Division of Molecular and Cellular Biology (DMCB) is seeking an enthusiastic postdoctoral fellow to study molecular mechanisms behind pathologies associated with mutations in the nuclear pore complex constituents.
The nuclear pore complex (NPC) is a multiprotein channel through the nuclear envelope that permits selective transport of macromolecules between the nucleus and cytoplasm. Beyond nucleocytoplasmic trafficking, the NPC plays important roles in chromosome organization, transcriptional control, RNA processing, and cell-cycle control.
The project will utilize CRISPR/Cas9-based methods to analyze the function of nucleoporins, individual constituent proteins of the NPC. The project will also employ a range of other cell biological, bioinformatic and biochemical approaches, and may use Drosophila melanogaster as a model genetic system to analyze nucleoporin function. The long-term goal of this project is to understand physiological roles of individual nucleoporins and how disease-associated mutations in NPC subunits cause human pathology.
Skills and Qualification:
To apply, please email CV, summary of research interests and three letters of reference to Mary Dasso (email@example.com).
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