achaete
Acar, M., et al. (2006). Senseless physically interacts with proneural proteins and functions as a transcriptional co-activator. Development 133: 1979-1989. Medline abstract: 16624856
Ahmad, I., Dooley, C. M. and Afiat, S. (1998). Involvement of Mash1 in EGF-mediated regulation of
differentiation in the vertebrate retina. Dev. Biol. 194(1): 86-98. PubMed Citation: 9473334
Ali, F. R., Cheng, K., Kirwan, P., Metcalfe, S., Livesey, F. J., Barker, R. A. and Philpott, A. (2014). The phosphorylation status of Ascl1 is a key determinant of neuronal differentiation and maturation in vivo and in vitro. Development 141: 2216-2224. PubMed ID: 24821983
Allende, M.L. and Weinberg, E.S. (1994). the expression pattern of two zebrafish achaete-scute homolog (ash) genes is altered in the embryonic brain of the cyclops mutant. Dev. Biol. 166: 509-530. PubMed Citation: 7813774
Andersen, J., Urban, N., Achimastou, A., Ito, A., Simic, M., Ullom, K., Martynoga, B., Lebel, M., Goritz, C., Frisen, J., Nakafuku, M. and Guillemot, F. (2014). A transcriptional mechanism integrating inputs from extracellular signals to activate hippocampal stem cells. Neuron 83: 1085-1097. PubMed ID: 25189209
Ashraf, S. I. and Ip, Y. T. (2001). The Snail protein family regulates neuroblast expression of inscuteable and string, genes involved in asymmetry and cell division in Drosophila. Development 128: 4757-4767. 11731456
Asmar, J., Biryukova, I. and Heitzler, P. (2008). Drosophila dLMO-PA isoform acts as an early activator of achaete/scute proneural expression. Dev. Biol. 316(2): 487-97. PubMed Citation: 18329012
Ayyar, S., et al. (2010). An arthropod cis-regulatory element functioning in sensory organ precursor development dates back to the Cambrian. BMC Biol. 8: 127. PubMed Citation: 20868489
Badenhorst, P., Finch, J. T. and Travers, A. A. (2002). Tramtrack co-operates to prevent inappropriate neural development in Drosophila. Mech. Dev. 117: 87-101. 12204250
Bae, S.-K., et al. (2000). The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation. Development 127: 2933-2943. PubMed Citation: 10851137
Battiste, J., et al. (2007). Ascl1 defines sequentially generated lineage-restricted neuronal and oligodendrocyte precursor cells in the spinal cord.
Development 134(2): 285-93. Medline abstract: 17166924
Bellefroid, E. J., et al. (1998). Xiro3 encodes a Xenopus homolog of the Drosophila Iroquois genes and functions in neural specification. EMBO J. 17: 191-203. PubMed Citation: 9427753
Bertrand, V. and Hobert, O. (2009). Linking asymmetric cell division to the terminal differentiation program of postmitotic neurons in C. elegans.
Dev. Cell 16(4): 563-75. PubMed Citation: 19386265
Biryukova, I. and Heitzler, P. (2005). The Drosophila LIM-homeodomain protein Islet antagonizes
proneural cell specification in the peripheral nervous system. Dev. Biol. 288: 559-570. 16259974
Borges, M., et al. (1997). An achaete-scute homologue essential for neuroendocrine differentiation in the lung. Nature 386(6627): 852-5. PubMed Citation: 9126746
Borromeo, M. D., Meredith, D. M., Castro, D. S., Chang, J. C., Tung, K. C., Guillemot, F. and Johnson, J. E. (2014). A transcription factor network specifying inhibitory versus excitatory neurons in the dorsal spinal cord. Development 141: 2803-2812. PubMed ID: 24924197
Brennan, K., et al. (1999). The Abruptex mutations of Notch disrupt the establishment of proneural clusters in Drosophila. Dev. Biol. 216(1): 230-42. PubMed Citation: 10588874
Brzezinski, J. A., Kim, E. J., Johnson, J. E. and Reh, T. A. (2011).Ascl1 expression defines a subpopulation of lineage-restricted progenitors in the mammalian retina. Development 138(16): 3519-31. PubMed Citation: 21771810
Brody, T., Rasband, W., Baler, K., Kuzin, A., Kundu, M. and Odenwald, W. F. (2008). Sequence conservation and combinatorial complexity of Drosophila neural precursor cell enhancers. BMC Genomics 9: 371. PubMed Citation: 18673565
Buescher, M., Hing, F. S. and Chia, W. (2002). Formation of neuroblasts in the embryonic central nervous system of Drosophila melanogaster is controlled by SoxNeuro. Development 129: 4193-4203. 12183372
Cabrera, C.V., Alonso, M.C. and Huikeshoven, H. (1994). Regulation of scute function by extramacrochaete in vitro and in vivo. Development 120: 3595-3603. PubMed Citation: 7821225
Cadigan, K. M. and Nusse, R. (1996). wingless signaling in the Drosophila eye and embryonic epidermis. Development 122: 2801-12. PubMed Citation: 8787754
Cadigan, K. M., et al. (1998). Wingless repression of Drosophila frizzled 2 expression shapes the wingless morphogen gradient in the wing. Cell 93: 767-777. PubMed Citation: 9630221
Campbell, G. and Tomlinson, A. (1998). The roles of the homeobox genes aristaless and Distal-less in patterning
the legs and wings of Drosophila. Development 125(22): 4483-4493. PubMed Citation: 9778507
Casarosa, S., Fode, C. and Guillemot, F. (1999). Mash1 regulates neurogenesis in the ventral telencephalon. Development 126(3): 525-534. PubMed Citation: 9876181
Castro, D. S., et al. (2006). Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif. Dev. Cell 11(6): 831-44. Medline abstract: 17141158
Castro, D. S., et al. (2011). A novel function of the proneural factor Ascl1 in progenitor proliferation identified by genome-wide characterization of its targets.
Genes Dev. 25(9): 930-45. PubMed Citation: 21536733
Cau, E., et al. (1997). Mash1 activates a cascade of bHLH regulators in olfactory neuron progenitors. Development 124: 1611-1621. PubMed Citation: 9108377
Cau, E., et al. (2000). Hes genes regulate sequential stages of neurogenesis in the olfactory epithelium. Development 127: 2323-2332. PubMed Citation: 10804175
Cau, E., Casarosa, S. and Guillemot, F. (2002). Mash1 and Ngn1 control distinct steps of determination and differentiation in the olfactory sensory neuron lineage. Development 129: 1871-1880. 11934853
Cau, E. and Wilson, S. W. (2003). Ash1a and Neurogenin1 function downstream of Floating head to regulate epiphysial neurogenesis. Development 130: 2455-2466. 12702659
Cave, J. W., Xia, L. and Caudy, M. (2011). Differential regulation of transcription through distinct Suppressor of Hairless DNA binding site architectures during Notch signaling in proneural clusters. Mol. Cell Biol. 31(1): 22-9. PubMed Citation: 21041480
Chang, J., et al. (2000). The CNS midline cells coordinate proper cell
cycle progression and identity determination
of the Drosophila ventral neuroectoderm. Dev. Biol. 227: 307-323. PubMed Citation: 11071757
Chen, H., et al. (1997a). Conservation of the Drosophila lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1)
directly represses achaete-scute homolog-1 expression.
Proc. Natl. Acad. Sci. 94 (10): 5355-5360. PubMed Citation: 9144241
Chen, H., et al. (1997b). Tissue-specific expression of human achaete-scute homologue-1 in neuroendocrine tumors: transcriptional regulation by dual inhibitory
regions. Cell Growth Differ, 8(6): 677-86. PubMed Citation: 9186001
Cho, J. H., Klein, W. H. and Tsai, M. J. (2007). Compensational regulation of bHLH transcription factors in the postnatal development of BETA2/NeuroD1-null retina.
Mech. Dev. 124(7-8): 543-50. PubMed citation: 17629466
Choksi, S. P., et al. (2006). Prospero acts as a binary switch between self-renewal and differentiation in Drosophila neural stem cells. Dev. Cell 11(6): 775-89. Medline abstract: 17141154
Cortazar, D., et al. (2007). The enigmatic thymine DNA glycosylase. DNA Repair (Amst.) 6: 489504. PubMed Citation: 17116428
Couso, J. P., Bishop, S. A., and Martinez Arias, A. (1994).
The wingless signalling pathway and the patterning of the
wing margin in Drosophila. Development 120: 621-36. PubMed Citation: 8162860
Cui, X. and Doe, C. Q. (1995). The role of the cell cycle and cytokinesis in regulating
neuroblast sublineage gene expression in the Drosophila
CNS. Development 121: 3233-3243 . PubMed Citation: 7588058
Culí, J., Martín-Blanco, E. and Modolell, J. (2001). The EGF receptor and N signalling pathways act antagonistically in
Drosophila mesothorax bristle patterning. Development 128: 299-308. PubMed Citation: 11124124
Doonan, R., Hatzold, J., Raut, S., Conradt, B. and Alfonso, A. (2008). HLH-3 is a C. elegans Achaete/Scute protein required for differentiation of the hermaphrodite-specific motor neurons. Mech. Dev. 125(9-10): 883-93. PubMed Citation: 18586090
Dove, H. and Stollewerk, A. (2003). Comparative analysis of neurogenesis in the myriapod Glomeris marginata (Diplopoda) suggests more similarities to chelicerates than to insects. Development 130: 2161-2171. 12668630
Dubois, L., et al. (1998). XCoe2, a transcription factor of the Col/Olf-1/EBF family involved
in the specification of primary neurons in Xenopus. Curr. Biol. 8(4): 199-209. PubMed Citation: 9501982
Dubreuil, V., et al. (2002). The role of Phox2b in synchronizing pan-neuronal and type-specific aspects of neurogenesis. Development 129: 5241-5253. 12399315
Dutriaux, A., Godart, A., Brachet, A. and Silber, J. (2013). The insulin receptor is required for the development of the Drosophila peripheral nervous system. PLoS One 8: e71857. PubMed ID: 24069139
Ferreiro, B. (1994). XASH genes promote neurogenesis in Xenopus embryos. Development 120: 3649-55. PubMed Citation: 7821228
Frank, C. A., Baum, P. D. and Garriga, G. (2003). HLH-14 is a C. elegans Achaete-Scute protein that promotes neurogenesis through asymmetric cell division. Development 130: 6507-6518. 14627726
Fromental-Ramain, C., Vanolst, L., Delaporte, C. and Ramain, P. (2008). pannier encodes two structurally related isoforms that are differentially expressed during Drosophila development and display distinct functions during thorax patterning.
Mech. Dev. 125(1-2): 43-57. PubMed citation: 18042352
Galant, R., et al. (1998). Expression pattern of a butterfly achaete-scute homolog reveals the homology of butterfly wing scales and insect
sensory bristles. Curr. Biol. 8(14): 807-813. PubMed Citation: 9663389
Garcia-Alonso, L. VanBerkum, M., Grenningloh, G., Schuster, C. and Goodman, C.S. (1995). Fasciclin II controls proneural gene expression in Drosophila. Proc Natl Acad Sci 92: 10501-10505. PubMed Citation: 7479828
Garcia-Bellido, A. and Santamaria, P. (1978). Developmental analysis of the
achaete-scute system of Drosophila melanogaster. Genetics 91: 469-486. PubMed Citation: 17248807
Garcia-Garcia, M. J., et al. (1999). Different contributions of pannier and wingless to the patterning of the dorsal
mesothorax of Drosophila. Development 126: 3523-3532. PubMed Citation: 10409499
Giagtzoglou, N., et al. (2003). Two modes of recruitment of E(spl) repressors onto target genes. Development 130: 259-270. 12466194
Giangrande, A. (1995). Proneural genes influence gliogenesis in Drosophila. Development 121: 429-438. PubMed Citation: 7768184
Gigliani, F., et al. (1996). Interactions among the bHLH domains of the proteins encoded by the Enhancer of split and achaete-scute gene complexes in Drosophila. Mol. Gen. Genet. 251: 628-634. PubMed Citation: 8757393
Gibert, J. M., Marcellini, S., David, J. R., Schlotterer, C. and Simpson, P. (2005). A major bristle QTL from a selected population of Drosophila uncovers the zinc-finger transcription factor Poils-au-dos, a repressor of achaete-scute. Dev. Biol. 288(1): 194-205. 16216235
Golovnin, A., et al. (1999). The su(Hw) insulator can disrupt enhancer-promoter interactions when located more than 20 kilobases away from the Drosophila
achaete-scute complex. Mol. Cell. Biol. 19: 3443-3456. PubMed Citation: 10207068
Gomez-Skarmeta, J. L., et al. (1995). Cis-regulation of achaete and scute: shared enhancer-like elements drive their coexpression in proneural clusters of the imaginal discs. Genes Dev 9: 1869-1882. PubMed Citation: 7649474
Gomez-Skarmeta, J.-L., et al. (1996). araucan and caupolican, two members of the novel iroquois complex, encode homeoproteins that control proneural and vein-forming genes. Cell 85: 95-105. PubMed Citation: 8620542
Gómez-Skarmeta, J. L., et al. (1998). Xiro, a Xenopus homolog of the Drosophila Iroquois complex genes, controls development at the neural plate. EMBO J. 17: 181-190. PubMed Citation: 9427752
Gonzalez-Crespo, S. and Levine, M. (1993). Interactions between dorsal and helix-loop-helix proteins initiate the differentiation of the embryonic mesoderm
and neuroectoderm in Drosophila. Genes Dev 7: 1703-13. PubMed Citation: 8370521
Gonzalez-Gaitan, M. and Jackle, H. (1995). Invagination centers within the Drosophila stomatogastric nervous system anlage are positioned by Notch-mediated
signaling which is spatially controlled through wingless. Development 121: 2313-2325. PubMed Citation: 7671798
Groves, A.K., George, K.M., Tissier-Seta, J.P., Engel, J.D., Brunet, J.F. and Anderson, D.J. (1995). Differential regulation of transcription factor gene expression and phenotypic markers in developing sympathetic neurons. Development 121(3): 887-901. PubMed Citation: 7720591
Gurganus, M. C., et al. (1998). Genotype-environment interaction at quantitative trait loci affecting
sensory bristle number in Drosophila melanogaster. Genetics 149(4): 1883-1898. PubMed Citation: 9691044
Haenlin, M., Kunisch, M., Kramatschek, B. and Campos-Ortega, J.A. (1994). Genomic regions regulating early embryonic expression of the Drosophila neurogenic gene Delta. Mech. Dev. 47: 99-110. PubMed Citation: 7947325
Hans, S. and Campos-Ortega, J. A. (2002). On the organisation of the regulatory region of the zebrafish deltaD gene.
Development 129: 4773-4784. 12361969
Hartenstein, V., Tepass, U. and Gruszynski-deFeo, E. (1996). Proneural and neurogenic genes control specification and morphogenesis of stomatogastric nerve cell precursors in Drosophila Dev. Biol. 173: 213-227 . PubMed Citation: 8575623
Hatakeyama, J., et al. (2001). Roles of homeobox and bHLH genes in specification of a retinal cell type. Development 128: 1313-1322. 11262232
Heitzler, M., et al. (1996). Genes of the Enhancer of split and achaete-scute complexes
are required for a regulatory loop between Notch and
Delta during lateral signalling in Drosophila. Development 122: 161-171. PubMed Citation: 8565827
Heitzler, P., Vanolst, L., Biryukova, I. and Ramain, P. (2003). Enhancer-promoter communication mediated by Chip during Pannier-driven proneural patterning is regulated by Osa. Genes Dev. 17: 591-596. 12629041
Henrique, D., et al. (1997). cash4, a novel achaete-scute homolog induced by Hensen's node during generation of the posterior
nervous system. Genes Dev. 11:603-615. PubMed Citation: 9119225
Hirsch, M.-R., et al. (1998). Control of noradrenergic differentiation and Phox2a expression by
MASH1 in the central and peripheral nervous system. Development 125(4): 599-608. PubMed Citation: 9435281
Hoch, M., Broadie, K., Jackle, H. and Skaer, H. (1994). Sequential fates in a single cell are established by the
neurogenic cascade in the Malpighian tubules of Drosophila. Development 120: 3439-3450. PubMed Citation: 7821213
Hoch, M. and Jackle, H. (1998). Kruppel acts as a developmental switch gene that mediates Notch signalling-dependent tip cell differentiation in the excretory organs of Drosophila. EMBO J. 17(19): 5766-75. PubMed Citation: 9755176
Hojo, M., et al. (2000). Glial cell fate specification modulated by the bHLH gene Hes5 in mouse retina. Development 127: 2515-2522. PubMed Citation: 10821751
Hsiao, Y. L., Chen, Y. J., Chang, Y. J., Yeh, H. F., Huang, Y. C. and Pi, H. (2013). Proneural proteins Achaete and Scute associate with nuclear actin to promote external sensory organ formation. J Cell Sci. 127(Pt 1): 182-90. PubMed ID: 24190881
Huang, M.-L., Hsu, C.-H. and Chien, C.-H. (2000). The proneural gene amos promotes multiple dendritic
neuron formation in the Drosophila peripheral nervous
system. Neuron 25: 57-67. PubMed Citation: 10707972
Huber, K., et al. (2002). Development of chromaffin cells depends on MASH1 function. Development 129: 4729-4738. 12361965
Jacobsen, T. L., et al. (1998). Cis-interactions between Delta and Notch modulate neurogenic
signalling in Drosophila. Development 125(22): 4531-4540. PubMed Citation: 9778511
Jafar-Nejad, H., et al. (2003). Senseless acts as a binary switch during sensory organ precursor selection. Genes Dev. 17: 2966-2978. 14665671
Jafar-Nejad, H., Tien, A. C., Acar, M. and Bellen, H. J. (2006). Senseless and Daughterless confer neuronal identity to epithelial cells in the Drosophila wing margin. Development 133(9): 1683-92. 16554363
Jennings, B. H., Tyler, D. M. and Bray, S. J. (1999). Target specificities of Drosophila Enhancer of split basic helix-loop-helix proteins. Mol. Cell. Biol. 19: 4600-4610. PubMed Citation: 10373509
Jimenez, F. and Campos-Ortega, J.A. (1990). Defective neuroblast commitment in mutants of the achaete-scute complex and adjacent genes of Drosophila melanogaster. Neuron 5:81-89
. PubMed Citation: 2114885
Johnston, L. A. and Edgar, B. A. (1998). Wingless and Notch regulate cell-cycle arrest in the developing
Drosophila wing. Nature 394(6688): 82-84. PubMed Citation: 9665132
Joshi, M., Buchanan, K. T., Shroff, S. and Orenic, T. V. (2006). Delta and Hairy establish a periodic prepattern that positions sensory bristles in Drosophila legs. Dev. Biol. 293(1): 64-76. 16542648
Ju, B. G., et al. (2004). Activating the PARP-1 sensor component of the Groucho/ TLE1 corepressor complex mediates a CaMKinase II-dependent neurogenic gene activation pathway. Cell 119: 815-829. 15607978
Kanekar, S., et al. (1997). Xath5 participates in a network of bHLH genes in the developing Xenopus retina. Neuron 19(5): 981-994. PubMed Citation: 9390513
Kankel, M. W., et al. (2007). Investigating the genetic circuitry of mastermind in Drosophila, a notch signal effector. Genetics 177: 24932505. PubMed Citation: 18073442
Kazanjian, A., Wallis, D., Au, N., Nigam, R., Venken, K. J., Cagle, P. T., Dickey, B. F., Bellen, H. J., Gilks, C. B. and Grimes, H. L. (2004). Growth factor
independence-1 is expressed in primary human neuroendocrine lung carcinomas
and mediates the differentiation of murine pulmonary neuroendocrine cells.
Cancer Res. 64: 6874-6882. 15466176
Kehl, B. T., Cho, K.-O. and Choi, K.-W. (1998). mirror, a Drosophila homeobox gene in the iroquois complex, is required for sensory organ and alula formation. Development 125: 1217-1227. PubMed Citation: 9477320
Kim, J., et al. (2002). SOX10 maintains multipotency and inhibits neuronal differentiation of neural crest stem cells. Neuron 38: 17-31. 12691661
Klein, T. and Campos-Ortega, J. A. (1997). klumpfuss, a Drosophila gene encoding a member of the EGR family of transcription factors, is involved in bristle and leg development. Development (16): 3123-3134. PubMed Citation: 9272953
Kondo, T. and Raff, M. (2000). Basic helix-loop-helix proteins and the timing of oligodendrocyte differentiation. Development 127: 2989-2998. PubMed Citation: 10862737
Korzh, V., et al. (1998). Expression of zebrafish bHLH genes ngn1 and nrd defines distinct stages of neural differentiation. Dev. Dyn. 213(1): 92-104. PubMed Citation: 9733104
Kovtun, I. V., and McMurray, C. T. (2007). Crosstalk of DNA glycosylases with pathways other than base excision repair. DNA Repair (Amst.) 6: 517529. PubMed Citation: 17129768
Kramatschek, B. and Campos-Ortega, J.A. (1994). Neuroecotdermal transcription of the Drosophila neurogenic genes E(spl) and HLH-m5 is regulated by proneural genes. Development 120: 815-826. PubMed Citation: 7600959
Küry, P., et al. (2002). Mammalian Achaete scute homolog 2 is expressed in the adult sciatic nerve and regulates the expression of Krox24, Mob-1, CXCR4, and p57kip2 in Schwann Cells. J. Neurosci. 22(17): 7586-7595. 12196582
Lai, E. C. and Posakony, J. W. (1998). Regulation of Drosophila neurogenesis byRNA:RNA duplexes? Cell 93: 1103-1104. PubMed Citation: 9657143
Leviten, M. W., Lai, E. C. and Posakony, J. W. (1997). The Drosophila gene encodes a novel small protein and shares 3'
UTR sequence motifs with multiple Enhancer of split Complex genes. Development 124: 4039-4051 . PubMed Citation: 9374401
Liu, Y., Helms, A. W. and Johnson, J. E. (2004). Distinct activities of Msx1 and Msx3 in dorsal neural tube development. Development 131: 1017-1028. 14973289
Lo, L., Tiveron, M.-C. and Anderson, D. J. (1998). MASH1 activates expression of the paired homeodomain transcription factor Phox2a, and couples pan-neuronal and
subtype-specific components of autonomic neuronal identity. Development 125(4): 609-620. PubMed Citation: 9435282
Lin, R., Hill, R. J. and Priess, J. R. (1998). POP-1 and anterior-posterior fate decisions in C. elegans embryos. Cell 92: 229-239. PubMed Citation: 9458047
Ma, Q, Kintner, C. and Anderson, D. J. (1996). Identivication of neurogenin, a vertebrate neuronal determination gene. Cell 87: 43-52. PubMed Citation: 8858147
Ma, Q., et al. (1997). Mash1 and neurogenin1 expression patterns define complementary domains of
neuroepithelium in the developing CNS and are correlated with regions expressing
notch ligands. J. Neurosci. 17: 3644-3652. PubMed Citation: 9133387
Ma, Y., et al. (1998). Gene regulatory functions of Drosophila fish-hook, a high mobility group domain Sox protein. Mech. Dev. 73(2): 169-82. Medline abstract: 9622621
Marcellini, S., Gibert, J.-M. and Simpson, P. (2005).
achaete, but not scute, is dispensable for the peripheral nervous system of Drosophila. Dev. Biol. 285: 545-553. PubMed citation: 16084506
Martinez, C. and Modolell, J. (1991). Cross-regulatory interactions between the proneural achaete and scute genes of Drosophila. Science 251: 1485-1487. PubMed Citation: 1900954
Masoudi, N., Tavazoie, S., Glenwinkel, L., Ryu, L., Kim, K. and Hobert, O. (2018). Unconventional function of an Achaete-Scute homolog as a terminal selector of nociceptive neuron identity. PLoS Biol 16(4): e2004979. PubMed ID: 29672507
Matter-Sadzinski, L., et al. (2001). Specification of neurotransmitter receptor identity in developing retina: the chick ATH5 promoter integrates the positive and negative effects of several bHLH proteins. Development 128: 217-231. PubMed Citation: 11124117
Meir, E., et al. (2002). Robustness, flexibility, and the role of lateral inhibition in the neurogenic network. Curr. Biol. 12: 778-786. 12015114
Meredith, A and Johnson. J. E. (2000). Negative autoregulation of Mash1 expression
in CNS development. Dev. Biol. 222: 336-346. PubMed Citation: 10837123
Mizumoto, K. and Sawa, H. (2007). Cortical beta-catenin and APC regulate asymmetric nuclear beta-catenin localization during asymmetric cell division in C. elegans. Dev. Cell 12(2): 287-99. PubMed Citation: 17276345
Mizuseki, K., et al. (1998). Xenopus Zic-related-1 and Sox-2, two factors induced by chordin,
have distinct activities in the initiation of neural induction. Development 125(4): 579-587. PubMed Citation: 9435279
Morikawa, Y., et al. (2009). BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways. Development 136(21): 3575-84. PubMed Citation: 19793887
Nakayama, H., et al. (1997). Developmental restriction of Mash-2 expression in trophoblast correlates with potential activation of the notch-2 pathway. Dev. Genet. 21(1): 21-30. PubMed Citation: 9291577
Nègre, N., Ghysen, A. and Martinez, A. M. (2003). Mitotic G2-arrest is required for neural cell fate determination in Drosophila. Mech. Dev. 120: 253-265. 12559497
Nellesen, D. T., Lai, E. C. and Posakony, J. W. (1999). Discrete enhancer elements mediate selective responsiveness of enhancer of split complex genes
to common transcriptional activators. Dev. Biol. 213(1): 33-53. PubMed Citation: 10452845
Neumann, C. J. and Cohen, S. M. (1997). Long-range action of Wingless organizes the dorsal-ventral axis of the Drosophila
wing. Development 124: 871-880 . PubMed Citation: 9043068
Nakada, Y., Hunsaker, T. L., Henke, R. M. and Johnson, J. E. (2004). Distinct domains within Mash1 and Math1 are required for function in neuronal differentiation versus neuronal cell-type specification.
Development 131(6): 1319-30. 14993186
Nolo, R., Abbott, L. A. and Bellen, H. J. (2000),
Senseless, a Zn finger transcription factor, is necessary and sufficient for
sensory organ development in Drosophila.
Cell. 102(3): 349-62. 10975525
Okamura, Y. and Saga, Y. (2008). Notch signaling is required for the maintenance of enteric neural crest progenitors. Development 135(21): 3555-65. PubMed Citation: 18832397
Oellers, N., Dehio, M., and Knust, E. (1994). bHLH proteins encoded by the Enhancer of split complex of Drosophila negatively interfere with the transcriptional activation mediated by proneural genes. Mol. Gen. Genet. 244: 465-73. PubMed Citation: 8078474
Ohsako, S. Hyer, J. Panganiban, G. Oliver, I. and Caudy, M. (1994). Hairy function as a DNA-binding helix-loop-helix repressor of Drosophila sensory organ formation. Genes Dev. 8: 2743-2755. PubMed Citation: 7958930
Orenic, T. W., et al. (1993). The spatial organization of epidermal structures: hairy establishes the geometrical pattern of Drosophila leg
bristles by delimiting the domains of achaete expression. Development 118: 9-20. PubMed Citation: 8375341
Overton, P. M., Meadows, L. A., Urban, J. and Russell, S. (2002). Evidence for differential and redundant function of the Sox genes Dichaete and SoxN during CNS development in Drosophila. Development 129: 4219-4228. 12183374
Parks, A. L., Huppert, S. S. and Muskavitch, M. A. (1997). The dynamics of neurogenic signalling underlying bristle
development in Drosophila melanogaster. Mech. Dev. 63 (1): 61-74. PubMed Citation: 9178257
Parras, C., et al. (1996). Control of neural precursor specification by proneural proteins in the CNS of Drosophila. EMBO J. 15: 6394-99. PubMed Citation: 8978666
Parras, C. M., et al. (2002). Divergent functions of the proneural genes Mash1 and Ngn2 in the specification of neuronal subtype identity. Genes Dev. 16: 324-338. 11825874
Pattyn, A., et al. (1999). The homeobox gene Phox2b is essential for the development of autonomic neural crest
derivatives. Nature 398(6734): 366-70. PubMed Citation: 10360575
Petryniak, M. A., et al. (2007). Dlx1 and Dlx2 control neuronal versus oligodendroglial cell fate acquisition in the developing forebrain. Neuron 55: 417-433. Medline abstract: 17678855
Phillips, R. G., Warner, N. L. and Whittle, J. R. (1999). Wingless signaling leads to an asymmetric response to Decapentaplegic-dependent signaling during sense organ patterning on the notum of Drosophila melanogaster. Dev. Biol. 207(1): 150-162. PubMed Citation: 10049571
Pi, H., Huang, S. K., Tang, C. Y., Sun, Y. H. and Chien, C. T. (2004). phyllopod is a target gene of proneural proteins in Drosophila external
sensory organ development. Proc. Natl. Acad. Sci. 101: 8378-8383. 15148389
Poitras, L., Ghanem, N., Hatch, G. and Ekker, M. (2007). The proneural determinant MASH1 regulates forebrain Dlx1/2 expression through the I12b intergenic enhancer.
Development 134(9): 1755-65. Medline abstract: 17409112
Ramachandran, R., Fausett, B. V. and Goldman, D. (2010). Ascl1a regulates Müller glia dedifferentiation and retinal regeneration through a Lin-28-dependent, let-7 microRNA signalling pathway. Nat. Cell Biol. 12(11): 1101-7. PubMed Citation: 20935637
Ramain, P., et al. (2000). Interactions between Chip and the
Achaete/Scute-Daughterless heterodimers are required for
Pannier-driven proneural patterning. Mol. Cell 6: 781-790. PubMed Citation: 11090617
Reeves, N. and Posakony, J. W. (2005). Genetic programs activated by proneural proteins in the developing Drosophila PNS. Dev. Cell 8(3): 413-25. 15737936
Romani, S. Campuzano, S. and Modolell, J. (1987). The achaete-scute complex is expressed in neurogenic regions of Drosophila embryos. EMBO J. 6: 2085-2092. PubMed Citation: 16453781
Ross, J. M., Kalis, A. K., Murphy, M. W. and Zarkower, D. (2005).
The DM domain protein MAB-3 promotes sex-specific neurogenesis in C. elegans by regulating bHLH proteins.
Dev. Cell 8(6): 881-92. 15935777
Rossant, J., et al. (1998). Mash2 is expressed in oogenesis and preimplantation development but is not required for blastocyst
formation. Mech. Dev. 73(2): 183-191. PubMed Citation: 9622625
Rulifson, E. J. and Blair, S. S. (1995). Notch regulates wingless expression and is not required for reception of the paracrine wingless signal during wing margin neurogenesis in Drosophila. Development 121: 2813-2824. PubMed Citation: 7555709
Saito, T., et al. (1996). Identification of novel paired homeodomain protein related to C. elegans unc-4 as a potential downstream target of MASH1. Dev. Biol. 180 (1): 143-155. PubMed Citation: 8948581
Sansom, S. N., et al. (2009). The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. PLoS Genet. 5(6): e1000511. PubMed Citation: 19521500
Sato, M, et al. (1999). Bar homeobox genes are latitudinal prepattern genes in the developing Drosophila notum whose expression is regulated by the concerted functions of decapentaplegic and wingless. Development 126: 1457-1466. PubMed Citation: 10068639
Schlatter, R. and Maier, D. (2005). The Enhancer of split and Achaete-Scute complexes of Drosophilids derived from simple ur-complexes preserved in mosquito and honeybee. BMC Evol. Biol. 5: 67. 16293187
Seugnet, L., Simpson, P. and Haenlin, M. (1997). Transcriptional regulation of Notch and Delta: requirement for neuroblast segregation in
Drosophila. Development 124: 2015-2025. PubMed Citation: 9169848
Shalaby, N. A., et al. (2009). A screen for modifiers of notch signaling uncovers Amun, a protein with a critical role in sensory organ development. Genetics 182(4): 1061-76. PubMed Citation: 19448274
Shroff, S., Joshi, M. and Orenic, T. V. (2007). Differential Delta expression underlies the diversity of sensory organ patterns among the legs of the Drosophila adult. Mech. Dev. 124: 43-58. Medline abstract: 17107776
Singson, A., Leviten, M.W., Bang, A.G., Hua, X.H. and Posakony, J.W. (1994). Direct downstream targets of proneural activators in the imaginal disc include genes involved in lateral inhibitory signaling. Genes Dev. 8(17): 2058-2071. PubMed Citation: 7958878
Skeath, J.B. and Carroll, S.B. (1992a). Regulation of proneural gene expression and cell fate during neuroblast segregation in the Drosophila embryo. Development 114: 939-946. PubMed Citation: 1618155
Skeath, J. B., et al. (1992b). Gene regulation in two dimensions: the proneural achaete-scute genes are controlled by combinations of axis-patterning genes through a common intergenic control region. Genes and Dev. 6: 2606-19. PubMed Citation: 1340472
Skeath, J.B. Panganiban, G. and Carroll, S.B. (1994). The ventral nervous system defective gene controls proneural gene expression at two distinct steps during neuroblast formation in Drosophila. Development 120: 1517-1524. PubMed Citation: 8050360
Skeath, J. B. (1998). The Drosophila EGF receptor controls the formation and specification of neuroblasts along the dorsal-ventral axis of
the Drosophila embryo. Development 125(17): 3301-3312. PubMed Citation: 9693134
Sriuranpong, V., et al. (2002). Notch signaling induces rapid degradation of achaete-scute homolog 1. Mol Cell Biol. 22(9): 3129-39. 11940670
Stollewerk, A. (2000). Changes in cell shape in the ventral neuroectoderm
of Drosophila melanogaster depend on the activity
of the achaete-scute complex genes. Dev. Genes Evol. 210: 190-199. PubMed Citation: 11180821
Sudarsan, V., et al. (2002). A genetic hierarchy establishes mitogenic signaling and mitotic competence in the renal tubules of Drosophila. Development 129: 935-944. 11861476
Sugimori, M., et al. (2007). Combinatorial actions of patterning and HLH transcription factors in the spatiotemporal control of neurogenesis and gliogenesis in the developing spinal cord. Development 134(8): 1617-29. Medline abstract: 17344230
Sugimori, M., et al. (2008). Ascl1 is required for oligodendrocyte development in the spinal cord. Development 135: 1271-1281. PubMed Citation: 18287202
Talikka, M., Perez, S. E. and Zimmerman, K. (2002). Distinct patterns of downstream target activation are specified by the helix-loop-helix domain
of proneural basic helix-loop-helix transcription factors. Dev. Bio. 247: 137-148. 12074558
Tanaka, M., et al. (1997). Mash2 acts cell autonomously in mouse spongiotrophoblast development. Dev. Biol. 190(1): 55-65. PubMed Citation: 9331331
Tepass, U. and Hartenstein, V. (1995). Neurogenic and proneural genes control cell fate specification in the Drosophila endoderm. Development 121: 393-405. PubMed Citation: 7768181
Thellmann, M., Hatzold, J. and Conradt, B. (2003).
The Snail-like CES-1 protein of C. elegans can block the expression of the BH3-only cell-death activator gene egl-1 by antagonizing the function of bHLH proteins. Development 130: 4057-4071. 12874127
Tini, M., et al. (2002). Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription. Mol. Cell 9 265277. PubMed Citation: 11864601
Tomita, K., et al. (1996). Mash1 promotes neuronal differentiation in the retina. Genes Cells 1 (8): 765-774. PubMed Citation: 9077445
Tomita, K., et al. (2000). Mammalian achaete-scute and atonal homologs regulate neuronal versus glial fate determination in the central nervous system. EMBO J. 19: 5460-5472 . PubMed Citation: 11032813
Tomoyasu, Y., Nakamura, M. and Ueno, N. (1998). Role of Dpp signalling in prepattern formation of the dorsocentral mechanosensory organ in Drosophila melanogaster. Development 125(21): 4215-4224 . PubMed Citation: 9753676
Torii, M.-A., et al. (1999). Transcription factors Mash-1 and Prox-1 delineate early steps in differentiation of neural stem cells in the developing central nervous system. Development 126(3): 443-456. PubMed Citation: 9876174
Tsubota, T., Saigo, K. and Kojima, T. (2008). Hox genes regulate the same character by different strategies in each segment. Mech. Dev. 125(9-10): 894-905. PubMed Citation: 18586088
Tucker, E. S., et al. (2010). Proliferative and transcriptional identity of distinct classes of neural precursors in the mammalian olfactory epithelium. Development 137(15): 2471-81. PubMed Citation: 20573694
Tulin, A., Stewart, D. and Spradling, A. C. (2002). The Drosophila heterochromatic gene encoding poly(ADP-ribose) polymerase (PARP) is required to modulate chromatin structure during development. Genes Dev. 16(16): 2108-19. 12183365
Tulin, A. and Spradling, A. (2003). Chromatin loosening by poly(ADP)-ribose polymerase (PARP) at Drosophila puff loci. Science 299: 560-562. 12543974
Tuttle, R., et al. (1999). Defects in thalamocortical axon pathfinding correlate with altered cell
domains in Mash-1-deficient mice. Development 126(9): 1903-1916. PubMed Citation: 10101124
van der Flier, L. G., et al. (2009). Transcription factor Achaete Scute-Like 2 controls intestinal stem cell fate. Cell 136: 903-912. PubMed Citation: 19269367
van Doren, M., Ellis, H.M. and Posakony, J.W. (1991). The Drosophila extramacrochaetae protein antagonizes sequence-specific DNA binding by daughterless/achaete-scute protein complexes. Development 113: 245--255. PubMed Citation: 1764999
van Doren, M., Bailey, A.M., Esnayra, J., Ede, K. and Posakony, J.W. (1994). Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete. Genes Dev. 8(22): 2729-42. PubMed Citation: 7958929
Vanolst, L., Fromental-Ramain, C. and Ramain, P. (2005). Toutatis, a TIP5-related protein, positively regulates Pannier function during Drosophila neural development.
Development 132(19): 4327-38. 16141224
Verma-Kurvari, S., et al. (1996). Lineage-specific regulation of the neural differentiatiion gene MASH1. Dev. Biol. 180: 605-617. PubMed Citation:
Verma-Kurvari, S., et al. (1998). Multiple elements regulate Mash1 expression in the developing
CNS. Dev. Biol. 197(1): 106-116. PubMed Citation: 9578622
Vierbuchen, T., et al. (2010). Direct conversion of fibroblasts to functional neurons by defined factors. Nature 463(7284): 1035-41. PubMed Citation: 20107439
Villares, R. and Cabrera, C.V. (1987). The achaete-scute gene complex of Drosophila melanogaster: conserved domains in a subset of genes required for neurogenesis and their homology to myc. Cell 50: 415-424. PubMed Citation: 3111716
Von Ohlen, T., Syu, L. J. and Mellerick, D. M. (2007). Conserved properties of the Drosophila homeodomain protein, Ind. Mech. Dev. 124(11-12): 925-34. PubMed Citation: 17900877
Vue, T. Y., Kim, E. J., Parras, C. M., Guillemot, F. and Johnson, J. E. (2014). Ascl1 controls the number and distribution of astrocytes and oligodendrocytes in the gray matter and white matter of the spinal cord. Development 141: 3721-3731. PubMed ID: 25249462
Wan, S., Cato, A.-M. and Skaer, H. (2000). Multiple signalling pathways establish cell fate
and cell number in Drosophila Malpighian tubules, Dev. Biol. 217: 153-165. PubMed Citation: 10625542
Wang, C., Wang, M., Arrington, J., Shan, T., Yue, F., Nie, Y., Tao, W. A. and Kuang, S. (2017). Ascl2 inhibits myogenesis by antagonizing the transcriptional activity of myogenic regulatory factors. Development 144(2): 235-247. PubMed ID: 27993983
Wapinski, O. L., Vierbuchen, T., Qu, K., Lee, Q. Y., Chanda, S., Fuentes, D. R., Giresi, P. G., Ng, Y. H., Marro, S., Neff, N. F., Drechsel, D., Martynoga, B., Castro, D. S., Webb, A. E., Sudhof, T. C., Brunet, A., Guillemot, F., Chang, H. Y. and Wernig, M. (2013). Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons. Cell 155: 621-635. PubMed ID: 24243019
Weiss, J. B., Ohlen, T. V., Mellerick, D. M., Dressler, G., Doe, C. Q. and Scott, M. P. (1998). Dorsoventral patterning in the Drosophila central nervous system: the intermediate neuroblasts defective homeobox gene specifies intermediate column identity. Genes Dev 12: 3591-3602. PubMed Citation: 9832510
Weatherbee, S. D., et al. (1999). Ultrabithorax function in butterfly wings and the evolution of insect
wing patterns. Curr. Biol. 9(3): 109-15. PubMed Citation: 10021383
Wheeler, S. R., et al. (2003). The expression and function of the achaete-scute genes in Tribolium castaneum reveals conservation and variation in neural pattern formation and cell fate specification. Development 130:4373-81. 12900453
Yagi, Y., Suzuki, T. and Hayashi, S. (1998). Interaction between Drosophila EGF receptor and vnd
determines three dorsoventral domains of the neuroectoderm. Development 125(18): 3625-3633. PubMed Citation: 9716528
Yamasaki, Y. and Nishida, Y. (2006). Mi-2 chromatin remodeling factor functions in sensory organ development through proneural gene repression in Drosophila. Dev. Growth Differ. 48(7): 411-8. Medline abstract: 16961588
Younossi-Hartenstein, A., et al. (1996). Early neurogenesis of the Drosophila brain. J. Comp. Neur. 370: 313-329. PubMed Citation: 8799858
Yun, K., et al. (2002). Modulation of the notch signaling by Mash1 and Dlx1/2 regulates sequential specification and differentiation of
progenitor cell types in the subcortical telencephalon. Development 129: 5029-5040. 12397111
Zenvirt, S., Nevo-Caspi, Y., Rencus-Lazar, S. and Segal, D. (2008). Drosophila LIM-only is a positive regulator of transcription during thoracic bristle development. Genetics 179(4): 1989-99. PubMed Citation: 18689881
Zhao, C. and Emmons, S.W. (1995). A transcription factor controlling development of peripheral sense organs in C. elegans. Nature 373(6509): 74-78. PubMed Citation: 7800042
Zhao, G. and Skeath, J. B. (2002). The Sox-domain containing gene Dichaete/fish-hook acts in concert with vnd and ind to regulate cell fate in the Drosophila neuroectoderm. Development 129: 1165-1174. 11874912
Zhao, G., Boekhoff-Falk, G., Wilson, B. A. and Skeath, J. B. (2007). Linking pattern formation to cell-type specification: Dichaete and Ind directly repress achaete gene expression in the Drosophila CNS. Proc. Natl. Acad. Sci. 104(10): 3847-52. Medline abstract: 17360441
achaete:
Biological Overview
| Evolutionary Homologs
| Transcriptional regulation
| Targets of activity
| Protein Interactions and Post-transcriptional Regulation
| Developmental Biology
| Effects of Mutation
date revised: 5 April 2015
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