dunce

Albin, S. D. and Davis, G. W. (2004). Coordinating structural and functional synapse development: postsynaptic p21-activated kinase independently specifies glutamate receptor abundance and postsynaptic morphology. J Neurosci 24(31): 6871-6879. PubMed ID: 15295021

Albin, S. D., Kaun, K. R., Knapp, J. M., Chung, P., Heberlein, U. and Simpson, J. H. (2015). A subset of serotonergic neurons evokes hunger in adult Drosophila. Curr Biol 25(18): 2435-2440. PubMed ID: 26344091 '

Barad, M., et al. (1998). Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory. Proc. Natl. Acad. Sci. 95(25): 15020-5. PubMed Citation: 9844008

Bellen, H. J., et al. (1987). Two Drosophila learning mutants, dunce and rutabaga, provide evidence of a maternal role for cAMP on embryogenesis. Dev. Biol. 121: 432-44. PubMed Citation: 9844008

Berke, B and Wu, C. F. (2002). Regional calcium regulation within cultured Drosophila neurons: Effects of altered cAMP metabolism by the learning mutations dunce and rutabaga. J. Neurosci. 22(11): 4437-4447. 12040051

Bhattacharya, A., Gu, G.G., Singh, S. (1999). Modulation of dihydropyridine-sensitive calcium channels in Drosophila by a cAMP-mediated pathway. J. Neurobiol. 39(4): 491-500. PubMed Citation: 10380071

Bolger, G. B., Rodgers, L. and Riggs, M. (1994). Differential CNS expression of alternative mRNA isoforms of the mammalian genes encoding cAMP-specific phosphodiesterases. Gene 149: 237-44. PubMed Citation: 7958996

Bolger, G., et al. (1993). A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs. Mol. Cell. Biol. 13: 6558-71. PubMed Citation: 8413254

Bouzaiane, E., Trannoy, S., Scheunemann, L., Placais, P. Y. and Preat, T. (2015). Two independent mushroom body output circuits retrieve the six discrete components of Drosophila aversive memory. Cell Rep 11(8): 1280-1292. PubMed ID: 25981036

Bromberg-Martin, E. S., Matsumoto, M. and Hikosaka, O. (2010). Dopamine in motivational control: rewarding, aversive, and alerting. Neuron 68(5): 815-834. PubMed ID: 21144997

Chen, C. N., Denome, S. and Davis, R. L. (1989). Molecular analysis of cDNA clones and the corresponding genomic coding sequences of the Drosophila dunce+ gene, the structural gene for cAMP phosphodiesterase. Proc. Natl. Acad. Sci. 83: 9313-7. PubMed Citation: 3025834

Chen, K. and Featherstone, D. E. (2005). Discs-large (DLG) is clustered by presynaptic innervation and regulates postsynaptic glutamate receptor subunit composition in Drosophila. BMC Biol 3: 1. PubMed ID: 15638945

Cherry, J. A. and Davis, R. L. (1995). A mouse homolog of dunce, a gene important for learning and memory in Drosophila, is preferentially expressed in olfactory receptor neurons. J. Neurobiol. 28: 102-113. PubMed Citation: 8586960

Cherry, J. A. and Davis, R. L. (1999). Cyclic AMP phosphodiesterases are localized in regions of the mouse brain associated with reinforcement, movement, and affect. J. Comp. Neurol. 407(2): 287-301. PubMed Citation: 10213096

Couto, A., Oda, S., Nikolaev, V. O., Soltesz, Z. and de Bono, M. (2013). In vivo genetic dissection of O₂-evoked cGMP dynamics in a Caenorhabditis elegans gas sensor. Proc Natl Acad Sci U S A 110: E3301-3310. PubMed ID: 23940325

Dauwalder, B. and Davis, R. L. (1995). Conditional rescue of the dunce learning/memory and female fertility defects with Drosophila or rat transgenes. J. Neurosci. 15: 3490-3499. PubMed Citation: 7751924

Davis, R. L., et al. (1995). The cyclic AMP system and Drosophila learning. Mol. Cell. Biochem. 149-150: 271-278. PubMed Citation: 8569740

Davis, G. W., Schuster, C. M. and Goodman, C. S. (1996). Genetic dissection of structural and functional components of synaptic plasticity. III. CREB is necessary for presynaptic functional plasticity. Neuron 17: 669-679. PubMed Citation: 8893024

Davis, G. W., DiAntonio, A., Petersen, S. A. and Goodman, C. S. (1998). Postsynaptic PKA controls quantal size and reveals a retrograde signal that regulates presynaptic transmitter release in Drosophila. Neuron 20(2): 305-315. PubMed ID: 9491991

Davis, R. L., et al. (1996). Physiology and biochemistry of Drosophila learning mutants. Physiol. Rev. 76: 299-317. PubMed Citation: 8618959

Davis, R. L. (2011). Traces of Drosophila memory. Neuron 70: 8-19. PubMed ID: 21482352

Delgado, R., et al. (1991). A cyclic AMP-activated K+ channel in Drosophila larval muscle is persistently activated in dunce. Proc. Natl. Acad. Sci 88: 557-560. PubMed Citation: 1846445

Delgado, R., et al. (1998). Outward currents in Drosophila larval neurons: dunce lacks a maintained outward current component downregulated by cAMP. J. Neurosci. 18(4): 1399-140. PubMed Citation: 9454849

Engel, J. E. and Wu, C. F. (1996). Altered habituation of an identified escape circuit in Drosophila memory mutants. J. Neurosci. 16: 3486-3499. PubMed Citation: 8627381

Engels, P., et al. (1995). Brain distribution of four rat homologues of the Drosophila dunce cAMP phosphodiesterase. J. Neurosci. Res. 41: 169-178. PubMed Citation: 7650752

Fagnon, D.D. and Tuchek, J.M. (1995). The biochemistry of learning and memory. Molecular and Cellular Biochemistry 149/150: 279-286. PubMed Citation:

Feany, M. B. (1990). Rescue of the learning defect in dunce, a Drosophila learning mutant, by an allele of rutabaga, a second learning mutant. Proc. Natl. Acad. Sci. 87: 2795-9. PubMed Citation: 2157213

Florio, V. A., et al. (1994). Phosphorylation of the 61-kDa calmodulin-stimulated cyclic nucleotide phosphodiesterase at serine 120 reduces its affinity for calmodulin. Biochemistry 33: 8948-8954. 8043581

Ganguly, A. and Lee, D. (2013). Suppression of inhibitory GABAergic transmission by cAMP signaling pathway: alterations in learning and memory mutants. Eur J Neurosci 37: 1383-1393. PubMed ID: 23387411

Ganguly-Fitzgerald, I., Donlea, J. and Shaw, P. J. (2006). Waking experience affects sleep need in Drosophila. Science 313(5794): 1775-81. PubMed Citation: 16990546

Gordon, M. D. and Scott, K. (2009). Motor control in a Drosophila taste circuit. Neuron 61(3): 373-384. PubMed ID: 19217375

Guan, Z., Buhl, L. K., Quinn, W. G. and Littleton, J. T. (2011). Altered gene regulation and synaptic morphology in Drosophila learning and memory mutants. Learn Mem 18: 191-206. PubMed ID: 21422168

Hanesch, U., Fischbach, K.-F. and Heisenberg, M. (1998). Neuronal architecture of the central complex in Drosophila melanogaster. Cell Tissue Res. 257: 343-366 . PubMed Citation:

Hendricks, J. C., et al. (2001). A non-circadian role for cAMP signaling and CREB activity in Drosophila rest homeostasis. Nat. Neurosci. 4: 1108-1115. 11687816

Ishimoto, H., Wang, Z., Rao, Y., Wu, C. F. and Kitamoto, T. (2013). Novel role for ecdysone in Drosophila conditioned behavior: Linking GPCR-mediated non-canonical steroid action to cAMP signaling in the adult brain. PLoS Genet 9: e1003843. PubMed ID: 24130506

Iwahashi, Y., et al. (1996). Differential distribution of mRNA encoding cAMP-specific phosphodiesterase isoforms in the rat brain. Brain Res. Mol. Brain Res. 38(1): 14-24. 8737663

Jin, S.-L. C., et al. (1999). Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice. Proc. Natl. Acad. Sci. 96: 11998-12003. 10518565

Kandel, E.R. and Hawkins, R.D. (1992). The biological basis of learning and individuality. Sci. Amer. 267(3): 78-86. PubMed Citation:

Kuromi, H. and Kidokoro, Y. (2000). Tetanic stimulation recruits vesicles from reserve pool via a cAMP-mediated process in Drosophila synapses. Neuron 27: 133-143. 10939337

Kurusu, M., et al. (2002). Embryonic and larval development of the Drosophila mushroom bodies: concentric layer subdivisions and the role of fasciclin II. Development 129: 409-419. 11807033

Lannutti, B. J. and Schneider, L. E. (2001). Gprk2 Controls cAMP Levels in Drosophila Development. Dev. Biol. 233(1): 174-185. 11319866

Lee, D. and O'Dowd, D. K. (2000). cAMP-dependent plasticity at excitatory cholinergic synapses in Drosophila neurons: Alterations in the memory mutant Dunce. J. of Neurosci. 20(6): 2104-2111. PubMed Citation: 10704484.

Levine, J. D., et al. (1994). Altered circadian pacemaker functions and cyclic AMP rhythms in the Drosophila learning mutant dunce. Neuron 13: 967-74. PubMed Citation: 7946340

Liu, X., Krause, W. C. and Davis, R. L. (2007). GABAA receptor RDL inhibits Drosophila olfactory associative learning. Neuron 56: 1090-1102. PubMed ID: 18093529

Liu, X. and Davis, R. L. (2009). The GABAergic anterior paired lateral neuron suppresses and is suppressed by olfactory learning. Nat Neurosci 12: 53-59. PubMed ID: 19043409

Loughney, K., et al. (1996). Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases. J. Biol. Chem. 271: 796-806. PubMed Citation: 8557689

Mohanty, S., et al. (2001). Regulated protein degradation controls PKA function and cell-type differentiation in Dictyostelium. Genes Dev. 15: 1435-1448. 11390363

Moore, M. S., et al. (1998). Ethanol intoxication in Drosophila: genetic and pharmacological evidence for regulation by the cAMP signaling pathway. Cell 93: 997-1007. PubMed Citation: 9635429

Nighorn, A., Healy, M. J. and Davis, R. L. (1991). The cyclic AMP phosphodiesterase encoded by the Drosophila dunce gene is concentrated in the mushroom body neuropil. Neuron 6: 455-67. PubMed Citation: 1848082

Nighorn, A., Qiu, Y., and Davis, R. L. (1994). Progress in understanding the Drosophila dnc locus. Comp. Biochem. Physiol. Biochem. Mol. Biol. 108: 1-9. PubMed Citation: 8205385

Neuser, K., Triphan, T., Mronz, M., Poeck, B. and Strauss, R. (2008). Analysis of a spatial orientation memory in Drosophila. Nature 453(7199): 1244-7. PubMed citation: 18509336

Olsen, A. E. and Bolger, G. B. (2000). Physical mapping and promoter structure of the murine cAMP-specific phosphodiesterase pde4a gene. Mamm. Genome 11(1): 41-5. PubMed Citation: 10602991

Olsen, S. R. and Wilson, R. I. (2008). Lateral presynaptic inhibition mediates gain control in an olfactory circuit. Nature 452: 956-960. PubMed ID: 18344978

Perez-Orive, J., Mazor, O., Turner, G. C., Cassenaer, S., Wilson, R. I. and Laurent, G. (2002). Oscillations and sparsening of odor representations in the mushroom body. Science 297: 359-365. PubMed ID: 12130775

Petrovich, T. Z., Merakovsky, J. and Kelly, L. E. (1993). A genetic analysis of the stoned locus and its interaction with dunce, shibire and Suppressor of stoned variants of Drosophila melanogaster. Genetics 133: 955-65. PubMed Citation: 8462853

Preat, T. (1998). Decreased odor avo. PubMed Citation: idance after electric shock in Drosophila mutants biases learning and memory tests. J. Neurosci. 18(20): 8534-8. PubMed Citation: 9763495

Putz, G., Bertolucci, F., Raabe, T., Zars, T. and Heisenberg, M. (2004). The S6KII (rsk) gene of Drosophila melanogaster differentially affects an operant and a classical learning task. J. Neurosci. 24: 9745-9751. PubMed citation: 15525759

Qiu, Y. H., et al. (1991). Characterization of the memory gene dunce of Drosophila melanogaster. J Mol Biol 222: 553-65. PubMed Citation: 1660926

Qiu, Y. and Davis, R. L. (1993). Genetic dissection of the learning/memory gene dunce of Drosophila melanogaster. Genes Dev 7: 1447-58. PubMed Citation: 7687228

Quinn, W.G., Harris, W.A. and Bencer, S. (1974). Conditioned behavior in Drosophila melanogaster. Proc Natl Acad Sci 71: 708-712. PubMed Citation: 4207071

Reed, T. M., et al. (1998). Genomic structure and chromosome location of the murine PDE1B phosphodiesterase gene. Mamm. Genome 9(7): 571-6 . PubMed Citation: 9657856

Ruppert, M., Franz, M., Saratsis, A., Velo Escarcena, L., Hendrich, O., Gooi, L. M., Schwenkert, I., Klebes, A. and Scholz, H. (2017). Hangover links nuclear RNA signaling to cAMP regulation via the phosphodiesterase 4d ortholog dunce. Cell Rep 18(2): 533-544. PubMed ID: 28076795

Scheunemann, L., Jost, E., Richlitzki, A., Day, J. P., Sebastian, S., Thum, A. S., Efetova, M., Davies, S. A. and Schwarzel, M. (2012). Consolidated and labile odor memory are separately encoded within the Drosophila brain. J Neurosci 32: 17163-17171. PubMed ID: 23197709

Scheunemann, L., Skroblin, P., Hundsrucker, C., Klussmann, E., Efetova, M. and Schwarzel, M. (2013). AKAPs act in a two-step mechanism of memory acquisition. J Neurosci 33: 17422-17428. PubMed ID: 24174675

Scheunemann, L., Placais, P. Y., Dromard, Y., Schwarzel, M. and Preat, T. (2018). Dunce phosphodiesterase acts as a checkpoint for Drosophila long-term memory in a pair of serotonergic neurons. Neuron 98(2): 350-365. PubMed ID: 29673482

Schuster, C. M., et al. (1996b). Genetic dissection of structural and functional components of synaptic plasticity. II. Fasciclin II controls presynaptic structural plasticity. Neuron 17: 655-667 . PubMed Citation: 8893024

Shaulsky, G., Fuller, D. and Loomis, W. F. (1998). A cAMP-phosphodiesterase controls PKA-dependent differentiation. Development 125(4): 691-9. PubMed Citation: 9435289

Shuai, Y., Lu, B., Hu, Y., Wang, L., Sun, K. and Zhong, Y. (2010). Forgetting is regulated through Rac activity in Drosophila. Cell 140: 579-589. PubMed ID: 20178749

Skoulakis, E. M., Kalderon, D. and Davis, R. L. (1993). Preferential expression in mushroom bodies of the catalytic subunit of protein kinase A and its role in learning and memory. Neuron 11: 197-208. PubMed Citation: 8352940

Sonnenburg, W. K., et al. (1995). Identification of inhibitory and calmodulin-binding domains of the PDE1A1 and PDE1A2 calmodulin-stimulated cyclic nucleotide phosphodiesterases. J. Biol. Chem. 270: 30989-31000. PubMed Citation: 8537356

Spence, S., et al. (1995). Induction of Ca2+/calmodulin-stimulated cyclic AMP phosphodiesterase (PDE1) activity in Chinese hamster ovary cells (CHO) by phorbol 12-myristate 13-acetate and by the selective overexpression of protein kinase C isoforms. Biochem J 310: 975-982. PubMed Citation: 7575435

Suda, S., et al. (1998). Transcriptional and translational regulation of phosphodiesterase type IV isozymes in rat brain by electroconvulsive seizure and antidepressant drug treatment. J. Neurochem. 71(4): 1554-63. PubMed Citation: 9751189

Swan, A., et al. (2001). Identification of new X-chromosomal genes required for Drosophila oogenesis and novel roles for fs(1)Yb, brainiac and dunce. Genome Res. 11(1): 67-77. 11156616

Tully, T. and Gold, D. (1993). Differential effects of dunce mutations on associative learning and memory in Drosophila. J Neurogenet 9: 55-71. PubMed Citation: 8295077

Ueda, A. and Wu, C. F. (2012). Cyclic adenosine monophosphate metabolism in synaptic growth, strength, and precision: neural and behavioral phenotype-specific counterbalancing effects between dnc phosphodiesterase and rut adenylyl cyclase mutations. J. Neurogenet. 26(1): 64-81. PubMed Citation: 22380612

van Swinderen, B. (2007). Attention-like processes in Drosophila require short-term memory genes. Science 315(5818): 1590-3. PubMed Citation: 17363675

van Swinderen, B. and Greenspan, R. J. (2003). Salience modulates 20-30 Hz brain activity in Drosophila. Nat. Neurosci. 6(6): 579-86. PubMed Citation: 12717438

van Swinderen, B. (2006). A succession of anesthetic endpoints in the Drosophila brain. J. Neurobiol. 66(11): 1195-211. PubMed Citation: 16858694

Wilson, R. I. and Laurent, G. (2005). Role of GABAergic inhibition in shaping odor-evoked spatiotemporal patterns in the Drosophila antennal lobe. J Neurosci 25: 9069-9079. PubMed ID: 16207866

Yan, C., et al. (1994). Differential expression of the 61 kDa and 63 kDa calmodulin-dependent phosphodiesterases in the mouse brain. J. Neurosci. 14: 973-84. PubMed Citation: 8120637

Yao, W.-D., et al. (2000). Spontaneous acetylcholine secretion from developing growth cones of Drosophila central neurons in culture: Effects of cAMP-pathway mutations. J. Neurosci. 20: 2626-2637. PubMed Citation: 10729343.

Yasuyama, K., Meinertzhagen, I. A. and Schurmann, F. W. (2002). Synaptic organization of the mushroom body calyx in Drosophila melanogaster. J Comp Neurol 445: 211-226. PubMed ID: 11920702

Yuan, N. and Lee, D. (2007). Suppression of excitatory cholinergic synaptic transmission by Drosophila dopamine D1-like receptors. Eur J Neurosci 26: 2417-2427. PubMed ID: 17986026

Yuan, Q., Xiang, Y., Yan, Z., Han, C., Jan, L. Y. and Jan, Y. N. (2011). Light-induced structural and functional plasticity in Drosophila larval visual system. Science 333: 1458-1462. Pubmed: 21903815

Yun, Y. and Davis, R. L. (1989). Levels of RNA from a family of putative serine protease genes are reduced in Drosophila melanogaster dunce mutants and are regulated by cyclic AMP. Mol Cell Biol 9: 692-700. PubMed Citation: 2469005

Zhang, Y., Liu, G., Yan, J., Zhang, Y., Li, B. and Cai, D. (2015). Metabolic learning and memory formation by the brain influence systemic metabolic homeostasis. Nat Commun 6: 6704. PubMed ID: 25848677

Zhao, K., Hong, H., Zhao, L., Huang, S., Gao, Y., Metwally, E., Jiang, Y., Sigrist, S. J. and Zhang, Y. Q. (2020). Postsynaptic cAMP signalling regulates the antagonistic balance of Drosophila glutamate receptor subtypes. Development 147(24). PubMed ID: 33234716

Zhao, M.-L., and Wu, C.-F. (1997). Alterations in frequency coding and activity dependence of excitability in cultured neurons of Drosophila memory mutants. J. Neurosci. 15: 2187-2199. PubMed Citation: 9045743

Zhong, Y. and Wu, C. F. (1991). Alterience 251: 198-201. PubMed Citation: 1670967

Zhong, Y., Budnik, V. and Wu, C. F. (1992). Synaptic plasticity in Drosophila memory and hyperexcitable mutants: role of cAMP cascaded synaptic plasticity in Drosophila memory mutants with a defective cyclic AMP cascade. Sce. J Neurosci 12: 644-51. PubMed Citation: 1371316

Zhong, Y. and Wu, C. F. (1993). Differential modulation of potassium currents by cAMP and its long-term and short-term effects: dunce and rutabaga mutants of Drosophila. J Neurogenet 9: 15-27. PubMed Citation: 8295075

date revised: 26 December 2015

Home page: The Interactive Fly © 1997 Thomas B. Brody, Ph.D.

The Interactive Fly resides on the
Society for Developmental Biology's Web server.