cdc2

Abe, S., et al. (2011). The initial phase of chromosome condensation requires Cdk1-mediated phosphorylation of the CAP-D3 subunit of condensin II. Genes Dev. 25(8): 863-74. PubMed Citation: 21498573

Ables, E. T. and Drummond-Barbosa, D. (2013). Cyclin E controls Drosophila female germline stem cell maintenance independently of its role in proliferation by modulating responsiveness to niche signals. Development 140: 530-540. PubMed ID: 23293285

Abrieu, A., Doree, M. and Picard, A. (1997a). Mitogen-activated protein kinase activation down-regulates a mechanism that inactivates cyclin B-cdc2 kinase in G2-arrested oocytes. Mol. Biol. Cell 8(2): 249-261. PubMed Citation: 9190205

Abrieu, A., et al. (1997b). MAPK inactivation is required for the G2 to M-phase transition of the first mitotic cell cycle. EMBO J. 16(21): 6407-6413. 9351823

Afonso, D.J., Liu, D., Machado, D.R., Pan, H., Jepson, J.E., Rogulja, D. and Koh, K. (2015). TARANIS functions with Cyclin A and Cdk1 in a novel arousal center to control sleep in Drosophila. Curr Biol 25(13):1717-26. PubMed ID: 26096977

Afonso, O., Castellani, C. M., Cheeseman, L. P., Ferreira, J. G., Orr, B., Ferreira, L. T., Chambers, J. J., Morais-de-Sa, E., Maresca, T. J. and Maiato, H. (2019). Spatiotemporal control of mitotic exit during anaphase by an Aurora B-Cdk1 crosstalk. Elife 8. PubMed ID: 31424385

Amon, A. (1997). Regulation of B-type cyclin proteolysis by Cdc28-associated kinases in budding yeast. EMBO J. 16(10): 2693-702. PubMed Citation: 9184216

Ayad, N., Hull, M. and Mellman, I. (1997). Mitotic phosphorylation of rab4 prevents binding to a specific receptor on endosome membranes. EMBO J. 16(15): 4497-4507. PubMed Citation: 9303294

Ayeni, J. O., Varadarajan, R., Mukherjee, O., Stuart, D. T., Sprenger, F., Srayko, M. and Campbell, S. D. (2013). Dual phosphorylation of Cdk1 coordinates cell proliferation with key developmental processes in Drosophila. Genetics 196(1): 197-210. PubMed ID: 24214341

Baeg, G. H., Zhou, R. and Perrimon, N. (2005). Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila. Genes Dev. 19: 1861-1870. 16055650

Barral, Y., et al. (1999). Nim1-related kinases coordinate cell cycle progression with the organization of the peripheral cytoskeleton in yeast. Genes Dev. 13(2): 176-187. PubMed Citation: 9925642

Banerjee, M., et al. (2002). Pak1 phosphorylation on T212 affects microtubules in cells undergoing mitosis. Curr. Biol. 12: 1233-1239. 12176334

Bejarano, E. R., Munoz, M. J. and Jimenez, J. (1995). Functional analysis of the Drosophila CDC2 Dm gene in fission yeast. Mol Gen Genet 248: 621-628. PubMed Citation: 7476862

Biggs, J. R., et al. (2006). AML1/RUNX1 phosphorylation by cyclin-dependent kinases regulates the degradation of AML1/RUNX1 by the anaphase-promoting complex. Mol. Cell. Biol. 26(20): 7420-9. Medline abstract: 17015473

Bitangcol, J. C., et al. (1998). Activation of the p42 mitogen-activated protein kinase pathway inhibits Cdc2 activation and entry into M-phase incycling Xenopus egg extracts. Mol. Biol. Cell 9(2): 451-467. 9450967

Blangy, A., et al. (1995). Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo. Cell 83(7): 1159-1169. PubMed Citation: 8548803

Blangy, A., Arnaud, L. and Nigg, E. A. (1997). Phosphorylation by p34cdc2 protein kinase regulates binding of the kinesin-related motor HsEg5 to the dynactin subunit p150. J. Biol. Chem. 272(31): 19418-19424. PubMed Citation: 9235942

Blasina, A., Paegle, E. S. and McGowan, C. H. (1997). The role of inhibitory phosphorylation of CDC2 following DNA replication block and radiation-induced damage in human cells. Mol. Biol. Cell 8(6): 1013-1023. PubMed Citation: 9201712

Booher, R. N., Holman, P. S. and Fattaey, A. (1997). Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity. J. Biol. Chem. 272(35): 22300-22306. PubMed Citation: 9268380

Boxem, M., Srinivasan, D. G. and van den Heuvel, S. (1999). The Caenorhabditis elegans gene ncc-1 encodes a cdc2-related kinase required for M phase in meiotic and mitotic cell divisions, but not for S phase. Development 126: 2227-2239. PubMed Citation: 10207147

Brown, G. W., et al. (1997). Interaction of the S phase regulator cdc18 with cyclin-dependent kinase in fission yeast. Proc. Natl. Acad. Sci. 94(12): 6142-6147. PubMed Citation: 9177184

Buttitta, L. A., Katzaroff, A. J., Perez, C. L., de la Cruz, A. and Edgar B. A. (2007). A double-assurance mechanism controls cell cycle exit upon terminal differentiation in Drosophila. Dev. Cell 12(4): 631-43. Medline abstract: 17419999

Campbell, S. D., et al. (1995). Drosophila Wee1 kinase rescues fission yeast from mitotic catastrophe and phosphorylates Drosophila Cdc2 in vitro. Mol. Biol. Cell 6(10): 1333-1347. PubMed Citation: 8573790

Caspari, T., Murray, J. M. and Carr, A. M. (2002). Cdc2-cyclin B kinase activity links Crb2 and Rqh1-topoisomerase III. Genes Dev. 16: 1195-1208. 12023299

Chen, S. et al. (2010). Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2. Nat. Cell Biol. 12: 1108–1114. PubMed Citation: 20935635

Chen, X., et al. (2003). Cyclin D-Cdk4 and cyclin E-Cdk2 regulate the Jak/STAT signal transduction pathway in Drosophila. Dev. Cell 4(2):179-90. 12586062

Chu, I., et al. (2007). p27 phosphorylation by Src regulates inhibition of Cyclin E-Cdk2. Cell 128: 281-294. Medline abstract: 17254967

Clegg, N. J., et al. (1993). A developmental and molecular analysis of Cdc2 mutations in Drosophila melanogaster. Genome 36: 676-85

Colgan, D. F., et al. (1998). Inhibition of poly(A) polymerase requires p34cdc2/cyclin B phosphorylation of multiple consensus and non-consensus sites. EMBO J. 17: 1053-1062

Collas, P. (1999). Sequential PKC- and Cdc2-mediated phosphorylation events elicit zebrafish nuclear envelope disassembly. J. Cell Sci. 112 ( Pt 6): 977-87

Connolly, T., Caligiuri, M., and Beach D. (1997). The Cdc2 protein kinase controls Cdc10/Sct1 complex formation. Mol. Biol. Cell 8(6): 1105-1115

Cornwell, W. D., Kaminski, P. J. and Jackson, J. R. (2002) Identification of Drosophila Myt1 kinase and its role in Golgi during mitosis. Cell Signal 14: 467-476. 11882391

Cosma, M. P., Panizza, S. and Nasmyth, S. (2001). Cdk1 triggers association of RNA polymerase to cell cycle promoters only after recruitment of the mediator by SBF. Mol. Cell 7: 1213-1220. 11430824

D'Angiolella, V., et al. (2001). Role for cyclin-dependent kinase 2 in mitosis exit. Curr. Bio. 11: 1221-1226. 11516956

D'Angiolella, V., et al. (2003). The spindle checkpoint requires cyclin-dependent kinase activity. Genes Dev. 17: 2520-2525. 14561775

Deneke, V.E., Melbinger, A., Vergassola, M. and Di Talia, S. (2016). Waves of Cdk1 activity in S phase synchronize the cell cycle in Drosophila embryos. Dev Cell 38: 399-412. PubMed ID: 27554859

Dienemann, A. and Sprenger, F. (2004). Requirements of Cyclin A for mitosis are independent of its subcellular localization. Curr. Biol. 14: 1117-1123. 15203007

Di Talia, S. and Wieschaus, E. F. (2012). Short-term integration of Cdc25 dynamics controls mitotic entry during Drosophila gastrulation. Dev. Cell 22(4): 763-74. PubMed Citation: 22483720

Den Haese, G. J., et al. (1995). The Wee1 protein kinase regulates T14 phosphorylation of fission yeast Cdc2. Mol Biol Cell 6: 371-385

Duda, H., Arter, M., Gloggnitzer, J., Teloni, F., Wild, P., Blanco, M.G., Altmeyer, M. and Matos, J. (2016). A mechanism for controlled breakage of under-replicated chromosomes during mitosis. Dev Cell 39: 740-755. PubMed ID: 27997828

Edgar, B. A., et al. (1994). Distinct molecular mechanism regulate cell cycle timing at successive stages of Drosophila embryogenesis. Genes Dev 8: 440-52

El-Hodiri, H. M., et al. (1997). Mitogen-activated protein kinase and cyclin B/Cdc2 phosphorylate Xenopus nuclear factor 7 (xnf7) in extracts from mature oocytes. Implications for regulation of xnf7 subcellular localization. J. Biol. Chem. 272(33): 20463-20470

Esashi, F. and Yanagida, M. (1999). Cdc2 phosphorylation of Crb2 Is required for reestablishing cell cycle progression after the damage checkpoint. Mol. Cell 4: 167-174

Espanel, X., et al. (1997). p34(cdc2) and mitotic cyclin expression in the developing quail neuroretina. Int. J. Dev. Biol. 41(3): 469-476

Fabbro, M., et al. (2005). Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis. Dev. Cell 9: 477-488. 16198290

Farrell, J. A., Shermoen, A. W., Yuan, K. and O'Farrell, P. H. (2012). Embryonic onset of late replication requires Cdc25 down-regulation. Genes Dev. 26(7): 714-25. PubMed Citation: 22431511

Fisher, D. L., et al. (1999). Dissociation of MAP kinase activation and MPF activation in hormone-stimulated maturation of Xenopus oocytes. Development 126: 4537-4546

Fogarty, P., et al. (1997). The Drosophila grapes gene is related to checkpoint gene chk1/rad27 and is required for late syncytial division fidelity. Curr. Biol. 7(6): 418-426

Fox, P. M., et al. (2011). Cyclin E and CDK-2 regulate proliferative cell fate and cell cycle progression in the C. elegans germline. Development 138: 2223-2234. PubMed Citation: 21558371

Francesconi, S., et al. (1997). p56(chk1) protein kinase is required for the DNA replication checkpoint at 37 degrees C in fission yeast. EMBO J. 16(6): 1332-1341

Frank-Vaillant, M., et al. (2001). Interplay between Cdc2 kinase and the c-Mos/MAPK pathway between metaphase I and metaphase II in Xenopus oocytes. Dev. Bio. 231: 279-288

Frouin, I., et al. (2002). Cell cycle-dependent dynamic association of cyclin/Cdk complexes with human DNA replication proteins. EMBO J. Vol. 21: 2485-2495. 12006500

Fujita, M., et al. (1998). Cell cycle- and chromatin binding state-dependent phosphorylation of human MCM heterohexameric complexes. A role for cdc2 kinase. J. Biol. Chem. 273(27): 17095-101

Gebara, M. M., Sayre, M. H. and Corden, J. L. (1997). Phosphorylation of the carboxy-terminal repeat domain in RNA polymerase II by cyclin-dependent kinases is sufficient to inhibit transcription. J. Cell. Biochem. 64(3): 390-402

Garrido, D., Bourouh, M., Bonneil, E., Thibault, P., Swan, A. and Archambault, V. (2020). Cyclin B3 activates the Anaphase-Promoting Complex/Cyclosome in meiosis and mitosis. PLoS Genet 16(11): e1009184. PubMed ID: 33137813

Golan, A., Yudkovsky, Y. and Hershko, A. (2002). The cyclin-ubiquitin ligase activity of cyclosome/APC is jointly activated by protein kinases Cdk1-cyclin B and Plk. J. Biol. Chem. 277: 15552-15557. 11859075

Grimmler, M., et al. (2007). Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases. Cell 128: 269-280. Medline abstract: 17254966

Gromley, A., et al. (2003). A novel human protein of the maternal centriole is required for the final stages of cytokinesis and entry into S phase, J. Cell Biol. 161: 535-545. 12732615

Grosskortenhaus, R. and Sprenger, F. (2002). Rca1 inhibits APC-Cdh1(Fzr) and is required to prevent cyclin degradation in G2. Dev. Cell 2: 29-40. 11782312

Guadagno, T. M. and Newport, J. W. (1996). Cdk2 kinase is required for entry into mitosis as a positive regulator of Cdc2-cyclin B kinase activity. Cell 84: 73-82

Haase, S. B., Winey, M. and Reed, S. I. (2001). Multi-step control of spindle pole body duplication by cyclin-dependent kinase. Nat. Cell Biol. 3: 38-42. 11146624

Hara, M., Petrova, B. and Orr-Weaver, T. L. (2017). Control of PNG kinase, a key regulator of mRNA translation, is coupled to meiosis completion at egg activation. Elife 6. PubMed ID: 28555567

Hartley, R. S., Rempel, R. E. and Maller, J. L. (1996). In vivo regulation of the early embryonic cell cycle in Xenopus. Dev. Biol. 173: 408-419

Hayashi, S. (1996). A Cdc2 dependent checkpoint maintains diploidy in Drosophila. Development 122(4): 1051-1058

Hayden, L., Chao, A., Deneke, V. E., Vergassola, M., Puliafito, A. and Di Talia, S. (2022). Cullin-5 mutants reveal collective sensing of the nucleocytoplasmic ratio in Drosophila embryogenesis. Curr Biol 32(9): 2084-2092. PubMed ID: 35334230

Heix, J., et al. (1999). Mitotic silencing of human rRNA synthesis: inactivation of the promoter selectivity factor SL1 by cdc2/cyclin B-mediated phosphorylation. EMBO J. 17(24): 7373-81

Honda, H., et al. (1995). Mouse p87wee1 kinase is regulated by M-phase specific phosphorylation. Chromosome Res 3: 300-308

Humbert, P. O., et al. (2000). E2f3 is critical for normal cellular proliferation. Genes Dev. 14: 690-703

Hümmer, S. and Mayer, T. U. (2009). Cdk1 negatively regulates midzone localization of the mitotic kinesin Mklp2 and the chromosomal passenger complex. Curr. Biol. 19(7): 607-12. PubMed Citation: 19303298

Hutterer, A., Berdnik, D., Wirtz-Peitz, F., Zigman, M., Schleiffer, A., Knoblich, J. A. (2006). Mitotic activation of the kinase Aurora-A requires its binding partner Bora. Dev. Cell 11(2): 147-57. 16890155

Ibar, C. and Glavic, A. (2017). Drosophila p115 is required for Cdk1 activation and G2/M cell cycle transition. Mech Dev [Epub ahead of print]. PubMed ID: 28396045

Inoue, D. and Sagata, N. (2005). The Polo-like kinase Plx1 interacts with and inhibits Myt1 after fertilization of Xenopus eggs. EMBO J. 24: 1057-1067. 15692562

Iwabuchi, M., et al. (2000). Residual Cdc2 activity remaining at meiosis I exit is essential for meiotic M-M transition in Xenopus oocyte extracts. EMBO J. 19: 4513-4523

Iwabuchi, M., et al. (2002). Coordinated regulation of M Phase exit and S phase entry by the Cdc2 activity level in the early embryonic cell cycle. Dev. Biol. 243: 34-43. 11846475

Jallepalli, P. V. and Kelly, T. J. (1996). Rum1 and Cdc18 link inhibition of cyclin-dependent kinase to the initiation of DNA replication in Schizosaccharomyces pombe. Genes Dev. 10: 541-552

Jang, Y. J., et al. (1997). A novel protein, Psp1, essential for cell cycle progression of Schizosaccharomyces pombe is phosphorylated by Cdc2-Cdc13 upon entry into G0-like stationary phase of cell growth. J. Biol. Chem. 272(32): 19993-20002

Jaspersen, S. L., Charles, J. F. and Morgan, D. O. (1999). Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14. Curr. Biol. 9(5): 227-36

Jaspersen, S. L., et al. (2004). Cdc28/Cdk1 regulates spindle pole body duplication through phosphorylation of Spc42 and Mps1. Dev. Cell 7: 263-274. 15296722

Jimenez, J., et al. (1990). Complementation of fission yeast cdc2ts and cdc25ts mutants identifies two cell cycle genes from Drosophila: a cdc2 homologue and string. EMBO J. 9: 3565-71

Jin, Z., Homola, E., Tiong, S. and Campbell, S. D. (2008). Drosophila myt1 is the major cdk1 inhibitory kinase for wing imaginal disc development. Genetics 180(4): 2123-33. PubMed Citation: 18940789

Jin, Z., Homola, E. M., Goldbach, P., Choi, Y., Brill, J. A. and Campbell, S. D. (2005). Drosophila Myt1 is a Cdk1 inhibitory kinase that regulates multiple aspects of cell cycle behavior during gametogenesis. Development 132(18): 4075-85. 16107480

Kaiser, P., et al. (1999). Cyclin-dependent kinase and Cks/Suc1 interact with the proteasome in yeast to control proteolysis of M-phase targets. Genes Dev. 13(9): 1190-20

Kaldis, P., Sutton, A. and Solomon, M. J. (1996). The Cdk-activating kinase (CAK) from budding yeast. Cell 86: 553-564

Kaldis, P., et al. (1998). Localization and regulation of the cdk-activating kinase (Cak1p) from budding yeast. J. Cell Sci. 111 (Pt 24): 3585-96

Kalous, J., Solc, P., Baran, V., Kubelka, M., Schultz, R. M. and Motlik, J. (2005). PKB/AKT is involved in resumption of meiosis in mouse oocytes. Biol. Cell. 98(2): 111-23. 15842198

Kaneko, S., et al. (2010). Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA. Genes Dev. 24(23): 2615-20. PubMed Citation: 21123648

Kara, A., et al. (1998). MPF amplification in Xenopus oocyte extracts depends on a two-step activation of Cdc25 phosphatase. Exp. Cell Res. 244(2): 491-500. PubMed Citation: 9806800

Karaiskou, A., et al. (2004). Polo-like kinase confers MPF autoamplification competence to growing Xenopus oocytes. Development 131: 1543-1552. 14985258

Katsu, Y., et al. (1999). Ca2+ is required for phosphorylation of clam p82/CPEB in vitro: implications for dual and independent roles of MAP and Cdc2 kinases. Dev. Biol. 209(1): 186-199

Kelley, C. A., et al. (1995). A Xenopus nonmuscle myosin heavy chain isoform is phosphorylated by cyclin-p34cdc2 kinase during meiosis. J. Biol. Chem. 270: 1395-1401

Kitagawa, M., Fung, S. Y., Hameed, U. F., Goto, H., Inagaki, M. and Lee, S. H. (2014). Cdk1 coordinates timely activation of MKlp2 kinesin with relocation of the chromosome passenger complex for cytokinesis. Cell Rep 7: 166-179. PubMed ID: 24656812

Kim, H. H., et al. (2008). Nuclear HuR accumulation through phosphorylation by Cdk1 Genes Dev. 22: 1804-1815. PubMed Citation: 18593881

Kim, S. H., Li, C. and Maller, J. L. (1999). A maternal form of the phosphatase Cdc25A regulates early embryonic cell cycles in Xenopus laevis. Dev. Biol. 212(2): 381-91

Knoblich, J. A., et al. (1994). Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation. Cell 77: 107-20

Koffa, M. D., et al. (2006). HURP is part of a Ran-dependent complex involved in spindle formation. Curr. Biol. 16(8): 743-54. 16631581

Kondo, T., et al. (1997). Introduction of cyclin B induces activation of the maturation-promoting factor and breakdown of germinal vesicle in growing zebrafish oocytes unresponsive to the maturation-inducing hormone. Dev. Biol. 190(1): 142-152

Konishi, Y., et al. (2002). Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery. Molec. Cell 9: 1005-1016. 1204973

Ku, D. H., et al. (1993). c-myb transactivates cdc2 expression via Myb binding sites in the 5'-flanking region of the human cdc2 gene. J. Biol. Chem. 268(3): 2255-2259

Kupfer, G. M., et al. (1997). The Fanconi anemia polypeptide, FAC, binds to the cyclin-dependent kinase, cdc2. Blood 90(3): 1047-1054

Kussel, P. and Frasch, M. (1995). Pendulin, a Drosophila protein with cell cycle-dependent nuclear localization, is required for normal cell proliferation. J Cell Biol 129(6): 1491-1507. PubMed ID: 7790350

Kwon, Y. G., et al. (1997). Cell cycle-dependent phosphorylation of mammalian protein phosphatase 1 by cdc2 kinase. Proc. Natl. Acad. Sci. 94(6): 2168-2173

Labib, K., Moreno, S. and Nurse, P. (1995). Interaction of cdc2 and rum1 regulates Start and S-phase in fission yeast. J. Cell Sci. 108: 3285-3294

Lahav-Baratz, S., et al. (1995). Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase. Proc Natl Acad Sci. 92: 9303-9307

Larochelle, S., et al. (1998). Cdk7 is essential for mitosis and for in vivo Cdk-activating kinase activity. Genes Dev. 12(3): 370-381

Leatherwood, J., Lopez-Girona, A. and Russell, P. (1996). Interaction of Cdc2 and Cdc18 with a fission yeast ORC2-like protein. Nature 379: 360-363

Lee, K. M., et al. (1999). Cdc2 activation in fission yeast depends on mcs6 and csk1, two partially redundant cdk-activating kinases. Curr. Biol. 9(8): 441-4

Lehner, C. F. and O'Farrell, P. H. (1990). Drosophila cdc2 homologs: a functional homolog is coexpressed with a cognate variant. EMBO J. 9: 3573-81

Li, H. Y., and Zheng, Y. (2004). Phosphorylation of RCC1 in mitosis is essential for producing a high RanGTP concentration on chromosomes and for spindle assembly in mammalian cells. Genes Dev. 18: 512-527. 15014043

Li, J., Meyer, A. N. and Donoghue, D. J. (1997). Nuclear localization of cyclin B1 mediates its biological activity and is regulated by phosphorylation. Proc. Natl. Acad. Sci. 94(2): 502-507

Li, S., Makovets, S., Matsuguchi, T., Blethrow, J. D., Shokat, K. M. and Blackburn, E. H. (2009). Cdk1-dependent phosphorylation of Cdc13 coordinates telomere elongation during cell-cycle progression. Cell 136(1): 50-61. PubMed Citation: 19135888

Lim, H. H., Goh, P. Y. and Surana, U. (1998). Spindle pole body separation in Saccharomyces cerevisiae requires dephosphorylation of the tyrosine 19 residue of Cdc28. Mol. Cell. Biol. 16(11): 6385-97

Lin, C. Y., et al. (2000). Peripheral Golgi protein GRASP65 is a target of mitotic polo-like kinase (Plk) and Cdc2. Proc. Natl. Acad. Sci. 97: 12589-12594. 11050165

Liu, F., et al. (1997). The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex. Mol. Cell. Biol. 17(2): 571-583

Liu, N., et al. (1997). CDF-1, a novel E2F-unrelated factor, interacts with cell cycle-regulated repressor elements in multiple promoters. Nucleic Acids Res. 25(24): 4915-4920

Lopez-Girona, A., et al. (1998). Negative regulation of cdc18 DNA replication protein by cdc2. Mol. Biol. Cell 9(1): 63-73

Lowe M., et al. (1998). Cdc2 kinase directly phosphorylates the cis-Golgi matrix protein GM130 and is required for Golgi fragmentation in mitosis. Cell 94(6): 783-93

Machida, Y. J., Teer, J. K. and Dutta, A. (2005). Acute reduction of an origin recognition complex (ORC) subunit in human cells reveals a requirement of ORC for Cdk2 activation. J. Biol. Chem. 280(30): 27624-30. 15944161

Maekawa, H. and Schiebel, E. (2004). Cdk1-Clb4 controls the interaction of astral microtubule plus ends with subdomains of the daughter cell cortex. Genes Dev. 18: 1709-1724. 15256500

Mailand, N., et al. (2002). Regulation of G2/M events by Cdc25A through phosphorylation-dependent modulation of its stability. EMBO J. 21: 5911-5920. 12411508

Martins, C. P. and Berns. A. (2002). Loss of p27Kip1 but not p21Cip1 decreases survival and synergizes with MYC in murine lymphomagenesis. EMBO J. 21: 3739-3748. 12110586

Maton, G., et al. (2003). Cdc2-cyclin B triggers H3 kinase activation of Aurora-A in Xenopus oocytes. J. Biol. Chem. 278: 21439-21449. 12670933

Maton, G., et al. (2005). Differential regulation of Cdc2 and Aurora-A in Xenopus oocytes: a crucial role of phosphatase 2A. J. Cell Sci. 118: 2485-2494. 15923661

Matsumoto, T. (1997). A fission yeast homolog of CDC20/p55CDC/Fizzy is required for recovery from DNA damage and genetically interacts with p34cdc2. Mol. Cell. Biol. 17(2): 742-750

McCleland, M. L. and O'Farrell, P. H. (2008). RNAi of mitotic cyclins in Drosophila uncouples the nuclear and centrosome cycle. Curr. Biol. 18: 245-254. PubMed Citation: 18291653

Mendez, R., Barnard, D. and Richter, J. D. (2002). Differential mRNA translation and meiotic progression require Cdc2-mediated CPEB destruction. EMBO J. 21: 1833-1844. 11927567

Minshull, J., Straight, A., Rudner, A. D., Dernburg, A. F., Belmont, A. and Murray, A. W. (1996). Protein phosphatase 2A regulates MPF activity and sister chromatid cohesion in budding yeast. Curr. Biol. 6: 1609-1620. 8994825

Mirkovic, M., Hutter, L.H., Novák, B. and Oliveira, R.A. (2015). Premature sister chromatid separation is poorly detected by the spindle assembly checkpoint as a result of system-level feedback. Cell Rep [Epub ahead of print]. PubMed ID: 26456822

Mishima, M., Pavicic, V., Gruneberg, U., Nigg, E. A. and Glotzer, M. (2004). Cell cycle regulation of central spindle assembly. Nature 430: 908-913. 15282614

Mueller, P. R., Coleman, T. R. and Dunphy, W. G. (1995a). Cell cycle regulation of a Xenopus Wee1-like kinase. Mol. Biol. Cell 6: 119-134

Mueller, P. R., et al. (1995b). Myt1: a membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15. Science 270: 86-90

Munoz, M. J., et al. (1999). The identification of Wos2, a p23 homologue that interacts with Wee1 and Cdc2 in the mitotic control of fission yeasts. Genetics 153(4): 1561-1572

Murakami, M. S., Moody, S. A., Daar, I. O. and Morrison, D. K. (2004). Morphogenesis during Xenopus gastrulation requires Wee1-mediated inhibition of cell proliferation. Development 131: 571-580. 14711880

Nabti, I., Marangos, P., Bormann, J., Kudo, N. R. and Carroll, J. (2014). Dual-mode regulation of the APC/C by CDK1 and MAPK controls meiosis I progression and fidelity. J Cell Biol 204: 891-900. PubMed ID: 24637322

Nakajima, H., et al. (2008). Myt1 protein kinase is essential for Golgi and ER assembly during mitotic exit. J. Cell Biol. 181: 89-103. PubMed Citation: 18378775

Nguyen, V. Q., et al. (2000). Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7 Curr. Biol. 10: 195-205. PubMed Citation: 10704410

Niiya, F., Xie, X., Lee, K. S., Inoue, H. and Miki, T. (2005). Inhibition of cyclin-dependent kinase 1 induces cytokinesis without chromosome segregation in an ECT2 and MgcRacGAP-dependent manner. J. Biol. Chem. 280(43): 36502-9. 16118207

Nikolakaki, E., et al. (1997). Mitotic phosphorylation of the lamin B receptor by a serine/arginine kinase and p34(cdc2). J. Biol. Chem. 272(10): 6208-6213. PubMed Citation: 9045635

Nishiyama, A., et al. (2000). A nonproteolytic function of the proteasome is required for the dissociation of Cdc2 and cyclin B at the end of M phase. Genes Dev. 14: 2344-2357. PubMed Citation: 10995390

Niu, H., et al. (1997). Mapping of amino acid residues in the p34 subunit of human single-stranded DNA-binding protein phosphorylated by DNA-dependent protein kinase and Cdc2 kinase in vitro. J. Biol. Chem. 272(19): 12634-12641. PubMed Citation: 9139719

Noton, E. and Diffley, J. F. X. (2000). CDK inactivation is the only essential function of the APC/C and the mitotic exit network proteins for origin resetting during mitosis. Mol. Cell. 5: 85-95. PubMed Citation: 10678171

O'Connell, M. J., et al. (1997). Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation. EMBO J. 16(3): 545-554. PubMed Citation: 9034337

Okano-Uchida, T., et al. (1998). In vivo regulation of Cyclin A/Cdc2 and Cyclin B/Cdc2 through meiotic and early cleavage cycles in starfish. Dev. Biol. 197(1): 39-53. PubMed Citation: 9578617

Okumura, E., Morita, A., Wakai, M., Mochida, S., Hara, M. and Kishimoto, T. (2014). Cyclin B-Cdk1 inhibits protein phosphatase PP2A-B55 via a Greatwall kinase-independent mechanism. J Cell Biol 204: 881-889. PubMed ID: 24616226

Pagano, M., et al. (1992). Cyclin A is required at two points in the human cell cycle. EMBO J. 11: 961-971. PubMed Citation: 1312467

Palmer, A., Gavin, A. C. and Nebreda, A. R. (1998). A link between MAP kinase and p34(cdc2)/cyclin B during oocyte maturation: p90(rsk) phosphorylates and inactivates the p34(cdc2) inhibitory kinase myt1. EMBO J. 17(17): 5037-47. PubMed Citation: 9724639

Patra, D. and Dunphy, W. G. (1998). Xe-p9, a Xenopus Suc1/Cks protein, is essential for the Cdc2-dependent phosphorylation of the anaphase- promoting complex at mitosis. Genes Dev. 12(16): 2549-2559. PubMed Citation: 9716407

Pearson, N. J., et al. (2005). A pre-anaphase role for a Cks/Suc1 in acentrosomal spindle formation of Drosophila female meiosis. EMBO reports 6(11): 1058-63. 16170306

Peng, Y. and Weisman, L. S. (2008). The cyclin-dependent kinase Cdk1 directly regulates vacuole inheritance. Dev. Cell 15(3): 478-85. PubMed Citation: 18804442

Phillips, K. P., et al. (2002). Inhibition of MEK or cdc2 kinase parthenogenetically activates mouse eggs and yields the same phenotypes as Mos^-/- parthenogenotes. Dev. Biol. 247: 210-223. 12074563

Pockwinse, S. M., et al. (1997). Cell cycle independent interaction of CDC2 with the centrosome, which is associated with the nuclear matrix-intermediate filament scaffold. Proc. Natl. Acad. Sci. 94(7): 3022-3027

Polanski Z., et al. (1998). Cyclin synthesis controls the progression of meiotic maturation in mouse oocytes. Development 125(24): 4989-97

Pomerening, J. R., Kim, S. Y. and Ferrell, J. E. (2005). Systems-level dissection of the cell-cycle oscillator: bypassing positive feedback produces damped oscillations. Cell 122: 565-578. 16122424

Preisinger, C., et al. (2005). Plk1 docking to GRASP65 phosphorylated by Cdk1 suggests a mechanism for Golgi checkpoint signalling. EMBO J. 24: 753-765. 15678101

Price, D., Rabinovitch, S., O'Farrell, P. H. and Campbell, S. D. (2000). Drosophila wee1 has an essential role in the nuclear divisions of early embryogenesis. Genetics, Vol. 155: 159-166. 1079039

Price, D. M., Jin, Z., Rabinovitch, S. and Campbell, S. D. (2002). Ectopic expression of the Drosophila cdk1 inhibitory kinases, Wee1 and Myt1, interferes with the second mitotic wave and disrupts pattern formation during eye development. Genetics 161: 721-731. 12072468

Rahal, R. and Amon, A. (2008). Mitotic CDKs control the metaphase-anaphase transition and trigger spindle elongation. Genes Dev. 22: 1534-1548. PubMed Citation: 18519644

Rattani, A., Vinod, P. K., Godwin, J., Tachibana-Konwalski, K., Wolna, M., Malumbres, M., Novak, B. and Nasmyth, K. (2014). Dependency of the spindle assembly checkpoint on Cdk1 renders the anaphase transition irreversible. Curr Biol 24: 630-637. PubMed ID: 24583015

Resino, J. and Garcia-Bellido, A. (2004). Drosophila genetic variants that change cell size and rate of proliferation affect cell communication and hence patterning. Mech. Dev. 121(4): 351-64. 15110045

Resnick, R. J., et al. (1997). Phosphorylation of the Src substrate Sam68 by Cdc2 during mitosis. Oncogene 15(11): 1247-1253

Rhind, N., Furnari, B. and Russell, P. (1996). Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast. Genes Dev. 11: 504-511

Rhind, N. and Russell, P. (1998). Tyrosine phosphorylation of cdc2 is required for the replication checkpoint in Schizosaccharomyces pombe. Mol. Cell. Biol. 18(7): 3782-3787

Rime, H., et al. (1998). Inhibition of small G proteins by clostridium sordellii lethal toxin activates cdc2 and MAP kinase in Xenopus oocytes. Dev. Biol. 204(2): 592-602

Rosse, C., et al. (2003). RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis. J. Biol. Chem. 278(33): 30597-604. 12775724

Rudner, A. D., Hardwick, K. G. and Murray, A. W. (2000a). Cdc28 activates exit from mitosis in budding yeast. J. Cell Bio. 149: 1361-1376. 10871278

Rudner, A. D. and Murray, A. W. (2000b). Phosphorylation by Cdc28 activates the Cdc20-dependent activity of the anaphase-promoting complex. J. Cell Bio. 149: 1377-1390. 10871279

Santaguida, M. and Nepveu, A. (2005). Differential regulation of CDP/Cux p110 by cyclin A/Cdk2 and cyclin A/Cdk1. J. Biol. Chem. 280(38): 32712-21. 16081423

Sauer, K., et al. (1996). Novel members of the cdc2-related kinase family in Drosophila: cdk4/6, cdk5, PFTAIRE, and PITSLRE kinase. Mol. Biol. Cell 7(11): 1759-1769

Schwab, M, S. and Dreyer C. (1997). Protein phosphorylation sites regulate the function of the bipartite NLS of nucleolin. Eur. J. Cell Biol. 73(4): 287-297

Schwanbeck, R. and Wisniewski, J. R. (1997). Cdc2 and mitogen-activated protein kinases modulate DNA binding properties of the putative transcriptional regulator chironomus high mobility group protein I. J. Biol. Chem. 272(43): 27476-27483

Servant, N., Marcantonio, D., Th'ng, J. P. and Chalifour, L. E. (2004). TBP-associated factor 1 overexpression induces tolerance to Doxorubicin in confluent H9c2 cells by an increase in cdk2 activity and cyclin E expression. Mol. Cell. Biochem. 259(1-2): 71-81. Medline abstract: 15124910

Shimizu, M., et al. (1997). The G1/S boundary-specific enhancer of the rat cdc2 promoter. Mol. Cell. Biol. 15: 2882-2892

Sigrist, S., Ried, G. and Lehner, C. F. (1995). Dmcdc2 kinase is required for both meiotic divisions during Drosophila spermatogenesis and is activated by the Twine/cdc25 phosphatase. Mech. Dev. 53: 247-260

Sjostrom, S. K., et al. (2005). The Cdk1 complex plays a prime role in regulating N-Myc phosphorylation and turnover in neural precursors. Dev. Cell 9: 327-338. 16139224

Snee, M. J., Wilson, W. C., Zhu, Y., Chen, S. Y., Wilson, B. A., Kseib, C., O'Neal, J., Mahajan, N., Tomasson, M. H., Arur, S. and Skeath, J. B. (2016). Collaborative control of cell cycle progression by the RNA exonuclease Dis3 and Ras is conserved across species. Genetics 203: 749-762. PubMed ID: 27029730

Spencer, S. L., Cappell, S. D., Tsai, F. C., Overton, K. W., Wang, C. L. and Meyer, T. (2013). The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit. Cell 155(2): 369-83. PubMed ID: 24075009

Sprenger, F., Yakubovich, N. and O'Farrell, P. H. (1997). S-phase function of Drosophila cyclin A and its downregulation in G1 phase. Curr. Biol. 7(7): 488-499

Stern, B., et al. (1993). Genetic analysis of the Drosophila cdc2 homolog. Development 117: 219-32

Stukenberg, P. T., et al. (1997). Systematic identification of mitotic phosphoproteins. Curr. Biol. 7(5): 338-48

Stumpff, J., et al. (2005). Drosophila Wee1 interacts with members of the γTURC and is required for proper mitotic-spindle morphogenesis and positioning. Curr. Biol. 15: 1525-1534. 16139207

Su, T. T., Campbell, S. D. and O'Farrell, P. H. (1998). The cell cycle program in germ cells of the Drosophila embryo. Dev. Biol. 196(2): 160-170

Su, T. T., Walker, J. and Stumpff. J. (2000). Activating the DNA damage checkpoint in a developmental context. Curr. Biol 10: 119-126. PubMed ID: 10679321

Su, T. T., et al. (2001). Cell cycle roles for the two 14-3-3 proteins during Drosophila development. J. Cell Sci. 114: 3445-3462. PubMed Citation: 11682604

Sutterlin, C., et al. (2001). Polo-like kinase is required for the fragmentation of pericentriolar Golgi stacks during mitosis. Proc. Natl. Acad. Sci. 98: 9128-9132. 11447294

Swaminathan, A. and Pile, L. A. (2010). Regulation of cell proliferation and wing development by Drosophila SIN3 and String. Mech. Dev. 127: 96-106. PubMed Citation: 19825413

Swan, A., Barcelo, G. and Schupbach, T. (2005a). Drosophila Cks30A interacts with Cdk1 to target Cyclin A for destruction in the female germline. Development 132(16): 3669-78. 16033797

Swan, A. and Schupbach, T. (2005b). Drosophila female meiosis and embryonic syncytial mitosis use specialized Cks and CDC20 proteins for cyclin destruction. Cell Cycle 4(10) [Epub ahead of print]. 16138012

Tan, M., et al. (2002). Phosphorylation on tyrosine-15 of p34Cdc2 by ErbB2 inhibits p34Cdc2 activation and is involved in resistance to taxol-induced apoptosis. Molec. Cell 9: 993-1004. 12049736

Tao, W., et al. (1999). Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity. Nat. Genet. 21(2): 177-81

Thiel, D. A., et al. (2002). Cell cycle-regulated phosphorylation of p21-activated kinase 1. Curr. Biol. 12: 1227-1232. 12176333

Tio, M., et al. (2001). cdc2 links the Drosophila cell cycle and asymmetric division machineries. Nature 409: 1063-1067. 11234018

Tommasi, S. and Pfeifer, G. P. (1995). In vivo structure of the human cdc2 promoter: release of a p130-E2F-4 complex from sequences immediately upstream of the transcription initiation site coincides with induction of cdc2 expression. Mol. Cell. Biol. 15: 6901-6913

Trzepacz, C., et al. (1997). Phosphorylation of the tumor suppressor adenomatous polyposis coli (APC) by the cyclin-dependent kinase p34. J. Biol. Chem. 272(35): 21681-21684

Uren, A., et al. (1997). Carboxyl-terminal domain of p27Kip1 activates CDC2. J. Biol. Chem. 272(35): 21669-21672

Varadarajan, R., Ayeni, J., Jin, Z., Homola, E. and Campbell, S. D. (2016). Myt1 inhibition of Cyclin A/Cdk1 is essential for fusome integrity and pre-meiotic centriole engagement in Drosophila spermatocytes. Mol Biol Cell [Epub ahead of print]. PubMed ID: 27170181

Vazquez-Novelle, M. D., Sansregret, L., Dick, A. E., Smith, C. A., McAinsh, A. D., Gerlich, D. W. and Petronczki, M. (2014). Cdk1 inactivation terminates mitotic checkpoint surveillance and stabilizes kinetochore attachments in anaphase. Curr Biol 24: 638-645. PubMed ID: 24583019

Vicent, G. P., et al. (2011). Four enzymes cooperate to displace histone H1 during the first minute of hormonal gene activation. Genes Dev. 25(8): 845-62. PubMed Citation: 21447625

Vidwans, S. J., Wong, M. L. and O'Farrell, P. H. (2003). Anomalous centriole configurations are detected in Drosophila wing disc cells upon Cdk1 inactivation. J. Cell Sci. 116: 137-143. 12456723

Wang, P., Larouche, M., Normandin, K., Kachaner, D., Mehsen, H., Emery, G. and Archambault, V. (2016). Spatial regulation of Greatwall by Cdk1 and PP2A-Tws in the cell cycle. Cell Cycle: [Epub ahead of print] PubMed ID: 26761639

Wang, Z., Fan, M., Candas, D., Zhang, T. Q., Qin, L., Eldridge, A., Wachsmann-Hogiu, S., Ahmed, K. M., Chromy, B. A., Nantajit, D., Duru, N., He, F., Chen, M., Finkel, T., Weinstein, L. S. and Li, J. J. (2014). Cyclin B1/Cdk1 coordinates mitochondrial respiration for cell-cycle G2/M progression. Dev Cell 29: 217-232. PubMed ID: 24746669

Wei, Y., et al. (2011). CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells. Nat. Cell Biol. 13(1): 87-94. PubMed Citation: 21131960

Weigmann, K., Cohen, S. M. and Lehner, C. F. (1997). Cell cycle progression, growth and patterning in imaginal discs despite inhibition of cell division after inactivation of Drosophila Cdc2 kinase. Development 124(18): 3555-3563

White, J., Stead, E., Faast, R., Conn, S., Cartwright, P. and Dalton, S. (2005). Developmental activation of the Rb-E2F pathway and establishment of cell cycle-regulated cyclin-dependent kinase activity during embryonic stem cell differentiation. Mol. Biol. Cell 16: 2018-2027. Medline abstract: 15703208

Wu, Q., et al. (2007). A role for Cdc2- and PP2A-mediated regulation of Emi2 in the maintenance of CSF arrest. Curr. Biol. 17: 213-224. Medline abstract: 17276914

Wuarin, J., et al. (2002). Stable association of mitotic Cyclin B/Cdc2 to replication origins prevents endoreduplication. Cell 111: 419-431. 12419251

Yamaguchi, S., Murakami, H. and Okayama, H. (1997). A WD repeat protein controls the cell cycle and differentiation by negatively regulating cdc2/B-type cyclin complexes. Mol. Biol. Cell 8(12): 2475-2486

Yamazoe, K., Inoue, Y. H. (2023). Cyclin B Export to the Cytoplasm via the Nup62 Subcomplex and Subsequent Rapid Nuclear Import Are Required for the Initiation of Drosophila Male Meiosis. Cells, 12(22) PubMed ID: 37998346

Zhang, L., Wei, Y., Pushel, I., Heinze, K., Elenbaas, J., Henry, R. W. and Arnosti, D. N. (2014). Integrated stability and activity control of the Drosophila Rbf1 retinoblastoma protein. J Biol Chem [Epub ahead of print]. PubMed ID: 25049232

Zhu, D., Dix, D. J. and Eddy, E. M. (1997). HSP70-2 is required for CDC2 kinase activity in meiosis I of mouse spermatocytes. Development 124(15): 3007-3014

Zhu, W., Giangrande, P. H. and Nevins, J. R. (2004) E2Fs link the control of G1/S and G2/M transcription. EMBO J. 23(23): 4615-26. 15510213

Zwicker, J., et al. (1995). Cell cycle regulation of the cyclin A, cdc25C and cdc2 genes is based on a common mechanism of transcriptional repression. EMBO J. 14: 4514-4522. PubMed Citation: 7556094

date revised: 22 August 2023

Home page: The Interactive Fly © 1997 Thomas B. Brody, Ph.D.

The Interactive Fly resides on the
Society for Developmental Biology's Web server.