hopscotch

Agaisse, H., et al. (2003). Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury. Dev. Cell 5: 441-450. PubMed ID: 12967563

Amcheslavsky, A., Jiang, J. and Ip, Y. T. (2009). Tissue damage-induced intestinal stem cell division in Drosophila. Cell Stem Cell 4: 49-61. PubMed ID: 19128792

Avila, F. W. and Erickson, J. W. (2007). Drosophila JAK/STAT pathway reveals distinct initiation and reinforcement steps in early transcription of Sxl. Curr. Biol. 17: 643-648. PubMed ID: 17363251

Badenhorst, P., Voas, M., Rebay, I. and Wu, C. (2002). Biological functions of the ISWI chromatin remodeling complex NURF. Genes Dev. 16: 3186-3198. PubMed ID: 12502740

Baeg, G. H., Zhou, R. and Perrimon, N. (2005). Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila. Genes Dev. 19: 1861-1870. PubMed ID: 16055650

Bäumer, D., et al. (2011). JAK-STAT signalling is required throughout telotrophic oogenesis and short-germ embryogenesis of the beetle Tribolium. Dev. Biol. 350(1): 169-82. PubMed ID: 20974121

Bausek, N. and Zeidler, M. P. (2013). Galpha73B is a downstream effector of JAK/STAT signalling and a regulator of Rho1 in Drosophila haematopoiesis. J Cell Sci. PubMed ID: 24163435

Beccari, S., Teixeira, L. and Rorth, P. (2002). The JAK/STAT pathway is required for border cell migration during Drosophila oogenesis. Mech. Dev. 111(1-2): 115-23. PubMed ID: 11804783

Betz, A., et al. (2001). A Drosophila PIAS homologue negatively regulates stat92E. Proc. Natl. Acad. Sci. 98: 9563-9568. PubMed ID: 11504941

Binari, R. and Perrimon, N. (1994). Stripe-specific regulation of pair-rule genes by hopscotch, a putative Jak family tyrosine kinase in Drosophila. Genes Dev 8: 300-12. PubMed ID: 8314084

Biteau, B., Hochmuth, C. E. and Jasper, H. (2008). JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut. Cell Stem Cell 3: 442-455. PubMed ID: 18940735

Bonni, A., et al. (1997). Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway. Science 278(5337): 477-483. PubMed ID: 9334309

Boutros, M., Agaisse, H. and Perrimon, N. (2002). Sequential activation of signaling pathways during innate immune responses in Drosophila. Dev. Cell 3: 711-722. PubMed ID: 12431377

Brown, S., Hu, N. and Hombria, J. C. (2003). Novel level of signalling control in the JAK/STAT pathway revealed by in situ visualisation of protein-protein interaction during Drosophila development. Development 130: 3077-3084. PubMed ID: 12783781

Buchon, N., Broderick, N. A., Poidevin, M., Pradervand, S. and Lemaitre, B. (2009). Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation. Cell Host Microbe 5: 200-211. PubMed ID: 19218090

Buchon, N., Broderick, N. A., Chakrabarti, S. and Lemaitre, B. (2009). Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila. Genes Dev. 23(19): 2333-44. PubMed ID: 19797770

Cao X., Pfaff S. L. and Gage F. H. (2008). YAP regulates neural progenitor cell number via the TEA domain transcription factor. Genes Dev. 22: 3320-3334. PubMed ID: 19015275

Chen, H. W., Chen, X., Oh, S. W., Marinissen, M. J., Gutkind, J. S. and Hou, S. X. (2002). mom identifies a receptor for the Drosophila JAK/STAT signal transduction pathway and encodes a protein distantly related to the mammalian cytokine receptor family. Genes Dev. 16(3): 388-98. PubMed ID: 11825879

Chen, X., et al. (2003). Cyclin D-Cdk4 and Cyclin E-Cdk2 regulate the JAK/STAT signal transduction pathway in Drosophila. Dev. Cell 4: 179-190. PubMed ID: 12586062

Copf, T., et al. (2011). Cytokine signaling through the JAK/STAT pathway is required for long-term memory in Drosophila. Proc. Natl. Acad. Sci. 108(19): 8059-64. PubMed ID: 21518857

Danial, N. N., Pernis, A. and Rothman, P. B. (1995). Jak-STAT signaling induced by the v-abl oncogene. Science 269: 1875-1877. PubMed ID: 7569929

Danial, N. N., et al., (1998). Direct interaction of jak1 and v-Abl is required for v-abl-induced activation of STATs and proliferation. Mol. Cell. Biol. 18(11): 6795-804. PubMed ID: 9774693

Davidson, C., Tirouvanziam, R., Herzenberg, L. and Lipsick, J. (2004). Functional Evolution of the Vertebrate Myb Gene Family: B-Myb, but neither A-Myb nor c-Myb, complements Drosophila Myb in Hemocytes. Genetics 169(1): 215-29. PubMed ID: 15489525

Dawson, M. A., et al. (2009). JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature 461(7265): 819-22. PubMed ID: 19783980

Domanski, P., et al. (1997). A region of the beta subunit of the interferon alpha receptor different from box 1 interacts with jak1 and is sufficient to activate the jak-stat pathway and induce an antiviral state. J. Biol. Chem. 272(42): 26388-26393. PubMed ID: 9334213

Erclik, T., Hartenstein V., Lipshitz H. D. and McInnes R. R. (2008). Conserved role of the Vsx genes supports a monophyletic origin for bilaterian visual systems. Curr. Biol. 18: 1278-1287. PubMed ID: 18723351

Feng, S., Thomas, S. and Wang, J. (2012). Diverse tumor pathology due to distinctive patterns of JAK/STAT pathway activation caused by different Drosophila polyhomeotic alleles. Genetics 190(1): 279-82. PubMed ID: 22048022

Garriga-Canut, M. and Orkin, S. H. (2004). Transforming acidic Coiled-Coil Protein 3 (TACC-3) controls Friend-of-GATA-1 (FOG-1) subcellular localization and regulates the association between GATA-1 and FOG-1 during hematopoiesis. J. Biol. Chem. 279: 23597-23605. PubMed ID: 15037632

Ghiglione, C., Devergne, O., Cerezo, D. and Noselli, S. (2008). Drosophila RalA is essential for the maintenance of Jak/Stat signalling in ovarian follicles. EMBO Rep. 9(7): 676-82. PubMed ID: 18552769

Gilbert, M. M., Weaver, B. K., Gergen, J. P. and Reich, N. C. (2005). A novel functional activator of the Drosophila JAK/STAT pathway, unpaired2, is revealed by an in vivo reporter of pathway activation. Mech. Dev. 122(7-8): 939-48. PubMed ID: 15925495

Haque, S. J., et al. (1997). Receptor-associated constitutive protein tyrosine phosphatase activity controls the kinase function of JAK1. Proc. Natl. Acad. Sci. 94(16): 8563-8568. PubMed ID: 9238016

Hanratty, H. P. and Dearolf, C. R. (1993). The Drosophila Tumorous-lethal hematopoietic oncogene is a dominant mutation in the hopscotch locus. Mol. Gen. Genet. 238: 33-7. PubMed ID: 8479437

Harrison, D. A. (1995). Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects. EMBO J. 14: 2857-2865. PubMed ID: 7796812

Harrison, D. A., et al. (1998). Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathway. Genes Dev. 12(20): 3252-63. PubMed ID: 9784499

Hou, X.S., Melnick, M.B. and Perrimon, N. (1996). marelle acts downstream of the Drosophila HOP/JAK kinase and encodes a protein similar to the Mammalian STATs. Cell 84: 411-419. PubMed ID: 8608595

Hou, X. S. and Perrimon, N. (1997). The JAK-STAT pathway in Drosophila. Trends Genet. 13: 105-110. PubMed ID: 9066269

Huang, L. J.-s., Constantinescu, S. N. and Lodish, H. F. (2001). The N-terminal domain of Janus kinase 2 is required for golgi processing and cell surface expression of erythropoietin receptor. Molec. Cell 8: 1327-1338. PubMed ID: 11779507

Ihle, J.N., et al. (1994). Signaling by the cytokine receptor superfamily: JAKs and STATs. Trends in Biochemical Sciences 19: 222-227. PubMed ID: 8048164

Jiang, H., et al. (2009). Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut. Cell 137(7): 1343-55. PubMed ID: 19563763

Jinks, T. M., et al. (2000). The JAK/STAT signaling pathway is required for the initial choice of sexual identity in Drosophila melanogaster. Molec. Cell 5: 581-587. PubMed ID: 10882142

Johansen, K. A., Iwaki, D. D. and Lengyel, J. A. (2003). Localized JAK/STAT signaling is required for oriented cell rearrangement in a tubular epithelium. Development 130: 135-145. PubMed ID: 12441298

Jung, S. H., Evans, C. J., Uemura, C. and Banerjee, U. (2005). The Drosophila lymph gland as a developmental model of hematopoiesis. Development 132: 2521-2533. PubMed ID: 15857916

Juni, N., Awasaki, T., Yoshida, K. and Hori, S. H. (1996). The Om(1E) mutation in Drosophila ananassae causes compound eye overgrowth due to tom retrotransposon-driven overexpression of a novel gene. Genetics 143: 1257-1270. PubMed ID: 8807298

Lagueux, M., et al. (2000). Constitutive expression of a complement-like protein in Toll and JAK gain-of-function mutants of Drosophila. Proc. Natl. Acad. Sci. 97: 11427-11432. PubMed ID: 11027343

Li, C. and Friedman, J. M. (1999). Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction. Proc. Natl. Acad. Sci. 96: 9677-9682. PubMed ID: 10449753

Liang, L., et al. (1999). Insulin receptor substrate-1 enhances growth hormone-induced proliferation. Endocrinology 140(5): 1972-83. PubMed ID: 10218944

Liu, K. D., et al. (1997). Janus kinases in interleukin-2-mediated signaling: JAK1 and JAK3 are differentially regulated by tyrosine phosphorylation. Curr. Biol. 7(11): 817-826. PubMed ID: 9382798

Luo, H., Hanratty, W. P. and Dearolf, C. R. (1995). An amino acid substitution in the Drosophila hopTum-l Jak kinase causes leukemia-like hematopoietic defects. EMBO J 14: 1412-1420. PubMed ID: 7729418

Luo, H., et al. (1997). Mutation in the Jak Kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways. Mol. Cell. Biol. 17: 1562-71. PubMed ID: 9032284

Luo, H., et al. (1999). The Drosophila Jak kinase Hopscotch is required for multiple developmental processes in the eye. Dev. Biol. 213(2): 432-41. PubMed ID: 10479459

Marrero, M. B., et al. (1997). Role of janus Kinase/Signal transducer and activator of transcription and mitogen-activated protein kinase cascades in angiotensin II- and platelet-derived growth factor-induced vascular smooth muscle cell proliferation. J. Biol. Chem. 272(39): 24684-24690. PubMed ID: 9305939

McGregor, J. B., Xi, R. and Harrison, D. A. (2002). JAK signaling is somatically required for follicle cell differentiation in Drosophila. Development 129: 705-717. PubMed ID: 11830571

Medioni, C. and Noselli, S. (2005). Dynamics of the basement membrane in invasive epithelial clusters in Drosophila. Development 132(13): 3069-77. PubMed ID: 15944190

Michel, M., Kupinski, A. P., Raabe, I. and Bõkel, C. (2012). Hh signalling is essential for somatic stem cell maintenance in the Drosophila testis niche. Development 139(15): 2663-9. PubMed ID: 22745310

Montresor, A., Bolomini-Vittori, M., Toffali, L., Rossi, B., Constantin, G. and Laudanna, C. (2013). JAK tyrosine kinases promote hierarchical activation of Rho and Rap modules of integrin activation. J Cell Biol 203: 1003-1019. PubMed ID: 24368807

Mukherjee, T., Schäfer, U. and Zeidler, M. P. (2006). Identification of Drosophila genes modulating janus kinase/signal transducer and activator of transcription signal transduction. Genetics 172(3): 1683-97. PubMed ID: 16387886

Munier, A.-I., et al. (2002). PVF2, a PDGF/VEGF-like growth factor, induces hemocyte proliferation in Drosophila larvae. EMBO Reports 3: 1195-1200. PubMed ID: 12446570

Neubauer H., et al. (1998). Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell 93(3): 397-409. PubMed ID: 9590174

Ngo, K. T., et al. (2010). Concomitant requirement for Notch and Jak/Stat signaling during neuro-epithelial differentiation in the Drosophila optic lobe. Dev. Biol. 346(2): 284-95. PubMed ID: 20692248

Parganas E., et al. (1998). Jak2 is essential for signaling through a variety of cytokine receptors. Cell 93(3): 385-395. PubMed ID: 9590173

Perrimon, N. and Mahowald, A. P. (1986). l(1)hopscotch, A larval-pupal zygotic lethal with a specific maternal effect on segmentation in Drosophila. Dev Biol 118: 28-41. PubMed ID: 3095163

Reddy, B. V., Rauskolb, C. and Irvine, K. D. (2010). Influence of fat-hippo and notch signaling on the proliferation and differentiation of Drosophila optic neuroepithelia. Development 137(14): 2397-408. PubMed ID: 20570939

Rodig, S. J., et al. (1998). Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses. Cell 93(3): 373-383. PubMed ID: 9590172

Rui, L., et al. (1997). Identification of SH2-Bbeta as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling. Mol. Cell. Biol. 17(11): 6633-6644. PubMed ID: 9343427

Sefton, L., et al. (2000). An extracellular activator of the Drosophila JAK/STAT pathway is a sex-determination signal element. Nature 405: 970-973. PubMed ID: 10879541

Shi, S., et al. (2006). JAK signaling globally counteracts heterochromatic gene silencing. Nat. Genet. 38(9): 1071-6. PubMed ID: 16892059

Silver, D. L. and Montell, D. J. (2001). Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila. Cell 107: 831-841. PubMed ID: 11779460

Singh, S. R., Liu, W. and Hou, S. X. (2007). The adult Drosophila malpighian tubules are maintained by multipotent stem cells. Cell Stem Cell 1(2): 191-203. PubMed ID: 18371350

Small, S., Blair, A. and Levine, M. (1996). Regulation of two pair-rule stripes by a single enhancer in the Drosophila embryo. Dev. Biol. 175: 314-324. PubMed ID: 8626035

Sorrentino, R. P., Carton, Y. and Govind, S. (2002). Cellular immune response to parasite infection in the Drosophila lymph gland is developmentally regulated. Dev. Biol. 243: 65-80. PubMed ID: 11846478

Sorrentino, R. P., Melk, J. P. and Govind, S. (2004). Genetic analysis of contributions of dorsal group and JAK-Stat92E pathway genes to larval hemocyte concentration and the egg encapsulation response in Drosophila. Genetics 166: 1343-1356. PubMed ID: 15082553

Sorrentino, R. P., Tokusumi, T. and Schulz, R. A. (2007). The Friend of GATA protein U-shaped functions as a hematopoietic tumor suppressor in Drosophila. Dev. Biol. 311(2): 311-23. PubMed ID: 17936744

Stofanko, M., Kwon, S. Y. and Badenhorst, P. (2010). Lineage tracing of lamellocytes demonstrates Drosophila macrophage plasticity. PLoS One 5(11): e14051. PubMed ID: 21124962

Takemoto, S., et al. (1997). Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins. Proc. Natl. Acad. Sci. 94(25): 13897-13902. PubMed ID: 9391124

Torres, P. L., López-Schier, H. and St Johnston, D. (2003). A Notch/Delta-dependent relay mechanism establishes anterior-posterior polarity in Drosophila. Dev. Cell 5: 547-558. PubMed ID: 14536057

Vied, C., Reilein, A., Field, N. S. and Kalderon, D. (2012). Regulation of stem cells by intersecting gradients of long-range niche signals. Dev Cell 23: 836-848. PubMed ID: 23079600

Wang, W., Li, Y., Zhou, L., Yue, H. and Luo, H. (2011). Role of JAK/STAT signaling in neuroepithelial stem cell maintenance and proliferation in the Drosophila optic lobe. Biochem Biophys Res Commun 410: 714-720. Pubmed: 21651897

Xi, R., McGregor, J. R. and Harrison, D. A. (2003). A gradient of JAK pathway activity patterns the anterior-posterior axis of the follicular epithelium. Dev. Cell 4: 167-177. PubMed ID: 12586061

Xu, N., et al. (2011). EGFR, Wingless and JAK/STAT signaling cooperatively maintain Drosophila intestinal stem cells. Dev. Biol 354(1): 31-43. PubMed ID: 21440535

Yamauchi, T., et al. (1997). Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone. Nature 389(6655): 91-96. PubMed ID: 9363897

Yan, R., et al. (1996a). Identification of a STAT gene that functions in Drosophila development. Cell 84: 421-30. PubMed ID: 8608596

Yan, R., et al. (1996b). A JAK-STAT pathwar regulates wing vein formation in Drosophila. Proc. Natl. Acad. Sci. 93: 5842-47. PubMed ID: 8650180

Yasugi, T., Umetsu, D., Murakami, S., Sato, M. and Tabata, T. (2008). Drosophila optic lobe neuroblasts triggered by a wave of proneural gene expression that is negatively regulated by JAK/STAT. Development 135: 1471-1480. PubMed ID: 18339672

Yasukawa, H., et al. (1999). The JAK-binding protein JAB inhibits janus tyrosine kinase activity through binding in the activation loop. EMBO J. 18(5): 1309-20. PubMed ID: 10064597

Zeidler, M. P., Perrimon, N. and Strutt, D. I. (1999a). Polarity determination in the Drosophila eye: a novel role for Unpaired and JAK/STAT signaling. Genes Dev. 13: 1342-1353. PubMed ID: 10346822

Zeidler, M. P., Perrimon, N. and Strutt, D. I. (1999b). The four-jointed gene is required in the Drosophila eye for ommatidial polarity specification. Curr. Biol. 9: 1363-1372. PubMed ID: 10607560

Zhang X. F., et al. (2001). Janus kinase 2 is involved in stromal cell-derived factor-1alpha-induced tyrosine phosphorylation of focal adhesion proteins and migration of hematopoietic progenitor cells. Blood 97: 3342-3348. PubMed ID: 11369622

Zhao, S., et al. (2002). JAK2, complemented by a second signal from c-kit or flt-3, triggers extensive self-renewal of primary multipotential hemopoietic cells. EMBO J. 21: 2159-2167. PubMed ID: 11980713

Zhou, Y. J., et al. (1997). Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity. Proc. Natl. Acad. Sci. 94(25): 13850-13855. PubMed ID: 9391116

Zhu, X., et al. (1997). Stat1 serine phosphorylation occurs independently of tyrosine phosphorylation and requires an activated Jak2 kinase. Mol. Cell. Biol. 17(11): 6618-6623. PubMed ID: 9343425

date revised: 25 March 2014 

Home page: The Interactive Fly © 1997 Thomas B. Brody, Ph.D.

The Interactive Fly resides on the
Society for Developmental Biology's Web server.