prospero

Akiyama-Oda, Y., et al. (2000). Mechanism of glia-neuron cell-fate switch in the Drosophila thoracic neuroblast 6-4 lineage. Development 127: 3513-3522. PubMed Citation: 10903176

Akong, K., McCartney, B. M. and Peifer, M. (2002). Drosophila APC2 and APC1 have overlapping roles in the larval brain despite their distinct intracellular localizations. Dev. Bio. 250: 71-90. 12297097

Aleksic, J., Ferrero, E., Fischer, B., Shen, S. P. and Russell, S. (2013). The role of Dichaete in transcriptional regulation during Drosophila embryonic development. BMC Genomics 14: 861. PubMed ID: 24314314

Ashraf, S. I. and Ip, Y. T. (2001). The Snail protein family regulates neuroblast expression of inscuteable and string, genes involved in asymmetry and cell division in Drosophila. Development 128: 4757-4767. 11731456

Avet-Rochex, A., Kaul, A. K., Gatt, A. P., McNeill, H. and Bateman, J. M. (2012). Concerted control of gliogenesis by InR/TOR and FGF signalling in the Drosophila post-embryonic brain. Development 139(15): 2763-2772. PubMed ID: 22745312

Awasaki, T., Lai, S. L., Ito, K. and Lee, T. (2008). Organization and postembryonic development of glial cells in the adult central brain of Drosophila. J Neurosci 28(51): 13742-13753. PubMed ID: 19091965

Bayraktar, O. A., Boone, J. Q., Drummond, M. L. and Doe, C. Q. (2010). Drosophila type II neuroblast lineages keep Prospero levels low to generate large clones that contribute to the adult brain central complex. Neural Dev 5: 26. PubMed ID: 20920301

Bello, B., Reichert, H. and Hirth, F. (2006). The brain tumor gene negatively regulates neural progenitor cell proliferation in the larval central brain of Drosophila. Development 133(14): 2639-48. 16774999

Behan, K. J., et al. (2002). Yan regulates Lozenge during Drosophila eye development. Dev. Genes Evol. 212: 267-276. 12111211

Belecky-Adams, T., et al. (1997). Pax-6, Prox 1, and Chx10 homeobox gene expression correlates with phenotypic fate of retinal precursor cells. Invest. Ophthalmol. Vis. Sci. 38(7): 1293-303. PubMed Citation: 9191592

Bello, B. C., Izergina, N., Caussinus, E. and Reichert. H. (2008). Amplification of neural stem cell proliferation by intermediate progenitor cells in Drosophila brain development. Neural Dev. 3: 5. PubMed Citation: 18284664

Berger, C., Pallavi, S. K., Prasad, M., Shashidhara, L. S. and Technau, G. M. (2005). A critical role for cyclin E in cell fate determination in the central nervous system of Drosophila melanogaster. Nat. Cell Biol. 7(1): 56-62. Medline abstract: 15580266

Betschinger, J., Mechtler, K. and Knoblich, J. A. (2006). Asymmetric segregation of the tumor suppressor Brat regulates self-renewal in Drosophila neural stem cells. Cell 124: 1241-1253. 16564014

Bi, X., Kajava, A. V., Jones, T., Demidenko, Z. N. and Mortin, M. A. (2003). The carboxy terminus of Prospero regulates its subcellular localization. Mol. Cell. Biol. 23(3): 1014-24. 12529405

Biteau, B. and Jasper, H. (2014). Slit/Robo signaling regulates cell fate decisions in the intestinal stem cell lineage of Drosophila. Cell Rep 7(6): 1867-75. PubMed ID: 24931602

Boone, J. Q. and Doe, C. Q. (2008). Identification of Drosophila type II neuroblast lineages containing transit amplifying ganglion mother cells. Dev Neurobiol. 68(9): 1185-1195. PubMed citation: 18548484

Bowman, S. K., Rolland, V., Betschinger, J., Kinsey, K. A., Emery, G. and Knoblich, J. A. (2008). The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in Drosophila. Dev Cell 14: 535-546. PubMed Citation: 18342578

Bozek, M., Cortini, R., Storti, A. E., Unnerstall, U., Gaul, U. and Gompel, N. (2019). ATAC-seq reveals regional differences in enhancer accessibility during the establishment of spatial coordinates in the Drosophila blastoderm. Genome Res 29(5): 771-783. PubMed ID: 30962180

Bravo González-Blas, C., Minnoye, L., Papasokrati, D., Aibar, S., Hulselmans, G., Christiaens, V., Davie, K., Wouters, J. and Aerts, S. (2019). cisTopic: cis-regulatory topic modeling on single-cell ATAC-seq data. Nat Methods 16(5): 397-400. PubMed ID: 30962623

Bravo Gonz&asacute;lez-Blas, C., B., Quan, X. J., Duran-Romana, R., Taskiran, II, Koldere, D., Davie, K., Christiaens, V., Makhzami, S., Hulselmans, G., de Waegeneer, M., Mauduit, D., Poovathingal, S., Aibar, S. and Aerts, S. (2020). Identification of genomic enhancers through spatial integration of single-cell transcriptomics and epigenomics. Mol Syst Biol 16(5): e9438. PubMed ID: 32431014

Broadus, J. and Doe, C. Q. (1995). Evolution of neuroblast identity: seven-up and prospero expression reveal homologous and divergent neuroblast fates in Drosophila and Schistocerca. Development 121: 3989-3996. PubMed Citation: 8575299

Broadus, J. and Doe, C. Q. (1997). Extrinsic cues, intrinsic cues and microfilaments regulate asymmetric protein localization in Drosophila neuroblasts. Curr. Biol. 7(11): 827-835. PubMed Citation: 9382803

Broadus, J., Fuerstenberg, S. and Doe, C. Q. (1998). Staufen-dependent localization of prospero mRNA contributes to neuroblast daughter-cell fate. Nature 391(6669): 792-795. PubMed Citation: 9486649

Burke, Z. and Oliver, G. (2002). Prox1 is an early specific marker for the developing liver and pancreas in the mammalian foregut endoderm. Mech. Dev. 118(1-2): 147-55. 12351178

Buescher, M. and Chia, W. (1997). Mutations in lottchen cause cell fate transformations in both neuroblast and glioblast lineages in the Drosophila embryonic central nervous system. Development 124: 673-681 . PubMed Citation: 9043082

Cannavo, E., Khoueiry, P., Garfield, D. A., Geeleher, P., Zichner, T., Gustafson, E. H., Ciglar, L., Korbel, J. O. and Furlong, E. E. (2016). Shadow enhancers are pervasive features of developmental regulatory networks. Curr Biol 26(1): 38-51. PubMed ID: 26687625

Carney, T. D., et al. (2012). Functional genomics identifies neural stem cell sub-type expression profiles and genes regulating neuroblast homeostasis. Dev. Biol. 361(1): 137-46. PubMed Citation: 22061480

Carney, T. D., Struck, A. J. and Doe, C. Q. (2013). midlife crisis encodes a conserved zinc-finger protein required to maintain neuronal differentiation in Drosophila. Development. PubMed ID: 24026126

Caussinus, E. and Gonzalez, C. (2005). Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster. Nature Genetics 37: 1125-9. 16142234

Ceron, J., Gonzalez, C. and Tejedor, F. J. (2001). Patterns of cell division and expression of asymmetric cell fate determinants in postembryonic neuroblast lineages of Drosophila. Dev. Bio. 230: 125-138. 11161567

Chang, C. J., Goulding, S., Adams, R. R., Earnshaw, W. C. and Carmena, M. (2006). Drosophila Incenp is required for cytokinesis and asymmetric cell division during development of the nervous system. J. Cell Sci. 119(Pt 6): 1144-53. 16507586

Charest-Marcotte, A., et al. (2010). The homeobox protein Prox1 is a negative modulator of ERRα/PGC-1α bioenergetic functions. Genes Dev. 24(6): 537-42. PubMed Citation: 20194433

Choksi, S. P., Southall, T. D., Bossing, T., Edoff, K., de Wit, E., Fischer, B. E., van Steensel, B., Micklem, G. and Brand, A. H. (2006). Prospero acts as a binary switch between self-renewal and differentiation in Drosophila neural stem cells. Dev. Cell 11: 775-789. PubMed Citation: 17141154

Chu-LaGraff, et al. (1991). The prospero gene encodes a divergent homeodomain protein that controls neuronal identity in Drosophila. Development (Suppl.) 2: 79-85. PubMed Citation: 1842358

Clark, B. S., Stein-O'Brien, G. L., Shiau, F., Cannon, G. H., Davis-Marcisak, E., Sherman, T., Santiago, C. P., Hoang, T. V., Rajaii, F., James-Esposito, R. E., Gronostajski, R. M., Fertig, E. J., Goff, L. A. and Blackshaw, S. (2019). Single-cell RNA-Seq analysis of retinal development identifies NFI factors as regulating mitotic exit and late-born cell specification. Neuron 102(6): 1111-1126 e1115. PubMed ID: 31128945

Colonques, J., Ceron, J., Reichert, H. and Tejedor, F. J. (2011). A transient expression of Prospero promotes cell cycle exit of Drosophila postembryonic neurons through the regulation of Dacapo. PLoS One. 6(4): e19342. PubMed Citation: 21552484

Cook, T., Pichaud, F., Sonneville, R., Papatsenko, D. and Desplan, C. (2003). Distinction between color photoreceptor cell fates is controlled by Prospero in Drosophila. Dev. Cell 4(6): 853-64. Medline abstract: 12791270

Demidenko, Z., Badenhorst, P., Jones, T., Bi, X. and Mortin, M. A. (2001). Regulated nuclear export of the homeodomain transcription factor Prospero. Development 128(8): 1359-67. 11262236

Doe, C.Q., Chu-LaGraff, Q., Wright, D.M. and Scott, M.P. (1991). The prospero gene specifies cell fates in the Drosophila central nervous system. Cell 65: 451-464. PubMed Citation: 1673362

Doe, C.Q. and Spana, E.P. (1995). A collection of cortical crescents: asymmetric protein localization in CNS precursor cells. Neuron 15: 991-995. PubMed Citation: 7576667

Duncan, M. K., et al. (2002). Prox1 is differentially localized during lens development. Mech. Dev. 112(1-2): 195-8. 11850194

Dyer, M. A., Livesey, F. J., Cepko, C. L. and Oliver, G. (2003). Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina. Nat. Genet. 34(1): 53-8. PubMed Citation: 12692551

Enriquez, J., Venkatasubramanian, L., Baek, M., Peterson, M., Aghayeva, U. and Mann, R. S. (2015). Specification of individual adult motor neuron morphologies by combinatorial transcription factor codes. Neuron 86(4):955-70. PubMed ID: 25959734

Enriquez, J., Rio, L. Q., Blazeski, R., Bellemin, S., Godement, P., Mason, C. and Mann, R. S. (2018). Differing strategies despite shared lineages of motor neurons and glia to achieve robust development of an adult neuropil in Drosophila. Neuron 97(3): 538-554 e535. PubMed ID: 29395908

Flores, G. V., et al. (2000). A combinatorial model involving permissive signals for specification of cell fate. Cell 103: 75-85. PubMed Citation: 11051549

Foo, L. C., Song, G. and Cohen, S. M. (2017). miR-31 mutants reveal continuous glial homeostasis in the adult Drosophila brain. EMBO. J. 36: 1215-1226. PubMed ID: 28320737

Forjanic, J. P., et al. (1997). Genetic analysis of stomatogastric nervous system development in Drosophila using enhancer trap lines. Development 186: 139-154. PubMed Citation: 9205135

Freeman, M. R. and Doe, C. Q. (2001). Asymmetric Prospero localization is required to generate mixed neuronal/glial lineages in the Drosophila CNS. Development 128: 4103-4112. 11641232

Fuerstenberg, S., et al. (1998). Identification of Miranda protein domains regulating asymmetric cortical localization, cargo binding, and cortical release. Mol. Cell. Neurosci. 12(6): 325-39. PubMed Citation: 9888987

Fuse, N., Hisata, K., Katzen, A. L. and Matsuzaki, F. (2003). Heterotrimeric G proteins regulate daughter cell size asymmetry in Drosophila neuroblast divisions. Curr. Biol. 13: 947-954. 12781133

Gao, F.-B., et al. (1999). Genes regulating dendritic outgrowth, branching, and routing in Drosophila. Genes Dev. 13: 2549-2561. PubMed Citation: 10521399

Genovese, S., Clement, R., Gaultier, C., Besse, F., Narbonne-Reveau, K., Daian, F., Foppolo, S., Luis, N. M. and Maurange, C. (2019). Coopted temporal patterning governs cellular hierarchy, heterogeneity and metabolism in Drosophila neuroblast tumors. Elife 8. PubMed ID: 31566561

Gertler, F. B., et al. (1993). Dosage-sensitive modifiers of Drosophila abl tyrosine kinase function: prospero, a regulator of axonal outgrowth, and disabled, a novel tyrosine kinase substrate. Genes Dev. 7 (3): 441-453. PubMed Citation: 7680635

Gho, M., Bellaiche, Y. and Schweisguth, F., (1999). Revisiting the Drosophila microchaete lineage: a novel intrinsically asymmetric cell division generates a glial cell. Development 126: 3573-3584. PubMed Citation: 10409503

Glasgow, E. and Tomarev, S. I. (1998). Restricted expression of the homeobox gene prox 1 in developing zebrafish. Mech. Dev. 76(1-2): 175-8. PubMed Citation: 9767161

Goulding, S. E., White, N. M. and Jarman, A. P. (2000). cato encodes a basic helix-loop-helix transcription factor implicated in the correct differentiation of Drosophila sense organs. Dev. Biol. 221: 120-131. PubMed Citation: 10772796

Granja, J. M., Klemm, S., McGinnis, L. M., Kathiria, A. S., Mezger, A., Corces, M. R., Parks, B., Gars, E., Liedtke, M., Zheng, G. X. Y., Chang, H. Y., Majeti, R. and Greenleaf, W. J. (2019). Single-cell multiomic analysis identifies regulatory programs in mixed-phenotype acute leukemia. Nat Biotechnol 37(12): 1458-1465. PubMed ID: 31792411

Griffiths, R. L. and Hidalgo, A. (2004). Prospero maintains the mitotic potential of glial precursors enabling them to respond to neurons. EMBO J. 23: 2440-2450. 15167898

Grosjean, Y., Lacaille, F., Acebes, A., Clemencet, J. and Ferveur, J. F. (2003). Taste, movement, and death: varying effects of new prospero mutants during Drosophila development. J. Neurobiol. 55(1):1-13. 12605454

Guenin, L., et al. (2010). Expression profiling of prospero in the Drosophila larval chemosensory organ: Between growth and outgrowth. BMC Genomics. 11: 47. PubMed Citation: 20085633

Guo, M., Jan, L. Y. and Jan, Y. N. (1996). Control of daughter cell fates during asymmetric division: Interaction of Numb and Notch. Neuron 17: 27-41. PubMed Citation: 8755476

Gutiérrez, L., et al. (2012). The role of the histone H2A ubiquitinase Sce in Polycomb repression. Development 139(1): 117-27. PubMed Citation: 22096074

Halfon, M. S., et al. (2000). Ras pathway specificity is determined by the integration of multiple signal-activated and tissue-restricted transcription factors. Cell 103: 63-74. PubMed Citation: 11051548

Hampoelz, B., Hoeller, O., Bowman, S. K. Dunican, D. and Knoblich, J. A. (2005). Drosophila Ric-8 is essential for plasma-membrane localization of heterotrimeric G proteins. Nat. Cell Biol. 7: 1099-1105. 16228011

Harada, K., et al. (2009). Identification of targets of Prox1 during in vitro vascular differentiation from embryonic stem cells: functional roles of HoxD8 in lymphangiogenesis. J. Cell Sci. 122(Pt 21): 3923-30. PubMed Citation: 19825936

Hartl, M., et al. (2011). A new Prospero and microRNA-279 pathway restricts CO₂ receptor neuron formation. J. Neurosci. 31(44): 15660-73. PubMed Citation: 22049409

Hassan, B, et al. (1997). Prospero is a panneural transcription factor that modulates homeodomain protein activity. Proc. Natl. Acad. Sci. 94(20): 10991-10996. PubMed Citation: 9380747

Hatfield, S. D., Shcherbata, H. R., Fischer, K. A., Nakahara, K., Carthew, R. W. and Ruohola-Baker, H. (2005). Stem cell division is regulated by the microRNA pathway. Nature 435: 974-978. 15944714

Hayashi, T. and Saigo, K. (2001). Diversification of cell types in the Drosophila eye by differential expression of prepattern genes. Mech. Dev. 108: 13-27. 11578858

Hirota, H., et al. (1995). Asymmetric segregation of the homeodomain protein prospero during Drosophila development. Nature 377: 627-630. PubMed Citation: 7566173

Hong, Y. K., et al. (2002). Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate. Dev. Dyn. 225(3): 351-7. 12412020

Ikeshima-Kataoka, H., et al. (1997). Miranda directs Prospero to a daughter cell during Drosophila asymmetric divisions. Nature 390(6660): 625-629. PubMed Citation: 9403694

Jacobs, J. R. (1993). Perturbed glial scaffold formation precedes axon tract malformation in Drosophila mutants. J Neurobiol 24 (5): 611-626. PubMed Citation: 8326301

Jacobs, J., Atkins, M., Davie, K., Imrichova, H., Romanelli, L., Christiaens, V., Hulselmans, G., Potier, D., Wouters, J., Taskiran, II, Paciello, G., Gonzalez-Blas, C. B., Koldere, D., Aibar, S., Halder, G. and Aerts, S. (2018). The transcription factor Grainy head primes epithelial enhancers for spatiotemporal activation by displacing nucleosomes. Nat Genet 50(7): 1011-1020. PubMed ID: 29867222

Jeffery, W. R., et al. (2000). Prox 1 in eye degeneration and sensory organ compensation during development and evolution of the cavefish Astyanax. Dev. Genes Evol. 210: 223-230. PubMed Citation: 11180826

Joy, T., Hirono, K. and Doe, C. Q. (2014). The RanGEF Bj1 promotes Prospero nuclear export and neuroblast self-renewal. Dev Neurobiol [Epub ahead of print]. PubMed ID: 25312250

Kage-Nakadai, E., Ohta, A., Ujisawa, T., Sun, S., Nishikawa, Y., Kuhara, A. and Mitani, S. (2016). Caenorhabditis elegans homologue of Prox1/Prospero is expressed in the glia and is required for sensory behavior and cold tolerance. Genes Cells [Epub ahead of print]. PubMed ID: 27402188

Kato, K., Orihara-Ono, M. and Awasaki, T. (2020). Multiple lineages enable robust development of the neuropil-glia architecture in adult Drosophila. Development 147(5). PubMed ID: 32051172

Kauffmann, R. C., et al. (1996). Ras1 and transcriptional compentence in the R7 cell of Drosophila. Genes Dev. 10: 2167-78. PubMed Citation: 8804311

Kielman, M. F., et al. (1996). Characterization and localization of the mProx1 gene directly upstream of the mouse alpha-globin gene cluster: identification of a polymorphic direct repeat in the 5'UTR. Mamm. Genome 7(12): 877-80. PubMed Citation: 8995756

Kim, J. K., et al. (2005). Functional genomic analysis of RNA interference in C. elegans. Science 308: 1164-1167. 15790806

Kitajima, A., Fuse, N., Isshiki, T. and Matsuzaki, F. (2010). Progenitor properties of symmetrically dividing Drosophila neuroblasts during embryonic and larval development. Dev. Biol. 347(1): 9-23. PubMed Citation: 20599889

Knoblich, J. A., Jan, L. Y. and Jan, Y. N. (1995). Asymetric segregation of numb and prospero during cell division. Nature 377: 624-7. PubMed Citation: 7566172

Kraut, R. K., et al. (1996). Role of inscuteable in orienting asymmetric cell divisions in Drosophila. Nature 383: 50-55. PubMed Citation: 8779714

Kremer, M. C., Jung, C., Batelli, S., Rubin, G. M. and Gaul, U. (2017). The glia of the adult Drosophila nervous system. Glia 65(4): 606-638. PubMed ID: 28133822

Kuzin, A., Brody, T., Moore, A. W. and Odenwald, W. F. (2005). Nerfin-1 is required for early axon guidance decisions in the developing Drosophila CNS. Dev. Biol. 277: 347-365. 15617679

Kurusu, M., et al. (2009). A conserved nuclear receptor, Tailless, is required for efficient proliferation and prolonged maintenance of mushroom body progenitors in the Drosophila brain. Dev. Biol. 326(1): 224-36. PubMed Citation: 19084514

Lai, S. L. and Doe, C. Q. (2014). Transient nuclear Prospero induces neural progenitor quiescence. Elife 3 [Epub ahead of print]. PubMed ID: 25354199

Lee, C.-Y., et al. (2006). Brat is a Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewal. Dev. Cell 10: 441-449. 16549393

Lengler, J., et al. (2001). Antagonistic action of Six3 and Prox1 at the gamma-crystallin promoter. Nucleic Acids Res. 29(2): 515-26. 11139622

Li, S., Mo, Z., Yang, X., Price, S. M., Shen, M. M. and Xiang, M. (2004). Foxn4 controls the genesis of amacrine and horizontal cells by retinal progenitors. Neuron 43(6): 795-807. 15363391

Li, P., et al. (1997). Inscuteable and Staufen mediate asymmetric localization and segregation of prospero RNA during Drosophila neuroblast cell divisions. Cell 90(3): 437-447. PubMed Citation: 9267024

Li, T., Jin, Y., Vershon, A. K. and Wolberger, C. (1998). Crystal structure of the MATa1/MATalpha2 homeodomain heterodimer in complex with DNA containing an A-tract. Nucleic Acids Res. 26(24): 5707-18. 9838003

Li, W., Bengtson, M. H., Ulbrich, A., Matsuda, A., Reddy, V. A., Orth, A., Chanda, S. K., Batalov, S. and Joazeiro, C. A. (2008). Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling. PLoS One 3: e1487. PubMed ID: 18213395

Lin, H. and Spradling, A. C. (1995). Fusome asymmetry and oocyte determination in Drosophila. Dev. Genet. 16: 6-12. PubMed Citation: 7758245

Liu, X., Shen, J., Xie, L., Wei, Z., Wong, C., Li, Y., Zheng, X., Li, P. and Song, Y. (2020). Mitotic Implantation of the Transcription Factor Prospero via Phase Separation Drives Terminal Neuronal Differentiation. Dev Cell 52(3): 277-293 e278. PubMed ID: 31866201

Mar, J., Makhijani, K., Flaherty, D. and Bhat, K. M. (2022). Nuclear Prospero allows one-division potential to neural precursors and post-mitotic status to neurons via opposite regulation of Cyclin E. PLoS Genet 18(8): e1010339. PubMed ID: 35939521

Maurange, C., Cheng, L. and Gould, A. P. (2008). Temporal transcription factors and their targets schedule the end of neural proliferation in Drosophila. Cell 133: 891-902. PubMed ID: 18510932

McDonald, J. A., et al. (2003). Specification of motoneuron fate in Drosophila: Integration of positive and negative transcription factor inputs by a minimal eve enhancer. J. Neurobiol. 57(2): 193-203. 14556285

McKimmie, C., Woerfel, G. and Russell, S. (2005). Conserved genomic organisation of Group B Sox genes in insects. BMC Genet 6: 26. PubMed ID: 15943880

Manning, L. and Doe, C. Q. (1999). Prospero distinguishes sibling cell fate without asymmetric localization in the Drosophila adult external sense organ lineage. Development 126: 2063-2071. PubMed Citation: 10207132

Matsuzaki, F., et al. (1998). Miranda localizes Staufen and Prospero asymmetrically in mitotic neuroblasts and epithelial cells in early Drosophila embryogenesis. Development 125: 4089-4098. PubMed Citation: 9735369

Maurange, C., Cheng, L. and Gould, A. P. (2008). Temporal transcription factors and their targets schedule the end of neural proliferation in Drosophila. Cell 133(5): 891-902. PubMed Citation: 18510932

Mettler, U., Voglerc G. and Urban, J. (2006). Timing of identity: spatiotemporal regulation of hunchback in neuroblast lineages of Drosophila by Seven-up and Prospero. Development 133(3): 429-37. 16396905

Meyer, C. A., et al. (2002). Drosophila p27Dacapo expression during embryogenesis is controlled by a complex regulatory region independent of cell cycle progression. Development 129: 319-328. 11807025

Micchelli, C. A. and Perrimon, N. (2006). Evidence that stem cells reside in the adult Drosophila midgut epithelium. Nature 439(7075): 475-9. 16340959

Narbonne-Reveau, K., Lanet, E., Dillard, C., Foppolo, S., Chen, C. H., Parrinello, H., Rialle, S., Sokol, N. S. and Maurange, C. (2016). Neural stem cell-encoded temporal patterning delineates an early window of malignant susceptibility in Drosophila. Elife 5. PubMed ID: 27296804

Nishijima, I. and Ohtoshi, A. (2006). Characterization of a novel prospero-related homeobox gene, Prox2. 275(5): 471-8. J. Molec. Genet. and Genomics. 16470382

Oliver, G., et al. (1993). Prox 1, a prospero-related homeobox gene expressed during mouse development. Mech. Dev. 44: 3-16

Orgogozo, V., Schweisguth, F. and Bellaiche, Y. (2001). Lineage, cell polarity and inscuteable function in the peripheral nervous system of the Drosophila embryo. Development 128: 631-643. 11171389

Peng, C.-Y., et al. (2000). The tumour-suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblasts. Nature 408: 596-600. 21003825

Pfeiffer, B. D., Jenett, A., Hammonds, A. S., Ngo, T. T., Misra, S., Murphy, C., Scully, A., Carlson, J. W., Wan, K.H., Laverty, T. R., et al. (2008). Tools for neuroanatomy and neurogenetics in Drosophila. Proc. Natl. Acad. Sci. 105: 9715-9720. PubMed Citation: 18621688

Pickup, A. T., Ming, L. and Lipshitz, H. D. (2009). Hindsight modulates Delta expression during Drosophila cone cell induction. Development 136(6): 975-82. PubMed Citation: 19234063

Plavicki, J., et al. (2012). Homeobox gene distal-less is required for neuronal differentiation and neurite outgrowth in the Drosophila olfactory system. Proc. Natl. Acad. Sci. 109(5): 1578-83. PubMed Citation: 22307614

Pliner, H. A., Packer, J. S., McFaline-Figueroa, J. L., Cusanovich, D. A., Daza, R. M., Aghamirzaie, D., Srivatsan, S., Qiu, X., Jackson, D., Minkina, A., Adey, A. C., Steemers, F. J., Shendure, J. and Trapnell, C. (2018). Cicero predicts cis-regulatory DNA interactions from single-cell chromatin accessibility data. Mol Cell 71(5): 858-871 e858. PubMed ID: 30078726

Ragone, G., Bernardoni, R. and Giangrande, A. (2001). A novel mode of asymmetric division identifies the fly neuroglioblast 6-4T. Dev. Bio. 235: 74-85. 11412028

Reddy, G. V. and Rodrigues, V. (1999a). Sibling cell fate in the Drosophila adult external sense organ lineage is specified by prospero function, which is regulated by Numb and Notch. Development 126: 2083-2092. PubMed ID: 10207134

Reddy, G. V. and Rodrigues, V. (1999b). A glial cell arises from an additional division within the mechanosensory lineage during development of the microchaete on the Drosophila notum. Development 126: 4617-4622. PubMed ID: 10498695

Ren, Q., Yang, C. P., Liu, Z., Sugino, K., Mok, K., He, Y., Ito, M., Nern, A., Otsuna, H. and Lee, T. (2017). Stem cell-intrinsic, Seven-up-triggered temporal factor gradients diversify intermediate neural progenitors. Curr Biol [Epub ahead of print]. PubMed ID: 28434858

Ren, Q., Awasaki, T., Wang, Y. C., Huang, Y. F. and Lee, T. (2018). Lineage-guided Notch-dependent gliogenesis by Drosophila multi-potent progenitors. Development 145(11). PubMed ID: 29764857

Risebro, C. A., et al. (2009). Prox1 maintains muscle structure and growth in the developing heart. Development 136(3): 495-505. PubMed Citation: 19091769

Rhyu, M. and Knoblich, J. (1995). Spindle orientation and asymmetric cell fate. Cell 82: 523-526. PubMed ID: 7664329

Rubin, A. N. and Kessaris, N. (2013). PROX1: a lineage tracer for cortical interneurons originating in the lateral/caudal ganglionic eminence and preoptic area. PLoS One 8: e77339. PubMed ID: 24155945

Ryter, J. M., Doe, C. Q. and Matthews, B. W. (2002). Structure of the DNA binding region of Prospero reveals a novel homeo-Prospero domain. Structure 10: 1541-1549. 12429095

Samuels, T. J., Arava, Y., Jarvelin, A. I., Robertson, F., Lee, J. Y., Yang, L., Yang, C. P., Lee, T., Ish-Horowicz, D. and Davis, I. (2020). Neuronal upregulation of Prospero protein is driven by alternative mRNA polyadenylation and Syncrip-mediated mRNA stabilisation. Biol Open. PubMed ID: 32205310

Sanchez-Soriano, N. and Russell, S. (2000). Regulatory mutations of the Drosophila Sox gene Dichaete reveal new functions in embryonic brain and hindgut development. Dev Biol 220: 307-321. PubMed ID: 10753518

San-Juan, B. P. and Baonza, A. (2011). The bHLH factor deadpan is a direct target of Notch signaling and regulates neuroblast self-renewal in Drosophila. Dev. Biol. 352: 70-82. PubMed Citation: 21262215

Scamborova, P., Wong, A. and Steitz, J. A. (2004). An intronic enhancer regulates splicing of the twintron of Drosophila melanogaster prospero pre-mRNA by two different spliceosomes. Molec. Cell. Biol. 1855-1869. 14966268

Schuldt, A. J., et al. (1998). Miranda mediates asymmetric protein and RNA localization in the developing nervous system. Genes Dev. 12(12): 1847-1857

Sen, A., Reddy, V. and Rodrigues, V. (2003). Combinatorial expression of Prospero, Seven-up, and Elav identifies progenitor cell types during sense-organ differentiation in the Drosophila antenna. Dev. Bio. 254: 79-92. 12606283

Shandala, T., Takizawa, K. and Saint, R. (2003). The dead ringer/retained transcriptional regulatory gene is required for positioning of the longitudinal glia in the Drosophila embryonic CNS. Development 130: 1505-1513. 12620977

Shen, C.-P., Jan, L. Y. and Jan, Y. N. (1997). Miranda is required for the asymmetric localization of Prospero during mitosis in Drosophila. Cell 90: 449-458

Shen, C. P., et al. (1998). Miranda as a multidomain adapter linking apically localized Inscuteable and basally localized Staufen and Prospero during asymmetric cell division in Drosophila. Genes Dev. 12(12): 1837-1846

Sosa-Pineda, B., Wigle, J. T. and Oliver, G. (2000). Hepatocyte migration during liver development requires Prox1. Nat. Genet. 25(3): 254-5. 10888866

Sousa-Nunes, R., Chia, W. and Somers, W. G. (2009). Protein phosphatase 4 mediates localization of the Miranda complex during Drosophila neuroblast asymmetric divisions. Genes Dev. 23(3): 359-72. PubMed Citation: 19204120

Southall, T. D. and Brand, A. H. (2009). Neural stem cell transcriptional networks highlight genes essential for nervous system development. EMBO J. 28(24): 3799-807. PubMed Citation: 19851284

Spana, E.P. and Doe, C.Q. (1995). The prospero transcription factor is asymmetrically localized to the cell cortex during neuroblast mitosis in Drosophila. Development 121: 3187-95. PubMed Citation: 7588053

Srinivasan, S., et al. (1998). Biochemical analysis of prospero protein during asymmetric cell division: cortical prospero is highly phosphorylated relative to nuclear prospero. Dev. Biol. 204(2): 478-87. PubMed Citation: 9882484

Srinivasan, R. S., et al. (2010). The nuclear hormone receptor Coup-TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cells. Genes Dev. 24(7): 696-707. PubMed Citation: 20360386

Tea, J. S., Chihara, T. and Luo, L. (2010). Histone deacetylase Rpd3 regulates olfactory projection neuron dendrite targeting via the transcription factor Prospero. J. Neurosci. 30(29): 9939-46. PubMed Citation: 20660276

Telley, L., Agirman, G., Prados, J., Amberg, N., Fievre, S., Oberst, P., Bartolini, G., Vitali, I., Cadilhac, C., Hippenmeyer, S., Nguyen, L., Dayer, A. and Jabaudon, D. (2019). Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex. Science 364(6440). PubMed ID: 31073041

Thomas, G. B. and van Meyel, D. J. (2007). The glycosyltransferase Fringe promotes Delta-Notch signaling between neurons and glia, and is required for subtype-specific glial gene expression. Development 134: 591-600. Medline abstract: 17215308

Tio, M., et al. (1999). A functional analysis of Inscuteable and its roles during Drosophila asymmetric cell divisions. J. Cell Sci. 112(Pt 10): 1541-1551. PubMed Citation: 10212148

Tomarev, S. I., et al. (1996). Chicken homeobox gene Prox 1 related to Drosophila prospero is expressed in the developing lens and retina. Dev. Dyn. 206(4): 354-67. PubMed Citation: 8853985

Tomarev, S. I., et al. (1998). Characterization of the mouse Prox1 gene. Biochem. Biophys. Res. Commun. 248(3): 684-9. PubMed Citation: 9703987

Toma, D. P., White, K. P., Hirsch, J. and Greenspan, R. J. (2002). Identification of genes involved in Drosophila melanogaster geotaxis, a complex behavioral trait. Nat. Genet. 31(4): 349-53. 12042820

Torii, M.-A., et al. (1999). Transcription factors Mash-1 and Prox-1 delineate early steps in differentiation of neural stem cells in the developing central nervous system. Development 126(3): 443-456. PubMed Citation: 9876174

Ulvklo, C., et al. (2012). Control of neuronal cell fate and number by integration of distinct daughter cell proliferation modes with temporal progression. Development 139(4): 678-89. PubMed Citation: 22241838

Vaessin, H.E., et al. (1991). prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila. Cell 67: 941-953. PubMed Citation: 1720353

Vaessin, H.E., et. al. (1994). daughterless is essential for neuronal precursor differentiation but not for initiation of neuronal precursor formation in Drosophila embryo. Development 120: 935-945. PubMed Citation: 7600969

Wallace, S. W., Singhvi, A., Liang, Y., Lu, Y. and Shaham, S. (2016). PROS-1/Prospero is a major regulator of the glia-specific secretome controlling sensory-neuron shape and function in C. elegans. Cell Rep 15: 550-562. PubMed ID: 27068465

van Wijk, S. J., de Vries, S. J., Kemmeren, P., Huang, A., Boelens, R., Bonvin, A. M. and Timmers, H. T. (2009). A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. Mol Syst Biol 5: 295. PubMed ID: 19690564

Vladoiu, M. C., El-Hamamy, I., Donovan, L. K., Farooq, H., Holgado, B. L., Sundaravadanam, Y., Ramaswamy, V., Hendrikse, L. D., Kumar, S., Mack, S. C., Lee, J. J. Y., Fong, V., Juraschka, K., Przelicki, D., Michealraj, A., Skowron, P., Luu, B., Suzuki, H., Morrissy, A. S., Cavalli, F. M. G., Garzia, L., Daniels, C., Wu, X., Qazi, M. A., Singh, S. K., Chan, J. A., Marra, M. A., Malkin, D., Dirks, P., Heisler, L., Pugh, T., Ng, K., Notta, F., Thompson, E. M., Kleinman, C. L., Joyner, A. L., Jabado, N., Stein, L. and Taylor, M. D. (2019). Childhood cerebellar tumours mirror conserved fetal transcriptional programs. Nature 572(7767): 67-73. PubMed ID: 31043743

Wang, H., Cai, Y., Chia, W. and Yang, X. (2006). Drosophila homologs of mammalian TNF/TNFR-related molecules regulate segregation of Miranda/Prospero in neuroblasts. EMBO J. 25(24): 5783-93. PubMed citation; Online text

Weng, M., Golden, K. L. and Lee, C. Y. (2010). dFezf/Earmuff maintains the restricted developmental potential of intermediate neural progenitors in Drosophila. Dev. Cell 18(1): 126-35. PubMed Citation: 20152183

Wigle, J. T., et al. (1999). Prox1 function is crucial for mouse lens-fibre elongation. Nat. Genet. 21(3): 318-22. PubMed Citation: 10080188

Wigle, J. T., et al. (2002). An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype. EMBO J. 21: 1505-1513. 11927535

Xie, Y., Li, X., Zhang, X., Mei, S., Li, H., Urso, A. and Zhu, S. (2014). The Sp8 transcription factor Buttonhead prevents premature differentiation of intermediate neural progenitors. Elife 3 [Epub ahead of print]. PubMed ID: 25285448

Xu, C., et al. (2000). Overlapping activators and repressors delimit transcriptional response to receptor tyrosine kinase signals in the Drosophila eye. Cell 103: 87-97. PubMed Citation: 11051550

Yasugi, T., Fischer, A., Jiang, Y., Reichert, H., Knoblich, J. A. (2014). A regulatory transcriptional loop controls proliferation and differentiation in Drosophila neural stem cells. PLoS One 9: e97034. PubMed ID: 24804774

Zacharioudaki, E., Magadi, S. S. and Delidakis, C. (2012) bHLH-O proteins are crucial for Drosophila neuroblast self-renewal and mediate Notch-induced overproliferation. Development 139: 1258-1269. PubMed Citation: 22357926

Zhu, S., et al. (2012). The bHLH repressor Deadpan regulates the self-renewal and specification of Drosophila larval neural stem cells independently of Notch. PLoS One 7(10): e46724. PubMed Citation: 23056424

Zinovieva, R. D., et al. (1996). Structure and chromosomal localization of the human homeobox gene Prox 1. Genomics 35(3): 517-22. PubMed Citation: 8812486

date revised: 15 August 2020
  

Home page: The Interactive Fly © 1997 Thomas B. Brody, Ph.D.

The Interactive Fly resides on the
Society for Developmental Biology's Web server.