Notch

PROTEIN INTERACTIONS
Table of Contents

page 1

General considerations
Notch interactions with its ligands
Signaling by Notch lacking a C-terminus
Notch nuclear repressor complex

page 2

Notch and Kuzbanian
Notch interaction with Wingless
Notch modulates Wnt signalling by associating with Armadillo/ß-catenin and regulating its transcriptional activity
Notch interaction with Fringe
Notch modulation by O-fucosyltransferase 1 is essential for Notch interaction with its ligands and for Fringe function
Rescue of Notch signaling in cells incapable of GDP-L-fucose synthesis by gap junction transfer of GDP-L-fucose in Drosophila
Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling
Multiple O-glucosylation sites on Notch function as a buffer against temperature-dependent loss of signaling
Gfr is involved in the fucosylation of Notch-linked glycans
Dual roles of O-glucose glycans redundant with monosaccharide O-fucose on Notch in Notch trafficking
Distinct functional units of the Golgi complex in Drosophila cells as revealed by the distribution of Fringe connection - Notch and the Golgi complex
Notch interaction with Scabrous

page 3

Notch and Suppressor of Hairless
Geometry and protein interactions at Su(H) binding sites
Notch and Numb
Notch and Sanpodo
Notch and Dishevelled
Notch and Canoe
Notch and Shaggy
Notch interaction with Deltex and Kurtz
Notch interaction with Disabled

page 4

Notch, Abl and Disabled
Notch and Notchless
Notch, Presenilin and Nicastrin
Notch cleavage by Furin
Notch cleavage regulated by Flap wing during oogenesis
Notch and Mastermind
Nipped-A and Notch signaling
Enhancer of Split Gene Complex: architecture and coordinate regulation by Notch, Cohesin and Polycomb group proteins

page 5

Warthog and trafficking of Notch
Lethal giant discs and Notch trafficking
Crumbs and Notch trafficking
Ligand-independent trafficking of Notch by Axin and Apc
Ral GTPase promotes asymmetric Notch activation in the Drosophila eye in response to Frizzled/PCP signaling by repressing ligand-independent receptor activation
Notch signaling at the wing margin is SNARE dependent
Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101,
       elicit non-cell-autonomous overgrowth caused by increased Notch-mediated signaling and ectopic expression
       of the Notch target gene unpaired
The Drosophila tumor suppressor vps25 prevents nonautonomous overproliferation by regulating Notch trafficking
The vacuolar proton pump, V-ATPase, is required for notch signaling and endosomal trafficking in Drosophila
Merlin and Expanded function cooperatively to modulate EGFR and Notch endocytosis and signaling
Clathrin heavy chain and Notch down-regulation by endocytosis
The functions of auxilin and rab11 in Drosophila suggest that the fundamental role of ligand endocytosis in notch signaling cells is not recycling
Fab1 phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptors
The Abelson tyrosine kinase regulates Notch endocytosis and signaling to maintain neuronal cell fate in Drosophila photoreceptors
Protein degradation and Notch signaling

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