The Alfandari lab, studies the regulation of cell migration during early frog development. Our current research focuses on the role of ADAM metalloproteases in cranial neural crest cell migration.
We are interested in how cells become sequentially determined to more precisely defined fates during vertebrate embryonic development, and how this process depends upon cell position and upon interactions among neighboring cells.
We are interested in how cells become sequentially determined to more precisely defined fates during vertebrate embryonic development, and how this process depends upon cell position and upon interactions among neighboring cells.
The Antin lab studies lineage diversification and morphogenesis in the chicken embryo.
Our lab studies the function and evolution of multipotency and gene regulatory networks in indirectly developing sea urchins and polychaetes
The Arur Lab studies germ cell development and developmental signaling events underlying co-ordinated progression of oogenesis in Caenorhabditis elegans.
research is focused on embryonic skin development and spans the developmental period of dermal cell induction including adult patterning of skin. There is relatively little known about the genetic and cellular events that lead to the acquisition of dermal identity. Our goal is to identify the genetic pathways that confer dermal cell identity which subsequently drives the development of various skin appendages such as hair follicles. We are currently using transgenic mice and conditional mouse mutants to address questions of dermal cell origin and signaling requirements for dermal cell development.
Uses the zebrafish model system to study axon guidance, axon-glial interactions, and the regulation of neural stem cell proliferation and differentiation. Created the "Biology Web Conferences" as an online resource of recorded video conferences between undergraduate students and the principle investigators behind the much of the current and seminal research in the field of developmental Biology.
The Barsi Lab aims to explain the mechanism by which genomic information is translated into anatomical structure. At its core, we study transcriptional control mechanisms. Experiments are directed at all levels of biological organization, ranging from transcription-factor DNA interactions that control spatial & temporal gene expression, up to a systems-level analysis of large regulatory networks. For our studies, we develop marine invertebrates into model organisms and exploit third-generation sequencing to decipher the transcriptional cis-regulatory code.
Focuses on the molecular and cellular mechanisms that lead to the formation of the mammalian body plan, the genesis of tissues and organs during embryogenesis and the pathology of developmental defects.
We use a combination of genetics, live cell imaging and large-scale transcriptional approaches to understand the interplay of asymmetric cell divisions, cell-cell communication and environmental inputs in the generation of cell fate and pattern in the plant epidermis.
Internationally known for establishing the plasticity of the differentiated state. Dr. Blau's elegant heterokaryon experiments proved that silent muscle genes could be activated in diverse specialized adult cells. Recently she showed that adult bone-marrow-derived stem cells are similarly plastic. Her innovative approaches have profoundly impacted biology and medicine.
The Brown lab wishes to understand the molecular mechanisms and genetic pathways regulating mammalian lens and retina development.
We are interested in organ morphogenesis and patterning. We are specifically focused on left-right patterning and the role of Nodal signaling in this process. Additionally we are interested in understanding how cilia function in development, both in left-right patterning and in kidney cyst formation.
Research interests include middle ear induction and patterning, the role of Fgfs in inner ear patterning and tail organiser function in avians.
Development of the cardiovascular system of zebrafish, with a particluar interest in angiogenesis and vascular integrity
The Chitnis lab studies how interactions between cells during early development lead to the self-organization of a functional nervous system in zebrafish. The laboratory uses a combination of cellular, molecular and genetic tools to identify genetic regulatory networks that direct early development in the nervous system. We also build computational models to understand how interactions identified through biological experiments lead to the emergence of patterned development. Current projects are directed toward understanding the genetic regulatory networks that coordinate cell fate and morphogenesis during development of the zebrafish hindbrain and the lateral line system.
The Clements laboratory uses zebrafish to investigate two major questions: What are the molecular and cellular components of the developmental specification niche for hematopoietic stem cells (HSCs)? How are normal signaling pathways co-opted during malignant transformation to induce cellular proliferation and migration—desirable processes when building an organism that can cause disease when activated in adult life?
Our research on sea urchin embryogenesis seeks to define genomic and cell physiological regulatory systems that control cell proliferation, differentiation, and the developmental specification of cell fate.
We use genetics and time-lapse imaging in zebrafish to study the three-dimensional patterning of the vertebrate head skeleton. In addition, we are interested in the origins of the skeletogenic neural crest and their role in tissue regeneration.
We study cell lineage specification and embry-maternal signaling in the laboratory opossum, /Mondelphis domestica/.
manages the GEISHA database (Gallus Expression In Situ Hybridization Analysis) with PI Parker Antin. The goal is to provide a comprehensive collection of embryonic chick gene expression images and associated metadata.
Our group works on the cellular mechanics and the physical mechanisms of morphogenesis. Our goals are to unravel the physical mechanical principles of tissue morphogenesis and to use these principles to control tissue assembly
The de Bellard lab works on neural crest and glial cell migration and evolution.
studies the development of zebrafish muscle cell identity.