myospheroid
Abe, M., et al. (2009). Membrane protein location-dependent regulation by PI3K (III) and rabenosyn-5 in Drosophila wing cells. PLoS ONE 4: e7306. PubMed ID: 19798413
Abraham, S., et al. (2008). Integrin β1 subunit controls mural cell adhesion, spreading, and blood vessel wall stability. Circ. Res. 102: 562-570. PubMed ID: 18202311
Alfandari, D., et al. (2003). Integrin alpha5ß1 supports the migration of Xenopus cranial neural crest on fibronectin. Dev. Biol. 260: 449-464. PubMed ID: 12921745
Anderson, M. J., Shi, Z. Q. and Zackson, S. L. (1997). Nerve-induced disruption and reformation of beta1-integrin aggregates during development of the neuromuscular junction. Mech. Dev. 67(2): 125-139. PubMed ID: 9392511
Aplin, A. E. and Juliano, R. L. (1999). Integrin and cytoskeletal regulation of growth factor signaling to the MAP kinase pathway. J. Cell Sci. 112 (Pt 5): 695-706. PubMed ID: 9973604
Anllo, L., Plasschaert, L. W., Sui, J. and DiNardo, S. (2018). Live imaging reveals hub cell assembly and compaction dynamics during morphogenesis of the Drosophila testis niche. Dev Biol. PubMed ID: 30553808
Araujo, H., Negreiros, E. and Bier, E. (2003). Integrins modulate Sog activity in the Drosophila wing. Development 130: 3851-3864. PubMed ID: 12835400
Ardini, E., et al. (1997). Co-regulation and physical association of the 67-kDa monomeric laminin receptor and the alpha6beta4 integrin. J. Biol. Chem. 272 (4): 2342-2345. PubMed ID: 8999943
Aszodi, A., et al. (2003). ß1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis. Genes Dev. 17: 2465-2479. PubMed ID: 14522949
Bagutti, C., et al. (2001). Dermal fibroblast-derived growth factors restore the ability of ß1 integrin-deficient embryonal stem cells to differentiate into keratinocytes. Dev. Bio. 231: 321-333. PubMed ID: 11237462
Baker, S. E., et al. (2002). Genetic interaction between integrins and moleskin, a gene encoding a Drosophila homolog of Importin-7. Genetics 162: 285-296. PubMed ID: 12242240
Barros, C. S., et al. (2009). Beta1 integrins are required for normal CNS myelination and promote AKT-dependent myelin outgrowth. Development 136(16): 2717-24. PubMed ID: 19633169
Barsukov, I. L., Prescot, A., Bate, N., Patel, B., Floyd, D. N., Bhanji, N., Bagshaw, C. R., Letinic, K., Di Paolo, G., De Camilli, P., Roberts, G. C. and Critchley, D. R. (2003). Phosphatidylinositol phosphate kinase type 1gamma and beta1-integrin cytoplasmic domain bind to the same region in the talin FERM domain. J. Biol. Chem. 278: 31202-31209. PubMed ID: 12782621
Bateman, J., et al. (2001). The receptor tyrosine phosphatase Dlar and integrins organize actin filaments in the Drosophila follicular epithelium. Curr. Biol. 11: 1317-1327. PubMed ID: 11553324
Baum, P. D. and Garriga, G. (1997). Neuronal migrations and axon fasciculation are disrupted in ina-1 integrin mutants. Neuron 19(1): 51-62. PubMed ID: 9247263
Belkin, A. M., et al. (1997). Muscle beta1D integrin reinforces the cytoskeleton-matrix link: modulation of integrin adhesive function by alternative splicing. J. Cell Biol. 139(6): 1583-1595. PubMed ID: 9396762
Berditchevski, F., Chang, S., Bodorova, J., and Hemler, M. E. (1997). Generation of monoclonal antibodies to integrin-associated proteins. Evidence that alpha 3beta1, (complexes with EMMPRIN/basigin/OX47/M6. J. Biol. Chem. 272: 29174-29180. PubMed ID: 9360995
Berti, C., et al. (2011). Non-redundant function of dystroglycan and β1 integrins in radial sorting of axons. Development 138(18): 4025-37. PubMed ID: 21862561
Beumer, K. J., et al. (1999). A role for PS integrins in morphological growth and synaptic function at the postembryonic neuromuscular junction of Drosophila. Development 126: 5833-5846. PubMed ID: 10572057
Beumer, K., Matthies, H. J. G., Bradshaw, A. and Broadie, K. (2002). Integrins regulate DLG/FAS2 via a CaM kinase II-dependent pathway to mediate synapse elaboration and stabilization during postembryonic development. Development 129: 3381-3391. PubMed ID: 12091308
Bhandari, P., Gargano, J. W., Goddeeris, M. M. and Grotewiel, M. S. (2006). Behavioral responses to odorants in Drosophila require nervous system expression of the β integrin gene myospheroid. Chem. Senses. 31(7): 627-39. PubMed ID: 16763085
Bharadwaj, R., Roy, M., Ohyama, T., Sivan-Loukianova, E., Delannoy, M., Lloyd, T. E., Zlatic, M., Eberl, D. F. and Kolodkin, A. L. (2013). Cbl-associated protein regulates assembly and function of two tension-sensing structures in Drosophila. Development 140: 627-638. PubMed ID: 23293294
Bialkowska, K., et al. (2000). Evidence that ß3 integrin-induced rac activation involves the calpain-dependent formation of integrin clusters that are distinct from the focal complexes and focal adhesions that form as rac and rhoa become active. J. Cell Bio. 151: 685-696. PubMed ID: 11062268
Billuart, P., Winter, C. G., Maresh, A., Zhao, X. and Luo, L. (2001). Regulating axon branch stability. the role of p190 RhoGAP in repressing a retraction signaling pathway. Cell 107(2): 195-207. PubMed ID: 11672527
Blair, S. S., et al. (1994). The role of apterous in the control of dorsoventral compartmentalization and PS integrin gene expression in the developing wing of Drosophila. Development 120: 1805-1815. PubMed ID: 7924988
Blanco-Bose, W. E. and Blau, H. M. (2001). Laminin-induced change in conformation of preexisting alpha7beta1 integrin signals secondary myofiber formation. Dev. Bio. 233: 148-160. PubMed ID: 11319864
Bloor, J. W. and Brown, N. H. (1998). Genetic analysis of the Drosophila alphaPS2 integrin subunit reveals discrete adhesive, morphogenetic and sarcomeric functions. Genetics 148(3): 1127-1142. PubMed ID: 9539430
Bloor, J. W. and Kiehart, D. P. (2001). zipper nonmuscle Myosin-II functions downstream of PS2 integrin in Drosophila myogenesis and is necessary for myofibril formation. Dev. Biol. 239: 215-228. PubMed ID: 11784030
Blystone, S. D., et al. (1995). Integrin beta 3 cytoplasmic tail is necessary and sufficient for regulation of alpha 5 beta 1 phagocytosis by alpha v beta 3 and integrin-associated protein. J. Cell Biol. 130(3): 745-54. PubMed ID: 7542659
Blystone S. D., et al. (1997). Requirement of integrin beta3 tyrosine 747 for beta3 tyrosine phosphorylation and regulation of alphavbeta3 avidity. J. Biol. Chem. 272(45): 28757-28761. PubMed ID: 9353346
Blystone, S. D., et al. (1999). A molecular mechanism of integrin crosstalk: alphavbeta3 suppression of Calcium/Calmodulin-dependent Protein Kinase II regulates alpha5beta1 function. J. Cell Biol. 145(4): 889-897. PubMed ID: 10330414
Bonar, N. A. and Petersen, C. P. (2017). Integrin suppresses neurogenesis and regulates brain tissue assembly in planarian regeneration. Development. PubMed ID: 28126842
Bouaouina, M., Jani, K., Long, J. Y., Czerniecki, S., Morse, E. M., Ellis, S. J., Tanentzapf, G., Schock, F. and Calderwood, D. A. (2012). Zasp regulates integrin activation. J Cell Sci 125: 5647-5657. PubMed ID: 22992465
Boube, M., et al. (2001). Specific tracheal migration is mediated by complementary expression of cell surface proteins. Genes Dev. 15: 1554-1562. PubMed ID: 11410535
Bradley, P. L., Myat, M. M., Comeaux, C. A. and Andrew, D. J. (2003). Posterior migration of the salivary gland requires an intact visceral mesoderm and integrin function. Dev. Biol. 257: 249-262. PubMed ID: 12729556
Brakebusch, C., et al. (2000). Skin and hair follicle integrity is crucially dependent on ß1 integrin expression on keratinocytes. EMBO J. 19: 3990-4003. PubMed ID: 10921880
Brower, D. L. and Jaffe, S. M. (1989). Requirement for integrins during Drosophila wing development. Nature 342: 285-7. PubMed ID: 2509946
Brower, D. L. (1995). Nonequivalent requirements for PS1 and PS2 integrin at cell attachments in Drosophila: genetic analysis of the alphaPS1 integrin subunit. Development 121: 1311-1320. PubMed ID: 7789263
Brown, N. H., King, D. L., Wilcox, M. and Kafatos, F. C. (1989). Developmentally regulated alternative splicing of Drosophila integrin PS2 alpha transcripts. Cell 59(1): 185-195. PubMed ID: 2507168
Brown, N. H., et al. (1993). Integrins and morphogenesis. Dev Suppl : 177-183. PubMed ID: 8049471
Brown, N. H. (1994). Null mutations in the alphaPS2 and betaPS integrin subunit genes have distinct phenotypes. Development 120: 1221-1231. PubMed ID: 17699602
Brown, N. H., et al. (2002). Talin Is Essential for Integrin Function in Drosophila Developmental Cell 3: 569-579. PubMed ID: 12408808
Bunch, T. A., et al. (1992). Characterization of mutant alleles of myospheroid, the gene encoding the beta subunit of the Drosophila PS integrins. Genetics 132(2): 519-528. PubMed ID: 1427041
Bunch, T. A., et al. (2006). Amino acid changes in Drosophila alphaPS2ßPS integrins that affect ligand affinity. J. Biol. Chem. 281: 5050-5057. PubMed ID: 16371365
Burgaya, F., et al. (1997). Alternatively spliced focal adhesion kinase in rat brain with increased autophosphorylation activity. J. Biol. Chem. 272(45): 28720-28725. PubMed ID: 9353341
Burkin, D. J., et al. (1998). A functional role for specific spliced variants of the alpha7beta1 integrin in acetylcholine receptor clustering. J. Cell Biol. 143(4): 1067-1075. PubMed ID: 9817762
Byzova, T. V. and Plow, E. F. (1998). Activation of alphaVbeta3 on vascular cells controls recognition of prothrombin. J. Cell Biol. 143(7): 2081-92. PubMed ID: 9864377
Cachaçol, A. S., et al. (2003). Knock-in of integrin ß1D affects primary but not secondary myogenesis in mice. Development 130: 1659-1671. PubMed ID: 12620989
Calderwood, D. A., et al. (2003). Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling. Proc. Natl. Acad. Sci. 100: 2272-2277. PubMed ID: 12606711
Cali G., et al. (1999). RhoA activity is required for fibronectin assembly and counteracts beta1B integrin inhibitory effect in FRT epithelial cells. J. Cell Sci. 112 ( Pt 6): 957-65
Campos, L. S., et al. (2004). ß1 integrins activate a MAPK signalling pathway in neural stem cells that contributes to their maintenance. Development 131: 3433-3444. PubMed ID: 15226259
Carroll, J. M., et al. (1998). Role of integrins in mouse eyelid development: studies in normal embryos and embryos in which there is a failure of eyelid fusion. Mech. Dev. 78(1-2): 37-45
Castrillon, D.H., Gonczy, P., Alexander, S., Rawson, R., Eberhart, C.G., Viswanathan, S., DiNardo, S., and Wasserman, S.A. (1993). Toward a molecular genetic analysis of spermatogenesis in Drosophila melanogaster: characterization of male-sterile mutants generated by single P element mutagenesis. Genetics 135: 489-505. PubMed ID: 8244010
Caswell, P. T., et al. (2007). Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments. Dev. Cell 13(4): 496-510. PubMed ID: 17925226
Chanana, B., Graf, R., Koledachkina, T., Pflanz, R. and Vorbruggen, G. (2007). αPS2 integrin-mediated muscle attachment in Drosophila requires the ECM protein Thrombospondin. Mech Dev. 124(6): 463-75. PubMed ID: 17482800
Chang, D. D., et al. (1997). ICAP-1, a novel beta1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of beta1 integrin. J. Cell Biol. 138(5): 1149-1157. PubMed ID: 9281591
Chen, D. Y., Li, M. Y., Wu, S. Y., Lin, Y. L., Tsai, S. P., Lai, P. L., Lin, Y. T., Kuo, J. C., Meng, T. C. and Chen, G. C. (2012). The Bro1-domain-containing protein Myopic/HDPTP coordinates with Rab4 to regulate cell adhesion and migration. J Cell Sci 125: 4841-4852. PubMed ID:22825871
Chen, M. S., et al. (1999). Evidence that distinct states of the integrin alpha6beta1 interact with Laminin and an ADAM. J. Cell Biol. 144(3): 549-561. PubMed ID: 9971748
Chicurel, M. E., et al. (1998). Integrin binding and mechanical tension induce movement of mRNA and ribosomes to focal adhesions. Nature 392(6677): 730-733. PubMed ID: 9565036
Chung, J., Gao, A. G. and Frazier, W. A. (1997). Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3. J. Biol. Chem. 272(23): 14740-6. PubMed ID: 9169439
Cingolani, L. A., et al. (2008). Activity-dependent regulation of synaptic AMPA receptor composition and abundance by β3 integrins. Neuron 58: 749-762. PubMed ID: 18549786
Clark, K. A., McGrail, M., and Beckerle, M. C. (2003). Analysis of PINCH function in Drosophila demonstrates its requirement in integrin-dependent cellular processes. Development 130(12): 2611-21. PubMed ID: 12736206
Condic, M. L. and Letourneau, P. C. (1997). Ligand-induced changes in integrin expression regulate neuronal adhesion and neurite outgrowth. Nature 389: 852-856. PubMed ID: 9349817
Cohen, M. W. Hoffstrom, B. G. and DeSimone, D. W. (2000). Active zones on motor nerve terminals contain alpha3 beta1 integrin. J Neurosci. 20(13):4912-21. PubMed ID: 10864949
Cox, E. A., Sastry, S. K. and Huttenlocher, A. (2001). Integrin-mediated adhesion regulates cell polarity and membrane protrusion through the rho family of GTPases. Mol. Biol. Cell 12: 265-277. PubMed ID: 11179414
Crawley, S., et al. (1997). The alpha7beta1 integrin mediates adhesion and migration of skeletal myoblasts on laminin. Exp. Cell Res. 235(1): 274-286. PubMed ID: 9281377
Curtin, K.D., Meinertzhagen, I. A. and Wyman, R. J. (2005). Basigin (EMMPRIN/CD147) interacts with integrin to affect cellular architecture. J. Cell Sci. 118: 2649-2660. PubMed ID: 15928045
Davidson, L. A., et al. (2002). Mesendoderm extension and mantle closure in Xenopus laevis gastrulation: combined roles for integrin alpha5 ß1, fibronectin, and tissue geometry. Dev. Biol. 242: 109-129. PubMed ID: 11820810
Defilippi, P., Di Stefano, P. and Cabodi, S. (2006). p130Cas: a versatile scaffold in signaling networks. Trends Cell Biol. 16: 257-263. PubMed ID: 16581250
Delcommenne. M., et al. (1998). Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proc. Natl. Acad. Sci. 95(19): 11211-6. PubMed ID: 9736715
Devenport, D. and Brown, N. H. (2004). Morphogenesis in the absence of integrins: mutation of both Drosophila ß subunits prevents midgut migration. Development 131: 5405-5415. PubMed ID: 15469969
Dominguez-Gimenez, P., Brown, N. H. and Martin-Bermudo, M. D. (2007). Integrin-ECM interactions regulate the changes in cell shape driving the morphogenesis of the Drosophila wing epithelium. J. Cell Sci. 120: 1061-1071. PubMed ID: 17327274
Dulabon, M. G. et al. (2000). Reelin binds alpha3beta1 integrin and inhibits neuronal migration. Neuron 27: 33-44. PubMed ID: 10939329
Egoz-Matia, N., et al. (2011). Spatial regulation of cell adhesion in the Drosophila wing is mediated by Delilah, a potent activator of βPS integrin expression. Dev. Biol. 351(1): 99-109. PubMed ID: 21215259
Emsley, J., et al. (2000). Structural basis of collagen recognition by integrin alpha2beta1. Cell 101: 47-56. PubMed ID: 10778855
Edenfeld, G., Altenhein, B., Zierau, A., Cleppien, D., Krukkert, K., Technau, G. and Klämbt, C. (2007). Notch and Numb are required for normal migration of peripheral glia in Drosophila. Dev. Biol. 301(1): 27-37. PubMed ID: 17157832
Ellis, S. J., Goult, B. T., Fairchild, M. J., Harris, N. J., Long, J., Lobo, P., Czerniecki, S., Van Petegem, F., Schock, F., Peifer, M. and Tanentzapf, G. (2013). Talin autoinhibition is required for morphogenesis. Curr Biol 23: 1825-1833. PubMed ID: 24012314
Fabbri, M., et al. (1999). A tyrosine-based sorting signal in the beta2 integrin cytoplasmic domain mediates its recycling to the plasma membrane and is required for ligand-supported migration. EMBO J.18: 4915-4925. PubMed ID: 10487744
Fahraeus, R. and Lane, D. P. (1999). The p16(INK4a) tumour suppressor protein inhibits alphavbeta3 integrin-mediated cell spreading on vitronectin by blocking PKC-dependent localization of alphavbeta3 to focal contacts. EMBO J. 18(8): 2106-2118. PubMed ID: 10205165
Falcioni, R., et al. (1997). alpha 6 beta 4 and alpha 6 beta 1 integrins associate with ErbB-2 in human carcinoma cell lines. Exp. Cell Res. 236(1): 76-85. PubMed ID: 9344587
Felding-Habermann, B., et al. (1997). A single immunoglobulin-like domain of the human neural cell adhesion molecule L1 supports adhesion by multiple vascular and platelet integrins. J. Cell Biol. 139(6): 1567-1581. PubMed ID: 9396761
Felsenfeld, D. P. and Schwartzberg, P. L. (1999). Selective regulation of integrin-cytoskeleton interactions by the tyrosine kinase Src. Nat. Cell Biol. 1: 200-206
Fenczik, C. A., et al. (1997). Complementation of dominant suppression implicates CD98 in integrin activation. Nature 389(6655): 81-85. PubMed ID: 9363894
Fernandez-Minan, A., Martín-Bermudo, M. D. and Gonzalez-Reyes, A. (2007). Integrin signaling regulates spindle orientation in Drosophila to preserve the follicular-epithelium monolayer. Curr. Biol. 17(8): 683-8. PubMed ID: 17363255
Figueiredo, J., Ferreira, R. M., Xu, H., Goncalves, M., Barros-Carvalho, A., Cravo, J., Maia, A. F., Carneiro, P., Figueiredo, C., Smith, M. L., Stamenovic, D., Morais-de-Sa, E. and Seruca, R. (2021). Integrin beta1 orchestrates the abnormal cell-matrix attachment and invasive behaviour of E-cadherin dysfunctional cells. Gastric Cancer. PubMed ID: 34486077
Fogerty, F. J., et al. (1994). Tiggrin, a novel Drosophila extracellular matrix protein that functions as a ligand for Drosophila alphaPS2 beta PS integrins. Development 120: 1747-1758. PubMed ID: 7924982
Fraichard, S., Bouge, A. L., Kendall, T., Chauvel, I., Bouhin, H. and Bunch, T. A. (2010). Tenectin is a novel alphaPS2betaPS integrin ligand required for wing morphogenesis and male genital looping in Drosophila. Dev Biol 340(2): 504-517. PubMed ID: 20152825
Frambrough, D., et al. (1996). The cell surface metalloprotease/disintegran Kuzbanian is required for axonal extension in Drosophila. Proc. Natl. Acad. Sci. 93: 13233-38. PubMed ID: 8917574
Fristrom, D., Wilcox, M. and Fristrom, J. (1993). The distribution of PS integrins, laminin A and F-actin during key stages in Drosophila wing development. Development 117: 509-23. PubMed ID: 8330522
Fristrom, D., et al. (1994). Blistered: a gene required for vein/intervein formation in wings of Drosophila. Development 120: 2661-71. PubMed ID: 7956840
Gao, A. G., et al. (1996). Integrin-associated protein is a receptor for the C-terminal domain of thrombospondin. J. Biol. Chem. 271(1): 21-4. PubMed ID: 8550562
Gao, J., et al. (1997). Regulation of the pp72(syk) protein tyrosine kinase by platelet integrin alphaIIbbeta3. EMBO J. 16(21): 6414-6425. PubMed ID: 8550562
Garciadiego-Cázares, D., et al. (2004). Coordination of chondrocyte differentiation and joint formation by alpha5ß1 integrin in the developing appendicular skeleton. Development 131: 4735-4742. PubMed ID: 15329344
Gilsohn, E. and Volk, T. (2010). Slowdown promotes muscle integrity by modulating integrin-mediated adhesion at the myotendinous junction. Development 137(5): 785-94. PubMed ID: 20110313
Geisbrecht, E. R., et al. (2008). Drosophila ELMO/CED-12 interacts with Myoblast city to direct myoblast fusion and ommatidial organization. Dev. Biol. 314(1): 137-49. PubMed ID: 18163987
Goodwin, K., Ellis, S. J., Lostchuck, E., Zulueta-Coarasa, T., Fernandez-Gonzalez, R. and Tanentzapf, G. (2016). Basal cell-extracellular matrix adhesion regulates force transmission during tissue morphogenesis. Dev Cell 39(5): 611-625. PubMed ID: 27923121
Gomez-Lamarca, M. J., Cobreros-Reguera, L., Ibanez-Jimenez, B., Palacios, I. M. and Martin-Bermudo, M. D. (2014). Integrins regulate epithelial cell differentiation by modulating Notch activity. J Cell Sci [Epub ahead of print]. PubMed ID: 25179603
Gotwals, P. J., et al. (1994a). Drosophila PS1 integrin is a laminin receptor and differs in ligand specificity from PS2. Proc. Natl. Acad. Sci. 91: 11447-51. PubMed ID: 7972082
Gotwals, P. J., et al. (1994b). Drosophila integrins and their ligands. Curr Opin Cell Biol 6: 734-739. PubMed ID: 7972082
Graner, M. W., Bunch, T. A., Baumgartner, S., Kerschen, A. and Brower, D. L. (1998). Splice variants of the Drosophila PS2 integrins differentially interact with RGD-containing fragments of the extracellular proteins tiggrin, ten-m, and D-laminin 2. J. Biol. Chem. 273: 18235-18241. PubMed ID: 9660786
Grose, R., et al. (2002). A crucial role of ß1 integrins for keratinocyte migration in vitro and during cutaneous wound repair. Development 129: 2303-2315. PubMed ID: 11959837
Gu, J., Tamura, M. and Yamada, K. M. (1998). Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways. J. Cell Biol. 143(5): 1375-83
Haack, H. and Hynes, R. O. (2001). Integrin receptors are required for cell survival and proliferation during development of the peripheral glial lineage. Dev. Biol. 233: 38-55. PubMed ID: 11319856
Hagedorn, E. J., et al. (2009). Integrin acts upstream of netrin signaling to regulate formation of the anchor cell's invasive membrane in C. elegans. Dev. Cell 17(2): 187-98. PubMed ID: 19686680
Hayflick, J. S., et al. (1997). Functional mapping of the cytoplasmic region of intercellular adhesion molecule-3 reveals important roles for serine residues. J. Biol. Chem. 272(35): 22207-22214. PubMed ID: 9268366
Hidai, C., et al., (1998). Cloning and characterization of developmental endothelial locus-1: An embryonic endothelial cell protein that binds the alphavbeta3 integrin receptor. Genes Dev. 12(1): 21-33. PubMed ID: 9420328
Hierck, B. P., et al. (1996). Differential expression of alpha-6 and other subunits of laminin binding integrins during development of the murine heart. Dev. Dyn. 206 (1): 100-111
Hirano, S., et al. (1991). Drosophila PS integrins recognize vertebrate vitronectin and function as cell-substratum adhesion receptors in vitro. Development 113: 1007-16. PubMed ID: 1726562
Ho, E., Irvine, T., Vilk, G. J., Lajoie, G., Ravichandran, K. S., D'Souza, S. J. and Dagnino, L. (2009). Integrin-linked kinase interactions with ELMO2 modulate cell polarity. Mol Biol Cell 20: 3033-3043. PubMed ID: 19439446
Hoang, B. and Chiba, A. (1998). Genetic analysis on the role of integrin during axon guidance in Drosophila. J. Neurosci. 18(19): 7847-55. PubMed ID: 9742153
Hocking, D. C., Sottile, J., McKeown-Longo. P. J. (1998). Activation of distinct alpha5 beta1-mediated signaling pathways by fibronectin's cell adhesion and matrix assembly domains. J. Cell Biol. 141(1): 241-253. PubMed ID: 98198481
Hodivala-Dilke, K. M., et al. (1998). Novel roles for alpha3beta1 integrin as a regulator of cytoskeletal assembly and as a trans-dominant inhibitor of integrin receptor function in mouse keratinocytes. J. Cell Biol. 142(5): 1357-69. PubMed ID: 9732295
Huang, A. M., et al. (1998). Expression of integrin-associated protein gene associated with memory formation in rats. J. Neurosci. 18(11): 4305-4313. PubMed ID: 9592107
Huang, Z., et al. (2007). Crk-associated substrate (Cas) signaling protein functions with integrins to specify axon guidance during development. Development 134(12): 2337-47. PubMed ID: 17537798
Hughes, A. L. (2001). Evolution of the integrins α and β protein family. J. Mol. Evol. 52: 63-72. PubMed ID: 11139295
Hughes, P. E., et al. (1997). Suppression of integrin activation: a novel function of a Ras/Raf-initiated MAP kinase activity. Cell 88: 521-530
Hutson M. S., Tokutake, Y., Chang, M. S., Bloor, J. W., Venakides, S., Kiehart, D. P. and Edwards, G. S. (2003). Forces for morphogenesis investigated with laser microsurgery and quantitative modeling. Science 300: 145-149. PubMed ID: 12574496
Huttenlocher, A., et al. (1997). Regulation of cell migration by the calcium-dependent protease calpain. J. Biol. Chem. 272(52): 32719-22. PubMed ID: 9407041
Ieda, M., et al. (2009). Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling. Dev. Cell 16(2): 233-44. PubMed ID: 19217425
Jacques, T. S., et al. (1998). Neural precursor cell chain migration and division are regulated through different beta1 integrins. Development 125(16): 3167-3177
James, B. P., Bunch, T. A., Krishnamoorthy, S., Perkins, L. A. and Brower, D. L. (2007). Nuclear localization of the ERK MAP kinase mediated by Drosophila alphaPS2betaPS integrin and importin-7. Mol. Biol. Cell 18(10): 4190-9. PubMed ID: 17699602
Jaumouille, E., Machado Almeida, P., Stahli, P., Koch, R. and Nagoshi, E. (2015). Transcriptional regulation via nuclear receptor crosstalk required for the Drosophila circadian clock. Curr Biol 25: 1502-1508. PubMed ID: 26004759
Jiang, R. and Grabel, L. B. (1995). Function and differential regulation of the alpha 6 integrin isoforms during parietal endoderm differentiation. Exp. Cell. Res. 217 (2): 195-204. PubMed ID: 7698219
Jones, P. L., Crack, J. and Rabinovitch, M. (1997). Regulation of Tenascin-C, a vascular smooth muscle cell survival factor that interacts with the alphavbeta3 Integrin to promote epidermal growth factor receptor phosphorylation and growth. J. Cell Biol. 139: 279-293. PubMed ID: 9314546
Jones, P. L., et al. (1999). Induction of vascular smooth muscle cell tenascin-C gene expression by denatured type I collagen is dependent upon a beta3 integrin-mediated mitogen-activated protein kinase pathway and a 122-base pair promoter element. J. Cell Sci. 112 (Pt 4): 435-45. PubMed ID: 9914156
Katz, B. Z., Zohar, M., Teramoto, H., Matsumoto, K., Gutkind, J. S., Lin, D. C., Lin, S. and Yamada, K. M. (2000). Tensin can induce JNK and p38 activation. Biochem. Biophys. Res. Commun. 272: 717-720. PubMed ID: 10860821
Kauselmann, G. et al. (1999). The polo-like protein kinases Fnk and Snk associate with a Ca2+- and integrin-binding protein and are regulated dynamically with synaptic plasticity. EMBO J. 18: 5528-5539. PubMed ID: 10523297
Kemperman, H., Wijnands, Y. M. and Roos, E. (1997). alphaV Integrins on HT-29 colon carcinoma cells: adhesion to fibronectin is mediated solely by small amounts of alphaVbeta6, and alphaVbeta5 is codistributed with actin fibers. Exp. Cell Res. 234(1): 156-164. PubMed ID: 9223381
Kendall, T., Mukai, L., Jannuzi, A. L. and Bunch, T. A. (2011). Identification of integrin beta subunit mutations that alter affinity for extracellular matrix ligand. J. Biol. Chem. 286(35): 30981-93. PubMed ID: 21757698
Kim, S. N., Jeibmann, A., Halama, K., Witte, H. T., Walte, M., Matzat, T., Schillers, H., Faber, C., Senner, V., Paulus, W. and Klambt, C. (2014). ECM stiffness regulates glial migration in Drosophila and mammalian glioma models. Development 141: 3233-3242. PubMed ID: 25063458
Kivens, W. J., et al. (1998). Identification of a proline-rich sequence in the CD2 cytoplasmic domain critical for regulation of integrin-mediated adhesion and activation of phosphoinositide 3-kinase. Mol. Cell. Biol. 18(9): 5291-307. PubMed ID: 9710614
Klinghoffer, R. A., et al. (1999). Src family kinases are required for integrin but not PDGFR signal transduction. EMBO J. 18(9): 2459-2471. PubMed ID: 10228160
Klinowska, T. C., et al. (1999). Laminin and beta1 integrins are crucial for normal mammary gland development in the mouse. Dev. Biol. 215(1): 13-32. PubMed ID: 10525347
Kogata, N., et al. (2009). Integrin-linked kinase controls vascular wall formation by negatively regulating Rho/ROCK-mediated vascular smooth muscle cell contraction. Genes Dev. 23: 2278-2283. PubMed ID: 19797768
Kozlova, T. and Thummel, C. S. (2003). Essential roles for ecdysone signaling during Drosophila mid-embryonic development. Science 301: 1911-1914. PubMed ID: 12958367
Kulkarni, S., et al. (1999). Calpain mediates integrin-induced signaling at a point upstream of Rho family members. J. Biol. Chem. 274(30): 21265-75. PubMed ID: 10409684
LaBeau-DiMenna, E. M., Clark, K. A., Bauman, K. D., Parker, D. S., Cripps, R. M. and Geisbrecht, E. R. (2012). Thin, a Trim32 ortholog, is essential for myofibril stability and is required for the integrity of the costamere in Drosophila. Proc Natl Acad Sci U S A 109: 17983-17988. PubMed ID: 23071324
Lampe, P. D., et al. (1998). Cellular interaction of integrin alpha3beta1 with laminin 5 promotes gap junctional communication. J. Cell Biol. 143(6): 1735-47
Lee, S. B., et al. (2003). blistery encodes Drosophila tensin protein and interacts with integrin and the JNK signaling pathway during wing development. Development 130: 4001-4010. PubMed ID: 12874122
Lee, S., Zhou, L., Kim, J., Kalbfleisch, S. and Schock F. (2008). Lasp anchors the Drosophila male stem cell niche and mediates spermatid individualization. Mech. Dev. 125(9-10): 768-76. PubMed ID: 18655828
Leenders, W. P., et al. (1997). Synergism between temporally distinct growth factors: bFGF, insulin and lens cell differentiation. Mech. Dev. 67(2): 193-201.
Leptin, M., et al. (1989). The function of PS integrins during Drosophila embryogenesis. Cell 56: 401-8. PubMed ID: 89119562
Leu, S. T., et al. (2004). Integrin alpha4beta1 function is required for cell survival in developing retina. Dev. Biol. 276(2): 416-30. PubMed ID: 15581875
Levi, B. P., Ghabrial, A. S. and Krasnow, M. A. (2006). Drosophila talin and integrin genes are required for maintenance of tracheal terminal branches and luminal organization. Development 133(12): 2383-93. PubMed ID: 16720877
Lewis, J. M., et al. (1996). Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic-nuclear transport. Proc. Natl. Acad. Sci 93: 15174-79.
Li, J., et al. (2005). Phosphorylation of ACAP1 by Akt regulates the stimulation-dependent recycling of Integrin β1 to control cell migration. Dev. Cell 9: 663-673. PubMed ID: 16256741
Li, N., et al. (2005). Beta1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoli. EMBO J. 24: 1942-1953. PubMed ID: 15889143
Li, R., Mitra, N., Gratkowski, H., Vilaire, G., Litvinov, R., Nagasami, C., Weisel, J. W., Lear, J. D., DeGrado, W. F. and Bennett, J. S. (2003). Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations. Science 300: 795-798. PubMed ID: 12730600
Li, X., et al. (1998). Requirements for the cytoplasmic domain of the (alpha)PS1, (alpha)PS2 and ßPS integrin subunits during Drosophila development. Development 125(4): 701-711. PubMed ID:
Lia, M. and Sakaguchi, D. S. (2004). Inhibition of integrin-mediated adhesion and signaling disrupts retinal development. Dev. Biol. 275: 202-214. PubMed ID: 15464583
Lin, G., Zhang, X., Ren, J., Pang, Z., Wang, C., Xu, N. and Xi, R. (2013). Integrin signaling is required for maintenance and proliferation of intestinal stem cells in Drosophila. Dev Biol 377: 177-187. PubMed ID: 23410794
Lindberg, F. P., et al. (1993). Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane-spanning domains implicated in alpha v beta 3-dependent ligand binding. J. Cell Biol. 123(2): 485-96. PubMed ID: 7691831
Lindberg, F. P., et al. (1996). Integrin-associated protein immunoglobulin domain is necessary for efficient vitronectin bead binding. J. Cell Biol. 134(5): 1313-22. PubMed ID: 8794870
Linton, J. M., Martin, G. R. and Reichardt, L. F. (2007). The ECM protein nephronectin promotes kidney development via integrin α8β1-mediated stimulation of Gdnf expression. Development 134: 2501-2509. PubMed ID: 17537792
Lipfert, L., et al. (1992). Integrin-dependent phorphorylation and activation of the protein tyrosine kinase pp 125 FAK in platelets. J. Cell Biol 119: 905-912
Liu, Y., et al. (2009). Coordinate integrin and c-Met signaling regulate Wnt gene expression during epithelial morphogenesis. Development 136(5): 843-53. PubMed ID: 19176588
Liu, Z. C., and Geisbrecht, E. R. (2011). Moleskin is essential for the formation of the myotendinous junction in Drosophila. Dev. Biol. 359: 176-189. PubMed ID: 21925492
Liu, Z. C., Odell, N. and Geisbrecht, E. R. (2013). Drosophila Importin-7 functions upstream of the Elmo signaling module to mediate the formation and stability of muscle attachments. J Cell Sci. PubMed ID: 24046451
Llense, F. and MartÌn-Blanco, E. (2008). JNK signaling controls border cell cluster integrity and collective cell migration. Curr. Biol. 18(7): 538-44. PubMed ID: 18394890
Longley, R. L. and Ready, D. F. (1995). Integrins and the development of three-dimensional structure in the Drosophila compound eye. Dev. Biol. 171: 415-433. PubMed ID: 7556924
Lyman, S., et al. (1997). Integrin-mediated activation of focal adhesion kinase is independent of focal adhesion formation or integrin activation. Studies with activated and inhibitory beta3 cytoplasmic domain mutants. J. Biol. Chem. 272(36): 22538-22547. PubMed ID: 9278407
Lynch, H. E., Crews, S. M., Rosenthal, B., Kim, E., Gish, R., Echiverri, K. and Hutson, M. S. (2013). Cellular mechanics of germ band retraction in Drosophila. Dev Biol. 384(2): 205-13. PubMed ID: 24135149
MacKrell, A. J., et al. (1988). The lethal myospheroid gene of Drosophila encodes a membrane protein homologous to vertebrate integrin beta subunits. Proc. Natl. Acad. Sci. 85: 2633-7. PubMed ID: 3128792
Mainiero, F., et al. (1995). Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes. EMBO J. 14 (18): 4470-4481. PubMed ID: 7556090
Mainiero, F., et al. (1997). The coupling of alpha6beta4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation. EMBO J. 16 (9): 2365-2375. PubMed ID: 9171350
Malan, D., et al. (2010). Endothelial β1 integrins regulate sprouting and network formation during vascular development. Development 137(6): 993-1002. PubMed ID: 20179098
Marsden, M., and Burke, R. D. (1997). Cloning and characterization of novel ß integrin subunits from a Sea Urchin. Dev. Biol. 181: 234-245. PubMed ID: 9013933
Martin, P. T. and Sanes, J. R. (1997). Integrins mediate adhesion to agrin and modulate agrin signaling. Development 124(19): 3909-3917. PubMed ID: 9367446
Martin-Bermudo, M. D. and Brown, N. H. (1996) Intracellular signals direct integrin localization to sites of function in embryonic muscles. J. Cell Biol. 134: 217-226. PubMed ID: 8698816
Martin-Bermudo, M. D., Dunin-Borkowski, O. M. and Brown, N. H. (1997). Specificity of PS integrin function during embryogenesis resides in the α subunit extracellular domain. EMBO 16: 4184-4193. PubMed ID: 9250662
Martin-Bermudo, M. D. and Brown, N. H. (1999a). Uncoupling integrin adhesion and signaling: the betaPS cytoplasmic domain is sufficient to regulate gene expression in the Drosophila embryo. Genes Dev. 13(6): 729-39. PubMed ID: 10090729
Martin-Bermudo, M. D. Alvarez-Garcia, I and Brown, N. H. (1999b). Migration of the Drosophila primordial midgut cells requires coordination of diverse PS integrin functions. Development 126: 5161-5169. PubMed ID: 10529432
Martin-Bermudo, M. D. (2000a). Integrins modulate the Egfr signaling pathway to regulate tendon cell differentiation in the Drosophila embryo. Development 127(12): 2607-15. PubMed ID: 10821759
Martin-Bermudo, M. D. and Brown, N. H. (2000b). The localized assembly of extracellular matrix integrin ligands requires cell-cell contact. J Cell Sci. 113 Pt 21: 3715-23. PubMed ID: 11034900
Martin-Blanco, E., Gampel, A., Ring, J., Virdee, K., Kirov, N., Tolkovsky, A.M., and Martinez-Arias, A. (1998). puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila. Genes Dev. 12: 557-570. PubMed ID: 9472024
Maruthamuthu, V., Sabass, B., Schwarz, U. S. and Gardel, M. L. (2011). Cell-ECM traction force modulates endogenous tension at cell-cell contacts. Proc Natl Acad Sci U S A 108(12): 4708-4713. PubMed ID: 21383129
Mawby, W. J., et al. (1994). Isolation and characterization of CD47 glycoprotein: a multispanning membrane protein which is the same as integrin-associated protein (IAP) and the ovarian tumour marker OA3. Biochem. J. 304: 525-30. PubMed ID: 7998989
McMahon, A., Supatto, W., Fraser S. E. and Stathopoulos, A. (2008). Dynamic analyses of Drosophila gastrulation provide insights into collective cell migration. Science 322: 1546-1550. PubMed ID: 19056986
McMahon, A., Reeves, G. T., Supatto, W. and Stathopoulos, A. (2010). Mesoderm migration in Drosophila is a multi-step process requiring FGF signaling and integrin activity. Development 137(13): 2167-75. PubMed ID: 20530544
Meng, F. and Lowell, C. A. (1998). A beta1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration EMBO J. 17: 4391-4403. PubMed ID: 9687507
Mettouchi, A., et al. (2001). Integrin-specific activation of Rac controls progression through the G1 phase of the cell cycle. Mol. Cell 8: 115-127. PubMed ID: 11511365
Miranti, C. K., et al. (1998). Identification of a novel integrin signaling pathway involving the kinase syk and the guanine nucleotide exchange factor vav1. Curr. Biol. 8(24): 1289-99. PubMed ID: 9843681
Miranti, C. K., Ohno, S. and Brugge, J. S. (1999). Protein kinase C regulates integrin-induced activation of the extracellular regulated kinase pathway upstream of Shc. J. Biol. Chem. 274(15): 10571-81. PubMed ID: 10187852
Monier-Gavelle, F. and Duband, J. L. (1997). Cross talk between adhesion molecules: control of N-cadherin activity by intracellular signals elicited by beta1 and beta3 integrins in migrating neural crest cells. J. Cell Biol. 137(7):1663-1681. PubMed ID: 9199179
Montagne, J., et al. (1996). The Drosophila Serum Response Factor gene is required for the formation of the intervein tissue of the wing and is allelic to blistered. Development 122: 2589-97. PubMed ID: 8787734
Moro L., et al. (1998). Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion-dependent cell survival. EMBO J. 17(22): 6622-32. PubMed ID: 9822606
Mould, A. P., et al. (1997). Defining the topology of integrin alpha5beta1-fibronectin interactions using inhibitory anti-alpha5 and anti-beta1 monoclonal antibodies. Evidence that the synergy sequence of fibronectin is recognized by the amino-terminal repeats of the alpha5 subunit. J. Biol. Chem. 272(28): 17283-17292. PubMed ID: 9211865
Moyano, J. V., et al. (1997). Fibronectin type III5 repeat contains a novel cell adhesion sequence, KLDAPT, which binds activated alpha4beta1 and alpha4beta7 integrins. J. Biol. Chem. 272(40): 24832-24836. PubMed ID: 9312081
Muller, U., et al. (1997). Integrin alpha8beta1 is critically important for epithelial-mesenchymal interactions during kidney morphogenesis. Cell 88 (5): 603-613. PubMed ID: 9054500
Munger, J. S., et al. (1998). Interactions between growth factors and integrins: latent forms of transforming growth factor-beta are ligands for the integrin alphavbeta1. Mol. Biol. Cell 9(9): 2627-38. PubMed ID: 9725916
Murakami, S., et al. (2007). Focal adhesion kinase controls morphogenesis of the Drosophila optic stalk. Development 134: 1539-1548. PubMed ID: 17360775
Murgia, C., et al. (1998). Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain. EMBO J. 17(14): 3940-3951
Continued: References part 2/2
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