The Interactive Fly
Zygotically transcribed genes
FGF receptor signaling
- FGF receptors and Ligands
- branchless - an FGF involved in tracheal development
- breathless FGF-receptor involved in development of the trachea - plays a role in migration of specific midline glia
- heartless (commonly known as Fibroblast growth factor receptor 1 or DFR-1) - receptor tyrosine kinase - involved in the development of mesodermal and neuronal cells
- pyramus and thisbe - FGFs involved in mesodermal development
- sugarless - required for the biosynthesis of heparan sulfate glycosaminoglycans which facilitate FGF ligand and/or ligand-receptor oligomerization
- sulfateless - required for the biosynthesis of heparan sulfate glycosaminoglycans which facilitate FGF ligand and/or ligand-receptor oligomerization
- terribly reduced optic lobes
extracellular matrix component - homolog of perlecan - regulates larval neuroblast division by modulating FGF signaling
- Signal transduction pathway
- Cbl - an E3-ubiquitin ligase, which promotes the downregulation of receptor tyrosine kinases - physically interacts with Sprouty
- corkscrew (a protein tyrosine phosphatase)
- Ras oncogene at 85D (common alternative name: Ras1)
- pole hole (common alternative name: raf)
- rolled - MAP kinase involved in FGF pathway signal transduction
- Survival motor neuron
- sprouty - antagonist of FGF signaling - functions during tracheal development
- stumps (also known as heartbroken) - signal transduction protein functioning downstream of two FGF receptors
- trachealess - bHLH-PAS transcription factor
Zygotically transcribed genes
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