Fly Labs and References

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Rongwen Xi National Institute of Biological Science, Beijing Shi, J., Jin, Z., Yu, Y., Zhang, Y., Yang, F., Huang, H., Cai, T. and Xi, R. (2020). A Progressive Somatic Cell Niche Regulates Germline Cyst Differentiation in the Drosophila Ovary. Curr Biol. PubMed ID: 33340458 Jin, Z., Chen, J., Huang, H., Wang, J., Lv, J., Yu, M., Guo, X., Zhang, Y., Cai, T. and Xi, R. (2020). The Drosophila Ortholog of Mammalian Transcription Factor Sox9 Regulates Intestinal Homeostasis and Regeneration at an Appropriate Level. Cell Rep 31(8): 107683. PubMed ID: 32460025 Li, Z., Guo, X., Huang, H., Wang, C., Yang, F., Zhang, Y., Wang, J., Han, L., Jin, Z., Cai, T. and Xi, R. (2020). A Switch in Tissue Stem Cell Identity Causes Neuroendocrine Tumors in Drosophila Gut. Cell Rep 30(6): 1724-1734.e1724. PubMed ID: 32049006 Guo, X., Yin, C., Yang, F., Zhang, Y., Huang, H., Wang, J., Deng, B., Cai, T., Rao, Y. and Xi, R. (2019). The cellular diversity and transcription factor code of Drosophila enteroendocrine cells. Cell Rep 29(12): 4172-4185.e4175. PubMed ID: 31851941 Yang, F., Quan, Z., Huang, H., He, M., Liu, X., Cai, T. and Xi, R. (2019). Ovaries absent links dLsd1 to HP1a for local H3K4 demethylation required for heterochromatic gene silencing. Elife 8. PubMed ID: 30648969 Yin, C. and Xi, R. (2018). A phyllopod-mediated feedback loop promotes intestinal stem cell enteroendocrine commitment in Drosophila. Stem Cell Reports 10(1): 43-57. PubMed ID: 29276156 Chen, J., Xu, N., Wang, C., Huang, P., Huang, H., Jin, Z., Yu, Z., Cai, T., Jiao, R. and Xi, R. (2018). Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells. Nat Cell Biol 20(2): 152-161. PubMed ID: 29335529 Li, Y., Pang, Z., Huang, H., Wang, C., Cai, T. and Xi, R. (2017). Transcription Factor Antagonism Controls Enteroendocrine Cell Specification from Intestinal Stem Cells. Sci Rep 7: 988. PubMed ID: 28428611 Li, X., Yang, F., Chen, H., Deng, B., Li, X. and Xi, R. (2016). Control of germline stem cell differentiation by polycomb and trithorax group genes in the niche microenvironment. Development [Epub ahead of print]. PubMed ID: 27510973 Chen, J., Xu, N., Huang, H., Cai, T. and Xi, R. (2016). A feedback amplification loop between stem cells and their progeny promotes tissue regeneration and tumorigenesis. Elife 5. PubMed ID: 27187149 Wang, C., Guo, X., Dou, K., Chen, H. and Xi, R. (2015). Ttk69 acts as a master repressor of enteroendocrine cell specification in Drosophila intestinal stem cell lineages. Development [Epub ahead of print]. PubMed ID: 26293304 Yang Xiang Neurobiology, University of Massachusetts Medical School, Worcester Gu, P., Gong, J., Shang, Y., Wang, F., Ruppell, K. T., Ma, Z., Sheehan, A. E., Freeman, M. R. and Xiang, Y. (2019). Polymodal Nociception in Drosophila Requires Alternative Splicing of TrpA1. Curr Biol. PubMed ID: 31735672 Yan, Z., Zhang, W., He, Y., Gorczyca, D., Xiang, Y., Cheng, L.E., Meltzer, S., Jan, L.Y, Jan, Y.N. (2013). Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation. Nature 493(7431): 221-5. PubMed ID: 23222543 Xiang, Y., Yuan, Q., Vogt, N., Looger, L. L., Jan, L. Y., Jan, Y. N. (2010). Light-avoidance-mediating photoreceptors tile the Drosophila larval body wall. 468(7326): 921-6. PubMed ID: 21068723 Ting Xie Stowers Institute for Medical Research, Kansas City Tu, R., Duan, B., Song, X., Chen, S., Scott, A., Hall, K., Blanck, J., DeGraffenreid, D., Li, H., Perera, A., Haug, J. and Xie, T. (2020). Multiple Niche Compartments Orchestrate Stepwise Germline Stem Cell Progeny Differentiation. Curr Biol. PubMed ID: 33357404 Tu, R., Duan, B., Song, X. and Xie, T. (2020). Dlp-mediated Hh and Wnt signaling interdependence is critical in the niche for germline stem cell progeny differentiation. Sci Adv 6(20): eaaz0480. PubMed ID: 32426496 Story, B., Ma, X., Ishihara, K., Li, H., Hall, K., Peak, A., Anoja, P., Park, J., Haug, J., Blanchette, M. and Xie, T. (2019). Defining the expression of piRNA and transposable elements in Drosophila ovarian germline stem cells and somatic support cells. Life Sci Alliance 2(5): e201800211. PubMed ID: 31624801 Mao, Y., Tu, R., Huang, Y., Mao, D., Yang, Z., Lau, P. K., Wang, J., Ni, J., Guo, Y. and Xie, T. (2019). The exocyst functions in niche cells to promote germline stem cell differentiation by directly controlling EGFR membrane trafficking. Development. PubMed ID: 31142545 Ma, X., Zhu, X., Han, Y., Story, B., Do, T., Song, X., Wang, S., Zhang, Y., Blanchette, M., Gogol, M., Hall, K., Peak, A., Anoja, P. and Xie, T. (2017). Aubergine controls germline stem cell self-renewal and progeny differentiation via distinct mechanisms. Dev Cell 41(2): 157-169.e155. PubMed ID: 28441530 Ma, X., Han, Y., Song, X., Do, T., Yang, Z., Ni, J and Xie, T. (2016). DNA damage-induced CHK2 activation compromises germline stem cell self-renewal and lineage differentiation. Development [Epub ahead of print]. PubMed ID: 27729408 Lu, T., Wang, S., Gao, Y., Mao, Y., Yang, Z., Liu, L., Song, X., Ni, J. and Xie, T. (2015). COP9-Hedgehog axis regulates the function of the germline stem cell progeny differentiation niche in the Drosophila ovary. Development 142: 4242-4252. PubMed ID: 26672093 Wang, S., Gao, Y., Song, X., Ma, X., Zhu, X., Mao, Y., Yang, Z., Ni, J., Li, H., Malanowski, K.E., Anoja, P., Park, J., Haug, J. and Xie, T. (2015). Wnt signaling-mediated redox regulation maintains the germ line stem cell differentiation niche. Elife 4. PubMed ID: 26452202 Wang, S., Gao, Y., Song, X., Ma, X., Zhu, X., Mao, Y., Yang, Z., Ni, J., Li, H., Malanowski, K. E., Anoja, P., Park, J., Haug, J. and Xie, T. (2015). Wnt signaling-mediated redox regulation maintains the germ line stem cell differentiation niche. Elife 4. PubMed ID: 26452202 Pan, L., Wang, S., Lu, T., Weng, C., Song, X., Park, J. K., Sun, J., Yang, Z. H., Yu, J., Tang, H., McKearin, D. M., Chamovitz, D. A., Ni, J. and Xie, T. (2014). Protein competition switches the function of COP9 from self-renewal to differentiation. Nature. PubMed ID: 25119050 Wei Xie Key Laboratory of Developmental Genes and Human Disease, Institute of Life Science, Southeast University, Nanjing Ou, M., Wang, S., Sun, M., An, J., Lv, H., Zeng, X., Hou, S. X. and Xie, W. (2018). The PDZ-GEF Gef26 regulates synapse development and function via FasII and Rap1 at the Drosophila neuromuscular junction. Exp Cell Res. PubMed ID: 30553967 Xing, G., Li, M., Sun, Y., Rui, M., Zhuang, Y., Lv, H., Han, J., Jia, Z. and Xie, W. (2018). Neurexin-Neuroligin 1 regulates synaptic morphology and function via the WAVE regulatory complex in Drosophila neuromuscular junction. Elife 7. PubMed ID: 29537369 Wu, J., Tao, N., Tian, Y., Xing, G., Lv, H., Han, J., Lin, C. and Xie, W. (2017). Proteolytic maturation of Drosophila Neuroligin 3 by tumor necrosis factor alpha-converting enzyme in the nervous system. Biochim Biophys Acta 1862(3):440-450. PubMed ID: 29107812 Rui, M., Qian, J., Liu, L., Cai, Y., Lv, H., Han, J., Jia, Z. and Xie, W. (2017). The Neuronal Protein Neurexin Directly Interacts with the Scribble-Pix Complex to Stimulate F-actin Assembly for Synaptic Vesicle Clustering. J Biol Chem. PubMed ID: 28710284 Zhang, X., Rui, M., Gan, G., Huang, C., Yi, J., Lv, H. and Xie, W. (2017). Neuroligin 4 regulates synaptic growth via the Bone morphogenetic protein (BMP) signaling pathway at the Drosophila neuromuscular junction. J Biol Chem [Epub ahead of print]. PubMed ID: 28912273 Tu, R., Qian, J., Rui, M., Tao, N., Sun, M., Zhuang, Y., Lv, H., Han, J., Li, M. and Xie, W. (2017). Proteolytic cleavage is required for functional Neuroligin 2 maturation and trafficking in Drosophila. J Mol Cell Biol. PubMed ID: 28498949 Qian, J., Tu, R., Yuan, L. and Xie, W. (2016). Intronic miR-932 targets the coding region of its host gene, Drosophila neuroligin2. Exp Cell Res [Epub ahead of print]. PubMed ID: 26844630 Sun, M., Zeng, X. and Xie, W. (2015). Temporal and spatial expression of Drosophila Neurexin during the life cycle visualized using a DNRX-Gal4/UAS-reporter. Sci China Life Sci. PubMed ID: 26501376 Xing, G., Gan, G., Chen, D., Sun, M., Yi, J., Lv, H., Han, J. and Xie, W. (2014). Drosophila Neuroligin3 regulates neuromuscular junction development and synaptic differentiation. J Biol Chem. [Epub ahead of print]. PubMed ID: 25228693 Gan, G., Lv, H. and Xie, W. (2014). Morphological identification and development of neurite in Drosophila ventral nerve cord neuropil. PLoS One 9: e105497. PubMed ID: 25166897 Hong Xu Laboratory of Molecular Genetics, NHLBI, NIH, Bethesda Zhang, F., Pirooznia, M. and Xu, H. (2020). Mitochondria regulate intestinal stem cell proliferation and epithelial homeostasis through FOXO. Mol Biol Cell: mbcE19100560. PubMed ID: 32374658 Chen, Z., Wang, Z. H., Zhang, G., Bleck, C. K. E., Chung, D. J., Madison, G. P., Lindberg, E., Combs, C., Balaban, R. S. and Xu, H. (2020). Mitochondrial DNA segregation and replication restrict the transmission of detrimental mutation. J Cell Biol 219(7). PubMed ID: 32375181 Wang, Z. H., Liu, Y., Chaitankar, V., Pirooznia, M. and Xu, H. (2019). Electron transport chain biogenesis activated by a JNK-insulin-Myc relay primes mitochondrial inheritance in Drosophila. Elife 8. PubMed ID: 31612862 Qi, Y., Liu, H., Daniels, M. P., Zhang, G. and Xu, H. (2015). Loss of Drosophila i-AAA protease, dYME1L, causes abnormal mitochondria and apoptotic degeneration. Cell Death Differ. PubMed ID: 26160069 Zhang, F., Qi, Y., Zhou, K., Zhang, G., Linask, K. and Xu, H. (2015). The cAMP phosphodiesterase Prune localizes to the mitochondrial matrix and promotes mtDNA replication by stabilizing TFAM. EMBO Rep. PubMed ID: 25648146 Chen, Z., Qi, Y., French, S., Zhang, G., Garcia, R. C., Balaban, R. and Xu, H. (2014). Genetic mosaic analysis of a deleterious mitochondrial DNA mutation in Drosophila reveals novel aspects of mitochondrial regulation and function. Mol Biol Cell [Epub ahead of print]. PubMed ID: 25501370 Hill, J. H., Chen, Z. and Xu, H. (2014). Selective propagation of functional mitochondrial DNA during oogenesis restricts the transmission of a deleterious mitochondrial variant. Nat Genet. PubMed ID: 24614072 Ma, H., Xu, H. and O'Farrell, P. H. (2014). Transmission of mitochondrial mutations and action of purifying selection in Drosophila melanogaster. Nat Genet. PubMed ID: 24614071 Tian Xu Biological & Biomedical Sciences, Yale University Mishra-Gorur, K., Li, D., Ma, X., Yarman, Y., Xue, L. and Xu, T. (2019). Spz/Toll-6 signal guides organotropic metastasis in Drosophila. Dis Model Mech. PubMed ID: 31477571 Dunn, B. S., Rush, L., Lu, J. Y. and Xu, T. (2018). Mutations in the Drosophila tricellular junction protein M6 synergize with Ras(V12) to induce apical cell delamination and invasion. Proc Natl Acad Sci U S A 115(33): 8358-8363. PubMed ID: 30061406 Ma, X., Lu, J. Y., Dong, Y., Li, D., Malagon, J. N. and Xu, T. (2017). PP6 Disruption Synergizes with Oncogenic Ras to Promote JNK-Dependent Tumor Growth and Invasion. Cell Rep 19(13): 2657-2664. PubMed ID: 28658615 Chabu, C., Li, D. M. and Xu, T. (2017). EGFR/ARF6 regulation of Hh signalling stimulates oncogenic Ras tumour overgrowth. Nat Commun 8: 14688. PubMed ID: 28281543 Chabu, C. and Xu, T. (2014). Oncogenic Ras stimulates Eiger/TNF exocytosis to promote growth. Development. PubMed ID: 25411211 Olds, W. H. and Xu, T. (2014). Regulation of food intake by mechanosensory ion channels in enteric neurons. Elife 3. PubMed ID: 25285450 Ren, J., Zhu, H., Chi, C., Mehrmohamadi, M., Deng, K., Wu, X. and Xu, T. (2014). Beadex affects gastric emptying in Drosophila. Cell Res. PubMed ID: 24566770 Pastor-Pareja, J. C. and Xu, T. (2013). Dissecting Social Cell Biology and Tumors Using Drosophila Genetics. Annu Rev Genet. PubMed ID: 23988119 Pastor-Pareja, J. C. and Xu, T. (2011). Shaping cells and organs in Drosophila by opposing roles of fat body-secreted Collagen IV and perlecan. Dev Cell 21: 245-256. PubMed ID: 21839919 Ohsawa, S., Sugimura, K., Takino, K., Xu, T., Miyawaki, A. and Igaki, T. (2011). Elimination of oncogenic neighbors by JNK-mediated engulfment in Drosophila. Dev Cell 20: 315-328. PubMed ID: 21397843 Lei Xue School of Life Science Tongji University, Shanghai, China Ding, X., Li, Z., Lin, G., Li, W. and Xue, L. (2022). Toll-7 promotes tumour growth and invasion in Drosophila. Cell Prolif: e13188. PubMed ID: 35050535 Wu, C., Ding, X., Li, Z., Huang, Y., Xu, Q., Zou, R., Zhao, M., Chang, H., Jiang, C., La, X., Lin, G., Li, W. and Xue, L. (2021). CtBP modulates Snail-mediated tumor invasion in Drosophila. Cell Death Discov 7(1): 202. PubMed ID: 34349099 Li, Z., Wu, C., Ding, X., Li, W. and Xue, L. (2020). Toll signaling promotes JNK-dependent apoptosis in Drosophila. Cell Div 15: 7. PubMed ID: 32174999 Sun, Y., Zhang, D., Li, C., Huang, J., Li, W., Qiu, Y., Mao, A., Zhou, M. and Xue, L. (2019). Lic regulates JNK-mediated cell death in Drosophila. Cell Prolif: e12593. PubMed ID: 30847993 Zhang, S., Guo, X., Wu, H., Sun, Y., Ma, X., Li, J., Xu, Q., Wu, C., Li, Q., Jiang, C., Li, W., Ho, M. S., Lv, Z. and Xue, L. (2019). Wingless modulates activator protein-1-mediated tumor invasion. Oncogene. PubMed ID: 30683884 Sun, Y., Zhang, D., Guo, X., Li, W., Li, C., Luo, J., Zhou, M. and Xue, L. (2019). MKK3 modulates JNK-dependent cell migration and invasion. Cell Death Dis 10(3): 149. PubMed ID: 30770795 Wang, X., Huang, X., Wu, C. and Xue, L. (2018). Pontin/Tip49 negatively regulates JNK-mediated cell death in Drosophila. Cell Death Discov 5: 8. PubMed ID: 30062057 Wang, X., Guo, X., Ma, Y., Wu, C., Li, W. and Xue, L. (2018). APLP2 Modulates JNK-Dependent Cell Migration in Drosophila. Biomed Res Int 2018: 7469714. PubMed ID: 30155482 Ma, X., Guo, X., Richardson, H. E., Xu, T. and Xue, L. (2018). POSH regulates Hippo signaling through ubiquitin-mediated expanded degradation. Proc Natl Acad Sci U S A 115(9): 2150-2155. PubMed ID: 29440430 Ren, P., Li, W. and Xue, L. (2017). GLYAT regulates JNK-mediated cell death in Drosophila. Sci Rep 7(1): 5183. PubMed ID: 28701716 Wang, X., Sun, Y., Han, S., Wu, C., Ma, Y., Zhao, Y., Shao, Y., Chen, Y., Kong, L., Li, W., Zhang, F. and Xue, L. (2017). Amyloid precursor like protein-1 promotes JNK-mediated cell migration in Drosophila. Oncotarget [Epub ahead of print]. PubMed ID: 28537903 Ma, X., Wang, H., Ji, J., Xu, W., Sun, Y., Li, W., Zhang, X., Chen, J. and Xue, L. (2017). Hippo signaling promotes JNK-dependent cell migration. Proc Natl Acad Sci U S A [Epub ahead of print]. PubMed ID: 28174264 Ma, X., Huang, J., Tian, Y., Chen, Y., Yang, Y., Zhang, X., Zhang, F. and Xue, L. (2017). Myc suppresses tumor invasion and cell migration by inhibiting JNK signaling. Oncogene [Epub ahead of print]. PubMed ID: 28068320 Zhuang, L., Sun, Y., Hu, M., Wu, C., La, X., Chen, X., Feng, Y., Wang, X., Hu, Y. and Xue, L. (2016). Or47b plays a role in Drosophila males' preference for younger mates. Open Biol 6. PubMed ID: 27278650 Zhang, S., Guo, X., Chen, C., Chen, Y., Li, J., Sun, Y., Wu, C., Yang, Y., Jiang, C.,

This listing of Fly Labs and References is a work in progress. Please contact Tom Brody ([email protected]) with your suggestions or corrections.

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