FGF receptor 1

Avet-Rochex, A., Kaul, A. K., Gatt, A. P., McNeill, H. and Bateman, J. M. (2012). Concerted control of gliogenesis by InR/TOR and FGF signalling in the Drosophila post-embryonic brain. Development 139(15): 2763-2772. PubMed ID: 22745312

Awasaki, T., Lai, S. L., Ito, K. and Lee, T. (2008). Organization and postembryonic development of glial cells in the adult central brain of Drosophila. J Neurosci 28(51): 13742-13753. PubMed ID: 19091965

Bateman J. M. and McNeill H. (2004). Temporal control of differentiation by the insulin receptor/tor pathway in Drosophila. Cell 119: 87-96. PubMed Citation: 15454083

Beati, H., Langlands, A., Ten Have, S. and Muller, H. J. (2019). SILAC-based quantitative proteomic analysis of Drosophila gastrula stage embryos mutant for fibroblast growth factor signalling. Fly (Austin): 1-19. PubMed ID: 31873056

Beiman, M., Shilo, B.-Z. and Volk, T. (1996). Heartless, a Drosophila FGF receptor homolog, is essential for cell migration and establishment of several mesodermal lineages. Genes Dev. 10: 2993-3002. 8957000

Bermingham-McDonogh, O., et al. (2001). FGFR3 expression during development and regeneration of the chick inner ear sensory epithelia. Dev. Bio. 238: 247-259

Bradley, P. L., Myat, M. M., Comeaux, C. A. and Andrew, D. J. (2003). Posterior migration of the salivary gland requires an intact visceral mesoderm and integrin function. Dev. Biol. 257: 249-262. 12729556

Bülow, H. E., Boulin, T. and Hobert, O. (2004). Differential functions of the C. elegans FGF receptor in axon outgrowth and maintenance of axon position. Neuron 42: 367-374. 15134634

Burdine, R. D., et al. (1997). egl-17 encodes an invertebrate fibroblast growth factor family member required specifically for sex myoblast migration in Caenorhabditis elegans Proc. Natl. Acad. Sci. 94: 2433-37. 9122212

Burgar, H. R., et al. (2002). Association of the signaling adaptor FRS2 with fibroblast growth factor receptor 1 (Fgfr1) is mediated by alternative splicing of the juxtamembrane domain. J. Biol. Chem. 277(6): 4018-23. 11729184

Campbell, J. S., et al. (1995). Differential activation of mitogen-activated protein kinase in response to basic fibroblast growth factor in skeletal muscle cells. Proc. Natl. Acad. Sci. 92: 870-874

Carmena, A., et al. (1998). Combinatorial signaling codes for the progressive determination of cell fates in the Drosophila embryonic mesoderm. Genes Dev. 12(24): 3910-3922

Carmena, A., et al. (2002). Reciprocal regulatory interactions between the Notch and Ras signaling pathways in the Drosophila embryonic mesoderm. Dev. Biol. 244: 226-242. 11944933

Cebria, F., et al. (2002). FGFR-related gene nou-darake restricts brain tissues to the head region of planarians. Nature 419: 620-624. 12374980

Chen, Y., Li, X., Eswarakumar, V. P., Seger, R. and Lonai, P. (2000). Fibroblast growth factor (FGF) signaling through PI 3-kinase and Akt/PKB is required for embryoid body differentiation. Oncogene 19: 3750-3756. 10949929

Ciruna, B. G., et al. (1997). Chimeric analysis of fibroblast growth factor receptor-1 (Fgfr1) function: a role for FGFR1 in morphogenetic movement through the primitive streak. Development 1997 (14): 2829-2841

Ciruna, B. and Rossant, J. (2001). FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak. Dev. Cell 1: 37-49

Condron, B. (1999). Spatially discrete FGF-mediated signalling directs glial morphogenesis. Development 126: 4635-4641

Cornell, R. A., Musci, T. J. and Kimelman, D. (1995). FGF is a prospective competence factor for early activin-type signals in Xenopus mesoderm induction. Development 121: 2429-2437

Curran, K. L. and Grainger, R. M. (2000). Expression of activated MAP kinase in Xenopus laevis embryos: Evaluating the roles of FGF and other signaling pathways in early induction and patterning. Dev. Bio. 228: 41-56.

de Frutos, C. A., et al. (2007). Snail1 is a transcriptional effector of FGFR3 signaling during chondrogenesis and achondroplasias. Dev. Cell 13(6): 872-83. PubMed citation: 18061568

Delaune, E., Lemaire, P. and Kodjabachian, L. (2005). Neural induction in Xenopus requires early FGF signalling in addition to BMP inhibition. Development 132(2): 299-310. 15590738

de Velasco, B., Mandal, L., Mkrtchyan, M. and Hartenstein, V. (2006). Subdivision and developmental fate of the head mesoderm in Drosophila melanogaster. Dev. Genes Evol. 216(1): 39-51. 16249873

Deng, C., et al. (1997). Fibroblast growth factor receptor-1 (FGFR-1) is essential for normal neural tube and limb development. Dev. Biol. 185: 42-54

De Moerlooze, L., et al. (2000). An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis. Development 127: 483-492

De Velasco, B., Shen, J., Go, S. and Hartenstein, V. (2004). Embryonic development of the Drosophila corpus cardiacum, a neuroendocrine gland with similarity to the vertebrate pituitary, is controlled by sine oculis and glass. Dev. Biol. 274: 280-294. 15385159

DeVore, D. L., Horvitz, H. R. and Stern, M. J. (1995). An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites. Cell 83: 611-620

Dixon, S. J., Alexander, M., Fernandes, R., Ricker, N. and Roy, P. J. (2006). FGF negatively regulates muscle membrane extension in Caenorhabditis elegans. Development 133(7):1263-75. 16495308

Dragojlovic-Munther, M. and Martinez-Agosto, J. A. (2013). Extracellular matrix-modulated Heartless signaling in Drosophila blood progenitors regulates their differentiation via a Ras/ETS/FOG pathway and target of rapamycin function. Dev Biol 384: 313-330. PubMed ID: 23603494

Doherty, P. and Walsh, F. S. (1996). CAM-FGF receptor interactions: A model for axonal growth. Mol. Cell. Neurosci. 8: 99-111

Dutta, D., Shaw, S., Maqbool, T., Pandya, H. and Vijayraghavan, K. (2005). Drosophila Heartless acts with Heartbroken/Dof in muscle founder differentiation. PLoS Biol. 3(10):e337. 16207075

Emori, Y. and Saigo, K. (1993). Distinct expression of two Drosophila homologs of fibroblast growth factor receptors in imaginal discs. FEBS Lett 332: 111-114

Englund, C., et al. (1999). adrift, a novel bnl-induced Drosophila gene, required for tracheal pathfinding into the CNS. Development 126: 1505-1514

Enriquez, J., Rio, L. Q., Blazeski, R., Bellemin, S., Godement, P., Mason, C. and Mann, R. S. (2018). Differing strategies despite shared lineages of motor neurons and glia to achieve robust development of an adult neuropil in Drosophila. Neuron 97(3): 538-554 e535. PubMed ID: 29395908

Esain, V., Postlethwait, J. H., Charnay, P. and Ghislain, J. (2010). FGF-receptor signalling controls neural cell diversity in the zebrafish hindbrain by regulating olig2 and sox9. Development 137(1): 33-42. PubMed Citation: 20023158

Eswarakumar, V. P., et al. (2002). The IIIc alternative of Fgfr2 is a positive regulator of bone formation. Development 129: 3783-3793. 12135917

Faber, S. C., et al. (2001). Fgf receptor signaling plays a role in lens induction. Development 128: 4425-4438. 11714669

Faloon, P., et al. 2000). Basic fibroblast growth factor positively regulates hematopoietic development. Development 127: 1931-1941

Flanagan-Steet, H., et al. (2000). Loss of FGF receptor 1 signaling reduces skeletal muscle mass and disrupts myofiber organization in the developing limb. Dev. Bio. 218: 21-37.

Fleming, T. C., Wolf, F. W. and Garriga, G. (2005). Sensitized genetic backgrounds reveal a role for C. elegans FGF EGL-17 as a repellent for migrating CAN neurons. Development 132(21): 4857-67. 16207764

Foo, L. C., Song, G. and Cohen, S. M. (2017). miR-31 mutants reveal continuous glial homeostasis in the adult Drosophila brain. EMBO. J. 36: 1215-1226. PubMed ID: 28320737

Furthauer, M., et al. (2001). sprouty4 acts in vivo as a feedback-induced antagonist of FGF signaling in zebrafish. Development 128: 2175-2186

Fürthauer, M., Lin, W., Ang, S. L., Thisse, B. and Thisse, C. (2002). Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling. Nat. Cell Biol. 4: 170-174. 11802165

Gabay, L., Seger, R. and Shilo, B. Z. (1997). MAP kinase in situ activation atlas during Drosophila embryogenesis. Development 124: 3535-3541. PubMed Citation: 9342046

Garcia-Alonso, L., Romani, S. and Jimenez, F. (2000). The EGF and FGF receptors mediate Neuroglian function to control growth cone decisions during sensory axon guidance in Drosophila. Neuron 28: 741-752. 11163263

Gillespie, L. L., Chen, G. and Paterno, G. D. (1995). Cloning of a fibroblast growth factor receptor 1 splice variant from Xenopus embryos that lacks a protein kinase C site important for the regulation of receptor activity. J Biol Chem 270: 22758-22763

Gisselbrecht, S., et al. (1996). heartless encodes a fibroblast growth factor receptor (DFR1/DFGF-R2) involved in the directional migration of early mesodermal cells in the Drosophila embryo. Genes Dev. 10: 3003-3017. 8957001

Golub, R., et al. (2000). Evolutionarily conserved and divergent expression of members of the FGF receptor family among vertebrate embryos, as revealed by FGFR expression patterns in Xenopus. Dev. Genes Evol. 210: 345-357

Gomm, J. J., et al. (1997). A paracrine role for myoepithelial cell-derived FGF2 in the normal human breast. Exp. Cell Res. 234(1): 165-173

Goodman, S. J., et al. (2003). Alternative splicing affecting a novel domain in the C. elegans EGL-15 FGF receptor confers functional specificity. Development 130: 3757-3766. 12835392

Gorivodsky, M. and Lonai, P. (2003). Novel roles of Fgfr2 in AER differentiation and positioning of the dorsoventral limb interface. Development 130: 5471-5479. 14507786

Govindarajan, V. and Overbeek, P. A. (2001). Secreted FGFR3, but not FGFR1, inhibits lens fiber differentiation. Development 128: 1617-1627. 11290300

Grigorian, M., Mandal, L., Hakimi, M., Ortiz, I. and Hartenstein, V. (2011). The convergence of Notch and MAPK signaling specifies the blood progenitor fate in the Drosophila mesoderm. Dev Biol. 353(1): 105-18. PubMed Citation: 21382367

Griffin, K., Patient, R. and Holder, N. (1995). Analysis of FGF function in normal and no tail zebrafish embryos reveals separate mechanisms for formation of the trunk and the tail. Development 121: 2983-2994

Gronke S., et al. Partridge L. (2010). Molecular evolution and functional characterization of Drosophila insulin-like peptides. PLoS Genet. 6: e1000857. PubMed Citation: 20195512

Gryzik, T. and Muller, H. A. (2004). FGF8-like1 and FGF8-like2 encode putative ligands of the FGF receptor Htl and are required for mesoderm migration in the Drosophila gastrula. Curr. Biol. 14(8): 659-67. 15084280

Guillonneau, X., et al. (1998). Fibroblast growth factor (FGF) soluble receptor 1 acts as a natural inhibitor of FGF2 neurotrophic activity during retinal degeneration. Mol. Biol. Cell 9(10): 2785-802

Hadari, Y. R., Gotoh, N., Kouhara, H., Lax, I. and Schlessinger J. (2001). Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways. Proc. Natl. Acad. Sci. 98(15): 8578-83. 11447289

Hajihosseini, M. K., et al. (2004). Skeletal development is regulated by fibroblast growth factor receptor 1 signalling dynamics. Development 131: 325-335. 14668415

Halfon, M. S., et al. (2000). Ras pathway specificity is determined by the integration of multiple signal-activated and tissue-restricted transcription factors. Cell 103: 63-74.

Harfe, B. D., et al. (1998). Analysis of a Caenorhabditis elegans Twist homolog identifies conserved and divergent aspects of mesodermal patterning. Genes Dev. 12(16): 2623-2635

Hardcastle, Z., Chalmers, A. D. and Papalopulu, N. (2000). FGF-8 stimulates neuronal differentiation through FGFR-4a and interferes with mesoderm induction in Xenopus embryos. Curr. Biol. 10: 1511-1514. 11114518

Hart, K. C., Robertson, S. C. and Donoghue, D. J. (2001). Identification of tyrosine residues in constitutively activated Fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and Phosphatidylinositol 3-kinase activation. Mol. Biol. Cell 12: 931-942. 11294897

Hébert, J. M., et al. (2003). FGF signaling through FGFR1 is required for olfactory bulb morphogenesis. Development 130: 1101-1111. 12571102

Howard, T. D., et al. (1997). Mutations in TWIST, a basic helix-loop-helix transcription factor, in Saethre-Chotzen syndrome. Nat. Genet. 15(1): 36-41

Inglis-Broadgate, S. L., et al. (2005). FGFR3 regulates brain size by controlling progenitor cell proliferation and apoptosis during embryonic development. Dev. Biol. 279(1): 73-85. 15708559

Irizarry, J. and Stathopoulos, A. (2015). FGF signaling supports Drosophila fertility by regulating development of ovarian muscle tissues. Dev Biol [Epub ahead of print]. PubMed ID: 25958090

Iseki, S., et al. (1997). Fgfr2 and osteopontin domains in the developing skull vault are mutually exclusive and can be altered by locally applied FGF2. Development 124(17): 3375-3384

Iseki, S., Wilkie, O. A. M. and Morriss-Kay, G. M. (1999). Fgfr1 and Fgfr2 have distinct differentiation- and proliferation-related roles in the developing mouse skull vault. Development 126: 5611-5620

Isono, F., et al. (1994). Epidermal growth factor induces PC12 cell differentiation in the presence of the protein kinase inhibitor K-252a. J. Neurochem. 63: 1235-45

Ito, M., et al. (1994). Alternative splicing generates two distinct transcripts for the Drosophila melanogaster fibroblast growth factor receptor homolog. Gene 139: 215-218

Itoh, N., Mima, T. and Mikawa, T. (1996). Loss of fibroblast growth factor receptors is necessary for terminal differentiation of embryonic limb muscle. Development 122: 291-300

Jackson, D., et al. (1997). Fibroblast growth factor receptor signalling has a role in lobuloalveolar development of the mammary gland. J. Cell Sci. 110:1261-1268

Kaabeche, K., et al. (2005). Cbl-mediated ubiquitination of alpha5 integrin subunit mediates fibronectin-dependent osteoblast detachment and apoptosis induced by FGFR2 activation. J. Cell Sci. 118(Pt 6): 1223-32. 15728256

Kadam, S., McMahon, A., Tzou, P. and Stathopoulos, A. (2009). FGF ligands in Drosophila have distinct activities required to support cell migration and differentiation. Development 136(5): 739-47. PubMed Citation: 19158183

Kanda, S., et al. (1997). Phosphatidylinositol 3'-kinase-independent p70 S6 kinase activation by fibroblast growth factor receptor-1 is important for proliferation but not differentiation of endothelial cells. J. Biol. Chem. 272(37): 23347-23353

Kato, K., Orihara-Ono, M. and Awasaki, T. (2020). Multiple lineages enable robust development of the neuropil-glia architecture in adult Drosophila. Development 147(5). PubMed ID: 32051172

Kessaris, N., Jamen, F., Rubin, L. L. and Richardson, W. D. (2004). Cooperation between sonic hedgehog and fibroblast growth factor/MAPK signalling pathways in neocortical precursors. Development 131(6): 1289-98. 14960493

Kokel, M., et al. (1998). clr-1 encodes a receptor tyrosine phosphatase that negatively regulates an FGF receptor signaling pathway in Caenorhabditis elegans. Genes Dev. 12(10): 1425-1437

Kremer, M. C., Jung, C., Batelli, S., Rubin, G. M. and Gaul, U. (2017). The glia of the adult Drosophila nervous system. Glia 65(4): 606-638. PubMed ID: 28133822

Kudla, A. J., et al. (1998). The FGF receptor-1 tyrosine kinase domain regulates myogenesis but is not sufficient to stimulate proliferation. J. Cell Biol. 142(1): 241-50

Kumano, G. and Smith, W. C. (2000). FGF signaling restricts the primary blood islands to ventral mesoderm. Dev. Bio. 228: 304-314

Kuriyama, S. and Mayor, R. (2009). A role for Syndecan-4 in neural induction involving ERK- and PKC-dependent pathways. Development 136(4): 575-84. PubMed Citation: 19144724

Kuslak, S. L., Thielen, J. L. and Marker, P. C. (2007). The mouse seminal vesicle shape mutation is allelic with Fgfr2. Development 134(3): 557-65. Medline abstract: 17202188

LaBonne, C., Burke, B., and Whitman, M. (1995). Role of MAP kinase in mesoderm induction and axial patterning during Xenopus development. Development 121: 1475-1486

Laufer, E., et al. (1994). Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud. Cell 79: 993-1003

Lax, I., et al. (2002). The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors Mol. Cell 10: 709-719. 12419216

Lee, Y., Grill, S., Sanchez, A., Murphy-Ryan, M. and Poss, K. D. (2005). Fgf signaling instructs position-dependent growth rate during zebrafish fin regeneration. Development 132(23): 5173-83. 16251209

Li, X., Brunton, V. G., Burgar, H. R., Wheldon, L. M. and Heath, J. K. (2004). FRS2-dependent SRC activation is required for fibroblast growth factor receptor-induced phosphorylation of Sprouty and suppression of ERK activity. J. Cell Sci. 117(Pt 25): 6007-17. 15564375

Li, C., et al. (2005). FGFR1 function at the earliest stages of mouse limb development plays an indispensable role in subsequent autopod morphogenesis. Development 132(21): 4755-64. 16207751

Lin, H. Y., et al. (1998). Identification of the cytoplasmic regions of fibroblast growth factor (FGF) receptor 1 which play important roles in induction of neurite outgrowth in PC12 cells by FGF-1. Mol. Cell. Biol. 18(7): 3762-3770

Lin, X., et al. (1999). Heparan sulfate proteoglycans are essential for FGF receptor signaling during Drosophila embryonic development. Development 126: 3715-3723. PubMed Citation: 10433902

Lin, Y., et al. (2007). Fibroblast growth factor receptor 2 tyrosine kinase is required for prostatic morphogenesis and the acquisition of strict androgen dependency for adult tissue homeostasis. Development 134: 723-734. Medline abstract: 17215304

Lupo, G., et al. (2005). Dorsoventral patterning of the Xenopus eye: a collaboration of Retinoid, Hedgehog and FGF receptor signaling. Development 132(7): 1737-48.15753216

Macabenta, F. and Stathopoulos, A. (2019). Migrating cells control morphogenesis of substratum serving as track to promote directional movement of the collective. Development. PubMed ID: 31239242

MacArthur, C. A., et al. (1995). FGF-8 isoforms activate receptor splice forms that are expressed in mesenchymal regions of mouse development. Development 121: 3603-3613

Makarenkova, H., et al. (1997). Fibroblast growth factor 4 directs gap junction expression in the mesenchyme of the vertebrate limb bud. J. Cell Biol. 138(5): 1125-1137

Martin, B. S. and Bate, M. (2001). Hindgut visceral mesoderm requires an ectodermal template for normal development in Drosophila. Development 128: 233-242. 11124118

Marcelle, C., Wolf, J. and Bronner-Fraser, M. (1995). The in vivo expression of the FGF receptor FREK mRNA in avian myoblasts suggests a role in muscle growth and differentiation. Dev Biol 172: 100-114. PubMed Citation: 7589791

Maier, E., et al. (2010). Opposing Fgf and Bmp activities regulate the specification of olfactory sensory and respiratory epithelial cell fates. Development 137(10): 1601-11. PubMed Citation: 20392740

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McCoon, P. E., et al. (1998). Sea urchin FGFR muscle-specific expression: posttranscriptional regulation in embryos and adults. Dev. Biol. 200(2): 171-181

McFarlane, S., Zuber, M. E. and Holt, C. E. (1998). A role for the fibroblast growth factor receptor in cell fate decisions in the developing vertebrate retina. Development 125(20): 3967-3975

McMahon, A., Supatto, W., Fraser, S. E. and Stathopoulos, A. (2008). Dynamic analyses of Drosophila gastrulation provide insights into collective cell migration. Science 322: 1546-1550. PubMed Citation: 19056986

McNeill H., Craig G. M. and Bateman J. M. (2008). Regulation of neurogenesis and epidermal growth factor receptor signalling by the insulin receptor/target of rapamycin pathway in Drosophila. Genetics 179: 843-853. PubMed Citation: 18505882

Michelson, A. M., et al. (1998a). Dual functions of the heartless fibroblast growth factor receptor in development of the Drosophila embryonic mesoderm. Dev. Genet. 22(3): 212-229

Michelson, A. M., et al. (1998b). Heartbroken is a specific downstream mediator of FGF receptor signalling in Drosophila. Development 125(22): 4379-4389.

Mima, T., et al. (1995) Fibroblast growth factor receptor is required for in vivo cardiac myocyte proliferation at early embryonic stages of heart development. Proc Natl Acad Sci 92: 467-471

Min, H., et al. (1998). Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless. Genes Dev. 12(20): 3156-61

Miralles, F., et al. (1999). Signaling through fibroblast growth factor receptor 2b plays a key role in the development of the exocrine pancreas. Proc. Natl. Acad. Sci. 96(11):6267-72. 99272682

Mitchell, T. S. and Sheets, M. D. (2001). The FGFR pathway is required for the trunk-inducing functions of Spemann's organizer. Dev. Bio. 237: 295-305. 11543615

Moftah, M. Z., et al. (2002). Ectodermal FGFs induce perinodular inhibition of limb chondrogenesis in vitro and in vivo via FGF receptor 2. Dev. Bio. 249: 270-282

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Mohammadi, M., et al. (1998). Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain. EMBO J. 17(20): 5896-5904

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date revised: 18 December 2017