

da Graca, L. S., et al. (2004). DAF-5 is a Ski oncoprotein homolog that functions in a neuronal TGFß pathway to regulate C. elegans dauer development. Development 131: 435-446. 14681186

Das, P., et al. (1998). The Drosophila gene Medea demonstrates the requirement for different classes of Smads in dpp signaling. Development 125: 1519-1528. PubMed Citation: 9502733

Das, P., et al. (1999). Drosophila dSmad2 and Atr-I transmit activin/TGFbeta signals. Genes to Cells 4: 123-134. PubMed Citation: 10320478

Datta, P. K., Blake, M. C. and Moses, H. L. (2000). Regulation of plasminogen activator inhibitor-1 expression by transforming growth factor-beta -induced physical and functional interactions between smads and Sp1. J. Biol. Chem. 275(51): 40014-9. 11054406

de Caestecker, M. P., et al. (1997). Characterization of functional domains within Smad4/DPC4. J. Biol. Chem. 272 (21): 13690-13696. PubMed Citation: 9153220

del Alamo Rodriguez, D., Terriente Felix, J., Diaz-Benjumea, F. J. (2004). The role of the T-box gene optomotor-blind in patterning the Drosophila wing. Dev. Biol. 268(2): 481-92. 15063183

Demagny, H., Araki, T. and De Robertis, E. M. (2014). The tumor suppressor Smad4/DPC4 is regulated by phosphorylations that integrate FGF, Wnt, and TGF-beta signaling. Cell Rep 9: 688-700. PubMed ID: 25373906

Dong, C., et al. (2000). Microtubule binding to Smads may regulate TGFbeta activity. Molec. Cell 5: 27-34. PubMed Citation: 10678166

Feng, X. H., et al. (1998). The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation. Genes Dev. 12(14): 2153-2163. PubMed Citation: 9679060

Feng, X.-H., Lin, X. and Derynck, R. (2000). Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15Ink4B transcription in response to TGF-beta. EMBO J. 19: 5178-5193. PubMed Citation: 11013220

Fischer, S., et al. (2012). fussel (fuss)--a negative regulator of BMP signaling in Drosophila melanogaster. PLoS One 7(8): e42349. PubMed Citation: 22879948

Furtado, M. B., et al. (2008). BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4. Genes Dev. 22(21): 3037-49. PubMed Citation: 18981480

Galant, R. and Carroll, S. B. (2002). Evolution of a transcriptional repression domain in an insect Hox protein. Nature 415: 910-913. PubMed citation: 11859369

Gao, S., Steffen, J. and Laughon, A. (2005). DPP-responsive silencers are bound by a trimeric mad-medea complex. J. Biol. Chem. 280(43): 36158-64. 16109720

Gao, S. and Laughon, A. (2006). Decapentaplegic-responsive silencers contain overlapping mad-binding sites. J. Biol. Chem. 281(35): 25781-90. 16829514

Hahn, S. A., et al. (1996). DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 271: 350-353

Hata, A., et al. (1997). Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4. Nature 388(6637): 82-87

Hata, A., et al. (1998). Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor Genes Dev. 12: 186-197

Henderson, K. D., Isaac, D. D. and Andrew, D. J. (1999). Cell fate specification in the Drosophila salivary gland: the integration of homeotic gene function with the DPP signaling cascade. Dev. Biol. 205(1): 10-21

Hodge, L. K., et al. (2007). Retrograde BMP signaling regulates trigeminal sensory neuron identities and the formation of precise face maps. Neuron 55(4): 572-86. PubMed citation: 17698011

Howe, J. R., et al. (1998). Mutations in the SMAD4/DPC4 gene in juvenile polyposis. Science 280(5366): 1086-1088

Howell, M., et al. (1999). Xenopus Smad4beta is the co-Smad component of developmentally regulated transcription factor complexes responsible for induction of early mesodermal genes. Dev. Biol. 214(2): 354-69

Howell, M., Inman, G. J. and Hill, C. S. (2002). A novel Xenopus Smad-interacting forkhead transcription factor (XFast-3) cooperates with XFast-1 in regulating gastrulation movements. Development 129: 2823-2834. 12050132

Hua, X., et al. (1998). Synergistic cooperation of TFE3 and smad proteins in TGF-beta-induced transcription of the plasminogen activator inhibitor-1 gene. Genes Dev. 12(19): 3084-95

Hudson, J. B., et al. (1998). The Drosophila Medea gene is required downstream of dpp and encodes a functional homolog of human Smad4. Development 125: 1407-1420. 9502722

Hullinger, T. G., et al. (2001). TGFbeta and BMP-2 activation of the OPN promoter: roles of smad- and hox-binding elements. Exp. Cell Res. 262(1): 69-74. 11120606

Inman, G. J., Nicolas, F. J. and Hill, C. S. (2002). Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-ß receptor activity. Molec. Cell 10: 283-294. 12191474

Inoue, H., et al. (1998). Interplay of signal mediators of Decapentaplegic (Dpp): Molecular characterization of Mothers against dpp, Medea, and Daughters against dpp. Mol. Biol. Cell 9(8): 2145-2156

Ito, Y., et al. (2001). Overexpression of Smad2 reveals its concerted action with Smad4 in regulating TGF-ß-mediated epidermal homeostasis. Dev. Bio. 236: 181-194. 11456453

Janknecht, R., Wells, N. J. and Hunter, T. (1998). TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300. Genes Dev. 12(14): 2114-2119

Ji, Y.-J., et al. (2004). RNT-1, the C. elegans homologue of mammalian RUNX transcription factors, regulates body size and male tail development. Dev. Biol. 274: 402-412. 15385167

Jiang, X., et al. (2008). Otefin, a nuclear membrane protein, determines the fate of germline stem cells in Drosophila via interaction with Smad complexes. Dev. Cell 14(4): 494-506. PubMed Citation: 18410727

Johnson, A. N., Bergman, C. M., Kreitman, M. and Newfeld, S. J. (2003). Embryonic enhancers in the dpp disk region regulate a second round of Dpp signaling from the dorsal ectoderm to the mesoderm that represses Zfh-1 expression in a subset of pericardial cells. Dev. Biol. 262: 137-151. 14512024

Kawabata, M., et al. (1998). Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors. EMBO J. 17(14): 4056-4065

Kim, R. H., et al. (2000). A novel Smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-ß signal transduction. Genes Dev. 14: 1605-1616.

Kirilly, D., Spana, E. P., Perrimon, N., Padgett, R. W. and Xie, T. (2005). BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary.Dev. Cell 9(5): 651-62. 16256740

Kopp, E., Medzhitov, R., Carothers, J., Xiao, C., Douglas, I., Janeway, C.A., and Ghosh, S. 1999. ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. Genes & Dev. 13: 2059-2071. 10465784

Kretzschmar, M., et al. (1997). The TGF-ß family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase. Genes Dev. 11: 984-995

Kurisaki, K., et al. (2003). Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein-induced cell differentiation. Mol. Cell. Biol. 23(13): 4494-510. 12808092

Labbe, E., et al. (1998). Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2. Mol. Cell (1): 109-20

Lagna, G., et al. (1996). Partnership between DPC4 and SMAD proteins in TGF-ß signaling pathways. Nature 383: 832-836

Leiblich, A., Marsden, L., Gandy, C., Corrigan, L., Jenkins, R., Hamdy, F. and Wilson, C. (2012). Bone morphogenetic protein- and mating-dependent secretory cell growth and migration in the Drosophila accessory gland. Proc Natl Acad Sci U S A 109: 19292-19297. PubMed ID: 23129615

LeSueur, J. A. and Graff, J. M. (1999). Spemann organizer activity of Smad10. Development 126(1): 137-146

LeSueur, J. A., et al. (2002). Smad10 is required for formation of the frog nervous system. Dev. Cell 2: 771-783. 12062089

Li, W., et al. (2003). Squamous cell carcinoma and mammary abscess formation through squamous metaplasia in Smad4/Dpc4 conditional knockout mice. Development 130: 6143-6153. 14597578

Lien, C. L., et al. (2002). Cardiac-specific activity of an Nkx2-5 enhancer requires an evolutionarily conserved Smad binding site. Dev. Biol. 244: 257-266. 11944935

Liberati, N. T., et al. (1999). Smads bind directly to the jun family of AP-1 transcription factors. Proc. Natl. Acad. Sci. 96(9): 4844-9

Liberatore, C. M., et al. (2002). Nkx-2.5 gene induction in mice is mediated by a Smad consensus regulatory region. Dev. Biol. 244: 243-256. 11944934

Liu, F., Pouponnot, C. and Massague, J. (1997). Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes. Genes Dev. 11(23): 3157-3167

Luo, K., et al. (1999). The Ski oncoprotein interacts with the Smad proteins to repress TGF signaling. Genes Dev. 17: 2196-2206

Marquez, R. M., et al. (2001). Transgenic analysis of the Smad family of TGF-ß signal transducers in Drosophila melanogaster suggests new roles and new interactions between family members. Genetics 157: 1639-1648. 11290719

McCabe, B. D., et al. (2004). Highwire regulates presynaptic BMP signaling essential for synaptic growth. Neuron 41(6): 891-905. 15046722

Miles, W. O., et al. (2008). Medea SUMOylation restricts the signaling range of the Dpp morphogen in the Drosophila embryo. Genes Dev. 22(18): 2578-90. PubMed Citation: 18794353

Minami, R., Wakabayashi, M., Sugimori, S., Taniguchi, K., Kokuryo, A., Imano, T., Adachi-Yamada, T., Watanabe, N. and Nakagoshi, H. (2012). The homeodomain protein defective proventriculus is essential for male accessory gland development to enhance fecundity in Drosophila. PLoS One 7: e32302. PubMed ID: 22427829

Morsut, L., et al. (2010). Negative control of Smad activity by ectodermin/Tif1gamma patterns the mammalian embryo. Development 137(15): 2571-8. PubMed Citation: 20573697

Morikawa, Y., et al. (2009). BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways. Development 136(21): 3575-84. PubMed Citation: 19793887

Müller, B., et al. (2003). Conversion of an extracellular Dpp/BMP morphogen gradient into an inverse transcriptional gradient. Cell 113: 221-233. 12705870

Muzzopappa, M. and Wappner, P. (2005). Multiple roles of the F-box protein Slimb in Drosophila egg chamber development. Development 132: 2561-2571. 15857915

Nakao, A, et al. (1997). TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4. EMBO J. 16(17): 5353-5362

Nguyen, H. T. and Xu, X. (1998). Drosophila mef2 expression during mesoderm development is controlled by a complex array of cis-acting regulatory modules. Dev. Biol. 204(2): 550-66

Nishimura, R., et al. (1998). Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12. J. Biol. Chem. 273(4): 1872-9

Patterson, G. I., et al. (1997). The DAF-3 smad protein antagonizes TGF-beta-related receptor signaling in the Caenorhabditis elegans dauer pathway. Genes Dev. 11(20): 2679-2690

Pyrowolakis, G., et al. (2004). A simple molecular complex mediates widespread BMP-induced repression during Drosophila development. Dev. Cell 7: 229-240. 15296719

Raftery, L. A., Twombly, V., Wharton, K., and Gelbart, W. M. (1995). Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila. Genetics 139: 241-254.

Raftery, L.A. and Sutherland, D. J. (1999). TGF-beta family signal transduction in Drosophila development: from Mad to Smads. Dev. Biol. 210(2): 251-68

Rawson, J. M., Lee, M., Kennedy, E. L. and Selleck, S. B. (2003). Drosophila neuromuscular synapse assembly and function require the TGF-beta type I receptor saxophone and the transcription factor Mad. J. Neurobiol. 55: 134-150. 12672013

Reddien, P. W., Bermange, A. L., Kicza, A. M. and Sánchez Alvarado, A. (2007). BMP signaling regulates the dorsal planarian midline and is needed for asymmetric regeneration. Development 134(22): 4043-51. Medline abstract: 17942485

Savage, C., et al. (1996). Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components. Proc. Natl. Acad. Sci. 93: 790-794

Sekelsky, J. J., et al. (1995). Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster. Genetics 139: 1347-1358

Shathasivam, P., Kollara, A., Ringuette, M. J., Virtanen, C., Wrana, J. L. and Brown, T. J. (2015). Human ortholog of Drosophila Melted impedes SMAD2 release from TGF-beta receptor I to inhibit TGF-beta signaling. Proc Natl Acad Sci U S A 112: E3000-3009. PubMed ID: 26039994

Shen, J. and Dahmann, C. (2005). The role of Dpp signaling in maintaining the Drosophila anteroposterior compartment boundary. Dev. Biol. 279(1): 31-43. 15708556

Shi, Y., et al. (1997). A structural basis for mutational inactivation of the tumour suppressor Smad4. Nature 388(6637): 87-93

Shioda, T., et al. (1998). Transcriptional activating activity of Smad4: roles of SMAD hetero-oligomerization and enhancement by an associating transactivator. Proc. Natl. Acad. Sci. 95(17): 9785-90

Sirard, C., et al., (1998). The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev. 12(1): 107-119.

Smith, M., Bhaskar, V., Fernandez, J. and Courey, A. J. (2004). Drosophila Ulp1, a nuclear pore-associated SUMO protease, prevents accumulation of cytoplasmic SUMO conjugates. J. Biol. Chem. 279: 43805-43814. PubMed Citation: 15294908

Song, X., et al. (2004). Bmp signals from niche cells directly repress transcription of a differentiation-promoting gene, bag of marbles, in germline stem cells in the Drosophila ovary. Development 131(6): 1353-64. 14973291

Sotillos, S. and de Celis, J. F. (2006). Regulation of decapentaplegic expression during Drosophila wing veins pupal development. Mech. Dev. 123(3): 241-51. 16423512

Souchelnytskyi, S., et al. (1997). Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling. J. Biol. Chem. 272: 28107-28115

Sun, K., Westholm, J. O., Tsurudome, K., Hagen, J. W., Lu, Y., Kohwi, M., Betel, D., Gao, F. B., Haghighi, A. P., Doe, C. Q. and Lai, E. C. (2012). Neurophysiological defects and neuronal gene deregulation in Drosophila mir-124 mutants. PLoS Genet 8: e1002515. Pubmed: 22347817

Sutherland, D. J., et al. (2003). Stepwise formation of a SMAD activity gradient during dorsal-ventral patterning of the Drosophila embryo. Development 130: 5705-5716. 14534137

Suzuki, A., et al. (1997). Smad5 induces ventral fates in Xenopus embryo. Dev. Biol. 184 (2): 402-405

Takaesu, N. T., et al. (2002). Combinatorial signaling by an unconventional Wg pathway and the Dpp pathway requires Nejire (CBP/p300) to regulate dpp expression in posterior tracheal branches. Dev. Biol. 247: 225-236. 12086463

Takaesu, N. T., Herbig, E., Zhitomersky, D., O'Connor, M. B. and Newfeld, S. J. (2005). DNA-binding domain mutations in SMAD genes yield dominant-negative proteins or a neomorphic protein that can activate WG target genes in Drosophila. Development 132(21): 4883-94. 16192307

Takaesu, N. T., et al. (2006). dSno facilitates baboon signaling in the Drosophila brain by switching the affinity of Medea away from Mad and toward dSmad2. Genetics 174(3): 1299-313. Medline abstract: 16951053

Takaku, K., et al. (1998). Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes. Cell 92(5): 645-656

Takeda, M., et al. (2004). Interaction with Smad4 is indispensable for suppression of BMP signaling by c-Ski. Mol. Biol. Cell 15(3): 963-72. Medline abstract: 14699069

Thatcher, J. D., Haun, C. and Okkema, P. G. (1999). The DAF-3 Smad binds DNA and represses gene expression in the Caenorhabditis elegans pharynx. Development 126(1): 97-107

Topper, J. N., et al. (1998). CREB binding protein is a required coactivator for smad-dependent, transforming growth factor beta transcriptional responses in endothelial cells. Proc. Natl. Acad. Sci. 95(16): 9506-9511

Tropepe, V., et al. (2001). Direct neural fate specification from embryonic stem cells: a primitive mammalian neural stem cell stage acquired through a default mechanism. Neuron 30: 65-78. 11343645

Van Bortle, K., Peterson, A. J., Takenaka, N., O'Connor, M. B. and Corces, V. G. (2015). CTCF-dependent co-localization of canonical Smad signaling factors at architectural protein binding sites in D. melanogaster. Cell Cycle 14(16):2677-87. PubMed ID: 26125535

Vindevoghel, L., et al. (1998). SMAD3/4-dependent transcriptional activation of the human type VII collagen gene (COL7A1) promoter by transforming growth factor beta. Proc. Natl. Acad. Sci. 95(25): 14769-74

Walsh, C. M. and Carroll, S. B. (2007). Collaboration between Smads and a Hox protein in target gene repression. Development 134(20): 3585-92. PubMed citation: 17855427

Wang, J. Mohler, W. A. and Savage-Dunn, C. (2005). C-terminal mutants of C. elegans Smads reveal tissue-specific requirements for protein activation by TGF-ß signaling. Development 132: 3505-3513. 16000380

Watanabe, M., Masuyama, N., Fukuda, M. and Nishida, E. (2000). Regulation of intracellular dynamics of Smad4 by its leucine-rich nuclear export signal. EMBO Rep. 1: 176-182. PubMed Citation: 11265759

Wharton, S. J., Basu, S. P. and Ashe, H. L. (2004). Smad affinity can direct distinct readouts of the embryonic extracellular Dpp gradient in Drosophila. Curr. Biol. 14: 1550-1558. 15341741

Watanabe, M. and Whitman, M. (1999). FAST-1 is a key maternal effector of mesoderm inducers in the early Xenopus embryo. Development 126: 5621-5634

Weiss, A., et al. (2010) A conserved activation element in BMP signaling during Drosophila development. Nat. Struct. Mol. Biol. 17(1): 69-76. PubMed Citation: 20010841

Wisotzkey, R. G., et al. (1998). Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses. Development 125: 1433-1445. 9502724

Wong, C., et al. (1999). Smad3-smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta. Mol. Cell. Biol. 19(3): 1821-30

Wu, J., et al. (2002). Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: insights on Ski-mediated repression of TGFβ signaling. Cell 111: 357-367. Medline abstract: 12419246

Wu, K.. et al. (2003). DACH1 inhibits TGF-beta signaling through binding Smad4. J. Biol. Chem. 278: 51673-51684. 14525983

Wu, R.-Y., et al. (1997). Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4. Mol. Cell. Biol. 17: 2521-28

Xiao, C., et al. (2003). Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. Genes Dev. 17: 2933-2949. 14633973

Xu, X., et al. (1998). Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm. Genes Dev. 12(15): 2354-2370

Xu, X., et al. (2008). Ectodermal Smad4 and p38 MAPK are functionally redundant in mediating TGF-beta/BMP signaling during tooth and palate development. PubMed Citation: 18694570

Yang, X., et al. (1998). The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice. Proc. Natl. Acad. Sci. 95(7): 3667-3672

Yingling, J. M., et al. (1997). Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein. Mol. Cell. Biol. 17(12): 7019-7028

Yoshida, S., Soustelle, L., Giangrande, A., Umetsu, D., Murakami, S., Yasugi, T., Awasaki, T., Ito, K., Sato, M. and Tabata, T. (2005). DPP signaling controls development of the lamina glia required for retinal axon targeting in the visual system of Drosophila. Development 132: 4587-4598. Pubmed: 16176948

Zhang, Y., (1996). Receptor-associated MAD homologues synergize as effectors of the TGF-ß response. Nature 383: 168-172

Zhang, Y., Feng, X. H. and Derynck, R. (1998). Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription. Nature 394: 909-913

date revised: 15 July 2015 

Home page: The Interactive Fly © 1997 Thomas B. Brody, Ph.D.

The Interactive Fly resides on the
Society for Developmental Biology's Web server.