Rho1
Abreu-Blanco, M. T., Verboon, J. M. and Parkhurst, S. M. (2013). Coordination of Rho family GTPase activities to orchestrate cytoskeleton responses during cell wound repair. Curr Biol 24(2): 144-55. PubMed ID: 24388847
Adini, I., et al. (2003). RhoB controls Akt trafficking and stage-specific survival of endothelial cells during vascular development. Genes Dev. 17: 2721-2732. 14597666
Aijaz, S., D'Atri, F., Citi, S., Balda, M. S. and Matter, K. (2005). Binding of GEF-H1 to the tight junction-associated adaptor cingulin results in inhibition of Rho signaling and G1/S phase transition. Dev. Cell 8(5): 777-86. 15866167
Alberts, A. S., Geneste, O. and Treisman, R. (1998a). Activation of SRF-regulated chromosomal templates by Rho-family GTPases requires a signal that also induces H4 hyperacetylation. Cell 92: 475-487. PubMed Citation: 9491889
Alberts, A. S. and Treisman, R. (1998b). Activation of RhoA and SAPK/JNK signalling pathways by the RhoA-specific exchange factor mNET1. EMBO J. 17(14): 4075-4085. PubMed Citation: 9670022
Altun-Gultekin, Z. F., et al. (1998). Activation of Rho-dependent cell spreading and focal adhesion biogenesis by the v-Crk adaptor protein. Mol. Cell. Biol. 18(5): 3044-3058. PubMed Citation: 9566923
Amano, M., et al. (1996). Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase). J. Biol. Chem. 271(34): 20246-20249. PubMed Citation: 8702756
Amano, M., et al. (1997). Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase. Science 275(5304): 1308-1311. PubMed Citation: 9036856
Anastasiadis, P. Z., Moon, S. Y., Thoreson, M. A., Mariner, D. J., Crawford, H. C., Zheng, Y. and Reynolds, A. B. (2000). Inhibition of RhoA by p120 catenin. Nature Cell Biol. 2: 637-644. 10980705
Appel, L.F., Prout, M., Abu-Shumays, R., Hammonds, A., Garbe, J.C., Fristrom, D., and Fristrom, J. (1993). The Drosophila Stubble-stubbloid gene encodes an apparent transmembrane serine protease required for epithelial morphogenesis. Proc. Natl. Acad. Sci. 90: 4937-4941. 6289325
Aspenstrom, P., Richnau, N. and Johansson, A. S. (2006). The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamics. Exp Cell Res. 312(12): 2180-94. 16630611
Atfi A., et al. (1997). Evidence for a role of Rho-like GTPases and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor beta-mediated signaling. J. Biol. Chem. 17;272(3): 1429-1432. PubMed Citation: 8999807
Audhya, A. and Emr, S. D. (2002). Stt4 PI 4-kinase localizes to the plasma membrane and functions in the Pkc1-mediated MAP kinase cascade. Developmental Cell 2: 593-605. 12015967
Arora, D., Stopp, S., Bohmer, S. A., Schons, J., Godfrey, R., Masson, K., Razumovskaya, E., Ronnstrand, L., Tanzer, S., Bauer, R., Bohmer, F. D. and Muller, J. P. (2011). Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling. J Biol Chem 286: 10918-10929. PubMed ID: 21262971
Banerjee, J. and Wedegaertner, P. B. (2004). Identification of a novel sequence in PDZ-RhoGEF that mediates interaction with the actin cytoskeleton. Mol. Biol. Cell 15(4): 1760-75. Medline abstract: 14742719
Barrett, K., Leptin, M. and Settleman, J. (1997). The Rho GTPase and a putative RhoGEF mediate a signaling pathway for the cell shape changes in Drosophila gastrulation. Cell 91(7): 905-915. Medline abstract: 9428514
Bashaw, G. J., Hu, H., Nobes, C. D. and Goodman, C. S. (2001). A novel Dbl family RhoGEF promotes Rho-dependent axon attraction to the central nervous system midline in Drosophila and overcomes Robo repulsion. J. Cell Bio. 155: 1117-1122. 11756465
Bassi, Z. I., et al. (2011). Sticky/Citron kinase maintains proper RhoA localization at the cleavage site during cytokinesis. J. Cell Biol. 195(4): 595-603. PubMed Citation: 22084308
Bausek, N. and Zeidler, M. P. (2013). Galpha73B is a downstream effector of JAK/STAT signalling and a regulator of Rho1 in Drosophila haematopoiesis. J Cell Sci. PubMed ID: 24163435
Berset, T. A., Hoier, E. F. and Hajnal, A. (2005). The C. elegans homolog of the mammalian tumor suppressor Dep-1/Scc1 inhibits EGFR signaling to regulate binary cell fate decisions. Genes Dev 19: 1328-1340. PubMed ID: 15901674
Besson, A., et al. (2004). p27Kip1 modulates cell migration through the regulation of RhoA activation. Genes Dev. 18: 862-876. 15078817
Bikkavilli, R. K., Feigin, M. E. and Malbon, C. C. (2008). G alpha o mediates WNT-JNK signaling through dishevelled 1 and 3, RhoA family members, and MEKK 1 and 4 in mammalian cells. J Cell Sci. 121(Pt 2): 234-45. PubMed Citation: 18187455
Billuart, P., Winter, C. G., Maresh, A., Zhao, X. and Luo, L. (2001). Regulating axon branch stability. the role of p190 RhoGAP in repressing a retraction signaling pathway. Cell 107(2): 195-207. 11672527
Birkenfeld, J., et al. (2007). GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases. Dev. Cell 12(5): 699-712. PubMed citation: 17488622
Bischoff, M. (2012). Lamellipodia-based migrations of larval epithelial cells are required for normal closure of the adult epidermis of Drosophila. Dev Biol 363(1): 179-190. PubMed ID: 22230614
Bischoff, M. C., Lieb, S., Renkawitz-Pohl, R. and Bogdan, S. (2021). Filopodia-based contact stimulation of cell migration drives tissue morphogenesis. Nat Commun 12(1): 791. PubMed ID: 33542237
Bito, H., et al. (2000). A critical role for a Rho-associated kinase, p160ROCK, in determining axon outgrowth in mammalian CNS neurons. Neuron 26: 431-441. PubMed Citation: 10839361
Bloor, J. W. and Kiehart, D. P. (2001). zipper nonmuscle Myosin-II functions downstream of PS2 integrin in Drosophila myogenesis and is necessary for myofibril formation. Dev. Biol. 239: 215-228. PubMed Citation: 11784030
Bloor, J. W. and Kiehart, D. P. (2002). Drosophila RhoA regulates the cytoskeleton and cell-cell adhesion in the developing epidermis. Development 129: 3173-3183. 12070092
Boutros, M., et al. (1998). Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. Cell 94(1): 109-118. PubMed Citation: 9674432
Brouns, M. R., et al. (2000). The adhesion signaling molecule p190 RhoGAP is required for morphogenetic processes in neural development. Development 127: 4891-4903. 11044403
Brouns, M. R., Matheson, S. F. and Settleman, J. (2001). p190 RhoGAP is the principal Src substrate in brain and regulates axon outgrowth, guidance and fasciculation. Nat. Cell Biol. 3: 361-367. 11283609
Brumby, A. M., Goulding, K. R., Schlosser, T., Loi, S., Galea, R., Khoo, P., Bolden, J. E., Aigaki, T., Humbert, P. O. and Richardson, H. E. (2011). Identification of novel Ras-cooperating oncogenes in Drosophila melanogaster: a RhoGEF/Rho-family/JNK pathway is a central driver of tumorigenesis. Genetics 188: 105-125. PubMed ID: 21368274
Burbelo, P. D., et al. (1995). p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking. J. Biol. Chem. 270(52): 30919-30926
Cali G., et al. (1999). RhoA activity is required for fibronectin assembly and counteracts beta1B integrin inhibitory effect in FRT epithelial cells. J. Cell Sci. 112 ( Pt 6): 957-65
Carnac, G., et al. (1998). RhoA GTPase and serum response factor control selectively the expression of MyoD without affecting myf5 in mouse myoblasts. Mol. Biol. Cell 9(7): 1891-1902
Causeret, F., et al. (2004). Distinct roles of Rac1/Cdc42 and Rho/Rock for axon outgrowth and nucleokinesis of precerebellar neurons toward netrin 1. Development 131: 2841-2852. 15151987
Cen, B., Selvaraj, A., Burgess, R. C., Hitzler, J. K., Ma, Z., Morris, S. W. and Prywes, R. (2003). Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes. Mol. Cell. Biol. 23: 6597-6608. 12944485
Chabot, C., Spring, K., Gratton, J. P., Elchebly, M. and Royal, I. (2009). New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival. Mol Cell Biol 29: 241-253. PubMed ID: 18936167
Chang, J. H., et al. (1998). The small GTP-binding protein Rho potentiates AP-1 transcription in T cells. Mol. Cell. Biol. 18(9): 4986-93
Chen, G-C., Gajowniczek, P. and Settleman, J. (2004). Rho-LIM kinase signaling regulates ecdysone-induced gene expression and morphogenesis during Drosophila metamorphosis. Current Biol. 14: 309-313. 14972681
Chen, G. C., et al. (2005). Regulation of Rho and Rac signaling to the actin cytoskeleton by Paxillin during Drosophila development. Molec. Cell. Biol. 25: 979-987. 15657426
Chihara, K., et al. (1997). Cytoskeletal rearrangements and transcriptional activation of c-fos serum response element by Rho-kinase. J. Biol. Chem. 272(40): 25121-25127
Chenouard, N., Xuan, F. and Tsien, R. W. (2020). Synaptic vesicle traffic is supported by transient actin filaments and regulated by PKA and NO. Nat Commun 11(1): 5318. PubMed ID: 33087709
Chong, L. D., et al. (1994). The small GTP-binding protein Rho regulates a phosphatidylinositol
4-phosphate 5-kinase in mammalian cells. Cell 79(3): 507-13
Cid, V. J., et al. (1998). A mutation in the Rho1-GAP-encoding gene BEM2 of Saccharomyces cerevisiae affects morphogenesis and cell wall
functionality. Microbiology 144( Pt 1): 25-36
Clark, E. A., et al. (1998). Integrin-mediated signals regulated by members of the rho family of GTPases. J. Cell Biol. 142(2): 573-86
Clark, E. A., et al. (2000). Genomic analysis of metastasis reveals an essential role for RhoC. Nature 406: 532-535.
Clayton, L., Hall, A. and Johnson, M. H. (1999). A role for Rho-like GTPases in the polarisation of mouse eight-cell blastomeres. Dev. Biol. 205(2): 322-331
Cook, T. A., et al. (1998). Rho guanosine triphosphatase mediates the selective stabilization of microtubules induced by lysophosphatidic acid. J. Cell Biol. 141(1): 175-185
Companys, P., Norris, A. and Bischoff, M. (2020). Coordination of cytoskeletal dynamics and cell behaviour during Drosophila abdominal morphogenesis. J Cell Sci 133(6). PubMed ID: 32229579
Costa, M., Wilson, E. T. and Wieschaus, E. (1994).
A putative cell signal encoded by the folded gastrulation gene coordinates cell shape changes during Drosophila gastrulation. Cell 76 (6): 1075-1089. Medline abstract: 8137424
Cox, E. A., Sastry, S. K. and Huttenlocher, A. (2001). Integrin-mediated adhesion regulates cell polarity and membrane protrusion through the rho family of GTPases. Mol. Biol. Cell 12: 265-277. 11179414
Crawford, J. M., et al. (1998). Cellularization in Drosophila melanogaster is disrupted by the inhibition of Rho activity and the activation of Cdc42 function. Dev. Biol. 204(1): 151-64
Dadke, D., Jarnik, M., Pugacheva, E. N., Singh, M. K. and Golemis, E. A. (2006). Deregulation of HEF1 impairs M-phase progression by disrupting the RhoA activation cycle. Mol. Biol. Cell 17(3): 1204-17. 16394104
Dahlgaard, K., Raposo, A. A., Niccoli, T. and St Johnston, D. (2007). Capu and Spire assemble a cytoplasmic actin mesh that maintains microtubule organization in the Drosophila oocyte. Dev. Cell 13(4): 539-53. PubMed Citation: 17925229
Dalpé, G., et al. (2004). Conversion of cell movement responses to Semaphorin-1 and Plexin-1 from attraction to repulsion by lowered levels of specific RAC GTPases in C. elegans. Development 131: 2073-2088. 15073148
Danen, E. H., et al. (2000). Dual stimulation of Ras/Mitogen-activated protein kinase and RhoA by cell adhesion to fibronectin supports growth factor-stimulated cell cycle progression. J. Cell Biol. 151(7): 1413-1422. 11134071
D'Avino, P. P., Savoian, M. S. and Glover, D. M. (2004). Mutations in sticky lead to defective organization of the contractile ring during cytokinesis and are enhanced by Rho and suppressed by Rac. J. Cell Biol. 166(1):61-71. 15240570
Dean, S. O., Rogers, S. L., Stuurman, N., Vale, R. D. and Spudich, J. A. (2005).
Distinct pathways control recruitment and maintenance of myosin II at the cleavage
furrow during cytokinesis. Proc. Natl. Acad. Sci. 102(38): 13473-8. 16174742
Debant, A., et al. (1996). The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has
separate rac-specific and rho-specific guanine nucleotide exchange
factor domains. Proc. Natl. Acad. Sci. 93(11): 5466-5471
Dehapiot, B., Clement, R., Alegot, H., Gazso-Gerhat, G., Philippe, J. M. and Lecuit, T. (2020). Assembly of a persistent apical actin network by the formin Frl/Fmnl tunes epithelial cell deformability. Nat Cell Biol. PubMed ID: 32483386
de Bettignies, G., et al. (2001). Overactivation of the Protein kinase C-signaling pathway suppresses the defects of cells lacking the Rho3/Rho4-GAP Rgd1p in Saccharomyces cerevisiae. Genetics 159: 1435-1448. 11779787
Deng, X., et al. (2003). Mirk/dyrk1B is a Rho-induced kinase active in skeletal muscle differentiation.
J. Biol. Chem. 278(42): 41347-54. 12902328
Denholm, B., Brown, S., Ray, R. P., Ruiz-Gomez, M., Skaer, H and Hombria, J. C. (2005). crossveinless-c is a RhoGAP required for actin reorganisation during morphogenesis.
Development 132(10): 2389-400. 15843408
Derewenda, U., et al. (2004). The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF, an activator of the Ca(2+) sensitization pathway in smooth muscle. Structure 12(11): 1955-65. Medline abstract: 15530360
Desai, R. A., Gao, L., Raghavan, S., Liu, W. F. and Chen, C. S. (2009). Cell polarity triggered by cell-cell adhesion via E-cadherin. J Cell Sci 122(Pt 7): 905-911. PubMed ID: 19258396
Di Cunto, F., et al. (1998). Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron. J. Biol. Chem. 273(45): 29706-11
Diogon, M., et al. (2007). The RhoGAP RGA-2 and LET-502/ROCK achieve a balance of actomyosin-dependent forces in C. elegans epidermis to control morphogenesis. Development 134: 2469-2479. Medline abstract: 17537791
di Pietro, F., Osswald, M., De Las Heras, J. M., Cristo, I., Lopez-Gay, J., Wang, Z., Pelletier, S., Gaugue, I., Leroy, A., Martin, C., Morais-de-Sa, E. and Bellaiche, Y. (2023). Systematic analysis of RhoGEF/GAP localizations uncovers regulators of mechanosensing and junction formation during epithelial cell division. Curr Biol 33(5): 858-874.e857. PubMed ID: 36917931
Dong, J. M., et al. (1998). cAMP-induced morphological changes are counteracted by the activated RhoA small GTPase and the Rho kinase ROKalpha. J. Biol. Chem. 273(35): 22554-22562
Estrach, S., et al. (2002). The human Rho-GEF Trio and its target GTPase RhoG are involved in the NGF pathway, leading to neurite outgrowth. Curr. Biol. 12: 307-312. 11864571
Fanto, M., et al. (2000). Nuclear signaling by Rac and Rho GTPases is required in the establishment of epithelial planar polarity in the Drosophila eye. Curr. Biol. 10: 979-988. PubMed ID: 10985385
Ferreira, T., Prudencio, P. and Goncalo Martinho, R. (2014). Drosophila protein kinase N (Pkn) is a negative regulator of actin-myosin activity during oogenesis. Dev Biol 394(2): 277-91. PubMed ID: 25131196
Fincham, V. J., Chudleigh, A. and Frame, M. C. (1999). Regulation of p190 Rho-GAP by v-Src is linked to cytoskeletal disruption during transformation. J. Cell Sci. 112 ( Pt 6): 947-56
Fox, D. T., Homem, C. C., Myster, S. H., Wang, F., Bain, E. E. and Peifer, M. (2005). Rho1 regulates Drosophila adherens junctions independently of p120ctn.
Development 132(21): 4819-31. 16207756
Fox, D. T. and Peifer, M. (2007). Abelson kinase (Abl) and RhoGEF2 regulate actin organization during cell constriction in Drosophila. Development 134(3): 567-78. Medline abstract: 17202187
Fritz, J. L. and VanBerkum, M. F. A. (2002). Regulation of rho family GTPases is required to prevent axons from crossing the midline. Dev. Bio. 252: 46-58. 12453459
Fujisawa, K., et al. (1996). Identification of the Rho-binding domain of p160ROCK, a
Rho-associated coiled-coil containing protein kinase. J. Biol. Chem. 271(38): 23022-23028
Fukuhara, S., et al. (1999). A novel PDZ domain containing guanine nucleotide exchange
factor links heterotrimeric G proteins to Rho. J. Biol. Chem. 274(9): 5868-79.
Furuyashiki, T., et al. (1999). Citron, a Rho-target, interacts with PSD-95/SAP-90 at glutamatergic synapses in
the thalamus. J. Neurosci. 19(1): 109-18
Geneste, O., Copeland, J.W., and Treisman, R. (2002). LIM kinase and Diaphanous cooperate to regulate serum response factor and actin dynamics. J. Cell Biol. 157: 831-838. 12034774
Gohla, A., Harhammer, R., and Schultz, G. (1998). The G-protein G13 but not G12 mediates signaling from lysophosphatidic acid receptor via epidermal growth factor receptor to Rho. J. Biol. Chem. 273(8): 4653-4659
Goode, B. L. and Eck, M. J. (2007). Mechanism and function of formins in the control of actin assembly. Annu. Rev. Biochem. 76: 593-627. PubMed Citation: 17373907
Grazia Lampugnani, M., Zanetti, A., Corada, M., Takahashi, T., Balconi, G., Breviario, F., Orsenigo, F., Cattelino, A., Kemler, R., Daniel, T. O. and Dejana, E. (2003). Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148. J Cell Biol 161: 793-804. PubMed ID: 12771128
Hsieh, H. H., Chang, W. T., Yu, L. and Rao, Y. (2014). Control of axon-axon attraction by Semaphorin reverse signaling. Proc Natl Acad Sci U S A. 111(31):11383-8. PubMed ID: 25049408
Jeon, M., Nguyen, H., Bahri, S. and Zinn, K. (2008). Redundancy and compensation in axon guidance: genetic analysis of the Drosophila Ptp10D/Ptp4E receptor tyrosine phosphatase subfamily. Neural Dev 3: 3. PubMed ID: 18237413
Jeon, M. and Zinn, K. (2009). Receptor tyrosine phosphatases control tracheal tube geometries through negative regulation of Egfr signaling. Development 136: 3121-3129. PubMed ID: 19675131
Jeon, M., Scott, M. P. and Zinn, K. (2012). Interactions between Type III receptor tyrosine phosphatases and growth factor receptor tyrosine kinases regulate tracheal tube formation in Drosophila. Biol Open 1: 548-558. PubMed ID: 23213447
Grosshans, J., Wenzl, C., Herz, H. M., Bartoszewski, S., Schnorrer, F., Vogt, N., Schwarz, H. and Muller, H. A. (2005). RhoGEF2 and the formin Dia control the formation of the furrow canal by directed actin assembly during Drosophila cellularisation. Development 132(5): 1009-20. 15689371
Guettler, S., Vartiainen, M. K., Miralles, F., Larijani, B. and Treisman, R. (2008). RPEL motifs link the serum response factor cofactor MAL but not myocardin to Rho signaling via actin binding. Mol. Cell Biol. 28(2): 732-42. PubMed Citation: 18025109
Guo, W., Tamanoi, F. and Novick, P. (2001). Spatial regulation of the exocyst
complex by Rho1 GTPase. Nat. Cell Biol. 3: 353-360. 11283608
Habas, R., Kato, Y. and He, X. (2001). Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel formin homology protein Daam1. Cell 107: 843-854. 11779461
Hacker, U. and Perrimon, N. (1998). DRhoGEF2 encodes a member of the Dbl family of oncogenes and controls cell shape changes during gastrulation in Drosophila. Genes Dev. 12: 274-284
Halsell, S. R., Chu, B. I. and Kiehart, D. P. (2000). Genetic analysis demonstrates a direct link between Rho
signaling and nonmuscle myosin function during Drosophila
morphogenesis. Genetics 155: 1253-1265
Harden, N., et al. (1999). Participation of small GTPases in dorsal closure of the Drosophila embryo: distinct roles for Rho subfamily proteins in epithelial morphogenesis. J. Cell Sci. 112: 273-84. 99104229
Hariharan, I. K., et al. (1995). Characterization of rho GTPase family homologues in Drosophila melanogaster: overexpressing Rho1 in retinal cells causes a late developmental defect. EMBO J 14 (2): 292-302
Hart, M. J., et al. (1998). Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13. Science 280(5372): 2112-2114
Helliwell, S. B., et al. (1998). The Rho1 effector Pkc1, but not Bni1, mediates signalling from Tor2 to the actin
cytoskeleton. Curr. Biol. 8(22): 1211-4
Heo, W. D. and Meyer, T. (2003). Switch-of-function mutants based on morphology classification of ras superfamily small GTPases. Cell 113: 315-328. 12732140
Hicks, M. S., et al. (2001). DrhoGEF3 encodes a new Drosophila DH domain protein that exhibits a highly dynamic embryonic expression pattern. Dev Genes Evol: 211: 263-267. 11455443
Hickson, G. R. and O'Farrell, P. H. (2008). Rho-dependent control of anillin behavior during cytokinesis. J. Cell Biol. 180(2): 285-94. PubMed citation: 18209105
Hidalgo-Carcedo, C., et al. (2011). Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6. Nat. Cell Biol. 13(1): 49-58. PubMed Citation: 21170030
Hildebrand, J. D., Taylor, J. M. and Parsons, J. T. (1996). An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase. Mol. Cell. Biol. 16(6): 3169-3178. PubMed Citation: 8649427
Hill, C. S., Wynne, J. and Treisman, R. (1995). The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate
transcriptional activation by SRF. Cell 81(7): 1159-1170. PubMed Citation: 7600583
Homem, C. C. F. and Peifer, M. (2008). Diaphanous regulates myosin and adherens junctions to control cell contractility and protrusive behavior during morphogenesis. Development 135: 1005-1018. PubMed Citation: 18256194
Hornstein, I., Mortin, M. A. and Katzav, S. (2003). DroVav, the Drosophila melanogaster homologue of the mammalian Vav proteins, serves as a signal transducer protein in the Rac and DER pathways. Oncogene 22: 6774-6784. PubMed citation: 14555990
Hu, H., Marton, T. F. and Goodman, C. S. (2001). Plexin B mediates axon guidance in Drosophila by simultaneously inhibiting active Rac and enhancing RhoA signaling. Neuron 32: 39-51. 11604137
Imamura, H., et al. (1998). Rho and Rab small G proteins coordinately reorganize stress fibers and focal
adhesions in MDCK cells. Mol. Biol. Cell 9(9): 2561-75. PubMed Citation: 9725912
Ishizaki, T, et al. (1996). The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy
kinase. EMBO J. 15(8): 1885-1893. PubMed Citation: 8617235
Ishizaki, T., et al. (1997). p160ROCK, a Rho-associated coiled-coil forming protein kinase,
works downstream of Rho and induces focal adhesions. FEBS Lett. 404(2-3): 118-124. PubMed Citation: 9119047
Izquierdo, E., Quinkler, T. and De Renzis, S. (2018). Guided morphogenesis through optogenetic activation of Rho signalling during early Drosophila embryogenesis. Nat Commun 9(1): 2366. PubMed ID: 29915285
Iyer, S. C., Wang, D., Iyer, E. P., Trunnell, S. A., Meduri, R., Shinwari, R., Sulkowski, M. J. and Cox, D. N. (2012). The RhoGEF trio functions in sculpting class specific dendrite morphogenesis in Drosophila sensory neurons. PLoS One 7: e33634. PubMed ID: 22442703
Jacinto, A., et al. (2002). Dynamic analysis of actin cable function during Drosophila dorsal closure. Curr. Biol. 12: 1245-1250. 12176336
Jaffe, A. B., Aspenstrom, P. and Hall, A. (2004). Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways. Mol. Cell Biol. 24(4): 1736-46. 14749388
Jaffe, A. B., Hall, A. and Schmidt, A. (2005). Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho.
Curr. Biol. 15(5): 405-12. 15753034
Jha, A., van Zanten, T. S., Philippe, J. M., Mayor, S. and Lecuit, T. (2018). Quantitative control of GPCR
organization and signaling by endocytosis in epithelial morphogenesis.
Curr Biol 28(10): 1570-1584 PubMed ID: 29731302
Jou, T. S. and Nelson, W. J. (1998a). Effects of regulated expression of mutant RhoA and Rac1 small GTPases
on the development of epithelial (MDCK) cell polarity. J. Cell Biol. 142(1): 85-100
Jou, T. S, Schneeberger, E. E. and Nelson, W. J. (1998b). Structural and functional regulation of tight junctions by RhoA and Rac1
small GTPases. J. Cell Biol. 142(1): 101-15
Kanamori T., et al. (2008). β-Catenin asymmetry is regulated by PLA1 and retrograde traffic in C. elegans stem cell divisions. EMBO J. 27: 1647-1657. PubMed Citation: 18497747
Kawano, Y., et al. (1999). Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo.
J. Cell Biol. 147(5): 1023-38.
Kappert, K., Paulsson, J., Sparwel, J., Leppanen, O., Hellberg, C., Ostman, A. and Micke, P. (2007). Dynamic changes in the expression of DEP-1 and other PDGF receptor-antagonizing PTPs during onset and termination of neointima formation. FASEB J 21: 523-534. PubMed ID: 17158785
Kerridge, S., Munjal, A., Philippe, J. M., Jha, A., de Las Bayonas, A. G., Saurin, A. J. and Lecuit, T. (2016). Modular activation of Rho1 by GPCR signalling imparts polarized myosin II activation during morphogenesis. Nat Cell Biol 18(3): 261-70. PubMed ID: 26780298
Kimura, K., et al. (1996). Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science 273(5272): 245-8
Klages, B., et al. (1999). Activation of G12/G13 results in shape change and
Rho/Rho-kinase-mediated myosin light chain phosphorylation in
mouse platelets. J. Cell Biol. 144(4): 745-754
Kolesnikov, T. and Beckendorf, S. K. (2007). 18 wheeler regulates apical constriction of salivary gland cells via the Rho-GTPase-signaling pathway. Dev. Biol. 307(1): 53-61. Medline abstract: 17512518
Koyano, Y., et al (1997). Molecular cloning and characterization of CDEP, a novel human
protein containing the ezrin-like domain of the band 4.1 superfamily
and the Dbl homology domain of Rho guanine nucleotide exchange
factors. Biochem. Biophys. Res. Commun. 241(2): 369-375
Kozasa, T., et al. (1998). p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13. Science 280(5372): 2109-2111
Krugmann, S., et al. (2004). ARAP3 is a PI3K- and Rap-Regulated
GAP for RhoA. Curr. Biol. 14: 1380-1384. 15296756
Kumakiri, J., et al. (2003). Involvement of Rho family G protein in the cell signaling for sperm incorporation during fertilization of mouse eggs: inhibition by Clostridium difficile toxin B. Dev. Bio. 260: 522-535. 12921750
Kunwar, P. S., Sano, H., Renault, A. D., Barbosa, V., Fuse, N. and Lehmann R. (2008). Tre1 GPCR initiates germ cell transepithelial migration by regulating Drosophila melanogaster E-cadherin. J. Cell Biol. 183(1): 157-68. PubMed Citation: 18824569
Kureishi, Y., et al. (1997). Rho-associated kinase directly induces smooth muscle contraction
through myosin light chain phosphorylation. J. Biol. Chem. 272(19): 12257-12260.
Kwan, K. M. and Kirschner, M. W. (2005). A microtubule-binding Rho-GEF controls cell morphology during convergent extension of Xenopus laevis. Development 132(20): 4599-610. 16176947
Ladoux, B. and Mege, R. M. (2017). Mechanobiology of collective cell behaviours. Nat Rev Mol Cell Biol 18(12): 743-757. PubMed ID: 29115298
Latham, V. M., et al. (2001). A Rho-dependent signaling pathway operating through myosin localizes ß-actin mRNA in fibroblasts. Cur. Bio. 11: 1010-1016. 11470405
Lebreton, G. and Casanova, J. (2013). Specification of leading and trailing cell features during collective migration in the Drosophila trachea. J Cell Sci. 127(Pt 2): 465-74. PubMed ID: 24213534
Leblanc, V., Tocque, B. and Delumeau, I. (1998). Ras-GAP controls Rho-mediated cytoskeletal reorganization through
its SH3 domain. Mol. Cell. Biol. 18(9): 5567-78
Lee, D. M. and Harris, T. J. (2013). An Arf-GEF Regulates Antagonism between Endocytosis and the Cytoskeleton for Drosophila Blastoderm Development. Curr Biol 23: 2110-2120. PubMed ID: 24120639
Lee, S. and Kolodziej, P. A. (2002). The plakin Short stop and the RhoA GTPase are required for E-cadherin-dependent apical surface remodeling during tracheal tube fusion. Development 129: 1509-1520. 11880359
Lee, S. and Helfman, D. M. (2003). Cytoplasmic p21Cip1 is involved in Ras-induced inhibition of the ROCK/LIMK/Cofilin pathway. J. Biol. Chem. 279: 1885-1891. 14559914
Lee, T., et al. (2000). Essential roles of Drosophila RhoA in the regulation of
neuroblast proliferation and dendritic but not axonal
morphogenesis. Neuron 25: 307-316.
Lehmann, M., et al. (1999). Inactivation of Rho signaling pathway promotes CNS axon regeneration. J. Neurosci. 19(17): 7537-7547
Leverrier, Y. and Ridley, A. J. (2001). Requirement for Rho GTPases and PI 3-kinases during apoptotic cell phagocytosis by macrophages. Curr. Biol. 11: 195-199. 11231156
Li, B. X., Satoh. A. K. and Ready, D. F. (2007). Myosin V, Rab11, and dRip11 direct apical secretion and cellular morphogenesis in developing Drosophila photoreceptors. J. Cell Biol. 177: 659-669. PubMed Citation: 17517962
Li, S., Tian, A., Li, S., Han, Y., Wang, B. and Jiang, J. (2020). Gilgamesh (Gish)/CK1gamma regulates tissue homeostasis and aging in adult Drosophila midgut. J Cell Biol 219(4). PubMed ID: 32328627
Li, Z., Aizenman, C. D. and Cline, H. T. (2002). Regulation of Rho GTPases by crosstalk and neuronal activity in vivo. Neuron 33: 741-750. 11879651
Liu, J. P. and Jessell, T. M. (1998). A role for rhoB in the delamination of neural crest cells from the
dorsal neural tube. Development 125(24): 5055-5067
Liu, R., Abreu-Blanco, M. T., Barry, K. C., Linardopoulou, E. V., Osborn, G. E. and Parkhurst, S. M. (2008). Wash functions downstream of Rho and links linear and branched actin nucleation factors. Development 136(16): 2849-60. PubMed Citation: 19633175
Lopez-Ilasaca, M. A., Bernabe-Ortiz, J. C., Na, S. Y., Dzau, V. J. and Xavier, R. J. (2005). Bioluminescence resonance energy transfer identify scaffold protein CNK1 interactions in intact cells. FEBS Lett. 579(3): 648-54. 15670823
Lu, J., et al. (2001). Coronary smooth muscle differentiation from proepicardial cells requires RhoA-mediated actin reorganization and p160 Rho-kinase activity. Dev. Biol. 240(2): 404-418. 11784072
Lu, Y. and Settleman, J. (1999). The Drosophila Pkn protein kinase is a Rho/Rac effector target required for dorsal closure
during embryogenesis. Genes Dev. 13(9): 1168-80. PubMed Citation: 10323867
Lutz, S., et al. (2007). Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs. Science 318(5858): 1923-7. PubMed citation: 18096806
Ma, X., Chen, Y., Xu, W., Wu, N., Li, M., Cao, Y., Wu, S., Li, Q. and Xue, L. (2015). Impaired Hippo signaling promotes Rho1-JNK-dependent growth. Proc Natl Acad Sci USA. 112(4):1065-70. PubMed ID: 25583514
Machacek, M., et al. (2009). Coordination of Rho GTPase activities during cell protrusion. Nature 461(7260): 99-103. PubMed Citation: 19693013
Maekawa, M., et al. (1999). Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. Science 285(5429): 895-8. PubMed Citation: 10436159
Magie, C. R., et al. (1999). Mutations in the Rho1 small GTPase disrupt
morphogenesis and segmentation during early Drosophila development
Development 126: 5353-5364. PubMed Citation: 10556060
Magie, C. R., Pinto-Santini, D. and Parkhurst, S. M. (2002). Rho1 interacts with p120ctn and alpha-catenin, and regulates cadherin-based adherens junction components in Drosophila. Development 129: 3771-3782. 12135916
Magie, C. R. and Parkhurst, S. M. (2005). Rho1 regulates signaling events required for proper Drosophila embryonic development. Dev. Biol. 278(1): 144-54. 15649467
Manning, B. D., Padmanabha, R. and Snyder, M. (1997). The Rho-GEF Rom2p localizes to sites of polarized cell growth and
participates in cytoskeletal functions in Saccharomyces cerevisiae. Mol. Biol. Cell 8(10): 1829-1844
Manning, A. J., Peters, K. A., Peifer, M. and Rogers, S. L. (2013). Regulation of epithelial morphogenesis by the G protein-coupled receptor mist and its ligand fog. Sci Signal 6: ra98. PubMed ID: 24222713
Mao, J., et al. (1998a). Tec/Bmx non-receptor tyrosine kinases are involved in regulation of
Rho and serum response factor by Galpha12/13. EMBO J. 17(19): 5638-5646
Mao, J., et al. (1998b). Guanine nucleotide exchange factor GEF115 specifically mediates
activation of Rho and serum response factor by the G protein alpha
subunit Galpha13. Proc. Natl. Acad. Sci. 95(22): 12973-6
Marquitz, A. R., et al. (2002). The Rho-GAP Bem2p plays a GAP-independent role in the morphogenesis checkpoint. EMBO J. 21: 4012-4025. 12145202
Massarwa, R., Schejter, E. D. and Shilo, B.-Z. (2009). Apical secretion in epithelial tubes of the Drosophila embryo is directed by the formin-family protein Diaphanous. Dev. Cell 16: 877-888. PubMed Citation: 19531358
Matusek, T., Djiane, A., Jankovics, F., Brunner, D., Mlodzik, M. and Mihaly, J. (2006). The Drosophila formin DAAM regulates the tracheal cuticle pattern through organizing the actin cytoskeleton. Development 133(5): 957-66. 16469972
Matsui, T., et al. (1998). Rho-Kinase Phosphorylates COOH-terminal Threonines of
Ezrin/Radixin/Moesin (ERM) Proteins and Regulates Their
Head-to-Tail Association. J. Cell Biol. 140(3):647-657
Matsui, T., et al. (2005). Noncanonical Wnt signaling regulates midline convergence of organ primordia during zebrafish development. Genes Dev. 19(1): 164-75. 15630025
McBeath, R., et al. (2003). Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev. Cell 6: 483-495. 15068789
McMullan, R., et al. (2004). Keratinocyte differentiation is regulated by the Rho and ROCK signaling pathway. Curr. Biol. 13: 2185-2189. 14680635
Michaelson, D., et al. (2001). Differential localization of Rho GTPases in live cells. Regulation by hypervariable regions and rhoGDI binding. J. Cell Biol. 152(1): 111-126. 11149925
Ming, G. L., et al. (1997). cAMP-dependent growth cone guidance by Netrin-1. Neuron 19(6): 1225-1235. PubMed Citation: 9427246
Minoshima, Y., et al. (2003). Phosphorylation by Aurora B converts MgcRacGAP to a RhoGAP during cytokinesis. Developmental Cell 4: 549-560. 12689593
Miralles, F., Posern, G., Zaromytidou, A.I. and Treisman, R. (2003). Actin dynamics control SRF activity by regulation of its coactivator MAL. Cell 113: 329-342. 12732141
Mizuno, T., Amano, M., Kaibuchi, K. and Nishida, Y. (1999). Identification and characterization of Drosophila homolog of Rho-kinase. Gene 238(2): 437-444. 10570971
Montresor, A., Bolomini-Vittori, M., Toffali, L., Rossi, B., Constantin, G. and Laudanna, C. (2013). JAK tyrosine kinases promote hierarchical activation of Rho and Rap modules of integrin activation. J Cell Biol 203: 1003-1019. PubMed ID: 24368807
Murphy, A. M. and Montell, D. J. (1996). Cell type-specific roles for Cdc42, Rac, and RhoL in Drosophila oogenesis. J. Cell Biol. 133: 617-630. PubMed ID: 8636236
Murray, M. J., Ng, M. M., Fraval, H., Tan, J., Liu, W., Smallhorn, M., Brill, J. A., Field, S. J. and Saint, R. (2012). Regulation of Drosophila mesoderm migration by phosphoinositides and the PH domain of the Rho GTP exchange factor Pebble. Dev Biol 372: 17-27. PubMed ID: 23000359
Myster, S. H., Cavallo, R., Anderson, C. T., Fox, D. T. and Peifer, M. (2003). Drosophila p120 catenin plays a supporting role in cell adhesion but is not an essential adherens junction component. J. Cell Biol. 160: 433-449. 12551951
Nakahara, H., et al. (1998). Activation of beta1 integrin signaling stimulates tyrosine phosphorylation of p190RhoGAP and membrane-protrusive
activities at invadopodia. J. Biol. Chem. 273(1): 9-12. PubMed ID: 9417037
Neisch, A. L., Formstecher, E. and Fehon, R. G. (2013). Conundrum, an ARHGAP18 orthologue, regulates RhoA and proliferation through interactions with Moesin. Mol Biol Cell 24: 1420-1433. PubMed ID: 23468526
Ng, J. (2008). TGF-β signals regulate axonal development through distinct Smad-independent mechanisms. Development 135(24): 4025-35. PubMed Citation: 19004854
Niiya, F., Xie, X., Lee, K. S., Inoue, H. and Miki, T. (2005).
Inhibition of cyclin-dependent kinase 1 induces cytokinesis without
chromosome segregation in an ECT2 and MgcRacGAP-dependent manner.
J. Biol. Chem. 280(43): 36502-9. 16118207
Niiya, F., et al. (2006). Phosphorylation of the cytokinesis regulator ECT2 at G2/M phase stimulates association of the mitotic kinase Plk1 and accumulation of GTP-bound RhoA. Oncogene 25: 827-837. PubMed citation: 16247472
Nikolaidou, K. K. and Barrett, K. (2004). A Rho GTPase signaling pathway is used reiteratively in epithelial folding and potentially selects the outcome of Rho activation. Curr. Biol. 14: 1822-1826. 15498489
Nishimura, Y. and Yonemura, S. (2006). Centralspindlin regulates ECT2 and RhoA accumulation at the equatorial cortex during cytokinesis. J. Cell Sci. 119: 104-114. PubMed citation: 16352658
Nobes, C. D., et al. (1998). A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion. J. Cell. Biol. 141(1): 187-197
Nolan, K.M., et al. (1998). Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a rac signaling pathway utilized for multiple developmental processes. Genes Dev. 12: 3337-3342
Noren, N. K., Liu, B. P., Burridge, K. and Kreft, B. (2000). p120ctn regulates the actin cytoskeleton via Rho family GTPases. J. Cell Biol. 150: 567-57. 10931868
O'Connell, C. B., et al. (1999). The small GTP-binding protein rho regulates cortical activities in
cultured cells during division. J. Cell Biol. 144(2): 305-13
Olson, M. F., Paterson, H. F. and Marshall, C. J. (1998). Signals from Ras and Rho GTPases interact to regulate expression of
p21Waf1/Cip1. Nature 394: 295-299
Otomo, T., Otomo, C., Tomchick, D. R., Machius, M. and Rosen, M. K. (2005). Structural basis of Rho GTPase-mediated activation of the formin mDia1. Mol. Cell 18: 273-281. 15866170
Padash Barmchi, M., Rogers, S. and Hacker, U. (2005). DRhoGEF2 regulates actin organization and contractility in the Drosophila blastoderm embryo. J. Cell Biol. 168: 575-585. 15699213
Palka, H. L., Park, M. and Tonks, N. K. (2003). Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1. J Biol Chem 278: 5728-5735. PubMed ID: 12475979
Panizzi, J. R., et al. (2007). New functions for a vertebrate Rho guanine nucleotide exchange factor in ciliated epithelia. Development 134: 921-931. Medline abstract: 17267448
Parnas, D., Haghighi, A. P., Fetter, R. D., Kim, S. W. and Goodman, C. S. (2001). Regulation of postsynaptic structure and protein localization by the Rho-type guanine nucleotide exchange factor dPix. Neuron 32(3): 415-24. 11709153
Perrot, V., Vazquez-Prado, J., Gutkind, J. S. (2002). Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF. J. Biol. Chem. 277(45): 43115-20. Medline abstract: 12183458
Philippar, U., et al. (2004). The SRF target gene Fhl2 antagonizes RhoA/MAL-dependent activation of SRF. Mol. Cell 16(6): 867-80. PubMed Citation: 15610731
Piekny, A. J. and Glotzer, M. (2008). Anillin is a scaffold protein that links RhoA, actin, and myosin during cytokinesis. Curr. Biol. 18(1): 30-6. PubMed Citation: 18158243
Prokopenko, S. N., Saint, R. and Bellen, H. J. (2000). Tissue distribution of PEBBLE RNA and Pebble protein during Drosophila embryonic
development. Mech. Dev. 90: 269-273
Qualmann, B. and Kessels, M. M. (2009). New players in actin polymerization - WH2-domain-containing actin nucleators. Trends Cell Biol. 19: 276-285. PubMed Citation: 19406642
Quilliam, L. A., et al. (1996). Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling. J. Biol. Chem. 271(46): 28772-28776
Raghavan, S., Vaezi, A. and Fuchs, E. (2003). A role for alphaß1 integrins in focal adhesion function and polarized cytoskeletal dynamics. Dev. Cell 5: 415-427. 12967561
Raymond, K., et al. (2004). A screen for modifiers of RacGAP(84C) gain-of-function in the Drosophila eye revealed the LIM kinase Cdi/TESK1 as a downstream effector of Rac1 during spermatogenesis. J. Cell Sci. 117(Pt. 13): 2777-2789. 15169836
Ren, X. D. and Schwartz, M. A. (1998). Regulation of inositol lipid kinases by Rho and Rac. Curr. Opin. Genet. Dev. 8(1): 63-7
Ren, X. D., Kiosses, W. B. and Schwartz, M. A. (1999). Regulation of the small GTP-binding protein Rho by cell adhesion
and the cytoskeleton. EMBO J. 18(3): 578-585
Reverte, C. G., et al. (2003). XGef is a CPEB-interacting protein involved
in Xenopus oocyte maturation. Dev. Bio. 255: 383-398. 12648498
Ricos, M. G., et al. (1999). Dcdc42 acts in TGF-beta signaling during Drosophila morphogenesis: distinct roles for the Drac1/JNK and Dcdc42/TGF-beta cascades in cytoskeletal regulation. J. Cell Sci. 112: 1225-35
Rittinger, K., et al. (1997). Crystal structure of a small G protein in complex with the
GTPase-activating protein rhoGAP. Nature 388(6643): 693-697
Rosales-Nieves, A. E., et al. (2006). Coordination of microtubule and microfilament dynamics by Drosophila Rho1, Spire and Cappuccino.
Nat. Cell Biol. 8(4): 367-76. 16518391
Rose, R., Weyand, M., Lammers, M., Ishizaki, T., Ahmadian, M. R. and Wittinghofer, A. (2005). Structural and mechanistic insights into the interaction between Rho and mammalian Dia. Nature 435: 513-518. 15864301
Sahai, E., Alberts, A. S. and Treisman, R. (1998). RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transformation. Embo J. 17(5): 1350-1361
Sahai, E., et al. (1999). Transformation mediated by RhoA requires activity of ROCK kinases. Curr. Biol. 9(3): 136-45. PubMed ID: 10021386
Sahai, E., Olson, M. F. and Marshall, C. J. (2001). Cross-talk between Ras and Rho signaling pathways in transformation favours proliferation and increased motility. EMBO J. 20: 755-766. 11179220
Sailem, H., Bousgouni, V., Cooper, S. and Bakal, C. (2014). Cross-talk between Rho and Rac GTPases drives deterministic exploration of cellular shape space and morphological heterogeneity. Open Biol 4: 130132. PubMed ID: 24451547
Sanders, L. C., et al. (1999). Inhibition of myosin light chain kinase by p21-activated kinase. Science 283(5410): 2083-5. PubMed ID: 10092231
Saras, J., et al. (1997). A novel GTPase-activating protein for Rho interacts with a PDZ domain of the protein-tyrosine phosphatase PTPL1. J. Biol. Chem. 272(39): 24333-24338
Sarkar, A., et al. (2007). Antagonistic roles of Rac and Rho in organizing the germ cell microenvironment. Curr. Biol. 17(14): 1253-8. PubMed citation: 17629483
Sasamura, T., et al. (1997). Molecular cloning and characterization of Drosophila
genes encoding small GTPases of the rab and rho
families. Mol. Gen. Genet. 254(5): 486-494
Schock, F. and Perrimon, N. (2002). Cellular processes associated with germ band retraction in Drosophila. Dev. Bio. 248: 29-39. 12142018
Schoenwaelder, S. M., et al. (2000). The protein tyrosine phosphatase Shp-2 regulates RhoA activity. Curr. Biol. 10: 1523-1526. 11114521
Schonegg, S. and Hyman, A. A. (2006). CDC-42 and RHO-1 coordinate acto-myosin contractility and PAR protein localization during polarity establishment in C. elegans embryos. Development 133: 3507-3516. Medline abstract: 16899536
Schonegg, S., Constantinescu, A. T., Hoege, C. and Hyman, A. A. (2007). The Rho GTPase-activating proteins RGA-3 and RGA-4 are required to set the initial size of PAR domains in Caenorhabditis elegans one-cell embryos. Proc. Natl. Acad. Sci. 104(38): 14976-81. Medline abstract: 17848508
Schuebel, K. E., et al. (1998). Phosphorylation-dependent and constitutive activation of Rho
proteins by wild-type and oncogenic Vav-2. EMBO J. 17(22): 6608-21. PubMed Citation: 9822605
Sekyrova, P., Bohmann, D., Jindra, M. and Uhlirova, M. (2010). Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis. Development 137(1): 141-50. PubMed Citation: 20023169
Sepp, K. J. and Auld, V. J. (2003). RhoA and Rac1 GTPases mediate the dynamic rearrangement of actin in peripheral glia. Development 130: 1825-1835. 12642488
Shandala, T., et al. (2004). Citron Kinase is an essential effector of the Pbl-activated Rho signalling pathway in Drosophila melanogaster. Development 131: 5053-5063. 15459099
Shaw, R. J., et al. (1998). RhoA-dependent phosphorylation and relocalization of ERM proteins into apical membrane/actin protrusions in fibroblasts. Mol. Biol. Cell 9(2): 403-419. PubMed Citation: 9450964
Shibasaki, Y., et al. (1997). Massive actin polymerization induced by phosphatidylinositol-4-phosphate
5-kinase in vivo. J. Biol. Chem. 272(12): 7578-81. PubMed Citation: 9065410
Simoes, S., Mainieri, A. and Zallen, J. A. (2014). Rho GTPase and Shroom direct planar polarized actomyosin contractility during convergent extension. J Cell Biol 204: 575-589. PubMed ID: 24535826
Simoes, S., et al. (2006). Compartmentalisation of Rho regulators directs cell invagination during tissue morphogenesis. Development 133: 4257-4267. Medline abstract: 17021037
Sin, W. C., et al., (1998). RhoA-binding kinase alpha translocation is facilitated by the collapse of the vimentin intermediate filament network. Mol. Cell. Biol. 18(11): 6325-39. PubMed Citation: 9774649
Sin, W. C., et al. (2002). Dendrite growth increased by visual activity requires NMDA receptor and Rho GTPases. Nature 419: 475-480. 12368855
Somma, M. P., et al. (2002). Molecular dissection of cytokinesis by RNA interference in Drosophila cultured cells. Mol. Biol. Cell 13: 2448-2460. 12134082
Song, H.-J., Ming, G.-L. and Poo, M.-M. (1997). cAMP-induced switching in turning direction of nerve growth cones. Nature 388: 275-279. PubMed Citation: 9230436
Sordella, R., et al. (2003). Modulation of Rho GTPase signaling regulates a switch between adipogenesis and myogenesis. Cell 113: 147-158. 12705864
Sotiropoulos, A., Gineitis, D., Copeland, J. and Treisman, R. (1999). Signal-regulated activation of serum response factor is mediated by changes in actin dynamics. Cell 98: 159-169. 10428028
Speck, O., Hughes, S. C., Noren, N. K., Kulikauskas, R. M. and Fehon, R. G. (2003). Moesin functions antagonistically to the Rho pathway to maintain epithelial integrity. Nature 421(6918): 83-7. 12511959
Storey, N. M., O'Bryan, J. P. and Armstrong, D. L. (2002). Rac and Rho mediate opposing hormonal regulation of the ether-a-go-go-related potassium channel. Curr. Biol. 12: 27-33. 11790300
Strutt, D. I., Weber. U., and Mlodzik, M. (1997). The role of RhoA in tissue polarity and Frizzled signalling. Nature 387 (6630): 292-295
Strutt, D., Johnson, R., Cooper, K. and Bray, S. (2002). Asymmetric localization of Frizzled and the determination of Notch-dependent cell fate in the Drosophila eye. Curr. Biol. 12: 813-824. 12015117
Sumi, T., et al. (1999). Cofilin phosphorylation and actin cytoskeletal dynamics regulated by rho- and Cdc42-activated LIM-kinase 2. J. Cell. Biol. 147: 1519-1532. 10613909
Szafer-Glusman, E., Fuller, M. T. and Giansanti, M. G. (2011). Role of Survivin in cytokinesis revealed by a separation-of-function allele. Mol Biol Cell 22: 3779-3790. PubMed ID: 21865602
Tahinci, E. and Symes, K. (2003). Distinct functions of Rho and Rac are required for convergent extension during Xenopus gastrulation. Dev. Biol. 259: 318-335. 12871704
Takano, H., et al. (1998). The Rho family G proteins play a critical role in muscle differentiation. Mol. Cell. Biol. 18(3): 1580-1589
Tanaka, H., Yamashita, T., Asada, M., Mizutani, S., Yoshikawa, H. and Tohyama, M. (2002). Cytoplasmic p21Cip1/Waf1 regulates neurite remodeling by inhibiting Rho-kinase activity. J. Cell. Biol. 158: 321-329. 12119358
Tanaka, K., Okubo, Y. and Abe, H. (2005). Involvement of slingshot in the Rho-mediated dephosphorylation of ADF/cofilin during Xenopus cleavage. Zoolog. Sci. 22(9): 971-84. 16219977
Tanaka, M., et al. (2003). Association of Dishevelled with Eph tyrosine kinase receptor and ephrin mediates cell repulsion. EMBO J. 22: 847-858. 12574121
Tanaka, T. and Nakamura, A. (2008). The endocytic pathway acts downstream of Oskar in Drosophila germ plasm assembly. Development 135: 1107-1117. PubMed Citation: 18272590
Tanaka, T., et al. (2011). Drosophila Mon2 couples Oskar-induced endocytosis with actin remodeling for cortical anchorage of the germ plasm. Development 138(12): 2523-32. PubMed Citation: 21610029
Tarcic, G., Boguslavsky, S. K., Wakim, J., Kiuchi, T., Liu, A., Reinitz, F., Nathanson, D., Takahashi, T., Mischel, P. S., Ng, T. and Yarden, Y. (2009). An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis. Curr Biol 19: 1788-1798. PubMed ID: 19836242
Taylor, J. M., et al. (1999). Cytoskeletal changes induced by GRAF, the GTPase regulator associated with focal adhesion kinase, are mediated by Rho. J. Cell Sci. 112: 231-42
Tatsumoto, T., Tatsumoto, T., Xie, X., Blumenthal, R., Okamoto, I. and Miki, T. (1999). Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis. J. Cell Biol. 147(5): 921-8.
Tolliday, N., VerPlank, L. and Li, R. (2002). Rho1 directs formin-mediated actin ring assembly during budding yeast cytokinesis. Curr. Biol. 12: 1864-1870. 12419188
Tominaga, T., et al. (1998). p160ROCK mediates RhoA activation of Na-H
exchange. EMBO J. 17(16): 4712-4722
Tsarouhas, V., et al. (2007). Sequential pulses of apical epithelial secretion and endocytosis drive airway maturation in Drosophila. Dev. Cell 13: 214-225. PubMed Citation: 17681133
Turkel, N., Portela, M., Poon, C., Li, J., Brumby, A. M. and Richardson, H. E. (2015). Cooperation of the BTB-Zinc finger protein, Abrupt, with cytoskeletal regulators in Drosophila epithelial tumorigenesis. Biol Open 4(8):1024-39. PubMed ID: 26187947
Vaughan, E. M., Miller, A. L., Yu, H. Y. and Bement, W. M. (2011). Control of local Rho GTPase crosstalk by Abr. Curr. Biol. 21(4): 270-7. PubMed Citation: 21295482
Vidal, M., Larson, D. E. and Cagan, R. L. (2006). Csk-deficient boundary cells are eliminated from normal Drosophila epithelia by exclusion, migration, and apoptosis. Dev. Cell 10: 33-44. PubMed citation: 16399076
Vlachos, S. and Harden, N. (2011). Genetic evidence for antagonism between Pak protein kinase and Rho1 small GTPase signaling in regulation of the actin cytoskeleton during Drosophila oogenesis. Genetics 187: 501-512. PubMed Citation: 21098722
Wahl, S., et al. (2000). Ephrin-A5 induces collapse of growth cones by activating Rho and Rho kinase. J. Cell Biol. 149: 263-270. PubMed Citation: 10769020
Watanabe, G., et al. (1996). Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho. Science 271(5249): 645-648. PubMed Citation: 8571126
Watanabe, N., et al. (1997). p140mDia, a mammalian homolog of Drosophila
diaphanous, is a target protein for Rho small GTPase and
is a ligand for profilin. EMBO J. 16(11): 3044-3056. PubMed Citation: 9214622
Watanabe, N., et al. (1999). Cooperation between mDia1 and ROCK in Rho-induced actin reorganization. Nat. Cell Biol. 1: 136-143. PubMed Citation: 10559899
Wei, L., et al. (2002). Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation. Development 129: 1705-1714. 11923206
Wei, L., et al. (2001). Rho kinases play an obligatory role in vertebrate embryonic organogenesis. Development 128: 2953-2962. 11532918
Weiner, O. D., et al. (2002). A PtdInsP3- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity, Nat. Cell Biol. 4: 509-513. Medline abstract: 12080346
Weiser, D. C., Row, R. H. and Kimelman, D. (2009). Rho-regulated myosin phosphatase establishes the level of protrusive activity required for cell movements during zebrafish gastrulation. Development 136(14): 2375-84. PubMed Citation: 19515695
Wellington, A., et al. (1999). Spire contains actin binding domains and is related to ascidian posterior end mark-5. Development 126: 5267-5274. PubMed Citation: 10556052
Wen, Y., et al. (2004). EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration. Nat. Cell Biol. 6(9): 820-30. 15311282
Werner, L. A. and Manseau, L. J. (1997). A Drosophila gene with predicted rhoGEF, a pleckstrin homology and SH3 domains is highly expressed in morphogenic tissues. Gene 187: 107-114
Widmann, T. J. and Dahmann, C. (2009). Dpp signaling promotes the cuboidal-to-columnar shape transition of Drosophila wing disc epithelia by regulating Rho1. J. Cell Sci. 122(Pt 9): 1362-73. PubMed Citation: 19366729
Winter, C. G., et al. (2001). Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton. Cell 105: 81-91. 11301004
Wissmann, A., et al. (1997). Caenorhabditis elegans LET-502 is related to Rho-binding kinases and human myotonic
dystrophy kinase and interacts genetically with a homolog of the regulatory subunit of smooth muscle myosin phosphatase to affect cell shape. Genes Dev.
11: 409-422. PubMed Citation: 9042856
Wissmann, A., Ingles, J. and Mains, P. E. (1999). The Caenorhabditis elegans mel-11 Myosin phosphatase regulatory subunit affects tissue contraction in the somatic gonad and the embryonic epidermis and genetically interacts with the Rac signaling pathway. Dev. Biol. 209(1): 111-127. PubMed Citation: 10208747
Wu, W. J., et al. (1997). Interaction between Cdc42Hs and RhoGDI is mediated through the Rho insert region. J. Biol. Chem. 272(42): 26153-26158. PubMed Citation: 9334181
Wu, Y. I., et al. (2009). A genetically encoded photoactivatable Rac controls the motility of living cells. PubMed Citation: 19693014
Wunnenberg-Stapleton, K., et al. (1999). Involvement of the small GTPases XRhoA and XRnd1 in cell adhesion and head formation in
early Xenopus development. Development 126(23): 5339-5351. PubMed Citation: 10556059
Xu, N., Bagumian, G., Galiano, M. and Myat, M. M. (2011). Rho GTPase controls Drosophila salivary gland lumen size through regulation of the actin cytoskeleton and Moesin. Development 138(24): 5415-27. PubMed Citation: 22071107
Yashiro, H., Loza, A. J., Skeath, J. B. and Longmore, G. D. (2014). Rho1 regulates adherens junction remodeling by promoting recycling endosome formation through activation of Myosin II. Mol Biol Cell 25(19):2956-69. PubMed ID: 25079692
Yokoo, T., Toyoshima, H., Miura, M., Wang, Y., Iida, K. T., Suzuki, H., Sone, H., Shimano, H., Gotoda, T., Nishimori, S., et al. (2003). p57Kip2 regulates actin dynamics by binding and translocating LIM-kinase 1 to the nucleus. J. Biol. Chem. 278: 52919-52923. 14530263
Yoshida, S., Bartolini, S. and Pellman, D. (2009). Mechanisms for concentrating Rho1 during cytokinesis. Genes Dev. 23(7): 810-23. PubMed Citation: 19339687
Yoshizaki, H., et al. (2004). Cell type-specific regulation of RhoA activity during cytokinesis. J. Biol. Chem. 279(43): 44756-62. 15308673
Zhai, J., Lin, H., Nie, Z., Wu, J., Canete-Soler, R., Schlaepfer, W. W. and Schlaepfer, D. D. (2003). Direct interaction of focal adhesion kinase with p190RhoGEF. J. Biol. Chem. 278: 24865-24873. Medline abstract: 12702722
Zhang, H. and Macara, I. G. (2008). The PAR-6 polarity protein regulates dendritic spine morphogenesis through p190 RhoGAP and the Rho GTPase. Dev. Cell 14(2): 216-26. PubMed Citation: 18267090
Zhang, W., et al. (1999). Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus. J. Neurosci. 19(1): 96-108. PubMed Citation: 9870942
Zhang, X., et al. (2008). Polar body emission requires a RhoA contractile ring and Cdc42-mediated membrane protrusion. Dev. Cell 15: 386-400. PubMed Citation: 18804436
Zheng, Y., et al. (1996). The pleckstrin homology domain mediates transformation by oncogenic dbl through specific intracellular targeting. J. Biol. Chem. 271(32): 19017-19020. PubMed Citation: 8702569
Zhong. C., et al. (1998). Rho-mediated contractility exposes a cryptic site in fibronectin and induces fibronectin matrix assembly. J. Cell. Biol. 141(2): 539-551. PubMed Citation: 9548730
date revised: 25 August 2023
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